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Protein

Apoptosis regulatory protein Siva

Gene

Siva1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis (By similarity).By similarity1 Publication

Cofactori

Zn2+By similarityNote: Isoform 1 binds 3 zinc ions. Isoform 2 binds 2 zinc ions.By similarity

GO - Molecular functioni

  • CD27 receptor binding Source: HGNC
  • tumor necrosis factor receptor binding Source: HGNC
  • virus receptor activity Source: HGNC
  • zinc ion binding Source: MGI

GO - Biological processi

Keywordsi

Biological processApoptosis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis regulatory protein Siva
Alternative name(s):
CD27-binding protein
Short name:
CD27BP
Gene namesi
Name:Siva1
Synonyms:Siva
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1353606 Siva1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000977751 – 175Apoptosis regulatory protein SivaAdd BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34Phosphotyrosine; by ABL2By similarity1
Modified residuei70PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by ABL2/ARG in response to oxidative stress.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO54926
MaxQBiO54926
PaxDbiO54926
PeptideAtlasiO54926
PRIDEiO54926

PTM databases

PhosphoSitePlusiO54926

Expressioni

Tissue specificityi

Highly expressed in testis, heart, liver, lung, and muscle, and less in kidney, spleen and brain.

Inductioni

By p53, camptothecin, stroke injury and infection with coxsackievirus B3. This up-regulation is sufficient to induce apoptosis in neural tissue.2 Publications

Gene expression databases

BgeeiENSMUSG00000064326 Expressed in 273 organ(s), highest expression level in urothelium
CleanExiMM_SIVA1
GenevisibleiO54926 MM

Interactioni

Subunit structurei

Binds through its N-terminal region to the C-terminus of CD27 and to PXMP2/PMP22. Binds to the C-terminus of TNFRSF18/GITR. Isoform 1 binds to BCL2L1/BCLX isoform Bcl-x(L) but not to BAX.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi206030, 1 interactor
IntActiO54926, 1 interactor
STRINGi10090.ENSMUSP00000021728

Structurei

3D structure databases

ProteinModelPortaliO54926
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni36 – 55Interaction with BCL2L1 isoform Bcl-x(L) and inhibition of BCL2L1 anti-apoptotic activityBy similarityAdd BLAST20

Phylogenomic databases

eggNOGiENOG410IZ95 Eukaryota
ENOG4112463 LUCA
GeneTreeiENSGT00390000004842
HOGENOMiHOG000253914
HOVERGENiHBG044526
InParanoidiO54926
KOiK22744
OMAiFRGAQAC
OrthoDBiEOG091G163Z
PhylomeDBiO54926
TreeFamiTF332962

Family and domain databases

InterProiView protein in InterPro
IPR022773 Siva_cd27-bd
PANTHERiPTHR14365 PTHR14365, 1 hit
PfamiView protein in Pfam
PF05458 Siva, 1 hit
PIRSFiPIRSF038096 Siva_cd27_bd, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O54926-1) [UniParc]FASTAAdd to basket
Also known as: Siva-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPKRSCPFAD AAPLQLKVHV GLKELSHGVF AERYSREVFE RTKQLLFQGA
60 70 80 90 100
RAYRDHISSE DCSVNHLQES LKSGVVGAPQ PARGQMLIGP DGRLTRCQAQ
110 120 130 140 150
ASEGGLPRTA PIACSSCMRS VDGKAVCSQC ERALCGQCVY TCWGCGALAC
160 170
VLCGLADYAD DGEKTLCTSC AMFEA
Length:175
Mass (Da):18,770
Last modified:June 1, 1998 - v1
Checksum:i1E132C1580ABE3F2
GO
Isoform 2 (identifier: O54926-2) [UniParc]FASTAAdd to basket
Also known as: Siva-2

The sequence of this isoform differs from the canonical sequence as follows:
     40-104: Missing.

Note: Mouse isoform 2 has been shown to have no pro-apoptotic activity.1 Publication
Show »
Length:110
Mass (Da):11,737
Checksum:iD1B83DA9596503F7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 15MPKRS…AAPLQ → MAKGRWRLAEAGAVE in BAB27029 (PubMed:16141072).CuratedAdd BLAST15
Sequence conflicti126V → A in AAH12279 (PubMed:15489334).Curated1
Sequence conflicti142C → S in AAD50060 (PubMed:10597319).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00752640 – 104Missing in isoform 2. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033115 Genomic DNA Translation: AAC04706.1
AF033113 mRNA Translation: AAD50059.1
AF033112 mRNA Translation: AAD50058.1
AF033114 mRNA Translation: AAD50060.1
AK010562 mRNA Translation: BAB27029.1
AK017570 mRNA Translation: BAB30811.1
AK153115 mRNA Translation: BAE31732.1
BC012279 mRNA Translation: AAH12279.1
CCDSiCCDS26193.1 [O54926-1]
CCDS49189.1 [O54926-2]
RefSeqiNP_001155209.1, NM_001161737.1 [O54926-2]
NP_038957.2, NM_013929.2 [O54926-1]
UniGeneiMm.289812

Genome annotation databases

EnsembliENSMUST00000021728; ENSMUSP00000021728; ENSMUSG00000064326 [O54926-1]
ENSMUST00000109755; ENSMUSP00000105377; ENSMUSG00000064326 [O54926-2]
GeneIDi30954
KEGGimmu:30954
UCSCiuc007pev.2 mouse [O54926-1]
uc007pew.2 mouse [O54926-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033115 Genomic DNA Translation: AAC04706.1
AF033113 mRNA Translation: AAD50059.1
AF033112 mRNA Translation: AAD50058.1
AF033114 mRNA Translation: AAD50060.1
AK010562 mRNA Translation: BAB27029.1
AK017570 mRNA Translation: BAB30811.1
AK153115 mRNA Translation: BAE31732.1
BC012279 mRNA Translation: AAH12279.1
CCDSiCCDS26193.1 [O54926-1]
CCDS49189.1 [O54926-2]
RefSeqiNP_001155209.1, NM_001161737.1 [O54926-2]
NP_038957.2, NM_013929.2 [O54926-1]
UniGeneiMm.289812

3D structure databases

ProteinModelPortaliO54926
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206030, 1 interactor
IntActiO54926, 1 interactor
STRINGi10090.ENSMUSP00000021728

PTM databases

PhosphoSitePlusiO54926

Proteomic databases

EPDiO54926
MaxQBiO54926
PaxDbiO54926
PeptideAtlasiO54926
PRIDEiO54926

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021728; ENSMUSP00000021728; ENSMUSG00000064326 [O54926-1]
ENSMUST00000109755; ENSMUSP00000105377; ENSMUSG00000064326 [O54926-2]
GeneIDi30954
KEGGimmu:30954
UCSCiuc007pev.2 mouse [O54926-1]
uc007pew.2 mouse [O54926-2]

Organism-specific databases

CTDi10572
MGIiMGI:1353606 Siva1

Phylogenomic databases

eggNOGiENOG410IZ95 Eukaryota
ENOG4112463 LUCA
GeneTreeiENSGT00390000004842
HOGENOMiHOG000253914
HOVERGENiHBG044526
InParanoidiO54926
KOiK22744
OMAiFRGAQAC
OrthoDBiEOG091G163Z
PhylomeDBiO54926
TreeFamiTF332962

Miscellaneous databases

PROiPR:O54926
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000064326 Expressed in 273 organ(s), highest expression level in urothelium
CleanExiMM_SIVA1
GenevisibleiO54926 MM

Family and domain databases

InterProiView protein in InterPro
IPR022773 Siva_cd27-bd
PANTHERiPTHR14365 PTHR14365, 1 hit
PfamiView protein in Pfam
PF05458 Siva, 1 hit
PIRSFiPIRSF038096 Siva_cd27_bd, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSIVA_MOUSE
AccessioniPrimary (citable) accession number: O54926
Secondary accession number(s): Q3U6J2
, Q921I8, Q9CWL1, Q9R1Q0, Q9R1Q1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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