Bcl-2-like protein 11

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• dynein complex binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 12142566
• microtubule binding Source: MGIInferred from direct assayⁱ
  • 16832056
• protein heterodimerization activity Source: CAFA <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 16645638
• protein kinase binding Source: ARUK-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 20371704

GO - Biological processⁱ

• activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
• apoptotic process involved in embryonic digit morphogenesis Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 15967824
• B cell apoptotic process Source: MGIInferred from genetic interactionⁱ
  • 16055554
• B cell homeostasis Source: MGIInferred from mutant phenotypeⁱ
  • 16055554
  • 16270031
• brain development Source: Ensembl
• cell-matrix adhesion Source: MGIInferred from mutant phenotypeⁱ
  • 17276340
• cellular process regulating host cell cycle in response to virus Source: MGIInferred from direct assayⁱ
  • 15231831
• developmental pigmentation Source: MGIInferred from genetic interactionⁱ
  • 11709185
• ear development Source: MGIInferred from genetic interactionⁱ
  • 11709185
• extrinsic apoptotic signaling pathway in absence of ligand Source: MGIInferred from mutant phenotypeⁱ
  • 15967824
• intrinsic apoptotic signaling pathway in response to DNA damage Source: MGIInferred from genetic interactionⁱ
  • 15967824
• in utero embryonic development Source: MGIInferred from genetic interactionⁱ
  • 16282979
• kidney development Source: MGIInferred from genetic interactionⁱ
  • 11709185
• leukocyte homeostasis Source: MGIInferred from mutant phenotypeⁱ
  • 15967824
• lymphocyte homeostasis Source: MGIInferred from mutant phenotypeⁱ
  • 11709185
• male gonad development Source: MGIInferred from genetic interactionⁱ
  • 16270031
• mammary gland development Source: MGIInferred from mutant phenotypeⁱ
  • 17276340
• myeloid cell homeostasis Source: MGIInferred from genetic interactionⁱ
  • 15967824
• odontogenesis of dentin-containing tooth Source: MGIInferred from genetic interactionⁱ
  • 15967824
• positive regulation of apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • 16270031
  • 16832056
  • 17276340
• positive regulation of apoptotic process by virus Source: MGIInferred from direct assayⁱ
  • 15231831
• positive regulation of cell cycle Source: MGIInferred from mutant phenotypeⁱ
  • 17705137
• positive regulation of cell death Source: MGI
• positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • 15967824
• positive regulation of fibroblast apoptotic process Source: MGI
• positive regulation of intrinsic apoptotic signaling pathway Source: MGI
• positive regulation of mitochondrial membrane permeability involved in apoptotic process Source: MGIInferred from genetic interactionⁱ
  • 15967824
• positive regulation of neuron apoptotic process Source: MGIInferred from direct assayⁱ
  • 15231831
• positive regulation of protein homooligomerization Source: MGI
• positive regulation of release of cytochrome c from mitochondria Source: MGI
• post-embryonic animal organ morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 17276340
• post-embryonic development Source: MGIInferred from genetic interactionⁱ
  • 11709185
• regulation of apoptotic process Source: MGIInferred from genetic interactionⁱ
  • 15818405
• regulation of developmental pigmentation Source: MGIInferred from genetic interactionⁱ
  • 15818405
• regulation of organ growth Source: MGIInferred from mutant phenotypeⁱ
  • 17276340
• response to endoplasmic reticulum stress Source: UniProtKBInferred from direct assayⁱ
  • 21159964
• spermatogenesis Source: MGIInferred from genetic interactionⁱ
  • 16270031
• spleen development Source: MGIInferred from genetic interactionⁱ
  • 15818405
• T cell homeostasis Source: MGIInferred from mutant phenotypeⁱ
  • 16270031
• thymocyte apoptotic process Source: MGIInferred from genetic interactionⁱ
  • 15967824
• thymus development Source: MGIInferred from genetic interactionⁱ
  • 15818405
• tube formation Source: MGIInferred from mutant phenotypeⁱ
  • 17276340

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• microtubule binding Source: MGIInferred from direct assayⁱ
  • 16832056
• protein heterodimerization activity Source: CAFAInferred from mutant phenotypeⁱ
  • 16645638
• protein kinase binding Source: ARUK-UCLInferred from physical interactionⁱ
  • 20371704

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Motif

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MAKQPSDVSS ECDREGGQLQ PAERPPQLRP GAPTSLQTEP QGNPDGEGDR 
        60         70         80         90        100
CPHGSPQGPL APPASPGPFA TRSPLFIFVR RSSLLSRSSS GYFSFDTDRS 
       110        120        130        140        150
PAPMSCDKST QTPSPPCQAF NHYLSAMASI RQSQEEPEDL RPEIRIAQEL 
       160        170        180        190 
RRIGDEFNET YTRRVFANDY REAEDHPQMV ILQLLRFIFR LVWRRH     

        10         20         30         40         50
MAKQPSDVSS ECDREGGQLQ PAERPPQLRP GAPTSLQTEP QDRSPAPMSC 
        60         70         80         90        100
DKSTQTPSPP CQAFNHYLSA MASIRQSQEE PEDLRPEIRI AQELRRIGDE 
       110        120        130        140
FNETYTRRVF ANDYREAEDH PQMVILQLLR FIFRLVWRRH            

        10         20         30         40         50
MAKQPSDVSS ECDREGGQLQ PAERPPQLRP GAPTSLQTEP QASIRQSQEE 
        60         70         80         90        100
PEDLRPEIRI AQELRRIGDE FNETYTRRVF ANDYREAEDH PQMVILQLLR 
       110
FIFRLVWRRH                                             

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
3. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot