Bcl-2-like protein 11

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• dynein complex binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Temporal profiles of the subcellular localization of Bim, a BH3-only protein, during middle cerebral artery occlusion in mice."
    Shibata M., Hattori H., Sasaki T., Gotoh J., Hamada J., Fukuuchi Y.
    J. Cereb. Blood Flow Metab. 22:810-820(2002) [PubMed] [Europe PMC] [Abstract]
• microtubule binding Source: MGIInferred from direct assayⁱ
  • "The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells."
    Bauer A., Villunger A., Labi V., Fischer S.F., Strasser A., Wagner H., Schmid R.M., Hacker G.
    Proc. Natl. Acad. Sci. U.S.A. 103:10979-10984(2006) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: ARUK-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis."
    Spokoini R., Kfir-Erenfeld S., Yefenof E., Sionov R.V.
    Mol. Endocrinol. 24:1136-1150(2010) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
• apoptotic process involved in embryonic digit morphogenesis Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis."
    Hutcheson J., Scatizzi J.C., Bickel E., Brown N.J., Bouillet P., Strasser A., Perlman H.
    J. Exp. Med. 201:1949-1960(2005) [PubMed] [Europe PMC] [Abstract]
• B cell apoptotic process Source: MGIInferred from genetic interactionⁱ
  • "Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease."
    Takeuchi O., Fisher J., Suh H., Harada H., Malynn B.A., Korsmeyer S.J.
    Proc. Natl. Acad. Sci. U.S.A. 102:11272-11277(2005) [PubMed] [Europe PMC] [Abstract]
• B cell homeostasis Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease."
    Takeuchi O., Fisher J., Suh H., Harada H., Malynn B.A., Korsmeyer S.J.
    Proc. Natl. Acad. Sci. U.S.A. 102:11272-11277(2005) [PubMed] [Europe PMC] [Abstract]
  • "Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis."
    Coultas L., Bouillet P., Loveland K.L., Meachem S., Perlman H., Adams J.M., Strasser A.
    EMBO J. 24:3963-3973(2005) [PubMed] [Europe PMC] [Abstract]
• brain development Source: Ensembl
• cell-matrix adhesion Source: MGIInferred from mutant phenotypeⁱ
  • "BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms."
    Mailleux A.A., Overholtzer M., Schmelzle T., Bouillet P., Strasser A., Brugge J.S.
    Dev. Cell 12:221-234(2007) [PubMed] [Europe PMC] [Abstract]
• cellular response to amyloid-beta Source: Ensembl
• cellular response to estradiol stimulus Source: Ensembl
• developmental pigmentation Source: MGIInferred from genetic interactionⁱ
  • "Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim."
    Bouillet P., Cory S., Zhang L.C., Strasser A., Adams J.M.
    Dev. Cell 1:645-653(2001) [PubMed] [Europe PMC] [Abstract]
• ear development Source: MGIInferred from genetic interactionⁱ
  • "Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim."
    Bouillet P., Cory S., Zhang L.C., Strasser A., Adams J.M.
    Dev. Cell 1:645-653(2001) [PubMed] [Europe PMC] [Abstract]
• extrinsic apoptotic signaling pathway in absence of ligand Source: MGIInferred from mutant phenotypeⁱ
  • "Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis."
    Hutcheson J., Scatizzi J.C., Bickel E., Brown N.J., Bouillet P., Strasser A., Perlman H.
    J. Exp. Med. 201:1949-1960(2005) [PubMed] [Europe PMC] [Abstract]
• intrinsic apoptotic signaling pathway in response to DNA damage Source: MGIInferred from genetic interactionⁱ
  • "Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis."
    Hutcheson J., Scatizzi J.C., Bickel E., Brown N.J., Bouillet P., Strasser A., Perlman H.
    J. Exp. Med. 201:1949-1960(2005) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: MGIInferred from genetic interactionⁱ
  • "Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms."
    Hughes P., Robati M., Lu W., Zhou J., Strasser A., Bouillet P.
    Cell Death Differ. 13:1123-1127(2006) [PubMed] [Europe PMC] [Abstract]
• kidney development Source: MGIInferred from genetic interactionⁱ
  • "Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim."
    Bouillet P., Cory S., Zhang L.C., Strasser A., Adams J.M.
    Dev. Cell 1:645-653(2001) [PubMed] [Europe PMC] [Abstract]
• leukocyte homeostasis Source: MGIInferred from mutant phenotypeⁱ
  • "Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis."
    Hutcheson J., Scatizzi J.C., Bickel E., Brown N.J., Bouillet P., Strasser A., Perlman H.
    J. Exp. Med. 201:1949-1960(2005) [PubMed] [Europe PMC] [Abstract]
• lymphocyte homeostasis Source: MGIInferred from mutant phenotypeⁱ
  • "Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim."
    Bouillet P., Cory S., Zhang L.C., Strasser A., Adams J.M.
    Dev. Cell 1:645-653(2001) [PubMed] [Europe PMC] [Abstract]
• male gonad development Source: MGIInferred from genetic interactionⁱ
  • "Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis."
    Coultas L., Bouillet P., Loveland K.L., Meachem S., Perlman H., Adams J.M., Strasser A.
    EMBO J. 24:3963-3973(2005) [PubMed] [Europe PMC] [Abstract]
• mammary gland development Source: MGIInferred from mutant phenotypeⁱ
  • "BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms."
    Mailleux A.A., Overholtzer M., Schmelzle T., Bouillet P., Strasser A., Brugge J.S.
    Dev. Cell 12:221-234(2007) [PubMed] [Europe PMC] [Abstract]
• meiosis I Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• myeloid cell homeostasis Source: MGIInferred from genetic interactionⁱ
  • "Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis."
    Hutcheson J., Scatizzi J.C., Bickel E., Brown N.J., Bouillet P., Strasser A., Perlman H.
    J. Exp. Med. 201:1949-1960(2005) [PubMed] [Europe PMC] [Abstract]
• odontogenesis of dentin-containing tooth Source: MGIInferred from genetic interactionⁱ
  • "Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis."
    Hutcheson J., Scatizzi J.C., Bickel E., Brown N.J., Bouillet P., Strasser A., Perlman H.
    J. Exp. Med. 201:1949-1960(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis."
    Coultas L., Bouillet P., Loveland K.L., Meachem S., Perlman H., Adams J.M., Strasser A.
    EMBO J. 24:3963-3973(2005) [PubMed] [Europe PMC] [Abstract]
  • "The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells."
    Bauer A., Villunger A., Labi V., Fischer S.F., Strasser A., Wagner H., Schmid R.M., Hacker G.
    Proc. Natl. Acad. Sci. U.S.A. 103:10979-10984(2006) [PubMed] [Europe PMC] [Abstract]
  • "BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms."
    Mailleux A.A., Overholtzer M., Schmelzle T., Bouillet P., Strasser A., Brugge J.S.
    Dev. Cell 12:221-234(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic process by virus Source: MGIInferred from direct assayⁱ
  • "BAD is a pro-survival factor prior to activation of its pro-apoptotic function."
    Seo S.Y., Chen Y.B., Ivanovska I., Ranger A.M., Hong S.J., Dawson V.L., Korsmeyer S.J., Bellows D.S., Fannjiang Y., Hardwick J.M.
    J. Biol. Chem. 279:42240-42249(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of autophagy in response to ER overload Source: MGI
• positive regulation of cell cycle Source: MGIInferred from mutant phenotypeⁱ
  • "Bim regulates BCR-induced entry of B cells into the cell cycle."
    Craxton A., Draves K.E., Clark E.A.
    Eur. J. Immunol. 37:2715-2722(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell death Source: MGI
• positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis."
    Hutcheson J., Scatizzi J.C., Bickel E., Brown N.J., Bouillet P., Strasser A., Perlman H.
    J. Exp. Med. 201:1949-1960(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of fibroblast apoptotic process Source: MGI
• positive regulation of intrinsic apoptotic signaling pathway Source: MGI
• positive regulation of mitochondrial membrane permeability involved in apoptotic process Source: MGIInferred from genetic interactionⁱ
  • "Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis."
    Hutcheson J., Scatizzi J.C., Bickel E., Brown N.J., Bouillet P., Strasser A., Perlman H.
    J. Exp. Med. 201:1949-1960(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neuron apoptotic process Source: MGIInferred from direct assayⁱ
  • "BAD is a pro-survival factor prior to activation of its pro-apoptotic function."
    Seo S.Y., Chen Y.B., Ivanovska I., Ranger A.M., Hong S.J., Dawson V.L., Korsmeyer S.J., Bellows D.S., Fannjiang Y., Hardwick J.M.
    J. Biol. Chem. 279:42240-42249(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein-containing complex assembly Source: MGI
• positive regulation of release of cytochrome c from mitochondria Source: MGI
• post-embryonic animal organ morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms."
    Mailleux A.A., Overholtzer M., Schmelzle T., Bouillet P., Strasser A., Brugge J.S.
    Dev. Cell 12:221-234(2007) [PubMed] [Europe PMC] [Abstract]
• post-embryonic development Source: MGIInferred from genetic interactionⁱ
  • "Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim."
    Bouillet P., Cory S., Zhang L.C., Strasser A., Adams J.M.
    Dev. Cell 1:645-653(2001) [PubMed] [Europe PMC] [Abstract]
• regulation of apoptotic process Source: MGIInferred from genetic interactionⁱ
  • "Polycystic kidney disease prevented by transgenic RNA interference."
    Bouillet P., Robati M., Bath M., Strasser A.
    Cell Death Differ. 12:831-833(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of developmental pigmentation Source: MGIInferred from genetic interactionⁱ
  • "Polycystic kidney disease prevented by transgenic RNA interference."
    Bouillet P., Robati M., Bath M., Strasser A.
    Cell Death Differ. 12:831-833(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of organ growth Source: MGIInferred from mutant phenotypeⁱ
  • "BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms."
    Mailleux A.A., Overholtzer M., Schmelzle T., Bouillet P., Strasser A., Brugge J.S.
    Dev. Cell 12:221-234(2007) [PubMed] [Europe PMC] [Abstract]
• response to endoplasmic reticulum stress Source: UniProtKBInferred from direct assayⁱ
  • Ref.7

    "Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA."
    Galehdar Z., Swan P., Fuerth B., Callaghan S.M., Park D.S., Cregan S.P.
    J. Neurosci. 30:16938-16948(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: INDUCTION.
• spermatogenesis Source: MGIInferred from genetic interactionⁱ
  • "Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis."
    Coultas L., Bouillet P., Loveland K.L., Meachem S., Perlman H., Adams J.M., Strasser A.
    EMBO J. 24:3963-3973(2005) [PubMed] [Europe PMC] [Abstract]
• spleen development Source: MGIInferred from genetic interactionⁱ
  • "Polycystic kidney disease prevented by transgenic RNA interference."
    Bouillet P., Robati M., Bath M., Strasser A.
    Cell Death Differ. 12:831-833(2005) [PubMed] [Europe PMC] [Abstract]
• T cell homeostasis Source: MGIInferred from mutant phenotypeⁱ
  • "Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis."
    Coultas L., Bouillet P., Loveland K.L., Meachem S., Perlman H., Adams J.M., Strasser A.
    EMBO J. 24:3963-3973(2005) [PubMed] [Europe PMC] [Abstract]
• thymocyte apoptotic process Source: MGIInferred from genetic interactionⁱ
  • "Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis."
    Hutcheson J., Scatizzi J.C., Bickel E., Brown N.J., Bouillet P., Strasser A., Perlman H.
    J. Exp. Med. 201:1949-1960(2005) [PubMed] [Europe PMC] [Abstract]
• thymus development Source: MGIInferred from genetic interactionⁱ
  • "Polycystic kidney disease prevented by transgenic RNA interference."
    Bouillet P., Robati M., Bath M., Strasser A.
    Cell Death Differ. 12:831-833(2005) [PubMed] [Europe PMC] [Abstract]
• tube formation Source: MGIInferred from mutant phenotypeⁱ
  • "BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms."
    Mailleux A.A., Overholtzer M., Schmelzle T., Bouillet P., Strasser A., Brugge J.S.
    Dev. Cell 12:221-234(2007) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• microtubule binding Source: MGIInferred from direct assayⁱ
  • "The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells."
    Bauer A., Villunger A., Labi V., Fischer S.F., Strasser A., Wagner H., Schmid R.M., Hacker G.
    Proc. Natl. Acad. Sci. U.S.A. 103:10979-10984(2006) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: ARUK-UCLInferred from physical interactionⁱ
  • "Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis."
    Spokoini R., Kfir-Erenfeld S., Yefenof E., Sionov R.V.
    Mol. Endocrinol. 24:1136-1150(2010) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Motif

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MAKQPSDVSS ECDREGGQLQ PAERPPQLRP GAPTSLQTEP QGNPDGEGDR 
        60         70         80         90        100
CPHGSPQGPL APPASPGPFA TRSPLFIFVR RSSLLSRSSS GYFSFDTDRS 
       110        120        130        140        150
PAPMSCDKST QTPSPPCQAF NHYLSAMASI RQSQEEPEDL RPEIRIAQEL 
       160        170        180        190 
RRIGDEFNET YTRRVFANDY REAEDHPQMV ILQLLRFIFR LVWRRH     

        10         20         30         40         50
MAKQPSDVSS ECDREGGQLQ PAERPPQLRP GAPTSLQTEP QDRSPAPMSC 
        60         70         80         90        100
DKSTQTPSPP CQAFNHYLSA MASIRQSQEE PEDLRPEIRI AQELRRIGDE 
       110        120        130        140
FNETYTRRVF ANDYREAEDH PQMVILQLLR FIFRLVWRRH            

        10         20         30         40         50
MAKQPSDVSS ECDREGGQLQ PAERPPQLRP GAPTSLQTEP QASIRQSQEE 
        60         70         80         90        100
PEDLRPEIRI AQELRRIGDE FNETYTRRVF ANDYREAEDH PQMVILQLLR 
       110
FIFRLVWRRH                                             

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references