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Protein

Bystin

Gene

Bysl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits.2 Publications

GO - Molecular functioni

  • snoRNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bystin
Gene namesi
Name:Bysl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1858419 Bysl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice show embryonic lethality around stage E6.5 shortly after implantation. Mice lacking maternal Bysl transcript upon injection of siRNA into fertilized eggs are arrested at the 16-cell stage, fail to induce trophectoderm, and show altered morphology of developing nucleoli. Embryonic stem cells lacking Bysl show accumulation of pre-20S rRNA precursors and a reduction of 40S ribosomal subunits in the cytoplasm.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861151 – 436BystinAdd BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40Omega-N-methylarginineBy similarity1
Modified residuei54PhosphoserineBy similarity1
Modified residuei97PhosphoserineCombined sources1
Modified residuei155PhosphothreonineBy similarity1
Modified residuei166PhosphoserineBy similarity1
Modified residuei413PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiO54825
MaxQBiO54825
PaxDbiO54825
PeptideAtlasiO54825
PRIDEiO54825

PTM databases

iPTMnetiO54825
PhosphoSitePlusiO54825

Expressioni

Tissue specificityi

High levels in preimplantation embryos, bone marrow, brain, testis and ovary.1 Publication

Developmental stagei

High levels of maternal transcript in unfertilized eggs. High levels up to blastocyst stage.1 Publication

Gene expression databases

BgeeiENSMUSG00000023988 Expressed in 282 organ(s), highest expression level in ear
CleanExiMM_BYSL
GenevisibleiO54825 MM

Interactioni

Subunit structurei

Binds trophinin, tastin and cytokeratins.By similarity

Protein-protein interaction databases

BioGridi207308, 3 interactors
IntActiO54825, 2 interactors
STRINGi10090.ENSMUSP00000024783

Structurei

3D structure databases

ProteinModelPortaliO54825
SMRiO54825
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the bystin family.Curated

Phylogenomic databases

eggNOGiKOG3871 Eukaryota
ENOG410XPH5 LUCA
GeneTreeiENSGT00390000007241
HOGENOMiHOG000178028
HOVERGENiHBG024425
InParanoidiO54825
KOiK14797
OMAiIAEMDYT
OrthoDBiEOG091G08JE
PhylomeDBiO54825
TreeFamiTF312968

Family and domain databases

InterProiView protein in InterPro
IPR007955 Bystin
PANTHERiPTHR12821 PTHR12821, 1 hit
PfamiView protein in Pfam
PF05291 Bystin, 1 hit

Sequencei

Sequence statusi: Complete.

O54825-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKFKVTRGA SNREKHAPLA EQILAGNAVR AGTREKRRGR EVEEEEEYVG
60 70 80 90 100
PRLSRRILQQ ARQQQEELET DHGAGDRSAP PRERATRLGP GLPQDGSDEE
110 120 130 140 150
DEEWPTLEKA AKMAGVDHQA EVIVDPEDER AIEMFMNKNP PVRRTLADII
160 170 180 190 200
MEKLTEKQTE VETVMSEVSG FPMPQLDPRV LEVYRGVREV LCKYRSGKLP
210 220 230 240 250
KAFKVIPALS NWEQILYVTE PEAWTAAAMY QATRIFASNL KERMAQRFYN
260 270 280 290 300
LVLLPRVRDD IAEYKRLNFH LYMALKKALF KPGAWFKGIL IPLCESGTCT
310 320 330 340 350
LREAIIVGSI ITKCSIPVLH SSAAMLKIAE MEYSGANSIF LRLLLDKKYA
360 370 380 390 400
LPYRVLDALV FHFLAFRTEK RQLPVLWHQC LLTLAQRYKA DLATEQKEAL
410 420 430
LELLRLQPHP QLSPEIRREL QSAVPRDVED GGVTME
Length:436
Mass (Da):49,784
Last modified:May 30, 2006 - v3
Checksum:iEFA148BED2072B72
GO

Sequence cautioni

The sequence AAH17530 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB31619 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC38736 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti284A → V in BAE40242 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019239 mRNA Translation: BAB31619.2 Different initiation.
AK083033 mRNA Translation: BAC38736.1 Different initiation.
AK143027 mRNA Translation: BAE25255.1
AK168301 mRNA Translation: BAE40242.1
BC017530 mRNA Translation: AAH17530.3 Different initiation.
AF007802 mRNA Translation: AAB94491.1
CCDSiCCDS50132.1
RefSeqiNP_058555.3, NM_016859.3
UniGeneiMm.472101

Genome annotation databases

EnsembliENSMUST00000024783; ENSMUSP00000024783; ENSMUSG00000023988
GeneIDi53414
KEGGimmu:53414
UCSCiuc008cvq.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019239 mRNA Translation: BAB31619.2 Different initiation.
AK083033 mRNA Translation: BAC38736.1 Different initiation.
AK143027 mRNA Translation: BAE25255.1
AK168301 mRNA Translation: BAE40242.1
BC017530 mRNA Translation: AAH17530.3 Different initiation.
AF007802 mRNA Translation: AAB94491.1
CCDSiCCDS50132.1
RefSeqiNP_058555.3, NM_016859.3
UniGeneiMm.472101

3D structure databases

ProteinModelPortaliO54825
SMRiO54825
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207308, 3 interactors
IntActiO54825, 2 interactors
STRINGi10090.ENSMUSP00000024783

PTM databases

iPTMnetiO54825
PhosphoSitePlusiO54825

Proteomic databases

EPDiO54825
MaxQBiO54825
PaxDbiO54825
PeptideAtlasiO54825
PRIDEiO54825

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024783; ENSMUSP00000024783; ENSMUSG00000023988
GeneIDi53414
KEGGimmu:53414
UCSCiuc008cvq.2 mouse

Organism-specific databases

CTDi705
MGIiMGI:1858419 Bysl

Phylogenomic databases

eggNOGiKOG3871 Eukaryota
ENOG410XPH5 LUCA
GeneTreeiENSGT00390000007241
HOGENOMiHOG000178028
HOVERGENiHBG024425
InParanoidiO54825
KOiK14797
OMAiIAEMDYT
OrthoDBiEOG091G08JE
PhylomeDBiO54825
TreeFamiTF312968

Miscellaneous databases

ChiTaRSiBysl mouse
PROiPR:O54825
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023988 Expressed in 282 organ(s), highest expression level in ear
CleanExiMM_BYSL
GenevisibleiO54825 MM

Family and domain databases

InterProiView protein in InterPro
IPR007955 Bystin
PANTHERiPTHR12821 PTHR12821, 1 hit
PfamiView protein in Pfam
PF05291 Bystin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBYST_MOUSE
AccessioniPrimary (citable) accession number: O54825
Secondary accession number(s): Q3THF4, Q3UPY9, Q8VD68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 30, 2006
Last modified: November 7, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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