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Protein

Probable G-protein coupled receptor 27

Gene

Gpr27

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Orphan receptor. Possible candidate for amine-like G-protein coupled receptor (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 27
Alternative name(s):
Super conserved receptor expressed in brain 1
Gene namesi
Name:Gpr27
Synonyms:Sreb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1202299 Gpr27

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 58CytoplasmicSequence analysisAdd BLAST11
Transmembranei59 – 79Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 142CytoplasmicSequence analysisAdd BLAST21
Transmembranei143 – 163Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini164 – 185ExtracellularSequence analysisAdd BLAST22
Transmembranei186 – 206Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini207 – 289CytoplasmicSequence analysisAdd BLAST83
Transmembranei290 – 310Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini311 – 324ExtracellularSequence analysisAdd BLAST14
Transmembranei325 – 345Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini346 – 379CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695491 – 379Probable G-protein coupled receptor 27Add BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 175PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO54897
PRIDEiO54897

PTM databases

iPTMnetiO54897
PhosphoSitePlusiO54897

Expressioni

Gene expression databases

BgeeiENSMUSG00000072875 Expressed in 223 organ(s), highest expression level in telencephalon
CleanExiMM_GPR27
GenevisibleiO54897 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098680

Structurei

3D structure databases

ProteinModelPortaliO54897
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139436
HOGENOMiHOG000231471
HOVERGENiHBG051805
InParanoidiO54897
KOiK04301
OMAiDEAYCIM
OrthoDBiEOG091G0AOZ
PhylomeDBiO54897
TreeFamiTF331163

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O54897-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANASEPGGG GSGGGAEAAA LGLRLATLSL LLCVSLAGNV LFALLIVRER
60 70 80 90 100
SLHRAPYYLL LDLCLADGLR ALACLPAVML AARRAAAAAG TPPGALGCKL
110 120 130 140 150
LAFLAALFCF HAAFLLLGVG VTRYLAIAHH RFYAERLAGW PCAAMLVCAA
160 170 180 190 200
WALALAAAFP PVLDGGGADD EDAPCALEQR PDGAPGALGF LLLLAAVVGA
210 220 230 240 250
THLVYLRLLF FIHDRRKMRP ARLVPAVSHD WTFHGPGATG QAAANWTAGF
260 270 280 290 300
GRGPTPPALV GIRPAGPGRG ARRLLVLEEF KTEKRLCKMF YAITLLFLLL
310 320 330 340 350
WGPYVVASYL RVLVRPGAVP QAYLTASVWL TFAQAGINPV VCFLFNRELR
360 370
DCFRAQFPCC QSPQATQATL PCDLKGIGL
Length:379
Mass (Da):40,036
Last modified:June 1, 1998 - v1
Checksum:i9DAE96D2857E30D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027955 Genomic DNA Translation: AAC53540.1
CCDSiCCDS20387.1
RefSeqiNP_032184.1, NM_008158.1
UniGeneiMm.394313

Genome annotation databases

EnsembliENSMUST00000101122; ENSMUSP00000098680; ENSMUSG00000072875
GeneIDi14761
KEGGimmu:14761
UCSCiuc009dbs.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027955 Genomic DNA Translation: AAC53540.1
CCDSiCCDS20387.1
RefSeqiNP_032184.1, NM_008158.1
UniGeneiMm.394313

3D structure databases

ProteinModelPortaliO54897
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098680

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO54897
PhosphoSitePlusiO54897

Proteomic databases

PaxDbiO54897
PRIDEiO54897

Protocols and materials databases

DNASUi14761
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101122; ENSMUSP00000098680; ENSMUSG00000072875
GeneIDi14761
KEGGimmu:14761
UCSCiuc009dbs.1 mouse

Organism-specific databases

CTDi2850
MGIiMGI:1202299 Gpr27

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139436
HOGENOMiHOG000231471
HOVERGENiHBG051805
InParanoidiO54897
KOiK04301
OMAiDEAYCIM
OrthoDBiEOG091G0AOZ
PhylomeDBiO54897
TreeFamiTF331163

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events

Miscellaneous databases

PROiPR:O54897
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000072875 Expressed in 223 organ(s), highest expression level in telencephalon
CleanExiMM_GPR27
GenevisibleiO54897 MM

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPR27_MOUSE
AccessioniPrimary (citable) accession number: O54897
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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