Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 166 (29 Sep 2021)
Sequence version 3 (16 Jun 2009)
Previous versions | rss
Add a publicationFeedback
Protein

Pro-interleukin-16

Gene

Il16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.

Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.

Isoform 2 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-449836, Other interleukin signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pro-interleukin-16
Cleaved into the following chain:
Interleukin-16
Short name:
IL-16
Alternative name(s):
Lymphocyte chemoattractant factor
Short name:
LCF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Il16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1270855, Il16

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000001741

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003775461 – 1322Pro-interleukin-16Add BLAST1322
ChainiPRO_00000154181205 – 1322Interleukin-16By similarityAdd BLAST118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei917PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Synthesized as a chemo-attractant inactive precursor which is proteolytically cleaved by caspase-3 to yield IL-16.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O54824

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O54824

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O54824

PeptideAtlas

More...
PeptideAtlasi
O54824

PRoteomics IDEntifications database

More...
PRIDEi
O54824

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
267230 [O54824-1]
267231 [O54824-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O54824

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O54824

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is expressed in neurons of the cerebellum and hippocampus. Isoform 2 is expressed in thymus, spleen and lung.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000001741, Expressed in granulocyte and 209 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O54824, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer (Probable).

Isoform 2 interacts with GRIN2A.

Isoform 1 interacts with GRIN2D, KCNJ10, KCNJ15 and CACNA1C. Isoform 2 interacts (via PDZ 3 domain) with PPP1R12A, PPP1R12B and PPP1R12C.

Isoform 1 interacts with PPP1R12B.

Isoform 3 interacts with GABPB1. Isoform 2 interacts (via PDZ 3 domain) with HDAC3 (By similarity).

By similarityCurated

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
200618, 16 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
O54824

Protein interaction database and analysis system

More...
IntActi
O54824, 13 interactors

Molecular INTeraction database

More...
MINTi
O54824

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000001792

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O54824, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O54824

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini213 – 299PDZ 1PROSITE-ProRule annotationAdd BLAST87
Domaini352 – 437PDZ 2PROSITE-ProRule annotationAdd BLAST86
Domaini1105 – 1190PDZ 3PROSITE-ProRule annotationAdd BLAST86
Domaini1226 – 1309PDZ 4PROSITE-ProRule annotationAdd BLAST84

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni104 – 147DisorderedSequence analysisAdd BLAST44
Regioni183 – 449Interaction with GRIN2ABy similarityAdd BLAST267
Regioni480 – 633DisorderedSequence analysisAdd BLAST154
Regioni651 – 695DisorderedSequence analysisAdd BLAST45
Regioni729 – 963DisorderedSequence analysisAdd BLAST235
Regioni1099 – 1195Interaction with PPP1R12A, PPP1R12B and PPP1R12CBy similarityAdd BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi104 – 146Polar residuesSequence analysisAdd BLAST43
Compositional biasi480 – 497Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi505 – 519Polar residuesSequence analysisAdd BLAST15
Compositional biasi531 – 545Polar residuesSequence analysisAdd BLAST15
Compositional biasi568 – 588Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi600 – 623Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi660 – 682Polar residuesSequence analysisAdd BLAST23
Compositional biasi729 – 745Polar residuesSequence analysisAdd BLAST17
Compositional biasi825 – 868Polar residuesSequence analysisAdd BLAST44
Compositional biasi887 – 908Polar residuesSequence analysisAdd BLAST22
Compositional biasi935 – 949Polar residuesSequence analysisAdd BLAST15

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3528, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156178

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007677_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O54824

Identification of Orthologs from Complete Genome Data

More...
OMAi
TCKERPL

Database of Orthologous Groups

More...
OrthoDBi
225688at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O54824

TreeFam database of animal gene trees

More...
TreeFami
TF326303

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020450, IL-16
IPR001478, PDZ
IPR036034, PDZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595, PDZ, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01931, INTRLEUKIN16

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228, PDZ, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156, SSF50156, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106, PDZ, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O54824-1) [UniParc]FASTAAdd to basket
Also known as: NIL-16

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPHGHSGKS RKSTKFRSIS RSLILCNAKT SDDGSSPDEK YPDPFETSLC
60 70 80 90 100
QGKEGFFHSS MQLADTFEAG LSNIPDLALA SDSAQLAAAG SDRGKHCRKM
110 120 130 140 150
FFMKESSSTS SKEKSGKPEA QSSSFLFPKA CHQRTRSNST SVNPYSAGEI
160 170 180 190 200
DFPMTKKSAA PTDRQPYSLC SNRKSLSQQL DYPILGTARP TRSLSTAQLG
210 220 230 240 250
QLSGGLQASV ISNIVLMKGQ AKGLGFSIVG GKDSIYGPIG IYVKSIFAGG
260 270 280 290 300
AAAADGRLQE GDEILELNGE SMAGLTHQDA LQKFKQAKKG LLTLTVRTRL
310 320 330 340 350
TTPPSLCSHL SPPLCRSLSS STCGAQDSSP FSLESPASPA STAKPNYRIM
360 370 380 390 400
VEVSLKKEAG VGLGIGLCSI PYFQCISGIF VHTLSPGSVA HLDGRLRCGD
410 420 430 440 450
EIVEINDSPV HCLTLNEVYT ILSHCDPGPV PIIVSRHPDP QVSEQQLKEA
460 470 480 490 500
VAQAVEGVKF GKDRHQWSLE GVKRLESSWH GRPTLEKERE KHSAPPHRRA
510 520 530 540 550
QKIMVRSSSD SSYMSGSPGG SPCSAGAEPQ PSEREGSTHS PSLSPGEEQE
560 570 580 590 600
PCPGVPSRPQ QESPPLPESL ERESHPPLRL KKSFEILVRK PTSSKPKPPP
610 620 630 640 650
RKYFKNDSEP QKKLEEKEKV TDPSGHTLPT CSQETRELLP LLLQEDTAGR
660 670 680 690 700
APCTAACCPG PAASTQTSSS TEGESRRSAS PETPASPGKH PLLKRQARMD
710 720 730 740 750
YSFDITAEDP WVRISDCIKN LFSPIMSENH SHTPLQPNTS LGEEDGTQGC
760 770 780 790 800
PEGGLSKMDA ANGAPRVYKS ADGSTVKKGP PVAPKPAWFR QSLKGLRNRA
810 820 830 840 850
PDPRRPPEVA SAIQPTPVSR DPPGPQPQAS SSIRQRISSF ENFGSSQLPD
860 870 880 890 900
RGVQRLSLQP SSGETTKFPG KQDGGRFSGL LGQGATVTAK HRQTEVESMS
910 920 930 940 950
TTFPNSSEVR DPGLPESPPP GQRPSTKALS PDPLLRLLTT QSEDTQGPGL
960 970 980 990 1000
KMPSQRARSF PLTRTQSCET KLLDEKASKL YSISSQLSSA VMKSLLCLPS
1010 1020 1030 1040 1050
SVSCGQITCI PKERVSPKSP CNNSSAAEGF GEAMASDTGF SLNLSELREY
1060 1070 1080 1090 1100
SEGLTEPGET EDRNHCSSQA GQSVISLLSA EELEKLIEEV RVLDEATLKQ
1110 1120 1130 1140 1150
LDSIHVTILH KEEGAGLGFS LAGGADLENK VITVHRVFPN GLASQEGTIQ
1160 1170 1180 1190 1200
KGNEVLSING KSLKGATHND ALAILRQARD PRQAVIVTRR TTVEATHDLN
1210 1220 1230 1240 1250
SSTDSAASAS AASDISVESK EATVCTVTLE KTSAGLGFSL EGGKGSLHGD
1260 1270 1280 1290 1300
KPLTINRIFK GTEQGEMVQP GDEILQLAGT AVQGLTRFEA WNVIKALPDG
1310 1320
PVTIVIRRTS LQCKQTTASA DS
Note: Produced by alternative promoter usage. Is probably proteolytically processed to yield IL-16.
Length:1,322
Mass (Da):141,435
Last modified:June 16, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDDB94003A5DCB738
GO
Isoform 2 (identifier: O54824-2) [UniParc]FASTAAdd to basket
Also known as: Pro-IL-16

The sequence of this isoform differs from the canonical sequence as follows:
     1-698: Missing.

Note: Produced by alternative promoter usage. Is proteolytically processed to yield IL-16.Curated
Show »
Length:624
Mass (Da):66,471
Checksum:iE46375FAABE9D6E0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RI15D6RI15_MOUSE
Pro-interleukin-16
Il16
238Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z3C7D3Z3C7_MOUSE
Pro-interleukin-16
Il16
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti264I → S in BAD90484 (Ref. 5) Curated1
Sequence conflicti733T → R in AAC04383 (PubMed:9637508).Curated1
Sequence conflicti921G → S in AAC16039 (PubMed:9510557).Curated1
Sequence conflicti1067S → P in AAC16039 (PubMed:9510557).Curated1
Sequence conflicti1224V → A in AAC16039 (PubMed:9510557).Curated1
Sequence conflicti1262 – 1264TEQ → DRT in AAC04383 (PubMed:9637508).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0374601 – 698Missing in isoform 2. 4 PublicationsAdd BLAST698

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF006001 mRNA Translation: AAC04383.1
AF017111 mRNA Translation: AAC16039.1
AF175292 mRNA Translation: AAD55393.1
AK038319 mRNA Translation: BAC29967.1
AK169551 mRNA Translation: BAE41224.1
AK220455 mRNA Translation: BAD90484.1
CH466543 Genomic DNA Translation: EDL06877.1
BC026894 mRNA Translation: AAH26894.1
BC058709 mRNA Translation: AAH58709.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS21412.1 [O54824-1]
CCDS90266.1 [O54824-2]

NCBI Reference Sequences

More...
RefSeqi
NP_034681.2, NM_010551.3 [O54824-1]
XP_006507449.1, XM_006507386.3 [O54824-1]
XP_011239983.1, XM_011241681.2 [O54824-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000001792; ENSMUSP00000001792; ENSMUSG00000001741 [O54824-1]
ENSMUST00000145610; ENSMUSP00000146496; ENSMUSG00000001741 [O54824-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
16170

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:16170

UCSC genome browser

More...
UCSCi
uc009idr.1, mouse [O54824-2]
uc009ids.1, mouse [O54824-1]

Keywords - Coding sequence diversityi

Alternative promoter usage

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006001 mRNA Translation: AAC04383.1
AF017111 mRNA Translation: AAC16039.1
AF175292 mRNA Translation: AAD55393.1
AK038319 mRNA Translation: BAC29967.1
AK169551 mRNA Translation: BAE41224.1
AK220455 mRNA Translation: BAD90484.1
CH466543 Genomic DNA Translation: EDL06877.1
BC026894 mRNA Translation: AAH26894.1
BC058709 mRNA Translation: AAH58709.1
CCDSiCCDS21412.1 [O54824-1]
CCDS90266.1 [O54824-2]
RefSeqiNP_034681.2, NM_010551.3 [O54824-1]
XP_006507449.1, XM_006507386.3 [O54824-1]
XP_011239983.1, XM_011241681.2 [O54824-1]

3D structure databases

SMRiO54824
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi200618, 16 interactors
ELMiO54824
IntActiO54824, 13 interactors
MINTiO54824
STRINGi10090.ENSMUSP00000001792

PTM databases

iPTMnetiO54824
PhosphoSitePlusiO54824

Proteomic databases

jPOSTiO54824
MaxQBiO54824
PaxDbiO54824
PeptideAtlasiO54824
PRIDEiO54824
ProteomicsDBi267230 [O54824-1]
267231 [O54824-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3932, 766 antibodies

The DNASU plasmid repository

More...
DNASUi
16170

Genome annotation databases

EnsembliENSMUST00000001792; ENSMUSP00000001792; ENSMUSG00000001741 [O54824-1]
ENSMUST00000145610; ENSMUSP00000146496; ENSMUSG00000001741 [O54824-2]
GeneIDi16170
KEGGimmu:16170
UCSCiuc009idr.1, mouse [O54824-2]
uc009ids.1, mouse [O54824-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3603
MGIiMGI:1270855, Il16
VEuPathDBiHostDB:ENSMUSG00000001741

Phylogenomic databases

eggNOGiKOG3528, Eukaryota
GeneTreeiENSGT00940000156178
HOGENOMiCLU_007677_0_0_1
InParanoidiO54824
OMAiTCKERPL
OrthoDBi225688at2759
PhylomeDBiO54824
TreeFamiTF326303

Enzyme and pathway databases

ReactomeiR-MMU-449836, Other interleukin signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
16170, 1 hit in 63 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Il16, mouse

Protein Ontology

More...
PROi
PR:O54824
RNActiO54824, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000001741, Expressed in granulocyte and 209 other tissues
GenevisibleiO54824, MM

Family and domain databases

Gene3Di2.30.42.10, 4 hits
InterProiView protein in InterPro
IPR020450, IL-16
IPR001478, PDZ
IPR036034, PDZ_sf
PfamiView protein in Pfam
PF00595, PDZ, 4 hits
PRINTSiPR01931, INTRLEUKIN16
SMARTiView protein in SMART
SM00228, PDZ, 4 hits
SUPFAMiSSF50156, SSF50156, 4 hits
PROSITEiView protein in PROSITE
PS50106, PDZ, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL16_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O54824
Secondary accession number(s): O70236
, Q3TEM4, Q5DTR5, Q8R0G5, Q9QZP6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 16, 2009
Last modified: September 29, 2021
This is version 166 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again