UniProtKB - O54826 (AF10_MOUSE)
Protein AF-10
Mllt10
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 22 – 74 | PHD-type 1PROSITE-ProRule annotationAdd BLAST | 53 | |
Zinc fingeri | 79 – 112 | C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST | 34 | |
Zinc fingeri | 135 – 198 | PHD-type 2PROSITE-ProRule annotationAdd BLAST | 64 |
GO - Molecular functioni
- chromatin binding Source: UniProtKB
- histone binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- nucleosome binding Source: UniProtKB
GO - Biological processi
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Protein AF-10Curated |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1329038, Mllt10 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytosol
- cytosol Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
Other locations
- protein-containing complex Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215936 | 1 – 1068 | Protein AF-10Add BLAST | 1068 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 217 | PhosphoserineBy similarity | 1 | |
Modified residuei | 252 | PhosphoserineBy similarity | 1 | |
Cross-linki | 280 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 436 | PhosphoserineCombined sources | 1 | |
Modified residuei | 532 | PhosphoserineCombined sources | 1 | |
Modified residuei | 686 | PhosphoserineCombined sources | 1 | |
Modified residuei | 688 | PhosphoserineCombined sources | 1 | |
Modified residuei | 691 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O54826 |
jPOSTi | O54826 |
MaxQBi | O54826 |
PaxDbi | O54826 |
PRIDEi | O54826 |
PTM databases
iPTMneti | O54826 |
PhosphoSitePlusi | O54826 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000026743, Expressed in secondary oocyte and 296 other tissues |
ExpressionAtlasi | O54826, baseline and differential |
Genevisiblei | O54826, MM |
Interactioni
Subunit structurei
Self-associates.
Interacts with FSTL3; the interaction enhances MLLT10 in vitro transcriptional activity and self-association.
Interacts with YEATS4.
Interacts with SS18.
Interacts with DOT1L (By similarity).
Interacts with histone H3; interaction is necessary for MLLT10 binding to nucleosomes; interaction is inhibited by histone H3 'Lys-27' methylations (H3K27me1, H3K27me2 and H3K27me3) amd acetylation; interaction stabilizes association of MLLT10 at chromatin; interaction is essential for histone H3 'Lys-79' dimethylation (H3K79me2) (By similarity).
By similarityBinary interactionsi
Hide detailsGO - Molecular functioni
- histone binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 201436, 5 interactors |
DIPi | DIP-58954N |
IntActi | O54826, 3 interactors |
MINTi | O54826 |
STRINGi | 10090.ENSMUSP00000110328 |
Miscellaneous databases
RNActi | O54826, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 106 – 190 | Required for interaction with histone H3By similarityAdd BLAST | 85 | |
Regioni | 752 – 780 | Leucine-zipperAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 229 – 250 | Glu/Lys-richAdd BLAST | 22 | |
Compositional biasi | 966 – 1018 | Gln-richAdd BLAST | 53 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 22 – 74 | PHD-type 1PROSITE-ProRule annotationAdd BLAST | 53 | |
Zinc fingeri | 79 – 112 | C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST | 34 | |
Zinc fingeri | 135 – 198 | PHD-type 2PROSITE-ProRule annotationAdd BLAST | 64 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0956, Eukaryota |
GeneTreei | ENSGT00940000157711 |
HOGENOMi | CLU_010286_0_1_1 |
InParanoidi | O54826 |
TreeFami | TF316118 |
Family and domain databases
Gene3Di | 3.30.40.10, 2 hits |
InterProi | View protein in InterPro IPR034732, EPHD IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
SMARTi | View protein in SMART SM00249, PHD, 2 hits |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS51805, EPHD, 1 hit PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MVSSDRPVSL EDEVSHSMKE MIGGCCVCSD ERGWAENPLV YCDGHGCSVA
60 70 80 90 100
VHQACYGIVQ VPTGPWFCRK CESQERAARV RCELCPHKDG ALKRTDNGGW
110 120 130 140 150
AHVVCALYIP EVQFANVSTM EPIVLQSVPH DRYNKTCYIC DEQGRESKAA
160 170 180 190 200
TGACMTCNKH GCRQAFHVTC AQFAGLLCEE EGNGADNVQY CGYCKYHFSK
210 220 230 240 250
LKKSKRGSNR SYEQSLSDSS SHSQDKHHEK EKKKYKEKDK HKQKHKKQPE
260 270 280 290 300
PSPALVPSLT VTTEKTYTST SNNSISGSLK RLEDTAARFT NANFQEVSAH
310 320 330 340 350
TSSGKDVSEA RGSEGKGKKS SAHSSGQRGR KPGAGRNPGT AVSASSPFPQ
360 370 380 390 400
GSFSGTPGSV KSSSGSSVQS PQDFLSFTDS DLRSDSYTHT QQPSSTKDVH
410 420 430 440 450
KGESGSQEAA VNSFSSLVGH PVTSTVISQP KSFDNSPGEL GSSSLPTAGY
460 470 480 490 500
KRAQTSGIEE EAVKEKKRKG NKQSKHGPGR PKGNKNQENV SHLSVSSASP
510 520 530 540 550
TSSVASAAGS VTSSSLQKSP TLLRNGSLQS LSVGSSPVGS EISMQYRHDG
560 570 580 590 600
ACPTTTFSEL LNAIHNGIYN SNDVAVSFPN VVSGSGSSTP VSSSHIPQQS
610 620 630 640 650
SGHLQQVGAL SPSAASSVTP AAATTQANTV SGSSLSQAPA HMYGSRLNQN
660 670 680 690 700
PSMAVLIAQS ESSQTDQDLG DNARSLGGRG SSPRGSLSPR SPVSNLQLRY
710 720 730 740 750
DQPSNSSLET VPPVAASIEQ LLERQWSEGQ QFLLEQGTPG DILGMLKSLH
760 770 780 790 800
QLQVENRRLE EQIKNLTAKK ERLQLLNAQL SVPFPAITTN PSPSHQMHTY
810 820 830 840 850
TAQTAPPPDS LNSSKSPHIG NSFLPDNSLP VLNQDLTSSG QSTSSSSALS
860 870 880 890 900
TPPPAGQSPA QQSSGVSGVQ QVNGVTVGAL ASGMQTVTST IPAVSAVGGI
910 920 930 940 950
IGALPGNQLA INGIVGALNG VIQTPVTISQ NPAPLTHTSV PPNAAHPMPA
960 970 980 990 1000
AALTNSASGL GLLSDQQRQM FIQQQQFQQL LNSQQLTPEQ HQAFLYQLMQ
1010 1020 1030 1040 1050
QQHHPPELQQ LQLPGPTQIP INNLLAGAQA PPLHTATTNP FLTIHGDSTS
1060
QKVTRLSDKT GPVAQEKS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2AS70 | A2AS70_MOUSE | Protein AF-10 | Mllt10 | 990 | Annotation score: | ||
A2AS72 | A2AS72_MOUSE | Protein AF-10 | Mllt10 | 525 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 280 | K → N in AAD11570 (PubMed:9878787).Curated | 1 | |
Sequence conflicti | 363 | S → P in AAD11570 (PubMed:9878787).Curated | 1 | |
Sequence conflicti | 374 | F → L in AAD11570 (PubMed:9878787).Curated | 1 | |
Sequence conflicti | 437 | P → T in AAD11570 (PubMed:9878787).Curated | 1 | |
Sequence conflicti | 445 | L → F in AAD11570 (PubMed:9878787).Curated | 1 | |
Sequence conflicti | 709 | E → G in AAD11570 (PubMed:9878787).Curated | 1 | |
Sequence conflicti | 991 – 993 | HQA → NKT in AAD11570 (PubMed:9878787).Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF010135 mRNA Translation: AAD11570.1 AL928557 Genomic DNA No translation available. AL928589 Genomic DNA No translation available. CH466542 Genomic DNA Translation: EDL08096.1 CH466542 Genomic DNA Translation: EDL08097.1 BC070475 mRNA Translation: AAH70475.1 |
CCDSi | CCDS15708.1 |
RefSeqi | NP_001239489.1, NM_001252560.1 NP_034934.2, NM_010804.4 XP_006497440.2, XM_006497377.3 |
Genome annotation databases
Ensembli | ENSMUST00000028076; ENSMUSP00000028076; ENSMUSG00000026743 ENSMUST00000114680; ENSMUSP00000110328; ENSMUSG00000026743 |
GeneIDi | 17354 |
KEGGi | mmu:17354 |
UCSCi | uc008ilm.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF010135 mRNA Translation: AAD11570.1 AL928557 Genomic DNA No translation available. AL928589 Genomic DNA No translation available. CH466542 Genomic DNA Translation: EDL08096.1 CH466542 Genomic DNA Translation: EDL08097.1 BC070475 mRNA Translation: AAH70475.1 |
CCDSi | CCDS15708.1 |
RefSeqi | NP_001239489.1, NM_001252560.1 NP_034934.2, NM_010804.4 XP_006497440.2, XM_006497377.3 |
3D structure databases
SMRi | O54826 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 201436, 5 interactors |
DIPi | DIP-58954N |
IntActi | O54826, 3 interactors |
MINTi | O54826 |
STRINGi | 10090.ENSMUSP00000110328 |
PTM databases
iPTMneti | O54826 |
PhosphoSitePlusi | O54826 |
Proteomic databases
EPDi | O54826 |
jPOSTi | O54826 |
MaxQBi | O54826 |
PaxDbi | O54826 |
PRIDEi | O54826 |
Protocols and materials databases
Antibodypediai | 1417, 375 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000028076; ENSMUSP00000028076; ENSMUSG00000026743 ENSMUST00000114680; ENSMUSP00000110328; ENSMUSG00000026743 |
GeneIDi | 17354 |
KEGGi | mmu:17354 |
UCSCi | uc008ilm.2, mouse |
Organism-specific databases
CTDi | 8028 |
MGIi | MGI:1329038, Mllt10 |
Phylogenomic databases
eggNOGi | KOG0956, Eukaryota |
GeneTreei | ENSGT00940000157711 |
HOGENOMi | CLU_010286_0_1_1 |
InParanoidi | O54826 |
TreeFami | TF316118 |
Miscellaneous databases
BioGRID-ORCSi | 17354, 1 hit in 19 CRISPR screens |
ChiTaRSi | Mllt10, mouse |
PROi | PR:O54826 |
RNActi | O54826, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026743, Expressed in secondary oocyte and 296 other tissues |
ExpressionAtlasi | O54826, baseline and differential |
Genevisiblei | O54826, MM |
Family and domain databases
Gene3Di | 3.30.40.10, 2 hits |
InterProi | View protein in InterPro IPR034732, EPHD IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
SMARTi | View protein in SMART SM00249, PHD, 2 hits |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS51805, EPHD, 1 hit PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AF10_MOUSE | |
Accessioni | O54826Primary (citable) accession number: O54826 Secondary accession number(s): Q6NS43 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | June 28, 2011 | |
Last modified: | December 2, 2020 | |
This is version 150 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot