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Protein

Carboxypeptidase Z

Gene

Cpz

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing (By similarity).By similarity

Cofactori

Zn2+By similarity

Enzyme regulationi

Inhibited by 2-mercaptomethyl-3-guanidinoethylthiopropanoic acid (MGTA) and guanidinoethylmercaptosuccinic acid (GEMSA). Inhibited by chelating agents such as EDTA and EGTA (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi251Zinc; catalyticBy similarity1
Metal bindingi254Zinc; catalyticBy similarity1
Metal bindingi383Zinc; catalyticBy similarity1
Active sitei475Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Metalloprotease, Protease
Biological processWnt signaling pathway
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM14.012

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Z (EC:3.4.17.-)
Short name:
CPZ
Gene namesi
Name:Cpz
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620496 Cpz

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000025245821 – 652Carboxypeptidase ZAdd BLAST632

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 112PROSITE-ProRule annotation
Disulfide bondi54 ↔ 105PROSITE-ProRule annotation
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi96 ↔ 132PROSITE-ProRule annotation
Disulfide bondi121 ↔ 160PROSITE-ProRule annotation
Disulfide bondi125 ↔ 149PROSITE-ProRule annotation
Glycosylationi284N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO54858
PRIDEiO54858

PTM databases

PhosphoSitePlusiO54858

Expressioni

Tissue specificityi

Abundantly expressed in the placenta, with low to moderate levels in the brain, lung, thymus and kidney.

Inductioni

By Alachlor.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012109

Structurei

3D structure databases

ProteinModelPortaliO54858
SMRiO54858
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 163FZPROSITE-ProRule annotationAdd BLAST123

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2649 Eukaryota
ENOG410XX0H LUCA
HOGENOMiHOG000232185
HOVERGENiHBG003410
InParanoidiO54858
KOiK13022
PhylomeDBiO54858
TreeFamiTF315592

Family and domain databases

CDDicd03867 M14_CPZ, 1 hit
Gene3Di1.10.2000.10, 1 hit
InterProiView protein in InterPro
IPR008969 CarboxyPept-like_regulatory
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR034239 M14_CPZ_CPD
IPR000834 Peptidase_M14
PfamiView protein in Pfam
PF01392 Fz, 1 hit
PF00246 Peptidase_M14, 1 hit
PRINTSiPR00765 CRBOXYPTASEA
SMARTiView protein in SMART
SM00063 FRI, 1 hit
SM00631 Zn_pept, 1 hit
SUPFAMiSSF49464 SSF49464, 1 hit
SSF63501 SSF63501, 1 hit
PROSITEiView protein in PROSITE
PS00133 CARBOXYPEPT_ZN_2, 1 hit
PS50038 FZ, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O54858-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTTPLLLAA LAALAALAVA AYPSCSPGPD PSGKCQRLAS THSATCVDLH
60 70 80 90 100
LRTCADAAYN HTSFPTPLEH RSWEAVEASP EYTLLGVLHF LLEGQCNPDL
110 120 130 140 150
RLLGCSVLAP RCQGGHTQRP CRRVCEGLRE ACQPAFDAID MAWPYFLDCT
160 170 180 190 200
QYFAPEEEGC YDPLEQLRGE LDVEEALPSG LPPTFIRFAH HSYAQMVRVL
210 220 230 240 250
KRTAARCSQV AKTYSIGRSF EGKDLVVIEF SSRPGQHELM EPEVKLIGNI
260 270 280 290 300
HGNEVAGREI LIYLAQYLCS EYLLGNPRIQ RLLNTTRIHL LPSMNPDGYE
310 320 330 340 350
VAAAEGAGYN GWTSGRQNAQ NLDLNRNFPD LTSEYYRLAS TRGVRTDHIP
360 370 380 390 400
ISQYYWWGKV APETKAIMKW IQTIPFVLSA SLHGGDLVVS YPFDFSKHPH
410 420 430 440 450
EEKMFSPTPD EKMFKLLARA YADVHPMMMD RSENRCGGNF LKRGSIINGA
460 470 480 490 500
DWYSFTGGMS DFNYLHTNCF EITVELGCVK FPPEEALYGL WQHNKEPLLN
510 520 530 540 550
FLEMVHRGIK GVVTDKYGKP VKNARILVKG IRHDVTTAPD GDYWRLLPPG
560 570 580 590 600
SHIVIAQAPG YSKVMKRVTI PLRMKRAGRV DFILQPLGTG PKNFLPGPSR
610 620 630 640 650
ALPRSLDPQG APAQLDFEPP RARRQPASGS KPWWWAYFTS LSPHKPRWLL

KY
Length:652
Mass (Da):73,082
Last modified:June 1, 1998 - v1
Checksum:iBE085394B91A978C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23P → S in AAC04669 (PubMed:9570147).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017637 mRNA Translation: AAC04668.1
AF017638 mRNA Translation: AAC04669.1
RefSeqiNP_113954.1, NM_031766.1
UniGeneiRn.11056

Genome annotation databases

GeneIDi83575
KEGGirno:83575

Similar proteinsi

Entry informationi

Entry nameiCBPZ_RAT
AccessioniPrimary (citable) accession number: O54858
Secondary accession number(s): O54859
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 1998
Last modified: June 20, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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