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Protein

WD repeat and SOCS box-containing protein 1

Gene

Wsb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat and SOCS box-containing protein 1
Short name:
WSB-1
Gene namesi
Name:Wsb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1926139 Wsb1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000514581 – 421WD repeat and SOCS box-containing protein 1Add BLAST421

Proteomic databases

PaxDbiO54927
PRIDEiO54927

PTM databases

iPTMnetiO54927
PhosphoSitePlusiO54927

Expressioni

Gene expression databases

BgeeiENSMUSG00000017677 Expressed in 288 organ(s), highest expression level in pineal body
CleanExiMM_WSB1
ExpressionAtlasiO54927 baseline and differential
GenevisibleiO54927 MM

Interactioni

Subunit structurei

Interacts with DIO2. Component of the probable ECS(WSB1) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and WSB1. Component of a probable ECS-like E3 ubiquitin-protein ligase complex which contains CUL5, RBX1, Elongin BC complex and WSB1. Interacts with CUL5, RNF7, ELOB and ELOC. Binds to HIPK2 through WD40 repeats (By similarity).By similarity

Protein-protein interaction databases

BioGridi219684, 11 interactors
IntActiO54927, 7 interactors
STRINGi10090.ENSMUSP00000017821

Structurei

3D structure databases

ProteinModelPortaliO54927
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati124 – 165WD 1Add BLAST42
Repeati168 – 208WD 2Add BLAST41
Repeati212 – 251WD 3Add BLAST40
Repeati254 – 293WD 4Add BLAST40
Repeati309 – 346WD 5Add BLAST38
Domaini372 – 421SOCS boxPROSITE-ProRule annotationAdd BLAST50

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0266 Eukaryota
ENOG410XP3K LUCA
GeneTreeiENSGT00890000139406
HOGENOMiHOG000063727
HOVERGENiHBG034543
InParanoidiO54927
KOiK10341
OMAiGHHNDVV
OrthoDBiEOG091G06GY
PhylomeDBiO54927
TreeFamiTF329216

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF07525 SOCS_box, 1 hit
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SM00320 WD40, 6 hits
SUPFAMiSSF158235 SSF158235, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50225 SOCS, 1 hit
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O54927-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASFPPRVNE KEIVRSRTIG ELLAPAAPFD KKCGGENWTV AFAPDGSYFA
60 70 80 90 100
WSQGYRIVKL VPWSQCRKNF LLHGSKNVTN SSCLKLARQN SNGGQKNKPP
110 120 130 140 150
EHVIDCGDIV WSLAFGSSVP EKQSRCVNIE WHRFRFGQDQ LLLATGLNNG
160 170 180 190 200
RIKIWDVYTG KLLLNLVDHI EMVRDLTFAP DGSLLLVSAS RDKTLRVWDL
210 220 230 240 250
KDDGNMVKVL RAHQNWVYSC AFSPDCSMLC SVGASKAVFL WNMDKYTMIR
260 270 280 290 300
KLEGHHHDVV ACDFSPDGAL LATASYDTRV YVWDPHNGDL LMEFGHLFPS
310 320 330 340 350
PTPIFAGGAN DRWVRAVSFS HDGLHVASLA DDKMVRFWRI DEDCPVQVAP
360 370 380 390 400
LSNGLCCAFS TDGSVLAAGT HDGSVYFWAT PRQVPSLQHI CRMSIRRVMS
410 420
TQEVQKLPVP SKILAFLSYR G
Length:421
Mass (Da):47,065
Last modified:June 1, 1998 - v1
Checksum:i4003D1FFE7A9A2EF
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6ZUJ8F6ZUJ8_MOUSE
WD repeat and SOCS box-containing p...
Wsb1
175Annotation score:
M0QWT9M0QWT9_MOUSE
WD repeat and SOCS box-containing p...
Wsb1
74Annotation score:
E9Q647E9Q647_MOUSE
WD repeat and SOCS box-containing p...
Wsb1
78Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033186 mRNA Translation: AAB96647.1
CCDSiCCDS25118.1
RefSeqiNP_062627.3, NM_019653.3
UniGeneiMm.307022
Mm.474790

Genome annotation databases

EnsembliENSMUST00000017821; ENSMUSP00000017821; ENSMUSG00000017677
GeneIDi78889
KEGGimmu:78889
UCSCiuc007kki.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033186 mRNA Translation: AAB96647.1
CCDSiCCDS25118.1
RefSeqiNP_062627.3, NM_019653.3
UniGeneiMm.307022
Mm.474790

3D structure databases

ProteinModelPortaliO54927
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219684, 11 interactors
IntActiO54927, 7 interactors
STRINGi10090.ENSMUSP00000017821

PTM databases

iPTMnetiO54927
PhosphoSitePlusiO54927

Proteomic databases

PaxDbiO54927
PRIDEiO54927

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017821; ENSMUSP00000017821; ENSMUSG00000017677
GeneIDi78889
KEGGimmu:78889
UCSCiuc007kki.1 mouse

Organism-specific databases

CTDi26118
MGIiMGI:1926139 Wsb1

Phylogenomic databases

eggNOGiKOG0266 Eukaryota
ENOG410XP3K LUCA
GeneTreeiENSGT00890000139406
HOGENOMiHOG000063727
HOVERGENiHBG034543
InParanoidiO54927
KOiK10341
OMAiGHHNDVV
OrthoDBiEOG091G06GY
PhylomeDBiO54927
TreeFamiTF329216

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiWsb1 mouse
PROiPR:O54927
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017677 Expressed in 288 organ(s), highest expression level in pineal body
CleanExiMM_WSB1
ExpressionAtlasiO54927 baseline and differential
GenevisibleiO54927 MM

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF07525 SOCS_box, 1 hit
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SM00320 WD40, 6 hits
SUPFAMiSSF158235 SSF158235, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50225 SOCS, 1 hit
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWSB1_MOUSE
AccessioniPrimary (citable) accession number: O54927
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: June 1, 1998
Last modified: September 12, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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