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Protein

NF-kappa-B inhibitor epsilon

Gene

Nfkbie

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1169091 Activation of NF-kappaB in B cells

Names & Taxonomyi

Protein namesi
Recommended name:
NF-kappa-B inhibitor epsilon
Short name:
NF-kappa-BIE
Alternative name(s):
I-kappa-B-epsilon
Short name:
IkB-E
Short name:
IkB-epsilon
Short name:
IkappaBepsilon
Gene namesi
Name:Nfkbie
Synonyms:Ikbe
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1194908 Nfkbie

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000670081 – 364NF-kappa-B inhibitor epsilonAdd BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineBy similarity1

Post-translational modificationi

Serine phosphorylated; followed by proteasome-dependent degradation.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO54910
MaxQBiO54910
PaxDbiO54910
PeptideAtlasiO54910
PRIDEiO54910

PTM databases

iPTMnetiO54910
PhosphoSitePlusiO54910

Expressioni

Gene expression databases

BgeeiENSMUSG00000023947 Expressed in 174 organ(s), highest expression level in mesenteric lymph node
GenevisibleiO54910 MM

Interactioni

Subunit structurei

Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit.By similarity

Binary interactionsi

Protein-protein interaction databases

IntActiO54910, 9 interactors
STRINGi10090.ENSMUSP00000024742

Structurei

3D structure databases

ProteinModelPortaliO54910
SMRiO54910
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati122 – 155ANK 1Add BLAST34
Repeati157 – 186ANK 2Add BLAST30
Repeati190 – 219ANK 3Add BLAST30
Repeati233 – 262ANK 4Add BLAST30
Repeati267 – 296ANK 5Add BLAST30
Repeati300 – 329ANK 6Add BLAST30

Sequence similaritiesi

Belongs to the NF-kappa-B inhibitor family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00550000074527
HOGENOMiHOG000059576
HOVERGENiHBG108320
InParanoidiO54910
KOiK05872
OMAiNMEDETA
OrthoDBiEOG091G092R
PhylomeDBiO54910
TreeFamiTF320166

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

Sequencei

Sequence statusi: Complete.

O54910-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDARKGPDE ADDSQCDSGI ESLRSLRSLP EPTAAPGSGS SQSGCPQPWR
60 70 80 90 100
HAPETHKEPE KEDADGERAD STYASSSLTE SFPLLERPEA KDPSPPAPGS
110 120 130 140 150
PLPPAGVLSP QQLEALTYIS EDGDTLLHLA VIHEAPSVLF CCLAFLPQEV
160 170 180 190 200
LDIQNNLYQT ALHLAVHLDQ PDVVRALVLK GASRILQDQH GDTALHVACR
210 220 230 240 250
RQNLACACCL LEEQPEPGRQ LSHPLDLQLK NWQGLACLHI ATLQRNQPLI
260 270 280 290 300
ELLLQNGADI DVQEGTSGKT ALHLAVETQE RSLVQFLLQA GARVDARMLN
310 320 330 340 350
GCTPLHLAAG RGLNSISSTL CEAGADSLLL NVEDETPQDL AEDLLSYLPF
360
DDLKISGKPL LCTD
Length:364
Mass (Da):39,200
Last modified:June 20, 2001 - v2
Checksum:i4426B58424187F3A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97A → V in AAB97517 (PubMed:9405619).Curated1
Sequence conflicti182 – 191ASRILQDQHG → PAEFCRSAC in BAB25924 (PubMed:16141072).Curated10
Sequence conflicti291G → R in AAB97517 (PubMed:9405619).Curated1
Sequence conflicti345 – 364LSYLP…LLCTD → GWVPTASHLEAGSAAAAVGT QAMSPLC in BAB27943 (PubMed:16141072).CuratedAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030896 mRNA Translation: AAB97517.1
AK008843 mRNA Translation: BAB25924.1
AK011965 mRNA Translation: BAB27943.1
AK151450 mRNA Translation: BAE30410.1
AK153248 mRNA Translation: BAE31839.1
BC030923 mRNA Translation: AAH30923.1
CCDSiCCDS28811.1
RefSeqiNP_001291885.1, NM_001304956.1
NP_032716.2, NM_008690.4
UniGeneiMm.57043

Genome annotation databases

EnsembliENSMUST00000024742; ENSMUSP00000024742; ENSMUSG00000023947
GeneIDi18037
KEGGimmu:18037
UCSCiuc008cqv.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030896 mRNA Translation: AAB97517.1
AK008843 mRNA Translation: BAB25924.1
AK011965 mRNA Translation: BAB27943.1
AK151450 mRNA Translation: BAE30410.1
AK153248 mRNA Translation: BAE31839.1
BC030923 mRNA Translation: AAH30923.1
CCDSiCCDS28811.1
RefSeqiNP_001291885.1, NM_001304956.1
NP_032716.2, NM_008690.4
UniGeneiMm.57043

3D structure databases

ProteinModelPortaliO54910
SMRiO54910
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO54910, 9 interactors
STRINGi10090.ENSMUSP00000024742

PTM databases

iPTMnetiO54910
PhosphoSitePlusiO54910

Proteomic databases

EPDiO54910
MaxQBiO54910
PaxDbiO54910
PeptideAtlasiO54910
PRIDEiO54910

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024742; ENSMUSP00000024742; ENSMUSG00000023947
GeneIDi18037
KEGGimmu:18037
UCSCiuc008cqv.2 mouse

Organism-specific databases

CTDi4794
MGIiMGI:1194908 Nfkbie

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00550000074527
HOGENOMiHOG000059576
HOVERGENiHBG108320
InParanoidiO54910
KOiK05872
OMAiNMEDETA
OrthoDBiEOG091G092R
PhylomeDBiO54910
TreeFamiTF320166

Enzyme and pathway databases

ReactomeiR-MMU-1169091 Activation of NF-kappaB in B cells

Miscellaneous databases

PROiPR:O54910
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023947 Expressed in 174 organ(s), highest expression level in mesenteric lymph node
GenevisibleiO54910 MM

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiIKBE_MOUSE
AccessioniPrimary (citable) accession number: O54910
Secondary accession number(s): Q3U686, Q9CZZ9, Q9D7U3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: September 12, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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