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Protein
Submitted name:

Phosphatase and tensin homolog

Gene

Pten

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei124Phosphocysteine intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BRENDAi3.1.3.67 5301
ReactomeiR-RNO-1660499 Synthesis of PIPs at the plasma membrane
R-RNO-1855204 Synthesis of IP3 and IP4 in the cytosol
R-RNO-199418 Negative regulation of the PI3K/AKT network
R-RNO-202424 Downstream TCR signaling
R-RNO-5689880 Ub-specific processing proteases
R-RNO-5689896 Ovarian tumor domain proteases
R-RNO-8948747 Regulation of PTEN localization
R-RNO-8948751 Regulation of PTEN stability and activity

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphatase and tensin homologImported
Submitted name:
Phosphatase and tensin homolog, isoform CRA_aImported
Submitted name:
Protein tyrosine phosphatase and tensin homolog/mutated in multiple advanced cancers proteinImported
Submitted name:
Protein tyrosine phosphatase and tensin-like proteinImported
Gene namesi
Name:PtenImported
Synonyms:PTEN/MMAC1Imported
ORF Names:rCG_47874Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi61995 Pten

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiO54857

Expressioni

Gene expression databases

BgeeiENSRNOG00000020723 Expressed in 10 organ(s), highest expression level in spleen

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

IntActiO54857, 3 interactors
MINTiO54857
STRINGi10116.ENSRNOP00000028143

Structurei

3D structure databases

SMRiO54857
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 185Phosphatase tensin-typeInterPro annotationAdd BLAST172
Domaini190 – 350C2 tensin-typeInterPro annotationAdd BLAST161

Phylogenomic databases

eggNOGiKOG2283 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000119113
HOGENOMiHOG000008008
HOVERGENiHBG000239
KOiK01110
OMAiREDKYMY
OrthoDBiEOG091G09VG
TreeFamiTF324513

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR017361 Bifunc_PIno_P3_Pase/Pase_PTEN
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR014020 Tensin_C2-dom
IPR029023 Tensin_phosphatase
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF10409 PTEN_C2, 1 hit
PIRSFiPIRSF038025 PTEN, 1 hit
SMARTiView protein in SMART
SM01326 PTEN_C2, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

O54857-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAIIKEIVS RNKRRYQEDG FDLDLTYIYP NIIAMGFPAE RLEGVYRNNI
60 70 80 90 100
DDVVRFLDSK HKNHYKIYNL CAERHYDTAK FNCRVAQYPF EDHNPPQLEL
110 120 130 140 150
IKPFCEDLDQ WLSEDDNHVA AIHCKAGKGR TGVMICAYLL HRGKFLKAQE
160 170 180 190 200
ALDFYGEVRT RDKKGVTIPS QRRYVYYYSY LLKNHLDYRP VALLFHKMMF
210 220 230 240 250
ETIPMFSGGT CNPQFVVCQL KVKIYSSNSG PTRREDKLMY FEFPQPLPVC
260 270 280 290 300
GDIKVEFFHK QNKMLKKDKM FHFWVNTFFI PGPEETSEKV ENGSLCDQEI
310 320 330 340 350
DSICSIERAD NDKEYLVLTL TKNDLDKANK DKANRYFSPN FKVKLYFTKT
360 370 380 390 400
VEEPSNPEAS SSTSVTPDVS DNEPDHYRYS DTTDSDPENE PFDEDQHSQI

TKV
Length:403
Mass (Da):47,118
Last modified:June 1, 1998 - v1
Checksum:i243BFE35FE209FE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07006753 Genomic DNA No translation available.
AABR07006754 Genomic DNA No translation available.
AF017185 mRNA Translation: AAB96620.1
AF455569 mRNA Translation: AAO31948.1
CH473953 Genomic DNA Translation: EDM13141.1
RefSeqiNP_113794.1, NM_031606.1
UniGeneiRn.22158

Genome annotation databases

EnsembliENSRNOT00000028143; ENSRNOP00000028143; ENSRNOG00000020723
GeneIDi50557
KEGGirno:50557

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07006753 Genomic DNA No translation available.
AABR07006754 Genomic DNA No translation available.
AF017185 mRNA Translation: AAB96620.1
AF455569 mRNA Translation: AAO31948.1
CH473953 Genomic DNA Translation: EDM13141.1
RefSeqiNP_113794.1, NM_031606.1
UniGeneiRn.22158

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K20NMR-B393-403[»]
SMRiO54857
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO54857, 3 interactors
MINTiO54857
STRINGi10116.ENSRNOP00000028143

Proteomic databases

PRIDEiO54857

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028143; ENSRNOP00000028143; ENSRNOG00000020723
GeneIDi50557
KEGGirno:50557

Organism-specific databases

CTDi5728
RGDi61995 Pten

Phylogenomic databases

eggNOGiKOG2283 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000119113
HOGENOMiHOG000008008
HOVERGENiHBG000239
KOiK01110
OMAiREDKYMY
OrthoDBiEOG091G09VG
TreeFamiTF324513

Enzyme and pathway databases

BRENDAi3.1.3.67 5301
ReactomeiR-RNO-1660499 Synthesis of PIPs at the plasma membrane
R-RNO-1855204 Synthesis of IP3 and IP4 in the cytosol
R-RNO-199418 Negative regulation of the PI3K/AKT network
R-RNO-202424 Downstream TCR signaling
R-RNO-5689880 Ub-specific processing proteases
R-RNO-5689896 Ovarian tumor domain proteases
R-RNO-8948747 Regulation of PTEN localization
R-RNO-8948751 Regulation of PTEN stability and activity

Gene expression databases

BgeeiENSRNOG00000020723 Expressed in 10 organ(s), highest expression level in spleen

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR017361 Bifunc_PIno_P3_Pase/Pase_PTEN
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR014020 Tensin_C2-dom
IPR029023 Tensin_phosphatase
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF10409 PTEN_C2, 1 hit
PIRSFiPIRSF038025 PTEN, 1 hit
SMARTiView protein in SMART
SM01326 PTEN_C2, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO54857_RAT
AccessioniPrimary (citable) accession number: O54857
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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