UniProtKB - O54834 (RHG06_MOUSE)
Protein
Rho GTPase-activating protein 6
Gene
Arhgap6
Organism
Mus musculus (Mouse)
Status
Functioni
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology (By similarity).By similarity
GO - Molecular functioni
- GTPase activator activity Source: MGI
- phospholipase activator activity Source: MGI
- phospholipase binding Source: MGI
- SH3 domain binding Source: UniProtKB-KW
GO - Biological processi
- actin filament organization Source: MGI
- activation of phospholipase C activity Source: MGI
- focal adhesion assembly Source: MGI
- negative regulation of focal adhesion assembly Source: MGI
- negative regulation of stress fiber assembly Source: MGI
- positive regulation of GTPase activity Source: BHF-UCL
- positive regulation of phospholipase activity Source: MGI
- regulation of GTPase activity Source: MGI
- signal transduction Source: InterPro
Keywordsi
Molecular function | GTPase activation |
Enzyme and pathway databases
Reactomei | R-MMU-194840, Rho GTPase cycle |
Names & Taxonomyi
Protein namesi | Recommended name: Rho GTPase-activating protein 6Alternative name(s): Rho-type GTPase-activating protein 6 Rho-type GTPase-activating protein RhoGAPX-1 |
Gene namesi | Name:Arhgap6 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1196332, Arhgap6 |
Subcellular locationi
Other locations
- Cytoplasm Curated
Cytoskeleton
- actin cytoskeleton Source: MGI
Cytosol
- cytosol Source: MGI
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056705 | 1 – 987 | Rho GTPase-activating protein 6Add BLAST | 987 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 37 | PhosphoserineCombined sources | 1 | |
Modified residuei | 265 | PhosphoserineBy similarity | 1 | |
Modified residuei | 365 | PhosphoserineBy similarity | 1 | |
Modified residuei | 669 | PhosphoserineCombined sources | 1 | |
Modified residuei | 675 | PhosphoserineCombined sources | 1 | |
Modified residuei | 682 | PhosphoserineBy similarity | 1 | |
Modified residuei | 713 | PhosphoserineCombined sources | 1 | |
Modified residuei | 758 | PhosphoserineBy similarity | 1 | |
Modified residuei | 776 | PhosphoserineBy similarity | 1 | |
Modified residuei | 781 | PhosphoserineBy similarity | 1 | |
Modified residuei | 790 | PhosphoserineBy similarity | 1 | |
Modified residuei | 824 | PhosphoserineCombined sources | 1 | |
Modified residuei | 941 | PhosphoserineBy similarity | 1 | |
Modified residuei | 944 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | O54834 |
PaxDbi | O54834 |
PeptideAtlasi | O54834 |
PRIDEi | O54834 |
PTM databases
iPTMneti | O54834 |
PhosphoSitePlusi | O54834 |
Expressioni
Tissue specificityi
Expressed in retina and lung.
Gene expression databases
Bgeei | ENSMUSG00000031355, Expressed in lateral septal nucleus and 245 other tissues |
ExpressionAtlasi | O54834, baseline and differential |
Genevisiblei | O54834, MM |
Interactioni
GO - Molecular functioni
- phospholipase binding Source: MGI
- SH3 domain binding Source: UniProtKB-KW
Protein-protein interaction databases
IntActi | O54834, 7 interactors |
STRINGi | 10090.ENSMUSP00000033721 |
Miscellaneous databases
RNActi | O54834, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 403 – 604 | Rho-GAPPROSITE-ProRule annotationAdd BLAST | 202 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 344 – 354 | SH3-bindingAdd BLAST | 11 |
Keywords - Domaini
SH3-bindingPhylogenomic databases
eggNOGi | KOG2710, Eukaryota |
GeneTreei | ENSGT00940000153904 |
HOGENOMi | CLU_012874_0_0_1 |
InParanoidi | O54834 |
OMAi | IPECQLQ |
OrthoDBi | 419555at2759 |
PhylomeDBi | O54834 |
TreeFami | TF316710 |
Family and domain databases
CDDi | cd04376, RhoGAP_ARHGAP6, 1 hit |
Gene3Di | 1.10.555.10, 1 hit |
InterProi | View protein in InterPro IPR041852, ARHGAP6_RhoGAP IPR008936, Rho_GTPase_activation_prot IPR030772, RhoGAP6 IPR037863, RHOGAP6/36 IPR000198, RhoGAP_dom |
PANTHERi | PTHR12635, PTHR12635, 1 hit PTHR12635:SF6, PTHR12635:SF6, 1 hit |
Pfami | View protein in Pfam PF00620, RhoGAP, 1 hit |
SMARTi | View protein in SMART SM00324, RhoGAP, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS50238, RHOGAP, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O54834-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSAQSLLHSV FSCSSPASGG TASAKGFSKR KLRQTRSLDP ALIGGCGSEM
60 70 80 90 100
GAEGGLRGST VSRLHSPQLL AEGLGSRLAS SPRSQHLRAT RFQTPRPLCS
110 120 130 140 150
SFSTPSTPQE KSPSGSFHFD YEVPLSRSGL KKSMAWDLPS VLAGSGSASS
160 170 180 190 200
RSPASILSSS GGGPNGIFSS PRRWLQQRKF QPPPNSRSHP YVVWRSEGDF
210 220 230 240 250
TWNSMSGRSV RLRSVPIQSL SELERARLQE VAFYQLQQDC DLGCQITIPK
260 270 280 290 300
DGQKRKKSLR KKLDSLGKEK NKDKEFIPQA FGMPLSQVIA NDRAYKLKQD
310 320 330 340 350
LQREEQKDAS SDFVSSLLPF GNKKQNKELS SSNSSLSSTS ETPNESTSPN
360 370 380 390 400
TPEPAPRARR RGAMSVDSIT DLDDNQSRLL EALQLSLPAE AQSKKEKARD
410 420 430 440 450
KKLSLNPIYR QVPRLVDSCC QHLEKHGLQT VGIFRVGSSK KRVRQLREEF
460 470 480 490 500
DRGVDVCLEE EHSVHDVAAL LKEFLRDMPD PLLTRELYTA FINTLLLEPE
510 520 530 540 550
EQLGTLQLLI YLLPPCNCDT LHRLLQFLSI VARHADDNVS KDGQEVTGNK
560 570 580 590 600
MTSLNLATIF GPNLLHKQKS SDKEYSVQSS ARAEESTAII AVVQKMIENY
610 620 630 640 650
EALFMVPPDL QNEVLISLLE TDPDVVDYLL RRKASQSSSP DILQTEVSFS
660 670 680 690 700
MGGRHSSTDS NKASSGDISP YDNNSPVLSE RSLLAMQEDR ARGGSEKLYK
710 720 730 740 750
VPEQYTLVGH LSSPKSKSRE SSPGPRLGKE MSEEPFNIWG TWHSTLKSGS
760 770 780 790 800
KDPGMTGSYG DIFESSSLRP RPCSLSQGNL SLNWPRCQGS PTGLDSGTQV
810 820 830 840 850
IRRTQTAATV EQCSVHLPVS RVCSTPHIQD GSRGTRRPAA SSDPFLSLNS
860 870 880 890 900
TEDLAEGKED VAWLQSQARP VYQRPQESGK DDRRPPPPYP GSGKPATTSA
910 920 930 940 950
QLPLEPPLWR LQRHEEGSET AVEGGQQASG EHQTRPKKLS SAYSLSASEQ
960 970 980
DKQNLGEASW LDWQRERWQI WELLSTDNPD ALPETLV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2ALX7 | A2ALX7_MOUSE | Rho GTPase-activating protein 6 | Arhgap6 | 385 | Annotation score: | ||
G3UZI7 | G3UZI7_MOUSE | Rho GTPase-activating protein 6 | Arhgap6 | 478 | Annotation score: | ||
A2ALX6 | A2ALX6_MOUSE | Rho GTPase-activating protein 6 | Arhgap6 | 294 | Annotation score: |
Sequence cautioni
The sequence BAC33263 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC37093 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 58 – 63 | GSTVSR → AHSKP in AAC53522 (PubMed:10699171).Curated | 6 | |
Sequence conflicti | 58 – 63 | GSTVSR → AHSKP in AAD55086 (PubMed:10699171).Curated | 6 | |
Sequence conflicti | 111 | K → N in AAC53522 (PubMed:10699171).Curated | 1 | |
Sequence conflicti | 111 | K → N in AAD55086 (PubMed:10699171).Curated | 1 | |
Sequence conflicti | 157 | L → V in AAC53522 (PubMed:10699171).Curated | 1 | |
Sequence conflicti | 157 | L → V in AAD55086 (PubMed:10699171).Curated | 1 | |
Sequence conflicti | 262 | K → N in AAC53522 (PubMed:10699171).Curated | 1 | |
Sequence conflicti | 262 | K → N in AAD55086 (PubMed:10699171).Curated | 1 | |
Sequence conflicti | 521 | L → P in BAE38520 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 580 | S → P in BAE38520 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 601 – 602 | EA → DS in AAC53522 (PubMed:10699171).Curated | 2 | |
Sequence conflicti | 601 – 602 | EA → DS in AAD55086 (PubMed:10699171).Curated | 2 | |
Sequence conflicti | 664 | S → F in AAC53522 (PubMed:10699171).Curated | 1 | |
Sequence conflicti | 723 | P → S in AAC53522 (PubMed:10699171).Curated | 1 | |
Sequence conflicti | 753 | P → Q in BAE38520 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_026051 | 1 – 197 | MSAQS…VWRSE → MYKIF in isoform 4. 1 PublicationAdd BLAST | 197 | |
Alternative sequenceiVSP_026052 | 1 – 58 | Missing in isoform 3. 1 PublicationAdd BLAST | 58 | |
Alternative sequenceiVSP_026053 | 59 – 197 | STVSR…VWRSE → MGDPSYSEKPRLHYA in isoform 3. 1 PublicationAdd BLAST | 139 | |
Alternative sequenceiVSP_001643 | 639 – 660 | SPDIL…SSTDS → TSSVLPAAGQACSQSPASDF TP in isoform 2. 1 PublicationAdd BLAST | 22 | |
Alternative sequenceiVSP_001644 | 661 – 987 | Missing in isoform 2. 1 PublicationAdd BLAST | 327 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF012273 mRNA Translation: AAC53522.2 AF177664 mRNA Translation: AAD55086.1 AK048162 mRNA Translation: BAC33263.1 Different initiation. AK048507 mRNA Translation: BAC33352.1 AK077996 mRNA Translation: BAC37093.1 Different initiation. AK166015 mRNA Translation: BAE38520.1 AL663026 Genomic DNA No translation available. AL663056 Genomic DNA No translation available. AL805974 Genomic DNA No translation available. AL831750 Genomic DNA No translation available. |
CCDSi | CCDS30534.1 [O54834-1] CCDS41212.1 [O54834-3] CCDS72472.1 [O54834-4] |
RefSeqi | NP_001274459.1, NM_001287530.1 [O54834-4] NP_033837.2, NM_009707.4 [O54834-1] NP_848869.1, NM_178754.3 [O54834-3] XP_006528757.1, XM_006528694.1 [O54834-1] XP_011246085.1, XM_011247783.1 [O54834-2] |
Genome annotation databases
Ensembli | ENSMUST00000033721; ENSMUSP00000033721; ENSMUSG00000031355 [O54834-1] ENSMUST00000112127; ENSMUSP00000107755; ENSMUSG00000031355 [O54834-4] ENSMUST00000112131; ENSMUSP00000107759; ENSMUSG00000031355 [O54834-3] |
GeneIDi | 11856 |
KEGGi | mmu:11856 |
UCSCi | uc009uxj.2, mouse [O54834-1] uc009uxo.2, mouse [O54834-3] uc009uxq.2, mouse [O54834-4] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF012273 mRNA Translation: AAC53522.2 AF177664 mRNA Translation: AAD55086.1 AK048162 mRNA Translation: BAC33263.1 Different initiation. AK048507 mRNA Translation: BAC33352.1 AK077996 mRNA Translation: BAC37093.1 Different initiation. AK166015 mRNA Translation: BAE38520.1 AL663026 Genomic DNA No translation available. AL663056 Genomic DNA No translation available. AL805974 Genomic DNA No translation available. AL831750 Genomic DNA No translation available. |
CCDSi | CCDS30534.1 [O54834-1] CCDS41212.1 [O54834-3] CCDS72472.1 [O54834-4] |
RefSeqi | NP_001274459.1, NM_001287530.1 [O54834-4] NP_033837.2, NM_009707.4 [O54834-1] NP_848869.1, NM_178754.3 [O54834-3] XP_006528757.1, XM_006528694.1 [O54834-1] XP_011246085.1, XM_011247783.1 [O54834-2] |
3D structure databases
SMRi | O54834 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | O54834, 7 interactors |
STRINGi | 10090.ENSMUSP00000033721 |
PTM databases
iPTMneti | O54834 |
PhosphoSitePlusi | O54834 |
Proteomic databases
MaxQBi | O54834 |
PaxDbi | O54834 |
PeptideAtlasi | O54834 |
PRIDEi | O54834 |
Protocols and materials databases
Antibodypediai | 23727, 58 antibodies |
DNASUi | 11856 |
Genome annotation databases
Ensembli | ENSMUST00000033721; ENSMUSP00000033721; ENSMUSG00000031355 [O54834-1] ENSMUST00000112127; ENSMUSP00000107755; ENSMUSG00000031355 [O54834-4] ENSMUST00000112131; ENSMUSP00000107759; ENSMUSG00000031355 [O54834-3] |
GeneIDi | 11856 |
KEGGi | mmu:11856 |
UCSCi | uc009uxj.2, mouse [O54834-1] uc009uxo.2, mouse [O54834-3] uc009uxq.2, mouse [O54834-4] |
Organism-specific databases
CTDi | 395 |
MGIi | MGI:1196332, Arhgap6 |
Phylogenomic databases
eggNOGi | KOG2710, Eukaryota |
GeneTreei | ENSGT00940000153904 |
HOGENOMi | CLU_012874_0_0_1 |
InParanoidi | O54834 |
OMAi | IPECQLQ |
OrthoDBi | 419555at2759 |
PhylomeDBi | O54834 |
TreeFami | TF316710 |
Enzyme and pathway databases
Reactomei | R-MMU-194840, Rho GTPase cycle |
Miscellaneous databases
BioGRID-ORCSi | 11856, 0 hits in 17 CRISPR screens |
ChiTaRSi | Arhgap6, mouse |
PROi | PR:O54834 |
RNActi | O54834, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031355, Expressed in lateral septal nucleus and 245 other tissues |
ExpressionAtlasi | O54834, baseline and differential |
Genevisiblei | O54834, MM |
Family and domain databases
CDDi | cd04376, RhoGAP_ARHGAP6, 1 hit |
Gene3Di | 1.10.555.10, 1 hit |
InterProi | View protein in InterPro IPR041852, ARHGAP6_RhoGAP IPR008936, Rho_GTPase_activation_prot IPR030772, RhoGAP6 IPR037863, RHOGAP6/36 IPR000198, RhoGAP_dom |
PANTHERi | PTHR12635, PTHR12635, 1 hit PTHR12635:SF6, PTHR12635:SF6, 1 hit |
Pfami | View protein in Pfam PF00620, RhoGAP, 1 hit |
SMARTi | View protein in SMART SM00324, RhoGAP, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS50238, RHOGAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RHG06_MOUSE | |
Accessioni | O54834Primary (citable) accession number: O54834 Secondary accession number(s): A2ABW4 Q9QZL8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | May 29, 2007 | |
Last modified: | December 2, 2020 | |
This is version 153 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot