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Protein

Suppressor of cytokine signaling 5

Gene

Socs5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: MGI
  • kinase inhibitor activity Source: UniProtKB
  • protein kinase inhibitor activity Source: GO_Central
  • receptor tyrosine kinase binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processGrowth regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-6785807 Interleukin-4 and Interleukin-13 signaling
R-MMU-8951664 Neddylation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of cytokine signaling 5
Short name:
SOCS-5
Alternative name(s):
Cytokine-inducible SH2-containing protein 5
Gene namesi
Name:Socs5
Synonyms:Cish5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2385459 Socs5

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001812501 – 536Suppressor of cytokine signaling 5Add BLAST536

Post-translational modificationi

Phosphorylated. Phosphorylation is induced by EGF (By similarity).By similarity

Proteomic databases

PaxDbiO54928
PRIDEiO54928

PTM databases

iPTMnetiO54928
PhosphoSitePlusiO54928
SwissPalmiO54928

Expressioni

Tissue specificityi

Widely expressed. Expressed in TH1 but not TH2 cells.1 Publication

Developmental stagei

During embryonic development, expressed from mid-to-late gestation and in yolk sac.

Inductioni

By a subset of cytokines including IL6 and LIF.

Gene expression databases

BgeeiENSMUSG00000037104 Expressed in 270 organ(s), highest expression level in substantia nigra
CleanExiMM_SOCS5
GenevisibleiO54928 MM

Interactioni

Subunit structurei

Interacts with EGFR. Interacts with ELOB and ELOC; mediates EGFR ubiquitination and degradation (By similarity). Interacts with IL4R; inhibits IL4 signaling.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208004, 9 interactors
MINTiO54928
STRINGi10090.ENSMUSP00000038591

Structurei

Secondary structure

1536
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO54928
SMRiO54928
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini381 – 476SH2PROSITE-ProRule annotationAdd BLAST96
Domaini471 – 520SOCS boxPROSITE-ProRule annotationAdd BLAST50

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 50Required for interaction with IL4RAdd BLAST50

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
GeneTreeiENSGT00760000119136
HOGENOMiHOG000027791
HOVERGENiHBG054138
InParanoidiO54928
KOiK04698
OMAiQVSGDSH
OrthoDBiEOG091G0EQ0
TreeFamiTF321368

Family and domain databases

CDDicd03739 SOCS_SOCS5, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR022252 SOCS4/SOCS5_dom
IPR028420 SOCS5
IPR037343 SOCS5_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR44282:SF3 PTHR44282:SF3, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF12610 SOCS, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit

Sequencei

Sequence statusi: Complete.

O54928-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKVGKMWNN LKYRCQNLFS HEGGSRNENV EMNPNRCPSV KEKSISLGEA
60 70 80 90 100
APQQESSPLR ENVALQLGLS PSKTFSRRNQ NCAAEIPQVV EISIEKDSDS
110 120 130 140 150
GATPGTRLAR RDSYSRHAPW GGKKKHSCST KTQSSLDTEK KFGRTRSGLQ
160 170 180 190 200
RRERRYGVSS MQDMDSVSSR AVGSRSLRQR LQDTVGLCFP MRTYSKQSKP
210 220 230 240 250
LFSNKRKIHL SELMLEKCPF PAGSDLAQKW HLIKQHTAPV SPHSTFFDTF
260 270 280 290 300
DPSLVSTEDE EDRLRERRRL SIEEGVDPPP NAQIHTFEAT AQVNPLYKLG
310 320 330 340 350
PKLAPGMTEI SGDGSAIPQT NCDSEEDSTT LCLQSRRQKQ RQVSGDSHAH
360 370 380 390 400
VSRQGAWKVH TQIDYIHCLV PDLLQITGNP CYWGVMDRYE AEALLEGKPE
410 420 430 440 450
GTFLLRDSAQ EDYLFSVSFR RYNRSLHARI EQWNHNFSFD AHDPCVFHSS
460 470 480 490 500
TVTGLLEHYK DPSSCMFFEP LLTISLNRTF PFSLQYICRA VICRCTTYDG
510 520 530
IDGLPLPSML QDFLKEYHYK QKVRVRWLER EPVKAK
Length:536
Mass (Da):61,086
Last modified:July 27, 2011 - v2
Checksum:iB63AD64BC8CEE254
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171A → T in AAB96648 (PubMed:9419338).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033187 mRNA Translation: AAB96648.1
AY902348 Genomic DNA Translation: AAY21058.1
CH466537 Genomic DNA Translation: EDL38623.1
BC053015 mRNA Translation: AAH53015.1
CCDSiCCDS29014.1
RefSeqiNP_062628.2, NM_019654.2
XP_006524734.1, XM_006524671.3
XP_006524735.1, XM_006524672.3
XP_006524737.1, XM_006524674.3
XP_006524738.1, XM_006524675.3
UniGeneiMm.126885

Genome annotation databases

EnsembliENSMUST00000041369; ENSMUSP00000038591; ENSMUSG00000037104
GeneIDi56468
KEGGimmu:56468
UCSCiuc008dup.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033187 mRNA Translation: AAB96648.1
AY902348 Genomic DNA Translation: AAY21058.1
CH466537 Genomic DNA Translation: EDL38623.1
BC053015 mRNA Translation: AAH53015.1
CCDSiCCDS29014.1
RefSeqiNP_062628.2, NM_019654.2
XP_006524734.1, XM_006524671.3
XP_006524735.1, XM_006524672.3
XP_006524737.1, XM_006524674.3
XP_006524738.1, XM_006524675.3
UniGeneiMm.126885

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N34NMR-A175-244[»]
ProteinModelPortaliO54928
SMRiO54928
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208004, 9 interactors
MINTiO54928
STRINGi10090.ENSMUSP00000038591

PTM databases

iPTMnetiO54928
PhosphoSitePlusiO54928
SwissPalmiO54928

Proteomic databases

PaxDbiO54928
PRIDEiO54928

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041369; ENSMUSP00000038591; ENSMUSG00000037104
GeneIDi56468
KEGGimmu:56468
UCSCiuc008dup.2 mouse

Organism-specific databases

CTDi9655
MGIiMGI:2385459 Socs5

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
GeneTreeiENSGT00760000119136
HOGENOMiHOG000027791
HOVERGENiHBG054138
InParanoidiO54928
KOiK04698
OMAiQVSGDSH
OrthoDBiEOG091G0EQ0
TreeFamiTF321368

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-6785807 Interleukin-4 and Interleukin-13 signaling
R-MMU-8951664 Neddylation

Miscellaneous databases

PROiPR:O54928
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037104 Expressed in 270 organ(s), highest expression level in substantia nigra
CleanExiMM_SOCS5
GenevisibleiO54928 MM

Family and domain databases

CDDicd03739 SOCS_SOCS5, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR022252 SOCS4/SOCS5_dom
IPR028420 SOCS5
IPR037343 SOCS5_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR44282:SF3 PTHR44282:SF3, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF12610 SOCS, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOCS5_MOUSE
AccessioniPrimary (citable) accession number: O54928
Secondary accession number(s): Q7TSK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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