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UniProtKB - O54852 (KCNH7_RAT)

Protein

Potassium voltage-gated channel subfamily H member 7

Gene

Kcnh7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi745 – 862cNMPAdd BLAST118

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Protein family/group databases

TCDBi1.A.1.20.3 the voltage-gated ion channel (vic) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily H member 7
Alternative name(s):
Ether-a-go-go-related gene potassium channel 3
Short name:
ERG-3
Short name:
Eag-related protein 3
Short name:
Ether-a-go-go-related protein 3
Voltage-gated potassium channel subunit Kv11.3
Gene namesi
Name:Kcnh7
Synonyms:Erg3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621112 Kcnh7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 412CytoplasmicSequence analysisAdd BLAST412
Transmembranei413 – 433Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini434 – 449ExtracellularSequence analysisAdd BLAST16
Transmembranei450 – 470Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini471 – 494CytoplasmicSequence analysisAdd BLAST24
Transmembranei495 – 515Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini516 – 521ExtracellularSequence analysis6
Transmembranei522 – 542Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST21
Topological domaini543 – 549CytoplasmicSequence analysis7
Transmembranei550 – 570Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini571 – 614ExtracellularSequence analysisAdd BLAST44
Intramembranei615 – 635Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Topological domaini636 – 641ExtracellularSequence analysis6
Transmembranei642 – 662Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini663 – 1195CytoplasmicSequence analysisAdd BLAST533

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi480E → S: Lower channel activity. 1

Chemistry databases

GuidetoPHARMACOLOGYi574

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540171 – 1195Potassium voltage-gated channel subfamily H member 7Add BLAST1195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei174PhosphoserineCombined sources1
Modified residuei238PhosphoserineBy similarity1
Modified residuei319PhosphoserineCombined sources1
Glycosylationi600N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei891PhosphoserineCombined sources1
Modified residuei894PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO54852
PRIDEiO54852

PTM databases

iPTMnetiO54852
PhosphoSitePlusiO54852

Expressioni

Tissue specificityi

Detected in total brain, in superior cervical, mesenteric and celiac ganglia, and at very low levels in retina. Found in pituitary.1 Publication

Gene expression databases

GenevisibleiO54852 RN

Interactioni

Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH2/ERG1 and KCNH6/ERG2.

Protein-protein interaction databases

BioGridi250984, 1 interactor
STRINGi10116.ENSRNOP00000009920

Structurei

3D structure databases

ProteinModelPortaliO54852
SMRiO54852
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 70PASAdd BLAST30
Domaini92 – 144PACAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi627 – 632Selectivity filterBy similarity6

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.3/KCNH7 sub-subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0498 Eukaryota
ENOG410XPSE LUCA
HOGENOMiHOG000230793
HOVERGENiHBG052232
InParanoidiO54852
KOiK04910
OrthoDBiEOG091G024C
PhylomeDBiO54852
TreeFamiTF313130

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
cd00130 PAS, 1 hit
Gene3Di1.20.120.350, 1 hit
2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR005821 Ion_trans_dom
IPR003938 K_chnl_volt-dep_EAG/ELK/ERG
IPR003967 K_chnl_volt-dep_ERG
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR014710 RmlC-like_jellyroll
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF00520 Ion_trans, 1 hit
PF13426 PAS_9, 1 hit
PRINTSiPR01463 EAGCHANLFMLY
PR01470 ERGCHANNEL
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
SSF55785 SSF55785, 1 hit
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

O54852-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVRRGHVAP QNTFLGTIIR KFEGQNKKFI IANARVQNCA IIYCNDGFCE 
        60         70         80         90        100
MTGFSRPDVM QKPCTCDFLH GPETKRHDIA QIAQALLGSE ERKVEVTYYH 
       110        120        130        140        150
KNGSTFICNT HIIPVKNQEG VAMMFIINFE YVTDEDNAAS PERVNPILPV 
       160        170        180        190        200
KSVNRKLFGF KFPGLRVLTY RKQSLPQEDP DVVVIDSSKH SDDSVAMKHF 
       210        220        230        240        250
KSPTKESCSP SEADDTKALI QPSQCSPLVN ISGPLDHSSP KRQWDRLYPD 
       260        270        280        290        300
MLQSSSQLTH SRSRESLCSI RRASSVHDIE GFNVHPKNIF RDRHASEDNG 
       310        320        330        340        350
RNVKGPFNHI KSSLLGSTSD SNLNKYSTIN KIPQLTLNFS DVKTEKKNTS 
       360        370        380        390        400
PPSSDKTIIA PKVKERTHNV TEKVTQVLSL GADVLPEYKL QTPRINKFTI 
       410        420        430        440        450
LHYSPFKAVW DWLILLLVIY TAIFTPYSAA FLLNDREEQK RRECGYSCSP 
       460        470        480        490        500
LNVVDLIVDI MFIIDILINF RTTYVNQNEE VVSDPAKIAV HYFKGWFLID 
       510        520        530        540        550
MVAAIPFDLL IFGSGSDETT TLIGLLKTAR LLRLVRVARK LDRYSEYGAA 
       560        570        580        590        600
VLMLLMCIFA LIAHWLACIW YAIGNVERPY LTDKIGWLDS LGTQIGKRYN 
       610        620        630        640        650
DSDSSSGPSI KDKYVTALYF TFSSLTSVGF GNVSPNTNSE KIFSICVMLI 
       660        670        680        690        700
GSLMYASIFG NVSAIIQRLY SGTARYHMQM LRVKEFIRFH QIPNPLRQRL 
       710        720        730        740        750
EEYFQHAWTY TNGIDMNMVL KGFPECLQAD ICLHLNQTLL QNCKAFRGAS 
       760        770        780        790        800
KGCLRALAMK FKTTHAPPGD TLVHCGDVLT ALYFLSRGSI EILKDDIVVA 
       810        820        830        840        850
ILGKNDIFGE MVHLYAKPGK SNADVRALTY CDLHKIQRED LLEVLDMYPE 
       860        870        880        890        900
FSDHFLTNLE LTFNLRHESA KSQSINDSEG DTCKLRRRRL SFESEGDKDF 
       910        920        930        940        950
SKENSANDAD DSTDTIRRYQ SSKKHFEEKK SRSSSFISSI DDEQKPLFLG 
       960        970        980        990       1000
TVDSTPRMVK ASRHHGEEAA PPSGRIHTDK RSHSCKDITD THSWEREHAR 
      1010       1020       1030       1040       1050
AQPEECSPSG LQRAAWGISE TESDLTYGEV EQRLDLLQEQ LNRLESQMTT 
      1060       1070       1080       1090       1100
DIQAILQLLQ KQTTVVPPAY SMVTAGAEYQ RPILRLLRTS HPRASIKTDR 
      1110       1120       1130       1140       1150
SFSPSSQCPE FLDLEKSKLK SKESLSSGKR LNTASEDNLT SLLKQDSDAS 
      1160       1170       1180       1190 
SELDPRQRKS YLHPIRHPSL PDSSLSTVGI LGLHRHVSDP GLPGK
Length:1,195
Mass (Da):134,901
Last modified:June 1, 1998 - v1
Checksum:iBA24C54BB86C59B7
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0H2UHF2A0A0H2UHF2_RAT
Potassium voltage-gated channel sub...
Kcnh7
1,093Annotation score:
A0A0G2K3B8A0A0G2K3B8_RAT
Potassium voltage-gated channel sub...
Kcnh7
1,078Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016191 mRNA Translation: AAB94741.1
RefSeqiNP_571987.1, NM_131912.1
UniGeneiRn.10874

Genome annotation databases

GeneIDi170739
KEGGirno:170739
UCSCiRGD:621112 rat

Similar proteinsi

Entry informationi

Entry nameiKCNH7_RAT
AccessioniPrimary (citable) accession number: O54852
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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