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Protein

Regulator of G-protein signaling 9

Gene

Rgs9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processSensory transduction, Vision

Enzyme and pathway databases

ReactomeiR-MMU-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 9
Short name:
RGS9
Gene namesi
Name:Rgs9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1338824 Rgs9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042041 – 675Regulator of G-protein signaling 9Add BLAST675

Post-translational modificationi

Retinal isoform 1 is light-dependent phosphorylated at 'Ser-475'. Phosphorylation is decreased by light exposition. Interaction with RGS9BP is decreased when isoform 1 is phosphorylated at 'Ser-475'.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO54828
PRIDEiO54828

PTM databases

iPTMnetiO54828
PhosphoSitePlusiO54828
SwissPalmiO54828

Expressioni

Tissue specificityi

Isoform 1 is expressed in photoreceptor outer segments. Isoform 2 is expressed in brain striatum.

Gene expression databases

BgeeiENSMUSG00000020599 Expressed in 154 organ(s), highest expression level in caudate-putamen
CleanExiMM_RGS9
ExpressionAtlasiO54828 baseline and differential
GenevisibleiO54828 MM

Interactioni

Subunit structurei

Heterodimer with GNB5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with GNB5 (PubMed:15632198, PubMed:15897264). Component of the RGS9-1-Gbeta5 complex composed of RGS9 (RGS9-1), Gbeta5 (GNB5) and RGS9BP (PubMed:12119397, PubMed:12499365, PubMed:14614075, PubMed:16908407). Interacts with PDE6G and GNAT1 (By similarity).By similarity6 Publications

Protein-protein interaction databases

BioGridi202886, 1 interactor
DIPiDIP-46389N
IntActiO54828, 5 interactors
STRINGi10090.ENSMUSP00000020920

Structurei

Secondary structure

1675
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO54828
SMRiO54828
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO54828

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 105DEPPROSITE-ProRule annotationAdd BLAST76
Domaini222 – 283G protein gammaAdd BLAST62
Domaini299 – 414RGSPROSITE-ProRule annotationAdd BLAST116

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000119142
HOGENOMiHOG000220864
HOVERGENiHBG007404
InParanoidiO54828
KOiK13765
OMAiRPSSTIC
OrthoDBiEOG091G05MO
TreeFamiTF351956

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di1.10.10.10, 1 hit
4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF00631 G-gamma, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SM00224 GGL, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48097 SSF48097, 1 hit
SSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50132 RGS, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: O54828-1) [UniParc]FASTAAdd to basket
Also known as: RGS9-2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTIRHQGQQY RPRMAFLQKI EALVKDMQNP ETGVRMHNQR VLVTSVPHAM
60 70 80 90 100
TGGDVLQWIT QRLWISNLEA QNLGNFIVKY GYIYPLQDPK NLILKPDSSL
110 120 130 140 150
YRFQTPYFWP TQQWPAEDTD YAIYLAKRNI KKKGILEEYE KENYDFLNKK
160 170 180 190 200
INYKWDFVIM QAKEQYRTGK ERNKADRYAL DCQEKAYWLV HRSPPGMNNV
210 220 230 240 250
LDYGLDRVTN PNEVKKQTVT AVRKEIMYYQ QALMRSTVKS SVSLGGIVKY
260 270 280 290 300
SEQFSSNDAI MSGCLPSNPW ITDDTQFWDL NAKLVEIPTK MRVERWAFNF
310 320 330 340 350
SELIRDPKGR QSFQYFLKKE FSGENLGFWE ACEDLKYGDQ SKVKEKAEEI
360 370 380 390 400
YKLFLAPGAR RWINIDGKTM DITVKGLRHP HRYVLDAAQT HIYMLMKKDS
410 420 430 440 450
YARYLKSPIY KEMLAKAIEP QETTKRSSTL PFMRRHLRSS PSPVILRQLE
460 470 480 490 500
EEEKAREAAN TVDITQPGQH LAPSPHLAVY TGTCVPPSPS SPFSPSCRSP
510 520 530 540 550
RKPFASPSRF IRRPSIAICP SPSRVALEGS SGLEPKGEAS WSGANSGPSV
560 570 580 590 600
TENREPSADH SRPQPRAPPK ARAALSLGRF LRRGCLASPV FARLSPKCPS
610 620 630 640 650
VSHGKVQPLG DMGQQLPRLK PKKVANFFQI KMEMPTDSGT CLMDSDDPRA
660 670
GESGDQTTEK EVICPWESLA EGKAG
Length:675
Mass (Da):76,978
Last modified:July 27, 2011 - v3
Checksum:i72F1652D7D59EB05
GO
Isoform 1 (identifier: O54828-2) [UniParc]FASTAAdd to basket
Also known as: RGS9-1

The sequence of this isoform differs from the canonical sequence as follows:
     467-484: PGQHLAPSPHLAVYTGTC → VMSKLDRRSQLKKELPPK
     485-675: Missing.

Show »
Length:484
Mass (Da):56,940
Checksum:i60B37878EBB4CD3C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A6V9A2A6V9_MOUSE
Regulator of G-protein-signaling 9
Rgs9
232Annotation score:
A2A6V6A2A6V6_MOUSE
Regulator of G-protein-signaling 9
Rgs9
449Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti76F → L in AAC99481 (PubMed:9459445).Curated1
Sequence conflicti76F → L in AAD20014 (PubMed:10066255).Curated1
Sequence conflicti161Q → R in AAC99481 (PubMed:9459445).Curated1
Sequence conflicti161Q → R in AAD20014 (PubMed:10066255).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005678467 – 484PGQHL…YTGTC → VMSKLDRRSQLKKELPPK in isoform 1. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_005679485 – 675Missing in isoform 1. 1 PublicationAdd BLAST191

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011358 mRNA Translation: AAC99481.1
AF125046 mRNA Translation: AAD20014.1
AL604043 Genomic DNA Translation: CAM22971.1
CH466558 Genomic DNA Translation: EDL34351.1
BC129899 mRNA Translation: AAI29900.1
CCDSiCCDS25576.1 [O54828-1]
CCDS48969.1 [O54828-2]
RefSeqiNP_035398.2, NM_011268.2 [O54828-1]
UniGeneiMm.38548

Genome annotation databases

EnsembliENSMUST00000020920; ENSMUSP00000020920; ENSMUSG00000020599 [O54828-1]
ENSMUST00000106706; ENSMUSP00000102317; ENSMUSG00000020599 [O54828-2]
GeneIDi19739
KEGGimmu:19739
UCSCiuc007mbx.1 mouse [O54828-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011358 mRNA Translation: AAC99481.1
AF125046 mRNA Translation: AAD20014.1
AL604043 Genomic DNA Translation: CAM22971.1
CH466558 Genomic DNA Translation: EDL34351.1
BC129899 mRNA Translation: AAI29900.1
CCDSiCCDS25576.1 [O54828-1]
CCDS48969.1 [O54828-2]
RefSeqiNP_035398.2, NM_011268.2 [O54828-1]
UniGeneiMm.38548

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PBIX-ray1.95A/C1-422[»]
ProteinModelPortaliO54828
SMRiO54828
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202886, 1 interactor
DIPiDIP-46389N
IntActiO54828, 5 interactors
STRINGi10090.ENSMUSP00000020920

PTM databases

iPTMnetiO54828
PhosphoSitePlusiO54828
SwissPalmiO54828

Proteomic databases

PaxDbiO54828
PRIDEiO54828

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020920; ENSMUSP00000020920; ENSMUSG00000020599 [O54828-1]
ENSMUST00000106706; ENSMUSP00000102317; ENSMUSG00000020599 [O54828-2]
GeneIDi19739
KEGGimmu:19739
UCSCiuc007mbx.1 mouse [O54828-1]

Organism-specific databases

CTDi8787
MGIiMGI:1338824 Rgs9

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000119142
HOGENOMiHOG000220864
HOVERGENiHBG007404
InParanoidiO54828
KOiK13765
OMAiRPSSTIC
OrthoDBiEOG091G05MO
TreeFamiTF351956

Enzyme and pathway databases

ReactomeiR-MMU-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Miscellaneous databases

ChiTaRSiRgs9 mouse
EvolutionaryTraceiO54828
PROiPR:O54828
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020599 Expressed in 154 organ(s), highest expression level in caudate-putamen
CleanExiMM_RGS9
ExpressionAtlasiO54828 baseline and differential
GenevisibleiO54828 MM

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di1.10.10.10, 1 hit
4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF00631 G-gamma, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SM00224 GGL, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48097 SSF48097, 1 hit
SSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRGS9_MOUSE
AccessioniPrimary (citable) accession number: O54828
Secondary accession number(s): A1L352, Q9Z0S0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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