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Protein

Exocyst complex component 6

Gene

Exoc6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.1 Publication

GO - Biological processi

Keywordsi

Biological processExocytosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 6
Alternative name(s):
Exocyst complex component Sec15A
SEC15-like protein 1
Short name:
rSec15
Gene namesi
Name:Exoc6
Synonyms:Sec15, Sec15a, Sec15l1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3653 Exoc6

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001189531 – 804Exocyst complex component 6Add BLAST804

Proteomic databases

PaxDbiO54923
PRIDEiO54923

PTM databases

CarbonylDBiO54923
iPTMnetiO54923
PhosphoSitePlusiO54923

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (PubMed:12954101). Interacts with CNTRL (By similarity). Interacts with RAB11A in a GTP-dependent manner (By similarity).By similarity1 Publication

Protein-protein interaction databases

CORUMiO54923
STRINGi10116.ENSRNOP00000051630

Structurei

3D structure databases

ProteinModelPortaliO54923
SMRiO54923
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SEC15 family.Curated

Phylogenomic databases

eggNOGiKOG2176 Eukaryota
ENOG410XQAE LUCA
HOVERGENiHBG057543
InParanoidiO54923
KOiK19985
PhylomeDBiO54923

Family and domain databases

InterProiView protein in InterPro
IPR007225 EXOC6/Sec15
PANTHERiPTHR12702 PTHR12702, 1 hit
PfamiView protein in Pfam
PF04091 Sec15, 1 hit
PIRSFiPIRSF025007 Sec15, 1 hit

Sequencei

Sequence statusi: Complete.

O54923-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESGEALGT VPEHERILQE IESTDTACVG PTLRSVYDGQ PNAHKKFMEK
60 70 80 90 100
LDACIRNHDK EIEKMCNFHH QGFVDAITEL LKVRADAEKL KVQVTDTNRR
110 120 130 140 150
FQDAGKEVIE QTEDIIRCRI QQRNITTVVE KLQLCLPVLE MYSKLKEQMS
160 170 180 190 200
MQRYYSALKT MEQLENVYFP RVSQYRFCQL MMDTLPKLRE DIKDISMSDL
210 220 230 240 250
KDFLESIRKH SDKIGETAMK QAQQQKSFSI AVQKQTNMRF GKNMHVNNDR
260 270 280 290 300
TLEEKSDIIL KHTLEEEAEN DEEVLTVQDL VDFSPVYRCS HIYSALGDEE
310 320 330 340 350
TFENYYRKQR KKQARLVLQP QSSVHETVDG YRRYFTQIVG FFVVEDHILH
360 370 380 390 400
VTQGLVTRAY TDELWNMALS KIIAVLRAHS SYCTDPDLVL ELKNLIVIFA
410 420 430 440 450
DTLQGYGFSV NRLFDLLFEI RDQYNETLLK KWAGIFRDIF EEDNYSPIPI
460 470 480 490 500
GSEEEYKMVI SKFPFQDPDL EKQSFPKKFP MSQSVPLIYI QVKEFIYASL
510 520 530 540 550
KFSESLHRSS TEIDDMLRKS TNLLLTRILS SCLLNLIRKP HIGLTELVQI
560 570 580 590 600
IINTTHLEQA CKYLEDFITN ITNISQETVH TTRLYGLSTF KDARHAAEGE
610 620 630 640 650
IYTKLNQKID EFVQLADYDW TMAESDGRAS GYLMDLINFL RSIFQVFTHL
660 670 680 690 700
PGKVAQTACM SACQHLSTSL MQMLLDSELK QISMGAVQQF NLDVIQCELF
710 720 730 740 750
ASSEPVPGFQ GDTLQLAFID LRQLLDLFMV WDWSTYLADY GQPASKYLRV
760 770 780 790 800
NPHAALTLLE KMKDTSKKNN IFAQFRKNDR DRQKLIETVV KQLRGLVTGM

SQHM
Length:804
Mass (Da):93,178
Last modified:October 25, 2002 - v2
Checksum:i5B6F669290ECB459
GO

Sequence cautioni

The sequence AAC01580 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032668 mRNA Translation: AAC01580.1 Different initiation.
PIRiT09221
RefSeqiNP_062150.2, NM_019277.2
UniGeneiRn.1188

Genome annotation databases

GeneIDi50556
KEGGirno:50556

Similar proteinsi

Entry informationi

Entry nameiEXOC6_RAT
AccessioniPrimary (citable) accession number: O54923
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: May 23, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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