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Protein

Nuclear receptor subfamily 1 group I member 2

Gene

Nr1i2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand-binding domain. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By similarity). Activated by naturally occurring steroids such as pregnenolone and progesterone, the cholesterol metabolite 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol, synthetic glucocorticoids and antiglucocorticoids and 16-alpha-carbonitrile (PCN).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei244AgonistBy similarity1
Binding sitei285AgonistBy similarity1
Binding sitei296AgonistBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi35 – 104Nuclear receptorPROSITE-ProRule annotationAdd BLAST70
Zinc fingeri38 – 58NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri74 – 99NR C4-typePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-383280 Nuclear Receptor transcription pathway
R-MMU-4090294 SUMOylation of intracellular receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 1 group I member 2
Alternative name(s):
Orphan nuclear receptor PXR
Pregnane X receptor
Gene namesi
Name:Nr1i2
Synonyms:Pxr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1337040 Nr1i2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1743244
GuidetoPHARMACOLOGYi606

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000535491 – 431Nuclear receptor subfamily 1 group I member 2Add BLAST431

Proteomic databases

PaxDbiO54915
PRIDEiO54915

PTM databases

PhosphoSitePlusiO54915

Expressioni

Gene expression databases

BgeeiENSMUSG00000022809 Expressed in 53 organ(s), highest expression level in colon
CleanExiMM_NR1I2
ExpressionAtlasiO54915 baseline and differential
GenevisibleiO54915 MM

Interactioni

Subunit structurei

Heterodimer with RXRA. Interacts with NCOA1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201839, 5 interactors
ComplexPortaliCPX-505 Rxralpha-Pxr retinoic acid receptor complex
STRINGi10090.ENSMUSP00000023504

Structurei

3D structure databases

ProteinModelPortaliO54915
SMRiO54915
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini143 – 430NR LBDPROSITE-ProRule annotationAdd BLAST288

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni105 – 142HingeAdd BLAST38

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi63 – 89Bipartite nuclear localization signalBy similarityAdd BLAST27

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri38 – 58NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri74 – 99NR C4-typePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136372
HOGENOMiHOG000220844
HOVERGENiHBG108655
InParanoidiO54915
KOiK08540
OMAiANGYHFN
OrthoDBiEOG091G05X3
PhylomeDBiO54915
TreeFamiTF316304

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O54915-1) [UniParc]FASTAAdd to basket
Also known as: PXR.1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRPEESWSRV GLVQCEEADS ALEEPINVEE EDGGLQICRV CGDKANGYHF
60 70 80 90 100
NVMTCEGCKG FFRRAMKRNV RLRCPFRKGT CEITRKTRRQ CQACRLRKCL
110 120 130 140 150
ESGMKKEMIM SDAAVEQRRA LIKRKKREKI EAPPPGGQGL TEEQQALIQE
160 170 180 190 200
LMDAQMQTFD TTFSHFKDFR LPAVFHSGCE LPEFLQASLL EDPATWSQIM
210 220 230 240 250
KDRVPMKISL QLRGEDGSIW NYQPPSKSDG KEIIPLLPHL ADVSTYMFKG
260 270 280 290 300
VINFAKVISY FRDLPIEDQI SLLKGATFEM CILRFNTMFD TETGTWECGR
310 320 330 340 350
LAYCFEDPNG GFQKLLLDPL MKFHCMLKKL QLHKEEYVLM QAISLFSPDR
360 370 380 390 400
PGVVQRSVVD QLQERFALTL KAYIECSRPY PAHRFLFLKI MAVLTELRSI
410 420 430
NAQQTQQLLR IQDSHPFATP LMQELFSSTD G
Length:431
Mass (Da):49,567
Last modified:June 1, 1998 - v1
Checksum:iF592AF91F689329E
GO
Isoform 2 (identifier: O54915-2) [UniParc]FASTAAdd to basket
Also known as: PXR.2

The sequence of this isoform differs from the canonical sequence as follows:
     171-211: Missing.

Show »
Length:390
Mass (Da):44,958
Checksum:i9425A40F980F08ED
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003670171 – 211Missing in isoform 2. CuratedAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031814 mRNA Translation: AAC39964.1
AK018630 mRNA Translation: BAB31316.1
CCDSiCCDS28164.1 [O54915-1]
RefSeqiNP_001091874.1, NM_001098404.1 [O54915-2]
NP_035066.1, NM_010936.3 [O54915-1]
XP_006521909.1, XM_006521846.3 [O54915-1]
XP_006521911.1, XM_006521848.3 [O54915-1]
UniGeneiMm.8509

Genome annotation databases

EnsembliENSMUST00000023504; ENSMUSP00000023504; ENSMUSG00000022809 [O54915-1]
GeneIDi18171
KEGGimmu:18171
UCSCiuc007zep.1 mouse [O54915-2]
uc007zeq.1 mouse [O54915-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031814 mRNA Translation: AAC39964.1
AK018630 mRNA Translation: BAB31316.1
CCDSiCCDS28164.1 [O54915-1]
RefSeqiNP_001091874.1, NM_001098404.1 [O54915-2]
NP_035066.1, NM_010936.3 [O54915-1]
XP_006521909.1, XM_006521846.3 [O54915-1]
XP_006521911.1, XM_006521848.3 [O54915-1]
UniGeneiMm.8509

3D structure databases

ProteinModelPortaliO54915
SMRiO54915
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201839, 5 interactors
ComplexPortaliCPX-505 Rxralpha-Pxr retinoic acid receptor complex
STRINGi10090.ENSMUSP00000023504

Chemistry databases

ChEMBLiCHEMBL1743244
GuidetoPHARMACOLOGYi606

PTM databases

PhosphoSitePlusiO54915

Proteomic databases

PaxDbiO54915
PRIDEiO54915

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023504; ENSMUSP00000023504; ENSMUSG00000022809 [O54915-1]
GeneIDi18171
KEGGimmu:18171
UCSCiuc007zep.1 mouse [O54915-2]
uc007zeq.1 mouse [O54915-1]

Organism-specific databases

CTDi8856
MGIiMGI:1337040 Nr1i2

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136372
HOGENOMiHOG000220844
HOVERGENiHBG108655
InParanoidiO54915
KOiK08540
OMAiANGYHFN
OrthoDBiEOG091G05X3
PhylomeDBiO54915
TreeFamiTF316304

Enzyme and pathway databases

ReactomeiR-MMU-383280 Nuclear Receptor transcription pathway
R-MMU-4090294 SUMOylation of intracellular receptors

Miscellaneous databases

PROiPR:O54915
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022809 Expressed in 53 organ(s), highest expression level in colon
CleanExiMM_NR1I2
ExpressionAtlasiO54915 baseline and differential
GenevisibleiO54915 MM

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNR1I2_MOUSE
AccessioniPrimary (citable) accession number: O54915
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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