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Protein

Tumor protein D53

Gene

Tpd52l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-432722 Golgi Associated Vesicle Biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor protein D53
Short name:
mD53
Alternative name(s):
Tumor protein D52-like 1
Gene namesi
Name:Tpd52l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1298386 Tpd52l1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001857421 – 204Tumor protein D53Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineBy similarity1
Modified residuei86PhosphoserineBy similarity1
Modified residuei122PhosphoserineBy similarity1
Modified residuei131PhosphoserineBy similarity1
Modified residuei133Omega-N-methylarginineBy similarity1
Modified residuei146PhosphothreonineBy similarity1
Modified residuei149PhosphoserineBy similarity1
Modified residuei174PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiO54818
PaxDbiO54818
PRIDEiO54818

PTM databases

iPTMnetiO54818
PhosphoSitePlusiO54818

Expressioni

Gene expression databases

BgeeiENSMUSG00000000296 Expressed in 280 organ(s), highest expression level in submandibular gland
CleanExiMM_TPD52L1
ExpressionAtlasiO54818 baseline and differential
GenevisibleiO54818 MM

Interactioni

Subunit structurei

Forms a homodimer or heterodimer with other members of the family.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000305

Structurei

3D structure databases

ProteinModelPortaliO54818
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili22 – 73Sequence analysisAdd BLAST52

Sequence similaritiesi

Belongs to the TPD52 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4010 Eukaryota
ENOG4111M9H LUCA
GeneTreeiENSGT00390000015988
HOVERGENiHBG058643
InParanoidiO54818
OrthoDBiEOG091G0MLN
PhylomeDBiO54818
TreeFamiTF317562

Family and domain databases

InterProiView protein in InterPro
IPR007327 TPD52
PANTHERiPTHR19307 PTHR19307, 1 hit
PfamiView protein in Pfam
PF04201 TPD52, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O54818-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAQAQGLLE TEPLQGRDGD AVGSADFSSM LSEEEKEELK AELIQLEDEI
60 70 80 90 100
TTLRQVLSAK ERHLVEIKQK LGMNLMNELK QNFSRSWHDM QTTTAYKKTH
110 120 130 140 150
ETLSHAGQKA TAAFNNVGTA ISKKFGDMRY SIRHSISMPA MRNSSTFKSF
160 170 180 190 200
EERVETTVAS LKTKVGGTNH GGGSFEEVLN STAHASSQNA SAGSRQTKDE

ELQC
Length:204
Mass (Da):22,515
Last modified:June 1, 1998 - v1
Checksum:iBAA49DAC7B7F6BE8
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B2RUC1B2RUC1_MOUSE
Tpd52l1 protein
Tpd52l1
209Annotation score:
Q3V2G6Q3V2G6_MOUSE
Tumor protein D52-like 1, isoform C...
Tpd52l1 mCG_15057
131Annotation score:
A0A1L1SR11A0A1L1SR11_MOUSE
Tumor protein D53
Tpd52l1
144Annotation score:
A0A1L1ST53A0A1L1ST53_MOUSE
Tumor protein D53
Tpd52l1
191Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004428 mRNA Translation: AAC98476.1
CCDSiCCDS35877.1
RefSeqiNP_033439.1, NM_009413.1
UniGeneiMm.439966

Genome annotation databases

EnsembliENSMUST00000000305; ENSMUSP00000000305; ENSMUSG00000000296
GeneIDi21987
KEGGimmu:21987
UCSCiuc007ets.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004428 mRNA Translation: AAC98476.1
CCDSiCCDS35877.1
RefSeqiNP_033439.1, NM_009413.1
UniGeneiMm.439966

3D structure databases

ProteinModelPortaliO54818
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000305

PTM databases

iPTMnetiO54818
PhosphoSitePlusiO54818

Proteomic databases

MaxQBiO54818
PaxDbiO54818
PRIDEiO54818

Protocols and materials databases

DNASUi21987
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000305; ENSMUSP00000000305; ENSMUSG00000000296
GeneIDi21987
KEGGimmu:21987
UCSCiuc007ets.1 mouse

Organism-specific databases

CTDi7164
MGIiMGI:1298386 Tpd52l1

Phylogenomic databases

eggNOGiKOG4010 Eukaryota
ENOG4111M9H LUCA
GeneTreeiENSGT00390000015988
HOVERGENiHBG058643
InParanoidiO54818
OrthoDBiEOG091G0MLN
PhylomeDBiO54818
TreeFamiTF317562

Enzyme and pathway databases

ReactomeiR-MMU-432722 Golgi Associated Vesicle Biogenesis

Miscellaneous databases

PROiPR:O54818
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000296 Expressed in 280 organ(s), highest expression level in submandibular gland
CleanExiMM_TPD52L1
ExpressionAtlasiO54818 baseline and differential
GenevisibleiO54818 MM

Family and domain databases

InterProiView protein in InterPro
IPR007327 TPD52
PANTHERiPTHR19307 PTHR19307, 1 hit
PfamiView protein in Pfam
PF04201 TPD52, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTPD53_MOUSE
AccessioniPrimary (citable) accession number: O54818
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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