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Entry version 134 (07 Nov 2018)
Sequence version 2 (01 Jan 1999)
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Protein

Voltage-dependent T-type calcium channel subunit alpha-1G

Gene

Cacna1g

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei354Calcium ion selectivity and permeabilityBy similarity1
Sitei924Calcium ion selectivity and permeabilityBy similarity1
Sitei1465Calcium ion selectivity and permeabilityBy similarity1
Sitei1770Calcium ion selectivity and permeabilityBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent T-type calcium channel subunit alpha-1G
Alternative name(s):
Voltage-gated calcium channel subunit alpha Cav3.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cacna1g
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
68942 Cacna1g

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 80CytoplasmicSequence analysisAdd BLAST80
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei81 – 101Helical; Name=S1 of repeat IAdd BLAST21
Topological domaini102 – 119ExtracellularSequence analysisAdd BLAST18
Transmembranei120 – 141Helical; Name=S2 of repeat ISequence analysisAdd BLAST22
Topological domaini142 – 150CytoplasmicSequence analysis9
Transmembranei151 – 170Helical; Name=S3 of repeat IAdd BLAST20
Topological domaini171 – 175ExtracellularSequence analysis5
Transmembranei176 – 193Helical; Name=S4 of repeat IAdd BLAST18
Topological domaini194 – 213CytoplasmicSequence analysisAdd BLAST20
Transmembranei214 – 234Helical; Name=S5 of repeat ISequence analysisAdd BLAST21
Topological domaini235 – 370ExtracellularSequence analysisAdd BLAST136
Transmembranei371 – 395Helical; Name=S6 of repeat IAdd BLAST25
Topological domaini396 – 744CytoplasmicSequence analysisAdd BLAST349
Transmembranei745 – 765Helical; Name=S1 of repeat IISequence analysisAdd BLAST21
Topological domaini766 – 778ExtracellularSequence analysisAdd BLAST13
Transmembranei779 – 800Helical; Name=S2 of repeat IISequence analysisAdd BLAST22
Topological domaini801 – 806CytoplasmicSequence analysis6
Transmembranei807 – 825Helical; Name=S3 of repeat IISequence analysisAdd BLAST19
Topological domaini826 – 833ExtracellularSequence analysis8
Transmembranei834 – 857Helical; Name=S4 of repeat IISequence analysisAdd BLAST24
Topological domaini858 – 868CytoplasmicSequence analysisAdd BLAST11
Transmembranei869 – 889Helical; Name=S5 of repeat IISequence analysisAdd BLAST21
Topological domaini890 – 940ExtracellularSequence analysisAdd BLAST51
Transmembranei941 – 965Helical; Name=S6 of repeat IISequence analysisAdd BLAST25
Topological domaini966 – 1251CytoplasmicSequence analysisAdd BLAST286
Transmembranei1252 – 1274Helical; Name=S1 of repeat IIISequence analysisAdd BLAST23
Topological domaini1275 – 1292ExtracellularSequence analysisAdd BLAST18
Transmembranei1293 – 1313Helical; Name=S2 of repeat IIISequence analysisAdd BLAST21
Topological domaini1314 – 1323CytoplasmicSequence analysis10
Transmembranei1324 – 1343Helical; Name=S3 of repeat IIISequence analysisAdd BLAST20
Topological domaini1344 – 1357ExtracellularSequence analysisAdd BLAST14
Transmembranei1358 – 1379Helical; Name=S4 of repeat IIISequence analysisAdd BLAST22
Topological domaini1380 – 1389CytoplasmicSequence analysis10
Transmembranei1390 – 1413Helical; Name=S5 of repeat IIISequence analysisAdd BLAST24
Topological domaini1414 – 1490ExtracellularSequence analysisAdd BLAST77
Transmembranei1491 – 1516Helical; Name=S6 of repeat IIISequence analysisAdd BLAST26
Topological domaini1517 – 1578CytoplasmicSequence analysisAdd BLAST62
Transmembranei1579 – 1599Helical; Name=S1 of repeat IVSequence analysisAdd BLAST21
Topological domaini1600 – 1613ExtracellularSequence analysisAdd BLAST14
Transmembranei1614 – 1635Helical; Name=S2 of repeat IVSequence analysisAdd BLAST22
Topological domaini1636 – 1642CytoplasmicSequence analysis7
Transmembranei1643 – 1661Helical; Name=S3 of repeat IVSequence analysisAdd BLAST19
Topological domaini1662 – 1675ExtracellularSequence analysisAdd BLAST14
Transmembranei1676 – 1699Helical; Name=S4 of repeat IVSequence analysisAdd BLAST24
Topological domaini1700 – 1713CytoplasmicSequence analysisAdd BLAST14
Transmembranei1714 – 1734Helical; Name=S5 of repeat IVSequence analysisAdd BLAST21
Topological domaini1735 – 1794ExtracellularSequence analysisAdd BLAST60
Transmembranei1795 – 1822Helical; Name=S6 of repeat IVSequence analysisAdd BLAST28
Topological domaini1823 – 2254CytoplasmicSequence analysisAdd BLAST432

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
535

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000539531 – 2254Voltage-dependent T-type calcium channel subunit alpha-1GAdd BLAST2254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi322N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei467PhosphoserineCombined sources1
Modified residuei716PhosphoserineCombined sources1
Modified residuei1118PhosphoserineCombined sources1
Modified residuei1124PhosphoserineCombined sources1
Modified residuei1125PhosphoserineCombined sources1
Glycosylationi1427N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1430N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1666N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O54898

PRoteomics IDEntifications database

More...
PRIDEi
O54898

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O54898

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O54898

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain. Moderate expression in heart; low expression in placenta, kidney and lung.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
248334, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000061436

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O54898

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati68 – 398IAdd BLAST331
Repeati730 – 968IIAdd BLAST239
Repeati1242 – 1519IIIAdd BLAST278
Repeati1564 – 1822IVAdd BLAST259

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi290 – 295Poly-Gly6
Compositional biasi496 – 506Poly-HisAdd BLAST11
Compositional biasi1527 – 1530Poly-Glu4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2302 Eukaryota
ENOG410XNP6 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007742

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050764

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O54898

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O54898

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821 Ion_trans_dom
IPR005445 VDCC_T_a1
IPR030154 VDCC_T_a1G
IPR027359 Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10037:SF137 PTHR10037:SF137, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520 Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01629 TVDCCALPHA1

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O54898-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEEEDGAGA EESGQPRSFT QLNDLSGAGG RQGPGSTEKD PGSADSEAEG
60 70 80 90 100
LPYPALAPVV FFYLSQDSRP RSWCLRTVCN PWFERVSMLV ILLNCVTLGM
110 120 130 140 150
FRPCEDIACD SQRCRILQAF DDFIFAFFAV EMVVKMVALG IFGKKCYLGD
160 170 180 190 200
TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR TVRVLRPLRA INRVPSMRIL
210 220 230 240 250
VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR CFLPENFSLP
260 270 280 290 300
LSVDLEPYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG EGGGGPPCSL
310 320 330 340 350
DYETYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV
360 370 380 390 400
ITLEGWVDIM YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE
410 420 430 440 450
TKQRESQLMR EQRVRFLSNA STLASFSEPG SCYEELLKYL VYILRKAARR
460 470 480 490 500
LAQVSRAIGV RAGLLSSPVA RSGQEPQPSG SCTRSHRRLS VHHLVHHHHH
510 520 530 540 550
HHHHYHLGNG TLRVPRASPE IQDRDANGSR RLMLPPPSTP TPSGGPPRGA
560 570 580 590 600
ESVHSFYHAD CHLEPVRCQA PPPRCPSEAS GRTVGSGKVY PTVHTSPPPE
610 620 630 640 650
ILKDKALVEV APSPGPPTLT SFNIPPGPFS SMHKLLETQS TGACHSSCKI
660 670 680 690 700
SSPCSKADSG ACGPDSCPYC ARTGAGEPES ADHVMPDSDS EAVYEFTQDA
710 720 730 740 750
QHSDLRDPHS RRRQRSLGPD AEPSSVLAFW RLICDTFRKI VDSKYFGRGI
760 770 780 790 800
MIAILVNTLS MGIEYHEQPE ELTNALEISN IVFTSLFALE MLLKLLVYGP
810 820 830 840 850
FGYIKNPYNI FDGVIVVISV WEIVGQQGGG LSVLRTFRLM RVLKLVRFLP
860 870 880 890 900
ALQRQLVVLM KTMDNVATFC MLLMLFIFIF SILGMHLFGC KFASERDGDT
910 920 930 940 950
LPDRKNFDSL LWAIVTVFQI LTQEDWNKVL YNGMASTSSW AALYFIALMT
960 970 980 990 1000
FGNYVLFNLL VAILVEGFQA EGDATKSESE PDFFSPSVDG DGDRKKRLAL
1010 1020 1030 1040 1050
VALGEHAELR KSLLPPLIIH TAATPMSHPK SSSTGVGEAL GSGSRRTSSS
1060 1070 1080 1090 1100
GSAEPGAAHH EMKCPPSARS SPHSPWSAAS SWTSRRSSRN SLGRAPSLKR
1110 1120 1130 1140 1150
RSPSGERRSL LSGEGQESQD EEESSEEDRA SPAGSDHRHR GSLEREAKSS
1160 1170 1180 1190 1200
FDLPDTLQVP GLHRTASGRS SASEHQDCNG KSASGRLART LRTDDPQLDG
1210 1220 1230 1240 1250
DDDNDEGNLS KGERIQAWVR SRLPACCRER DSWSAYIFPP QSRFRLLCHR
1260 1270 1280 1290 1300
IITHKMFDHV VLVIIFLNCI TIAMERPKID PHSAERIFLT LSNYIFTAVF
1310 1320 1330 1340 1350
LAEMTVKVVA LGWCFGEQAY LRSSWNVLDG LLVLISVIDI LVSMVSDSGT
1360 1370 1380 1390 1400
KILGMLRVLR LLRTLRPLRV ISRAQGLKLV VETLMSSLKP IGNIVVICCA
1410 1420 1430 1440 1450
FFIIFGILGV QLFKGKFFVC QGEDTRNITN KSDCAEASYR WVRHKYNFDN
1460 1470 1480 1490 1500
LGQALMSLFV LASKDGWVDI MYDGLDAVGV DQQPIMNHNP WMLLYFISFL
1510 1520 1530 1540 1550
LIVAFFVLNM FVGVVVENFH KCRQHQEEEE ARRREEKRLR RLEKKRRSKE
1560 1570 1580 1590 1600
KQMAEAQCKP YYSDYSRFRL LVHHLCTSHY LDLFITGVIG LNVVTMAMEH
1610 1620 1630 1640 1650
YQQPQILDEA LKICNYIFTV IFVFESVFKL VAFGFRRFFQ DRWNQLDLAI
1660 1670 1680 1690 1700
VLLSIMGITL EEIEVNLSLP INPTIIRIMR VLRIARVLKL LKMAVGMRAL
1710 1720 1730 1740 1750
LHTVMQALPQ VGNLGLLFML LFFIFAALGV ELFGDLECDE THPCEGLGRH
1760 1770 1780 1790 1800
ATFRNFGMAF LTLFRVSTGD NWNGIMKDTL RDCDQESTCY NTVISPIYFV
1810 1820 1830 1840 1850
SFVLTAQFVL VNVVIAVLMK HLEESNKEAK EEAELEAELE LEMKTLSPQP
1860 1870 1880 1890 1900
HSPLGSPFLW PGVEGVNSTD SPKPGAPHTT AHIGAASGFS LEHPTMVPHP
1910 1920 1930 1940 1950
EEVPVPLGPD LLTVRKSGVS RTHSLPNDSY MCRNGSTAER SLGHRGWGLP
1960 1970 1980 1990 2000
KAQSGSILSV HSQPADTSCI LQLPKDVHYL LQPHGAPTWG AIPKLPPPGR
2010 2020 2030 2040 2050
SPLAQRPLRR QAAIRTDSLD VQGLGSREDL LSEVSGPSCP LTRSSSFWGG
2060 2070 2080 2090 2100
SSIQVQQRSG IQSKVSKHIR LPAPCPGLEP SWAKDPPETR SSLELDTELS
2110 2120 2130 2140 2150
WISGDLLPSS QEEPLFPRDL KKCYSVETQS CRRRPGFWLD EQRRHSIAVS
2160 2170 2180 2190 2200
CLDSGSQPRL CPSPSSLGGQ PLGGPGSRPK KKLSPPSISI DPPESQGSRP
2210 2220 2230 2240 2250
PCSPGVCLRR RAPASDSKDP SVSSPLDSTA ASPSPKKDTL SLSGLSSDPT

DMDP
Length:2,254
Mass (Da):250,407
Last modified:January 1, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i697BBE06360CF0F6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9WUB8Q9WUB8_RAT
Voltage-dependent T-type calcium ch...
Cacna1g rCG_32907
2,288Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2K1Q5A0A0G2K1Q5_RAT
RCG32907, isoform CRA_c
Cacna1g rCG_32907
2,254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF027984 mRNA Translation: AAC67372.1
AF290212 mRNA Translation: AAG35186.2

Protein sequence database of the Protein Information Resource

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PIRi
T09053

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Rn.86960

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027984 mRNA Translation: AAC67372.1
AF290212 mRNA Translation: AAG35186.2
PIRiT09053
UniGeneiRn.86960

3D structure databases

ProteinModelPortaliO54898
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248334, 1 interactor
STRINGi10116.ENSRNOP00000061436

Chemistry databases

GuidetoPHARMACOLOGYi535

PTM databases

iPTMnetiO54898
PhosphoSitePlusiO54898

Proteomic databases

PaxDbiO54898
PRIDEiO54898

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi68942 Cacna1g

Phylogenomic databases

eggNOGiKOG2302 Eukaryota
ENOG410XNP6 LUCA
HOGENOMiHOG000007742
HOVERGENiHBG050764
InParanoidiO54898
PhylomeDBiO54898

Miscellaneous databases

Protein Ontology

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PROi
PR:O54898

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR005445 VDCC_T_a1
IPR030154 VDCC_T_a1G
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF137 PTHR10037:SF137, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PRINTSiPR01629 TVDCCALPHA1

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAC1G_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O54898
Secondary accession number(s): Q548R1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1999
Last modified: November 7, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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