UniProtKB - O54918 (B2L11_MOUSE)
Bcl-2-like protein 11
Bcl2l11
Functioni
Induces apoptosis and anoikis. The isoforms vary in cytotoxicity with isoform BimS being the most potent and isoform BimEL being the least potent.
1 PublicationGO - Molecular functioni
- microtubule binding Source: MGI
- protein kinase binding Source: ARUK-UCL
GO - Biological processi
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
- apoptotic process involved in embryonic digit morphogenesis Source: MGI
- B cell homeostasis Source: MGI
- cell-matrix adhesion Source: MGI
- developmental pigmentation Source: MGI
- ear development Source: MGI
- extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
- intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
- in utero embryonic development Source: MGI
- kidney development Source: MGI
- leukocyte homeostasis Source: MGI
- lymphocyte homeostasis Source: MGI
- male gonad development Source: MGI
- mammary gland development Source: MGI
- meiosis I Source: GO_Central
- myeloid cell homeostasis Source: MGI
- odontogenesis of dentin-containing tooth Source: MGI
- positive regulation of apoptotic process Source: MGI
- positive regulation of apoptotic process by virus Source: MGI
- positive regulation of autophagy in response to ER overload Source: MGI
- positive regulation of cell cycle Source: MGI
- positive regulation of cell death Source: MGI
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
- positive regulation of fibroblast apoptotic process Source: MGI
- positive regulation of intrinsic apoptotic signaling pathway Source: MGI
- positive regulation of mitochondrial membrane permeability involved in apoptotic process Source: MGI
- positive regulation of neuron apoptotic process Source: MGI
- positive regulation of protein-containing complex assembly Source: MGI
- positive regulation of release of cytochrome c from mitochondria Source: MGI
- post-embryonic animal organ morphogenesis Source: MGI
- post-embryonic development Source: MGI
- regulation of apoptotic process Source: MGI
- regulation of developmental pigmentation Source: MGI
- regulation of organ growth Source: MGI
- response to endoplasmic reticulum stress Source: UniProtKB
- spermatogenesis Source: MGI
- spleen development Source: MGI
- T cell homeostasis Source: MGI
- thymocyte apoptotic process Source: MGI
- thymus development Source: MGI
- tube formation Source: MGI
Keywordsi
Biological process | Apoptosis |
Enzyme and pathway databases
Reactomei | R-MMU-111446, Activation of BIM and translocation to mitochondria R-MMU-111453, BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-MMU-193648, NRAGE signals death through JNK |
Names & Taxonomyi
Protein namesi | Recommended name: Bcl-2-like protein 11Short name: Bcl2-L-11 Alternative name(s): Bcl2-interacting mediator of cell death |
Gene namesi | Name:Bcl2l11 Synonyms:Bim |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1197519, Bcl2l11 |
VEuPathDBi | HostDB:ENSMUSG00000027381 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Other locations
- Membrane 1 Publication; Peripheral membrane protein 1 Publication
Note: Associated with intracytoplasmic membranes.
Cytosol
- cytosol Source: MGI
Mitochondrion
- mitochondrion Source: MGI
Other locations
- Bcl-2 family protein complex Source: CAFA
- BIM-BCL-2 complex Source: MGI
- BIM-BCL-xl complex Source: MGI
- cytoplasm Source: MGI
- extrinsic component of membrane Source: MGI
- intracellular membrane-bounded organelle Source: MGI
Keywords - Cellular componenti
Membrane, MitochondrionPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 55 | S → A: Loss of TRIM2-binding; when associated with A-65 and A-73. 1 Publication | 1 | |
Mutagenesisi | 65 | S → A: Loss of TRIM2-binding; when associated with A-55 and A-73. 1 Publication | 1 | |
Mutagenesisi | 73 | S → A: Loss of TRIM2-binding; when associated with A-55 and A-65. 1 Publication | 1 | |
Mutagenesisi | 150 | Missing : Loss of MCL1-binding, strong decrease in BCL2L1-binding, no effect on USP27X-binding; when associated with I-153 del. 1 Publication | 1 | |
Mutagenesisi | 153 | Missing : Loss of MCL1-binding, strong decrease in BCL2L1-binding, no effect on USP27X-binding; when associated with L-150 del. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000143110 | 1 – 196 | Bcl-2-like protein 11Add BLAST | 196 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 65 | Phosphoserine; by MAPK2 Publications | 1 | |
Modified residuei | 73 | PhosphoserineBy similarity | 1 | |
Modified residuei | 83 | PhosphoserineBy similarity | 1 | |
Modified residuei | 90 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | O54918 |
MaxQBi | O54918 |
PaxDbi | O54918 |
PeptideAtlasi | O54918 |
PRIDEi | O54918 |
ProteomicsDBi | 277164 [O54918-1] 277165 [O54918-2] 277166 [O54918-3] |
PTM databases
iPTMneti | O54918 |
PhosphoSitePlusi | O54918 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000027381, Expressed in urinary bladder urothelium and 272 other tissues |
ExpressionAtlasi | O54918, baseline and differential |
Genevisiblei | O54918, MM |
Interactioni
Subunit structurei
Forms heterodimers with a number of antiapoptotic Bcl-2 proteins, including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1, and BCL2L2/BCLW (PubMed:16543145, PubMed:27013495, PubMed:14499110).
Interacts with BAX (in vitro); this interaction may induce the conformationally active form of BAX (PubMed:14499110). Does not heterodimerize with proapoptotic proteins such as BAD, BOK or BAK.
Identified in a complex containing BCL2L11, DYNLL1 and BCL2L1 isoform Bcl-X(L); BH3 integrity is required for BCL2L1-binding (PubMed:21478148, PubMed:27013495, PubMed:14499110).
Interacts with YWHAZ. When phosphorylated, interacts with TRIM2; this interaction is associated with ubiquitination and degradation (PubMed:21478148).
Interacts (via BH3) with MCL1; this interaction may sequester BCL2L11 and prevent its pro-apoptotic activity (PubMed:16543145, PubMed:27013495). When phosphorylated, isoform BimEL interacts with USP27X; this interaction leads to BCL2L11 deubiquitination and stabilization (PubMed:27013495).
Interacts with GIMAP5 (PubMed:16509771).
5 PublicationsBinary interactionsi
O54918
With | #Exp. | IntAct |
---|---|---|
Mcl1 [P97287] | 5 | EBI-526067,EBI-707292 |
BHRF1 [P03182] from Epstein-Barr virus (strain B95-8). | 3 | EBI-526067,EBI-1207659 |
Isoform BimEL [O54918-1]
With | #Exp. | IntAct |
---|---|---|
Bcl2 [P10417] | 2 | EBI-526076,EBI-526314 |
Prkar1a [Q9DBC7] | 2 | EBI-526076,EBI-645677 |
RACK1 [P63244] from Homo sapiens. | 2 | EBI-526076,EBI-296739 |
Isoform BimS [O54918-3]
With | #Exp. | IntAct |
---|---|---|
BCL2L1 - isoform Bcl-X(L) [Q07817-1] from Homo sapiens. | 3 | EBI-526084,EBI-287195 |
GO - Molecular functioni
- microtubule binding Source: MGI
- protein kinase binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 198352, 13 interactors |
ComplexPortali | CPX-2025, BIM:BCL-XL complex CPX-2036, BIM:BCL-2 complex CPX-629, MCL-1-BIM complex |
CORUMi | O54918 |
DIPi | DIP-29214N |
ELMi | O54918 |
IntActi | O54918, 17 interactors |
MINTi | O54918 |
STRINGi | 10090.ENSMUSP00000105970 |
Miscellaneous databases
RNActi | O54918, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O54918 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O54918 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 68 | DisorderedSequence analysisAdd BLAST | 68 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 146 – 160 | BH3Add BLAST | 15 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502S0DF, Eukaryota |
GeneTreei | ENSGT00390000003178 |
HOGENOMi | CLU_104244_1_1_1 |
InParanoidi | O54918 |
OMAi | PETWIAQ |
OrthoDBi | 1460067at2759 |
PhylomeDBi | O54918 |
TreeFami | TF335898 |
Family and domain databases
DisProti | DP00518 |
InterProi | View protein in InterPro IPR014771, Apoptosis_Bim_N IPR017288, Bcl-2-like_11 IPR015040, Bcl-x_interacting_BH3_dom |
Pfami | View protein in Pfam PF08945, Bclx_interact, 1 hit PF06773, Bim_N, 1 hit |
PIRSFi | PIRSF037827, Bcl-2-like_p11, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAKQPSDVSS ECDREGGQLQ PAERPPQLRP GAPTSLQTEP QGNPDGEGDR
60 70 80 90 100
CPHGSPQGPL APPASPGPFA TRSPLFIFVR RSSLLSRSSS GYFSFDTDRS
110 120 130 140 150
PAPMSCDKST QTPSPPCQAF NHYLSAMASI RQSQEEPEDL RPEIRIAQEL
160 170 180 190
RRIGDEFNET YTRRVFANDY REAEDHPQMV ILQLLRFIFR LVWRRH
The sequence of this isoform differs from the canonical sequence as follows:
42-97: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
42-127: Missing.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ6PEB3 | Q6PEB3_MOUSE | Bcl-2-like protein 11 | Bcl2l11 | 91 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000537 | 42 – 127 | Missing in isoform BimS. CuratedAdd BLAST | 86 | |
Alternative sequenceiVSP_000536 | 42 – 97 | Missing in isoform BimL. CuratedAdd BLAST | 56 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF032459 mRNA Translation: AAC40029.1 AF032460 mRNA Translation: AAC40030.1 AF032461 mRNA Translation: AAC40031.1 AL805950 Genomic DNA No translation available. BC019556 mRNA Translation: AAH19556.1 |
CCDSi | CCDS16712.1 [O54918-3] CCDS16713.1 [O54918-1] CCDS16714.1 [O54918-2] |
RefSeqi | NP_033884.1, NM_009754.3 [O54918-3] NP_997563.1, NM_207680.2 [O54918-1] NP_997564.1, NM_207681.2 [O54918-2] |
Genome annotation databases
Ensembli | ENSMUST00000019281; ENSMUSP00000019281; ENSMUSG00000027381 [O54918-3] ENSMUST00000103210; ENSMUSP00000099499; ENSMUSG00000027381 [O54918-2] ENSMUST00000103211; ENSMUSP00000099500; ENSMUSG00000027381 [O54918-3] ENSMUST00000110341; ENSMUSP00000105970; ENSMUSG00000027381 [O54918-1] |
GeneIDi | 12125 |
KEGGi | mmu:12125 |
UCSCi | uc008mgh.1, mouse [O54918-1] uc008mgk.1, mouse [O54918-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF032459 mRNA Translation: AAC40029.1 AF032460 mRNA Translation: AAC40030.1 AF032461 mRNA Translation: AAC40031.1 AL805950 Genomic DNA No translation available. BC019556 mRNA Translation: AAH19556.1 |
CCDSi | CCDS16712.1 [O54918-3] CCDS16713.1 [O54918-1] CCDS16714.1 [O54918-2] |
RefSeqi | NP_033884.1, NM_009754.3 [O54918-3] NP_997563.1, NM_207680.2 [O54918-1] NP_997564.1, NM_207681.2 [O54918-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1PQ1 | X-ray | 1.65 | B | 139-171 | [»] | |
SMRi | O54918 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 198352, 13 interactors |
ComplexPortali | CPX-2025, BIM:BCL-XL complex CPX-2036, BIM:BCL-2 complex CPX-629, MCL-1-BIM complex |
CORUMi | O54918 |
DIPi | DIP-29214N |
ELMi | O54918 |
IntActi | O54918, 17 interactors |
MINTi | O54918 |
STRINGi | 10090.ENSMUSP00000105970 |
PTM databases
iPTMneti | O54918 |
PhosphoSitePlusi | O54918 |
Proteomic databases
jPOSTi | O54918 |
MaxQBi | O54918 |
PaxDbi | O54918 |
PeptideAtlasi | O54918 |
PRIDEi | O54918 |
ProteomicsDBi | 277164 [O54918-1] 277165 [O54918-2] 277166 [O54918-3] |
Protocols and materials databases
Antibodypediai | 3621, 1278 antibodies from 44 providers |
DNASUi | 12125 |
Genome annotation databases
Ensembli | ENSMUST00000019281; ENSMUSP00000019281; ENSMUSG00000027381 [O54918-3] ENSMUST00000103210; ENSMUSP00000099499; ENSMUSG00000027381 [O54918-2] ENSMUST00000103211; ENSMUSP00000099500; ENSMUSG00000027381 [O54918-3] ENSMUST00000110341; ENSMUSP00000105970; ENSMUSG00000027381 [O54918-1] |
GeneIDi | 12125 |
KEGGi | mmu:12125 |
UCSCi | uc008mgh.1, mouse [O54918-1] uc008mgk.1, mouse [O54918-2] |
Organism-specific databases
CTDi | 10018 |
MGIi | MGI:1197519, Bcl2l11 |
VEuPathDBi | HostDB:ENSMUSG00000027381 |
Phylogenomic databases
eggNOGi | ENOG502S0DF, Eukaryota |
GeneTreei | ENSGT00390000003178 |
HOGENOMi | CLU_104244_1_1_1 |
InParanoidi | O54918 |
OMAi | PETWIAQ |
OrthoDBi | 1460067at2759 |
PhylomeDBi | O54918 |
TreeFami | TF335898 |
Enzyme and pathway databases
Reactomei | R-MMU-111446, Activation of BIM and translocation to mitochondria R-MMU-111453, BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-MMU-193648, NRAGE signals death through JNK |
Miscellaneous databases
BioGRID-ORCSi | 12125, 1 hit in 63 CRISPR screens |
ChiTaRSi | Bcl2l11, mouse |
EvolutionaryTracei | O54918 |
PROi | PR:O54918 |
RNActi | O54918, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027381, Expressed in urinary bladder urothelium and 272 other tissues |
ExpressionAtlasi | O54918, baseline and differential |
Genevisiblei | O54918, MM |
Family and domain databases
DisProti | DP00518 |
InterProi | View protein in InterPro IPR014771, Apoptosis_Bim_N IPR017288, Bcl-2-like_11 IPR015040, Bcl-x_interacting_BH3_dom |
Pfami | View protein in Pfam PF08945, Bclx_interact, 1 hit PF06773, Bim_N, 1 hit |
PIRSFi | PIRSF037827, Bcl-2-like_p11, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B2L11_MOUSE | |
Accessioni | O54918Primary (citable) accession number: O54918 Secondary accession number(s): A2ALQ6, O54919, O54920 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 18, 2001 |
Last sequence update: | June 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 191 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families