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Protein

Regulator of G-protein signaling 7

Gene

Rgs7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation, Signal transduction inhibitor

Enzyme and pathway databases

ReactomeiR-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 7
Short name:
RGS7
Gene namesi
Name:Rgs7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1346089 Rgs7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041971 – 469Regulator of G-protein signaling 7Add BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei229PhosphoserineBy similarity1
Modified residuei241PhosphoserineCombined sources1
Modified residuei243PhosphothreonineCombined sources1
Modified residuei434PhosphoserineBy similarity1

Post-translational modificationi

Palmitoylated.By similarity
Ubiquitinated, leading to rapid proteasomal degradation.By similarity
Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO54829
PaxDbiO54829
PeptideAtlasiO54829
PRIDEiO54829

PTM databases

iPTMnetiO54829
PhosphoSitePlusiO54829

Expressioni

Tissue specificityi

Detected in brain (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000026527 Expressed in 134 organ(s), highest expression level in cerebral cortex
CleanExiMM_RGS7
ExpressionAtlasiO54829 baseline and differential
GenevisibleiO54829 MM

Interactioni

Subunit structurei

Interacts with PKD1; this prevents rapid proteasomal degradation. Interacts with GNB5 (By similarity). Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with GNB5 (PubMed:15632198, PubMed:15897264). Interacts (phosphorylated form) with 14-3-3 protein YWHAQ (PubMed:10862767). Interacts with SNAPIN. Interacts with GNAI1 (By similarity). Interacts with GNAO1, GNAI3 and GNAZ (By similarity).By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204852, 1 interactor
IntActiO54829, 2 interactors
MINTiO54829
STRINGi10090.ENSMUSP00000027812

Structurei

3D structure databases

ProteinModelPortaliO54829
SMRiO54829
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 112DEPPROSITE-ProRule annotationAdd BLAST76
Domaini255 – 316G protein gammaAdd BLAST62
Domaini333 – 448RGSPROSITE-ProRule annotationAdd BLAST116

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000119142
HOGENOMiHOG000220864
HOVERGENiHBG007404
InParanoidiO54829
KOiK16449
TreeFamiTF351956

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF00631 G-gamma, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SM00224 GGL, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48097 SSF48097, 1 hit
SSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50132 RGS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

O54829-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQGNNYGQT SNGVADESPN MLVYRKMEDV IARMQDEKNG IPIRTVKSFL
60 70 80 90 100
SKIPSVFSGS DIVQWLIKNL TIEDPVEALH LGTLMAAHGY FFPISDHVLT
110 120 130 140 150
LKDDGTFYRF QTPYFWPSNC WEPENTDYAV YLCKRTMQNK ARLELADYEA
160 170 180 190 200
ESLARLQRAF ARKWEFIFMQ AEAQAKVDKK RDKIERKILD SQERAFWDVH
210 220 230 240 250
RPVPGCVNTT EVDIKKSSRM RNPHKTRKSV YGLQNDIRSH SPTHTPTPET
260 270 280 290 300
KPPTEDELHQ QIKYWQIQLD RHRLKMSKVA DSLLSYTEQY VEYDPFLVPP
310 320 330 340 350
DPSNPWLSDD TTFWELEASK EPSQQRVKRW GFGMDEALKD PVGREQFLKF
360 370 380 390 400
LESEFSSENL RFWLAVEDLK RRPIREVPSR VQEIWQEFLA PGAPSAINLD
410 420 430 440 450
SKSYDKTTQN VKEPGRYTFE DAQEHIYKLM KSDSYPRFIR SSAYQELLQA
460
KRKGKTLTSK RLTSLVQSY
Length:469
Mass (Da):54,792
Last modified:July 27, 2011 - v2
Checksum:iAE4B91280D87F211
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YW36A0A0A6YW36_MOUSE
Regulator of G-protein-signaling 7
Rgs7
477Annotation score:
Q80XD3Q80XD3_MOUSE
Regulator of G-protein-signaling 7
Rgs7
470Annotation score:
Q45FE2Q45FE2_MOUSE
Regulator of G-protein signaling 7 ...
Rgs7
191Annotation score:
Q45FE1Q45FE1_MOUSE
Regulator of G-protein signaling 7 ...
Rgs7
178Annotation score:
A0A0A6YVV6A0A0A6YVV6_MOUSE
Regulator of G-protein-signaling 7
Rgs7
71Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti461R → S in AAC99483 (PubMed:9459445).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011360 mRNA Translation: AAC99483.1
AC102499 Genomic DNA No translation available.
AC113050 Genomic DNA No translation available.
AC117693 Genomic DNA No translation available.
AC117734 Genomic DNA No translation available.
AC159973 Genomic DNA No translation available.
CCDSiCCDS15546.1
RefSeqiNP_036010.2, NM_011880.3
UniGeneiMm.7956

Genome annotation databases

EnsembliENSMUST00000027812; ENSMUSP00000027812; ENSMUSG00000026527
ENSMUST00000192227; ENSMUSP00000142278; ENSMUSG00000026527
GeneIDi24012
KEGGimmu:24012
UCSCiuc007dtk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011360 mRNA Translation: AAC99483.1
AC102499 Genomic DNA No translation available.
AC113050 Genomic DNA No translation available.
AC117693 Genomic DNA No translation available.
AC117734 Genomic DNA No translation available.
AC159973 Genomic DNA No translation available.
CCDSiCCDS15546.1
RefSeqiNP_036010.2, NM_011880.3
UniGeneiMm.7956

3D structure databases

ProteinModelPortaliO54829
SMRiO54829
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204852, 1 interactor
IntActiO54829, 2 interactors
MINTiO54829
STRINGi10090.ENSMUSP00000027812

PTM databases

iPTMnetiO54829
PhosphoSitePlusiO54829

Proteomic databases

MaxQBiO54829
PaxDbiO54829
PeptideAtlasiO54829
PRIDEiO54829

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027812; ENSMUSP00000027812; ENSMUSG00000026527
ENSMUST00000192227; ENSMUSP00000142278; ENSMUSG00000026527
GeneIDi24012
KEGGimmu:24012
UCSCiuc007dtk.2 mouse

Organism-specific databases

CTDi6000
MGIiMGI:1346089 Rgs7

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000119142
HOGENOMiHOG000220864
HOVERGENiHBG007404
InParanoidiO54829
KOiK16449
TreeFamiTF351956

Enzyme and pathway databases

ReactomeiR-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Miscellaneous databases

PROiPR:O54829
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026527 Expressed in 134 organ(s), highest expression level in cerebral cortex
CleanExiMM_RGS7
ExpressionAtlasiO54829 baseline and differential
GenevisibleiO54829 MM

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF00631 G-gamma, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SM00224 GGL, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48097 SSF48097, 1 hit
SSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRGS7_MOUSE
AccessioniPrimary (citable) accession number: O54829
Secondary accession number(s): E9QLB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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