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Protein

Probable phospholipid-transporting ATPase VA

Gene

Atp10a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (By similarity).By similarity

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4314-aspartylphosphate intermediateBy similarity1
Metal bindingi1045MagnesiumBy similarity1
Metal bindingi1049MagnesiumBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • magnesium ion binding Source: InterPro
  • phospholipid-translocating ATPase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionTranslocase
Biological processLipid transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase VA (EC:7.6.2.1)
Alternative name(s):
ATPase class V type 10A
P-locus fat-associated ATPase
P4-ATPase flippase complex alpha subunit ATP10A
Gene namesi
Name:Atp10a
Synonyms:Atpc5, Pfatp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1330809 Atp10a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 79CytoplasmicSequence analysisAdd BLAST79
Transmembranei80 – 101HelicalSequence analysisAdd BLAST22
Topological domaini102 – 107Exoplasmic loopSequence analysis6
Transmembranei108 – 129HelicalSequence analysisAdd BLAST22
Topological domaini130 – 313CytoplasmicSequence analysisAdd BLAST184
Transmembranei314 – 335HelicalSequence analysisAdd BLAST22
Topological domaini336 – 366Exoplasmic loopSequence analysisAdd BLAST31
Transmembranei367 – 388HelicalSequence analysisAdd BLAST22
Topological domaini389 – 1101CytoplasmicSequence analysisAdd BLAST713
Transmembranei1102 – 1122HelicalSequence analysisAdd BLAST21
Topological domaini1123 – 1134Exoplasmic loopSequence analysisAdd BLAST12
Transmembranei1135 – 1154HelicalSequence analysisAdd BLAST20
Topological domaini1155 – 1184CytoplasmicSequence analysisAdd BLAST30
Transmembranei1185 – 1206HelicalSequence analysisAdd BLAST22
Topological domaini1207 – 1213Exoplasmic loopSequence analysis7
Transmembranei1214 – 1236HelicalSequence analysisAdd BLAST23
Topological domaini1237 – 1242CytoplasmicSequence analysis6
Transmembranei1243 – 1263HelicalSequence analysisAdd BLAST21
Topological domaini1264 – 1281Exoplasmic loopSequence analysisAdd BLAST18
Transmembranei1282 – 1306HelicalSequence analysisAdd BLAST25
Topological domaini1307 – 1508CytoplasmicSequence analysisAdd BLAST202

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463801 – 1508Probable phospholipid-transporting ATPase VAAdd BLAST1508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei470PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO54827
PaxDbiO54827
PeptideAtlasiO54827
PRIDEiO54827

PTM databases

iPTMnetiO54827
PhosphoSitePlusiO54827

Expressioni

Tissue specificityi

Found in testis and in white adipose tissue. Also detected in fetal tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000025324 Expressed in 228 organ(s), highest expression level in brain blood vessel
CleanExiMM_ATP10A
ExpressionAtlasiO54827 baseline and differential
GenevisibleiO54827 MM

Interactioni

Subunit structurei

Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000129811

Structurei

3D structure databases

ProteinModelPortaliO54827
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 23Poly-Arg7
Compositional biasi471 – 474Poly-Glu4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0206 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00920000149048
HOVERGENiHBG107129
InParanoidiO54827
KOiK01530
OMAiPHRDLMN
OrthoDBiEOG091G0139
PhylomeDBiO54827
TreeFamiTF354252

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR030357 ATP10A/ATP10C
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PTHR24092:SF81 PTHR24092:SF81, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01652 ATPase-Plipid, 2 hits
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O54827-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERELPAAEE SASSGWRRPR RRRWEGRTRT VRSNLLPPLG TEDSTIGAPK
60 70 80 90 100
GERLLMRGCI QHLADNRLKT TKYTLLSFLP KNLFEQFHRL ANVYFVFIAL
110 120 130 140 150
LNFVPAVNAF QPGLALAPVL FILAVTAIKD LWEDYSRHRS DHEINHLGCL
160 170 180 190 200
VFSREEKKYV NRYWKEIRVG DFVRLCCNEI IPADILLLSS SDPDGLCHIE
210 220 230 240 250
TANLDGETNL KRRQVVRGFS ELVSEFNPLT FTSVIECEKP NNDLSRFRGY
260 270 280 290 300
IMHSNGEKAG LHKENLLLRG CTIRNTEAVA GIVIYAGHET KALLNNSGPR
310 320 330 340 350
YKRSQLERQM NCDVLWCVLL LVCISLFSAV GHGLWVRRYQ EKKALFDVPE
360 370 380 390 400
SDGSSLSPAT AAVYSFFTMI IVLQVLIPIS LYVSIEIVKV CQVYFINQDI
410 420 430 440 450
ELYDEETDSQ LQCRALNITE DLGQIKYIFS DKTGTLTENK MVFRRCTVSG
460 470 480 490 500
IEYSHDANAQ RLARYQEADS EEEEVVSKVG TISHRGSTGS HQSIWMTHKT
510 520 530 540 550
QSIKSHRRTG SRAEAKRASM LSKHTAFSSP MEKDITPDPK LLEKVSECDR
560 570 580 590 600
FLAIARHQEH PLAHLSPELS DVFDFFIALT ICNTVVVTSP DQPRQKVRVR
610 620 630 640 650
FELKSPVKTI EDFLRRFTPS RLASGCSSIG NLSTSKSSHK SGSAFLPSLS
660 670 680 690 700
QDSMLLGLEE KLGQTAPSIA SNGYASQAGQ EESWASECTT DQKCPGEQRE
710 720 730 740 750
QQEGELRYEA ESPDEAALVY AARAYNCALV DRLHDQVSVE LPHLGRLTFE
760 770 780 790 800
LLHTLGFDSI RKRMSVVIRH PLTDEINVYT KGADSVVMDL LLPCSSDDAR
810 820 830 840 850
GRHQKKIRSK TQNYLNLYAV EGLRTLCIAK RVLSKEEYAC WLQSHIEAEA
860 870 880 890 900
SVESREELLF QSAVRLETNL HLLGATGIED RLQEGVPETI AKLRQAGLQI
910 920 930 940 950
WVLTGDKQET AINIAYACKL LDHGEEVITL NADSQEACAA LLDQCLSYVQ
960 970 980 990 1000
SRNPRSTLQN SESNLSVGFS FNPVSTSTDA SPSPSLVIDG RSLAYALEKS
1010 1020 1030 1040 1050
LEDKFLFLAK QCRSVLCCRS TPLQKSMVVK LVRSKLKAMT LAIGDGANDV
1060 1070 1080 1090 1100
SMIQVADVGV GISGQEGMQA VMASDFAVPR FRYLERLLIV HGHWCYSRLA
1110 1120 1130 1140 1150
NMVLYFFYKN TMFVGLLFWF QFYCGFSASA MIDQWYLIFF NLLFSSLPQL
1160 1170 1180 1190 1200
VTGVLDKDVP ADMLLREPQL YKSGQNMEEY RPRAFWLNMV DAAFQSLVCF
1210 1220 1230 1240 1250
FIPYLAYYDS DVDVFTWGTP VTAIALFTFL LHLGIETKTW TWLNWLACGF
1260 1270 1280 1290 1300
STFLFFSVAL IYNTSCATCY PPSNPYWTMQ TLLGDPLFYL TCLIAPIAAL
1310 1320 1330 1340 1350
LPRLFFKALQ GSLFPTQLQL GRQLAKKPLN KFSDPKETFA QGQPPGHSET
1360 1370 1380 1390 1400
ELSERKTMGP FETLPRDCAS QASQFTQQLT CSPEASGEPS AVDTNMPLRE
1410 1420 1430 1440 1450
NTLLEGLGSQ ASGSSMPRGA ISEVCPGDSK RQSTSASQTA RLSSLFHLPS
1460 1470 1480 1490 1500
FGSLNWISSL SLASGLGSVL QLSGSSLQMD KQDGEFLSNP PQPEQDLHSF

QGQVTGYL
Length:1,508
Mass (Da):168,788
Last modified:May 10, 2005 - v4
Checksum:iB542F86C9CD80E5B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LHF0A0A140LHF0_MOUSE
Probable phospholipid-transporting ...
Atp10a
141Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16 – 22WRRPRRR → KLAAAKK in AAC02902 (PubMed:9548971).Curated7
Sequence conflicti435T → L in AAC02902 (PubMed:9548971).Curated1
Sequence conflicti554I → V in AAM20894 (PubMed:12105293).Curated1
Sequence conflicti687E → D in AAF09447 (PubMed:11015572).Curated1
Sequence conflicti840 – 842CWL → TRP in AAH25643 (PubMed:15489334).Curated3
Sequence conflicti978T → A in AAM20894 (PubMed:12105293).Curated1
Sequence conflicti1113F → S in AAF09447 (PubMed:11015572).Curated1
Sequence conflicti1434T → S in AAF09447 (PubMed:11015572).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156549 mRNA Translation: AAF09447.1
AF011337 mRNA Translation: AAC02902.1
AF372979 Genomic DNA Translation: AAM20894.1
BC025643 mRNA Translation: AAH25643.1
CCDSiCCDS39972.1
RefSeqiNP_033858.2, NM_009728.2
XP_006540643.1, XM_006540580.3
XP_006540644.1, XM_006540581.3
UniGeneiMm.135129

Genome annotation databases

EnsembliENSMUST00000168747; ENSMUSP00000129811; ENSMUSG00000025324
GeneIDi11982
KEGGimmu:11982
UCSCiuc009hef.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF156549 mRNA Translation: AAF09447.1
AF011337 mRNA Translation: AAC02902.1
AF372979 Genomic DNA Translation: AAM20894.1
BC025643 mRNA Translation: AAH25643.1
CCDSiCCDS39972.1
RefSeqiNP_033858.2, NM_009728.2
XP_006540643.1, XM_006540580.3
XP_006540644.1, XM_006540581.3
UniGeneiMm.135129

3D structure databases

ProteinModelPortaliO54827
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000129811

PTM databases

iPTMnetiO54827
PhosphoSitePlusiO54827

Proteomic databases

EPDiO54827
PaxDbiO54827
PeptideAtlasiO54827
PRIDEiO54827

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000168747; ENSMUSP00000129811; ENSMUSG00000025324
GeneIDi11982
KEGGimmu:11982
UCSCiuc009hef.2 mouse

Organism-specific databases

CTDi57194
MGIiMGI:1330809 Atp10a

Phylogenomic databases

eggNOGiKOG0206 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00920000149048
HOVERGENiHBG107129
InParanoidiO54827
KOiK01530
OMAiPHRDLMN
OrthoDBiEOG091G0139
PhylomeDBiO54827
TreeFamiTF354252

Enzyme and pathway databases

ReactomeiR-MMU-936837 Ion transport by P-type ATPases

Miscellaneous databases

PROiPR:O54827
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025324 Expressed in 228 organ(s), highest expression level in brain blood vessel
CleanExiMM_ATP10A
ExpressionAtlasiO54827 baseline and differential
GenevisibleiO54827 MM

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR030357 ATP10A/ATP10C
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PTHR24092:SF81 PTHR24092:SF81, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01652 ATPase-Plipid, 2 hits
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAT10A_MOUSE
AccessioniPrimary (citable) accession number: O54827
Secondary accession number(s): Q8R3B8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 10, 2005
Last modified: November 7, 2018
This is version 165 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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