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UniProtKB - O54852 (KCNH7_RAT)
Protein
Potassium voltage-gated channel subfamily H member 7
Gene
Kcnh7
Organism
Rattus norvegicus (Rat)
Status
Functioni
Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 745 – 862 | cNMPAdd BLAST | 118 |
GO - Molecular functioni
- inward rectifier potassium channel activity Source: RGD
- potassium channel activity Source: RGD
- protein-containing complex binding Source: RGD
- voltage-gated potassium channel activity Source: RGD
GO - Biological processi
- circadian rhythm Source: RGD
- membrane repolarization during action potential Source: GO_Central
- potassium ion transmembrane transport Source: GO_Central
- potassium ion transport Source: RGD
- regulation of ion transmembrane transport Source: UniProtKB-KW
- regulation of membrane potential Source: GO_Central
Keywordsi
Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Enzyme and pathway databases
Reactomei | R-RNO-1296072, Voltage gated Potassium channels |
Protein family/group databases
TCDBi | 1.A.1.20.3, the voltage-gated ion channel (vic) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium voltage-gated channel subfamily H member 7Alternative name(s): Ether-a-go-go-related gene potassium channel 3 Short name: ERG-3 Short name: Eag-related protein 3 Short name: Ether-a-go-go-related protein 3 Voltage-gated potassium channel subunit Kv11.3 |
Gene namesi | Name:Kcnh7 Synonyms:Erg3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621112, Kcnh7 |
Subcellular locationi
Other locations
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 412 | CytoplasmicSequence analysisAdd BLAST | 412 | |
Transmembranei | 413 – 433 | Helical; Name=Segment S1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 434 – 449 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 450 – 470 | Helical; Name=Segment S2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 471 – 494 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 495 – 515 | Helical; Name=Segment S3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 516 – 521 | ExtracellularSequence analysis | 6 | |
Transmembranei | 522 – 542 | Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 543 – 549 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 550 – 570 | Helical; Name=Segment S5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 571 – 614 | ExtracellularSequence analysisAdd BLAST | 44 | |
Intramembranei | 615 – 635 | Pore-forming; Name=Segment H5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 636 – 641 | ExtracellularSequence analysis | 6 | |
Transmembranei | 642 – 662 | Helical; Name=Segment S6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 663 – 1195 | CytoplasmicSequence analysisAdd BLAST | 533 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 480 | E → S: Lower channel activity. | 1 |
Chemistry databases
GuidetoPHARMACOLOGYi | 574 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054017 | 1 – 1195 | Potassium voltage-gated channel subfamily H member 7Add BLAST | 1195 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 174 | PhosphoserineCombined sources | 1 | |
Modified residuei | 238 | PhosphoserineBy similarity | 1 | |
Modified residuei | 319 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 600 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 891 | PhosphoserineCombined sources | 1 | |
Modified residuei | 894 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | O54852 |
PTM databases
GlyGeni | O54852, 1 site |
iPTMneti | O54852 |
PhosphoSitePlusi | O54852 |
Expressioni
Tissue specificityi
Detected in total brain, in superior cervical, mesenteric and celiac ganglia, and at very low levels in retina. Found in pituitary.1 Publication
Gene expression databases
Genevisiblei | O54852, RN |
Interactioni
Subunit structurei
The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH2/ERG1 and KCNH6/ERG2.
Protein-protein interaction databases
BioGRIDi | 250984, 1 interactor |
STRINGi | 10116.ENSRNOP00000009920 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 70 | PASAdd BLAST | 30 | |
Domaini | 92 – 144 | PACAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 194 – 216 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 894 – 914 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 958 – 987 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 1144 – 1174 | DisorderedSequence analysisAdd BLAST | 31 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 627 – 632 | Selectivity filterBy similarity | 6 |
Domaini
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Sequence similaritiesi
Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.3/KCNH7 sub-subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0498, Eukaryota |
InParanoidi | O54852 |
OrthoDBi | 247304at2759 |
PhylomeDBi | O54852 |
TreeFami | TF313130 |
Family and domain databases
CDDi | cd00038, CAP_ED, 1 hit cd00130, PAS, 1 hit |
Gene3Di | 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR018490, cNMP-bd-like IPR000595, cNMP-bd_dom IPR005821, Ion_trans_dom IPR003938, K_chnl_volt-dep_EAG/ELK/ERG IPR003967, K_chnl_volt-dep_ERG IPR000014, PAS IPR035965, PAS-like_dom_sf IPR014710, RmlC-like_jellyroll |
Pfami | View protein in Pfam PF00027, cNMP_binding, 1 hit PF00520, Ion_trans, 1 hit PF13426, PAS_9, 1 hit |
PRINTSi | PR01463, EAGCHANLFMLY PR01470, ERGCHANNEL |
SMARTi | View protein in SMART SM00100, cNMP, 1 hit |
SUPFAMi | SSF51206, SSF51206, 1 hit SSF55785, SSF55785, 1 hit |
TIGRFAMsi | TIGR00229, sensory_box, 1 hit |
PROSITEi | View protein in PROSITE PS50042, CNMP_BINDING_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
O54852-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPVRRGHVAP QNTFLGTIIR KFEGQNKKFI IANARVQNCA IIYCNDGFCE
60 70 80 90 100
MTGFSRPDVM QKPCTCDFLH GPETKRHDIA QIAQALLGSE ERKVEVTYYH
110 120 130 140 150
KNGSTFICNT HIIPVKNQEG VAMMFIINFE YVTDEDNAAS PERVNPILPV
160 170 180 190 200
KSVNRKLFGF KFPGLRVLTY RKQSLPQEDP DVVVIDSSKH SDDSVAMKHF
210 220 230 240 250
KSPTKESCSP SEADDTKALI QPSQCSPLVN ISGPLDHSSP KRQWDRLYPD
260 270 280 290 300
MLQSSSQLTH SRSRESLCSI RRASSVHDIE GFNVHPKNIF RDRHASEDNG
310 320 330 340 350
RNVKGPFNHI KSSLLGSTSD SNLNKYSTIN KIPQLTLNFS DVKTEKKNTS
360 370 380 390 400
PPSSDKTIIA PKVKERTHNV TEKVTQVLSL GADVLPEYKL QTPRINKFTI
410 420 430 440 450
LHYSPFKAVW DWLILLLVIY TAIFTPYSAA FLLNDREEQK RRECGYSCSP
460 470 480 490 500
LNVVDLIVDI MFIIDILINF RTTYVNQNEE VVSDPAKIAV HYFKGWFLID
510 520 530 540 550
MVAAIPFDLL IFGSGSDETT TLIGLLKTAR LLRLVRVARK LDRYSEYGAA
560 570 580 590 600
VLMLLMCIFA LIAHWLACIW YAIGNVERPY LTDKIGWLDS LGTQIGKRYN
610 620 630 640 650
DSDSSSGPSI KDKYVTALYF TFSSLTSVGF GNVSPNTNSE KIFSICVMLI
660 670 680 690 700
GSLMYASIFG NVSAIIQRLY SGTARYHMQM LRVKEFIRFH QIPNPLRQRL
710 720 730 740 750
EEYFQHAWTY TNGIDMNMVL KGFPECLQAD ICLHLNQTLL QNCKAFRGAS
760 770 780 790 800
KGCLRALAMK FKTTHAPPGD TLVHCGDVLT ALYFLSRGSI EILKDDIVVA
810 820 830 840 850
ILGKNDIFGE MVHLYAKPGK SNADVRALTY CDLHKIQRED LLEVLDMYPE
860 870 880 890 900
FSDHFLTNLE LTFNLRHESA KSQSINDSEG DTCKLRRRRL SFESEGDKDF
910 920 930 940 950
SKENSANDAD DSTDTIRRYQ SSKKHFEEKK SRSSSFISSI DDEQKPLFLG
960 970 980 990 1000
TVDSTPRMVK ASRHHGEEAA PPSGRIHTDK RSHSCKDITD THSWEREHAR
1010 1020 1030 1040 1050
AQPEECSPSG LQRAAWGISE TESDLTYGEV EQRLDLLQEQ LNRLESQMTT
1060 1070 1080 1090 1100
DIQAILQLLQ KQTTVVPPAY SMVTAGAEYQ RPILRLLRTS HPRASIKTDR
1110 1120 1130 1140 1150
SFSPSSQCPE FLDLEKSKLK SKESLSSGKR LNTASEDNLT SLLKQDSDAS
1160 1170 1180 1190
SELDPRQRKS YLHPIRHPSL PDSSLSTVGI LGLHRHVSDP GLPGK
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0H2UHF2 | A0A0H2UHF2_RAT | Potassium voltage-gated channel sub... | Kcnh7 | 1,078 | Annotation score: | ||
A0A0G2K3B8 | A0A0G2K3B8_RAT | Potassium voltage-gated channel sub... | Kcnh7 | 1,071 | Annotation score: | ||
A0A8I5ZLI3 | A0A8I5ZLI3_RAT | Potassium voltage-gated channel sub... | Kcnh7 | 1,112 | Annotation score: | ||
A0A8I5ZLU2 | A0A8I5ZLU2_RAT | Potassium voltage-gated channel sub... | Kcnh7 | 515 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF016191 mRNA Translation: AAB94741.1 |
RefSeqi | NP_571987.1, NM_131912.1 |
Genome annotation databases
Ensembli | ENSRNOT00000112058; ENSRNOP00000078922; ENSRNOG00000007528 |
GeneIDi | 170739 |
KEGGi | rno:170739 |
UCSCi | RGD:621112, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF016191 mRNA Translation: AAB94741.1 |
RefSeqi | NP_571987.1, NM_131912.1 |
3D structure databases
AlphaFoldDBi | O54852 |
BMRBi | O54852 |
SMRi | O54852 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 250984, 1 interactor |
STRINGi | 10116.ENSRNOP00000009920 |
Chemistry databases
GuidetoPHARMACOLOGYi | 574 |
Protein family/group databases
TCDBi | 1.A.1.20.3, the voltage-gated ion channel (vic) superfamily |
PTM databases
GlyGeni | O54852, 1 site |
iPTMneti | O54852 |
PhosphoSitePlusi | O54852 |
Proteomic databases
PaxDbi | O54852 |
Protocols and materials databases
ABCDi | O54852, 2 sequenced antibodies |
Genome annotation databases
Ensembli | ENSRNOT00000112058; ENSRNOP00000078922; ENSRNOG00000007528 |
GeneIDi | 170739 |
KEGGi | rno:170739 |
UCSCi | RGD:621112, rat |
Organism-specific databases
CTDi | 90134 |
RGDi | 621112, Kcnh7 |
Phylogenomic databases
eggNOGi | KOG0498, Eukaryota |
InParanoidi | O54852 |
OrthoDBi | 247304at2759 |
PhylomeDBi | O54852 |
TreeFami | TF313130 |
Enzyme and pathway databases
Reactomei | R-RNO-1296072, Voltage gated Potassium channels |
Miscellaneous databases
PROi | PR:O54852 |
Gene expression databases
Genevisiblei | O54852, RN |
Family and domain databases
CDDi | cd00038, CAP_ED, 1 hit cd00130, PAS, 1 hit |
Gene3Di | 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR018490, cNMP-bd-like IPR000595, cNMP-bd_dom IPR005821, Ion_trans_dom IPR003938, K_chnl_volt-dep_EAG/ELK/ERG IPR003967, K_chnl_volt-dep_ERG IPR000014, PAS IPR035965, PAS-like_dom_sf IPR014710, RmlC-like_jellyroll |
Pfami | View protein in Pfam PF00027, cNMP_binding, 1 hit PF00520, Ion_trans, 1 hit PF13426, PAS_9, 1 hit |
PRINTSi | PR01463, EAGCHANLFMLY PR01470, ERGCHANNEL |
SMARTi | View protein in SMART SM00100, cNMP, 1 hit |
SUPFAMi | SSF51206, SSF51206, 1 hit SSF55785, SSF55785, 1 hit |
TIGRFAMsi | TIGR00229, sensory_box, 1 hit |
PROSITEi | View protein in PROSITE PS50042, CNMP_BINDING_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KCNH7_RAT | |
Accessioni | O54852Primary (citable) accession number: O54852 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2002 |
Last sequence update: | June 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families