Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - O54834 (RHG06_MOUSE)

Entry version 154 (10 Feb 2021)
Sequence version 3 (29 May 2007)
Previous versions | rss
Add a publicationFeedback
Protein

Rho GTPase-activating protein 6

Gene

Arhgap6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-194840, Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 6
Alternative name(s):
Rho-type GTPase-activating protein 6
Rho-type GTPase-activating protein RhoGAPX-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arhgap6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1196332, Arhgap6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000567051 – 987Rho GTPase-activating protein 6Add BLAST987

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei37PhosphoserineCombined sources1
Modified residuei265PhosphoserineBy similarity1
Modified residuei365PhosphoserineBy similarity1
Modified residuei669PhosphoserineCombined sources1
Modified residuei675PhosphoserineCombined sources1
Modified residuei682PhosphoserineBy similarity1
Modified residuei713PhosphoserineCombined sources1
Modified residuei758PhosphoserineBy similarity1
Modified residuei776PhosphoserineBy similarity1
Modified residuei781PhosphoserineBy similarity1
Modified residuei790PhosphoserineBy similarity1
Modified residuei824PhosphoserineCombined sources1
Modified residuei941PhosphoserineBy similarity1
Modified residuei944PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		O54834

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O54834

PeptideAtlas

More...PeptideAtlasi		O54834

PRoteomics IDEntifications database

More...PRIDEi		O54834

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O54834

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O54834

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in retina and lung.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000031355, Expressed in lateral septal nucleus and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O54834, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O54834, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		O54834, 7 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000033721

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O54834, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O54834

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini403 – 604Rho-GAPPROSITE-ProRule annotationAdd BLAST202

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi344 – 354SH3-bindingAdd BLAST11

Keywords - Domaini

SH3-binding

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2710, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153904

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012874_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O54834

Identification of Orthologs from Complete Genome Data

More...OMAi		IPECQLQ

Database of Orthologous Groups

More...OrthoDBi		419555at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O54834

TreeFam database of animal gene trees

More...TreeFami		TF316710

Family and domain databases

Conserved Domains Database

More...CDDi		cd04376, RhoGAP_ARHGAP6, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.555.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR041852, ARHGAP6_RhoGAP
IPR008936, Rho_GTPase_activation_prot
IPR030772, RhoGAP6
IPR037863, RHOGAP6/36
IPR000198, RhoGAP_dom

The PANTHER Classification System

More...PANTHERi		PTHR12635, PTHR12635, 1 hit
PTHR12635:SF6, PTHR12635:SF6, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00620, RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00324, RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48350, SSF48350, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50238, RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O54834-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAQSLLHSV FSCSSPASGG TASAKGFSKR KLRQTRSLDP ALIGGCGSEM 
        60         70         80         90        100
GAEGGLRGST VSRLHSPQLL AEGLGSRLAS SPRSQHLRAT RFQTPRPLCS 
       110        120        130        140        150
SFSTPSTPQE KSPSGSFHFD YEVPLSRSGL KKSMAWDLPS VLAGSGSASS 
       160        170        180        190        200
RSPASILSSS GGGPNGIFSS PRRWLQQRKF QPPPNSRSHP YVVWRSEGDF 
       210        220        230        240        250
TWNSMSGRSV RLRSVPIQSL SELERARLQE VAFYQLQQDC DLGCQITIPK 
       260        270        280        290        300
DGQKRKKSLR KKLDSLGKEK NKDKEFIPQA FGMPLSQVIA NDRAYKLKQD 
       310        320        330        340        350
LQREEQKDAS SDFVSSLLPF GNKKQNKELS SSNSSLSSTS ETPNESTSPN 
       360        370        380        390        400
TPEPAPRARR RGAMSVDSIT DLDDNQSRLL EALQLSLPAE AQSKKEKARD 
       410        420        430        440        450
KKLSLNPIYR QVPRLVDSCC QHLEKHGLQT VGIFRVGSSK KRVRQLREEF 
       460        470        480        490        500
DRGVDVCLEE EHSVHDVAAL LKEFLRDMPD PLLTRELYTA FINTLLLEPE 
       510        520        530        540        550
EQLGTLQLLI YLLPPCNCDT LHRLLQFLSI VARHADDNVS KDGQEVTGNK 
       560        570        580        590        600
MTSLNLATIF GPNLLHKQKS SDKEYSVQSS ARAEESTAII AVVQKMIENY 
       610        620        630        640        650
EALFMVPPDL QNEVLISLLE TDPDVVDYLL RRKASQSSSP DILQTEVSFS 
       660        670        680        690        700
MGGRHSSTDS NKASSGDISP YDNNSPVLSE RSLLAMQEDR ARGGSEKLYK 
       710        720        730        740        750
VPEQYTLVGH LSSPKSKSRE SSPGPRLGKE MSEEPFNIWG TWHSTLKSGS 
       760        770        780        790        800
KDPGMTGSYG DIFESSSLRP RPCSLSQGNL SLNWPRCQGS PTGLDSGTQV 
       810        820        830        840        850
IRRTQTAATV EQCSVHLPVS RVCSTPHIQD GSRGTRRPAA SSDPFLSLNS 
       860        870        880        890        900
TEDLAEGKED VAWLQSQARP VYQRPQESGK DDRRPPPPYP GSGKPATTSA 
       910        920        930        940        950
QLPLEPPLWR LQRHEEGSET AVEGGQQASG EHQTRPKKLS SAYSLSASEQ 
       960        970        980 
DKQNLGEASW LDWQRERWQI WELLSTDNPD ALPETLV
Length:987
Mass (Da):108,844
Last modified:May 29, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB621845ECF1C7EBD
GO
Isoform 2 (identifier: O54834-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     639-660: SPDILQTEVSFSMGGRHSSTDS → TSSVLPAAGQACSQSPASDFTP
     661-987: Missing.

Show »
Length:660
Mass (Da):72,713
Checksum:i7DB2D964FEF9A5F9
GO
Isoform 3 (identifier: O54834-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.
     59-197: STVSRLHSPQ...SHPYVVWRSE → MGDPSYSEKPRLHYA

Show »
Length:805
Mass (Da):89,722
Checksum:i31C024E718236D05
GO
Isoform 4 (identifier: O54834-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-197: MSAQSLLHSV...SHPYVVWRSE → MYKIF

Show »
Length:795
Mass (Da):88,672
Checksum:i50805457C81512DB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ALX7A2ALX7_MOUSE
Rho GTPase-activating protein 6
Arhgap6
385Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UZI7G3UZI7_MOUSE
Rho GTPase-activating protein 6
Arhgap6
478Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2ALX6A2ALX6_MOUSE
Rho GTPase-activating protein 6
Arhgap6
294Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC33263 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC37093 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti58 – 63GSTVSR → AHSKP in AAC53522 (PubMed:10699171).Curated6
Sequence conflicti58 – 63GSTVSR → AHSKP in AAD55086 (PubMed:10699171).Curated6
Sequence conflicti111K → N in AAC53522 (PubMed:10699171).Curated1
Sequence conflicti111K → N in AAD55086 (PubMed:10699171).Curated1
Sequence conflicti157L → V in AAC53522 (PubMed:10699171).Curated1
Sequence conflicti157L → V in AAD55086 (PubMed:10699171).Curated1
Sequence conflicti262K → N in AAC53522 (PubMed:10699171).Curated1
Sequence conflicti262K → N in AAD55086 (PubMed:10699171).Curated1
Sequence conflicti521L → P in BAE38520 (PubMed:16141072).Curated1
Sequence conflicti580S → P in BAE38520 (PubMed:16141072).Curated1
Sequence conflicti601 – 602EA → DS in AAC53522 (PubMed:10699171).Curated2
Sequence conflicti601 – 602EA → DS in AAD55086 (PubMed:10699171).Curated2
Sequence conflicti664S → F in AAC53522 (PubMed:10699171).Curated1
Sequence conflicti723P → S in AAC53522 (PubMed:10699171).Curated1
Sequence conflicti753P → Q in BAE38520 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0260511 – 197MSAQS…VWRSE → MYKIF in isoform 4. 1 PublicationAdd BLAST197
Alternative sequenceiVSP_0260521 – 58Missing in isoform 3. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_02605359 – 197STVSR…VWRSE → MGDPSYSEKPRLHYA in isoform 3. 1 PublicationAdd BLAST139
Alternative sequenceiVSP_001643639 – 660SPDIL…SSTDS → TSSVLPAAGQACSQSPASDF TP in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_001644661 – 987Missing in isoform 2. 1 PublicationAdd BLAST327

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF012273 mRNA Translation: AAC53522.2
AF177664 mRNA Translation: AAD55086.1
AK048162 mRNA Translation: BAC33263.1 Different initiation.
AK048507 mRNA Translation: BAC33352.1
AK077996 mRNA Translation: BAC37093.1 Different initiation.
AK166015 mRNA Translation: BAE38520.1
AL663026 Genomic DNA No translation available.
AL663056 Genomic DNA No translation available.
AL805974 Genomic DNA No translation available.
AL831750 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30534.1 [O54834-1]
CCDS41212.1 [O54834-3]
CCDS72472.1 [O54834-4]

NCBI Reference Sequences

More...RefSeqi		NP_001274459.1, NM_001287530.1 [O54834-4]
NP_033837.2, NM_009707.4 [O54834-1]
NP_848869.1, NM_178754.3 [O54834-3]
XP_006528757.1, XM_006528694.1 [O54834-1]
XP_011246085.1, XM_011247783.1 [O54834-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000033721; ENSMUSP00000033721; ENSMUSG00000031355 [O54834-1]
ENSMUST00000112127; ENSMUSP00000107755; ENSMUSG00000031355 [O54834-4]
ENSMUST00000112131; ENSMUSP00000107759; ENSMUSG00000031355 [O54834-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11856

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:11856

UCSC genome browser

More...UCSCi		uc009uxj.2, mouse [O54834-1]
uc009uxo.2, mouse [O54834-3]
uc009uxq.2, mouse [O54834-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012273 mRNA Translation: AAC53522.2
AF177664 mRNA Translation: AAD55086.1
AK048162 mRNA Translation: BAC33263.1 Different initiation.
AK048507 mRNA Translation: BAC33352.1
AK077996 mRNA Translation: BAC37093.1 Different initiation.
AK166015 mRNA Translation: BAE38520.1
AL663026 Genomic DNA No translation available.
AL663056 Genomic DNA No translation available.
AL805974 Genomic DNA No translation available.
AL831750 Genomic DNA No translation available.
CCDSiCCDS30534.1 [O54834-1]
CCDS41212.1 [O54834-3]
CCDS72472.1 [O54834-4]
RefSeqiNP_001274459.1, NM_001287530.1 [O54834-4]
NP_033837.2, NM_009707.4 [O54834-1]
NP_848869.1, NM_178754.3 [O54834-3]
XP_006528757.1, XM_006528694.1 [O54834-1]
XP_011246085.1, XM_011247783.1 [O54834-2]

3D structure databases

SMRiO54834
ModBaseiSearch...

Protein-protein interaction databases

IntActiO54834, 7 interactors
STRINGi10090.ENSMUSP00000033721

PTM databases

iPTMnetiO54834
PhosphoSitePlusiO54834

Proteomic databases

MaxQBiO54834
PaxDbiO54834
PeptideAtlasiO54834
PRIDEiO54834

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23727, 60 antibodies

The DNASU plasmid repository

More...DNASUi		11856

Genome annotation databases

EnsembliENSMUST00000033721; ENSMUSP00000033721; ENSMUSG00000031355 [O54834-1]
ENSMUST00000112127; ENSMUSP00000107755; ENSMUSG00000031355 [O54834-4]
ENSMUST00000112131; ENSMUSP00000107759; ENSMUSG00000031355 [O54834-3]
GeneIDi11856
KEGGimmu:11856
UCSCiuc009uxj.2, mouse [O54834-1]
uc009uxo.2, mouse [O54834-3]
uc009uxq.2, mouse [O54834-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		395
MGIiMGI:1196332, Arhgap6

Phylogenomic databases

eggNOGiKOG2710, Eukaryota
GeneTreeiENSGT00940000153904
HOGENOMiCLU_012874_0_0_1
InParanoidiO54834
OMAiIPECQLQ
OrthoDBi419555at2759
PhylomeDBiO54834
TreeFamiTF316710

Enzyme and pathway databases

ReactomeiR-MMU-194840, Rho GTPase cycle

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11856, 0 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Arhgap6, mouse

Protein Ontology

More...PROi		PR:O54834
RNActiO54834, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000031355, Expressed in lateral septal nucleus and 245 other tissues
ExpressionAtlasiO54834, baseline and differential
GenevisibleiO54834, MM

Family and domain databases

CDDicd04376, RhoGAP_ARHGAP6, 1 hit
Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR041852, ARHGAP6_RhoGAP
IPR008936, Rho_GTPase_activation_prot
IPR030772, RhoGAP6
IPR037863, RHOGAP6/36
IPR000198, RhoGAP_dom
PANTHERiPTHR12635, PTHR12635, 1 hit
PTHR12635:SF6, PTHR12635:SF6, 1 hit
PfamiView protein in Pfam
PF00620, RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324, RhoGAP, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238, RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG06_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O54834
Secondary accession number(s): A2ABW4
, A2AC55, Q3TMC2, Q8BG83, Q8C842, Q9QZL8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 29, 2007
Last modified: February 10, 2021
This is version 154 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again