UniProtKB - O54851 (CXD2_MOUSE)
Protein
Gap junction delta-2 protein
Gene
Gjd2
Organism
Mus musculus (Mouse)
Status
Functioni
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
GO - Molecular functioni
- gap junction channel activity Source: GO_Central
GO - Biological processi
- action potential Source: MGI
- cell-cell signaling Source: MGI
- chemical synaptic transmission Source: MGI
- visual perception Source: MGI
Enzyme and pathway databases
Reactomei | R-MMU-112303, Electric Transmission Across Gap Junctions R-MMU-190861, Gap junction assembly |
Names & Taxonomyi
Protein namesi | Recommended name: Gap junction delta-2 proteinAlternative name(s): Connexin-36 Short name: Cx36 Gap junction alpha-9 protein |
Gene namesi | Name:Gjd2 Synonyms:Gja9 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1334209, Gjd2 |
Subcellular locationi
Plasma membrane
Other locations
Plasma Membrane
- connexin complex Source: GO_Central
Other locations
- gap junction Source: MGI
- integral component of membrane Source: UniProtKB-KW
- synapse Source: GOC
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 19 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 20 – 42 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 43 – 75 | ExtracellularSequence analysisAdd BLAST | 33 | |
Transmembranei | 76 – 98 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 99 – 197 | CytoplasmicSequence analysisAdd BLAST | 99 | |
Transmembranei | 198 – 220 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 221 – 252 | ExtracellularSequence analysisAdd BLAST | 32 | |
Transmembranei | 253 – 275 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 276 – 321 | CytoplasmicSequence analysisAdd BLAST | 46 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Gap junction, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000057836 | 1 – 321 | Gap junction delta-2 proteinAdd BLAST | 321 |
Proteomic databases
PaxDbi | O54851 |
PRIDEi | O54851 |
PTM databases
iPTMneti | O54851 |
PhosphoSitePlusi | O54851 |
Expressioni
Tissue specificityi
Highly expressed in neurons.
Gene expression databases
Bgeei | ENSMUSG00000068615, Expressed in islet of Langerhans and 114 other tissues |
Genevisiblei | O54851, MM |
Interactioni
Subunit structurei
A connexon is composed of a hexamer of connexins.
Protein-protein interaction databases
BioGRIDi | 199930, 1 interactor |
STRINGi | 10090.ENSMUSP00000087742 |
Miscellaneous databases
RNActi | O54851, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QV4X, Eukaryota |
GeneTreei | ENSGT01010000222399 |
HOGENOMi | CLU_037388_4_0_1 |
InParanoidi | O54851 |
OMAi | DRDQDSM |
OrthoDBi | 872373at2759 |
TreeFami | TF329606 |
Family and domain databases
Gene3Di | 1.20.1440.80, 2 hits |
InterProi | View protein in InterPro IPR000500, Connexin IPR002260, Connexin36 IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf |
PANTHERi | PTHR11984, PTHR11984, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit |
PRINTSi | PR00206, CONNEXIN PR01131, CONNEXIN36 |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
PROSITEi | View protein in PROSITE PS00407, CONNEXINS_1, 1 hit PS00408, CONNEXINS_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O54851-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGEWTILERL LEAAVQQHST MIGRILLTVV VIFRILIVAI VGETVYDDEQ
60 70 80 90 100
TMFVCNTLQP GCNQACYDRA FPISHIRYWV FQIIMVCTPS LCFITYSVHQ
110 120 130 140 150
SAKQRERRYS TVFLALDRDP AESIGGPGGT GGGGSGGSKR EDKKLQNAIV
160 170 180 190 200
NGVLQNTETT SKETEPDCLE VKELTPHPSG LRTAARSKLR RQEGISRFYI
210 220 230 240 250
IQVVFRNALE IGFLVGQYFL YGFSVPGLYE CNRYPCIKEV ECYVSRPTEK
260 270 280 290 300
TVFLVFMFAV SGICVVLNLA ELNHLGWRKI KLAVRGAQAK RKSVYEIRNK
310 320
DLPRVSVPNF GRTQSSDSAY V
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 17 | Missing in AAF86379 (PubMed:10876089).Curated | 1 | |
Sequence conflicti | 76 | I → V in AAD13684 (PubMed:9753189).Curated | 1 | |
Sequence conflicti | 149 | I → M in AAD13684 (PubMed:9753189).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF016190 Genomic DNA Translation: AAD13684.1 AF226992 Genomic DNA Translation: AAF86379.1 AL844569 Genomic DNA No translation available. CH466519 Genomic DNA Translation: EDL27860.1 BC058595 mRNA Translation: AAH58595.1 |
CCDSi | CCDS16563.1 |
RefSeqi | NP_034420.2, NM_010290.2 XP_017171134.1, XM_017315645.1 |
Genome annotation databases
Ensembli | ENSMUST00000090275; ENSMUSP00000087742; ENSMUSG00000068615 |
GeneIDi | 14617 |
KEGGi | mmu:14617 |
UCSCi | uc008lpu.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF016190 Genomic DNA Translation: AAD13684.1 AF226992 Genomic DNA Translation: AAF86379.1 AL844569 Genomic DNA No translation available. CH466519 Genomic DNA Translation: EDL27860.1 BC058595 mRNA Translation: AAH58595.1 |
CCDSi | CCDS16563.1 |
RefSeqi | NP_034420.2, NM_010290.2 XP_017171134.1, XM_017315645.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 199930, 1 interactor |
STRINGi | 10090.ENSMUSP00000087742 |
PTM databases
iPTMneti | O54851 |
PhosphoSitePlusi | O54851 |
Proteomic databases
PaxDbi | O54851 |
PRIDEi | O54851 |
Protocols and materials databases
Antibodypediai | 9771, 262 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000090275; ENSMUSP00000087742; ENSMUSG00000068615 |
GeneIDi | 14617 |
KEGGi | mmu:14617 |
UCSCi | uc008lpu.1, mouse |
Organism-specific databases
CTDi | 57369 |
MGIi | MGI:1334209, Gjd2 |
Phylogenomic databases
eggNOGi | ENOG502QV4X, Eukaryota |
GeneTreei | ENSGT01010000222399 |
HOGENOMi | CLU_037388_4_0_1 |
InParanoidi | O54851 |
OMAi | DRDQDSM |
OrthoDBi | 872373at2759 |
TreeFami | TF329606 |
Enzyme and pathway databases
Reactomei | R-MMU-112303, Electric Transmission Across Gap Junctions R-MMU-190861, Gap junction assembly |
Miscellaneous databases
BioGRID-ORCSi | 14617, 2 hits in 17 CRISPR screens |
PROi | PR:O54851 |
RNActi | O54851, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000068615, Expressed in islet of Langerhans and 114 other tissues |
Genevisiblei | O54851, MM |
Family and domain databases
Gene3Di | 1.20.1440.80, 2 hits |
InterProi | View protein in InterPro IPR000500, Connexin IPR002260, Connexin36 IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf |
PANTHERi | PTHR11984, PTHR11984, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit |
PRINTSi | PR00206, CONNEXIN PR01131, CONNEXIN36 |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
PROSITEi | View protein in PROSITE PS00407, CONNEXINS_1, 1 hit PS00408, CONNEXINS_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXD2_MOUSE | |
Accessioni | O54851Primary (citable) accession number: O54851 Secondary accession number(s): Q6PDP3, Q9JII0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 149 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families