UniProtKB - O54814 (CCR3_RAT)
Protein
C-C chemokine receptor type 3
Gene
Ccr3
Organism
Rattus norvegicus (Rat)
Status
Functioni
Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1.By similarity
GO - Molecular functioni
- C-C chemokine binding Source: RGD
- C-C chemokine receptor activity Source: RGD
- chemokine binding Source: GO_Central
- chemokine receptor activity Source: RGD
GO - Biological processi
- angioblast cell migration Source: RGD
- calcium-mediated signaling Source: GO_Central
- cell chemotaxis Source: GO_Central
- chemotaxis Source: RGD
- eosinophil chemotaxis Source: RGD
- ERK1 and ERK2 cascade Source: RGD
- immune response Source: GO_Central
- inflammatory response Source: GO_Central
- mast cell chemotaxis Source: RGD
- positive regulation of angiogenesis Source: RGD
- positive regulation of cytosolic calcium ion concentration Source: GO_Central
- positive regulation of endothelial cell proliferation Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-RNO-380108, Chemokine receptors bind chemokines R-RNO-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: C-C chemokine receptor type 3Short name: C-C CKR-3 Short name: CC-CKR-3 Short name: CCR-3 Short name: CCR3 Short name: CKR3 Alternative name(s): CD_antigen: CD193 |
Gene namesi | Name:Ccr3 Synonyms:Cmkbr3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620593, Ccr3 |
Subcellular locationi
Plasma membrane
- Cell membrane ; Multi-pass membrane protein Sequence analysis
Endosome
- endosome Source: RGD
Extracellular region or secreted
- extracellular space Source: RGD
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- plasma membrane Source: RGD
Other locations
- cytoplasm Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 43 | ExtracellularSequence analysisAdd BLAST | 43 | |
Transmembranei | 44 – 64 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 65 – 74 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 75 – 95 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 96 – 112 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 113 – 133 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 134 – 154 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 155 – 175 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 176 – 206 | ExtracellularSequence analysisAdd BLAST | 31 | |
Transmembranei | 207 – 227 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 228 – 243 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 244 – 264 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 265 – 288 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 289 – 309 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 310 – 359 | CytoplasmicSequence analysisAdd BLAST | 50 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069243 | 1 – 359 | C-C chemokine receptor type 3Add BLAST | 359 |
Proteomic databases
PaxDbi | O54814 |
PTM databases
PhosphoSitePlusi | O54814 |
Expressioni
Tissue specificityi
Expressed in spleen but not in astrocytes or microglia.1 Publication
Interactioni
GO - Molecular functioni
- C-C chemokine binding Source: RGD
- chemokine binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000008809 |
Chemistry databases
BindingDBi | O54814 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
InParanoidi | O54814 |
OrthoDBi | 900867at2759 |
PhylomeDBi | O54814 |
TreeFami | TF330966 |
Family and domain databases
InterProi | View protein in InterPro IPR002238, Chemokine_CCR3 IPR000355, Chemokine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00657, CCCHEMOKINER PR01108, CHEMOKINER3 PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O54814-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASNEEELKT VVETFETTPY EYEWAPPCEK VSIRELGSWL LPPLYSLVFI
60 70 80 90 100
VGLLGNMMVV LILIKYRKLQ IMTNIYLLNL AISDLLFLFT VPFWIHYVLW
110 120 130 140 150
NEWGFGHCMC KMLSGLYYLA LYSEIFFIIL LTIDRYLAIV HAVLALRART
160 170 180 190 200
VTFATITSII TWGFAVLAAL PEFIFHESQD NFGDLSCSPR YPEGEEDSWK
210 220 230 240 250
RFHALRMNIF GLALPLLIMV ICYSGIIKTL LRCPNKKKHK AIQLIFVVMI
260 270 280 290 300
VFFIFWTPYN LVLLLSAFHS TFLETSCQQS IHLDLAMQVT EVITHTHCCI
310 320 330 340 350
NPIIYAFVGE RFRKHLRLFF HRNVAIYLRK YISFLPGEKL ERTSSVSPST
GEQEISVVF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MXU9 | A0A0A0MXU9_RAT | C-C chemokine receptor type 3 | Ccr3 | 360 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 164 | F → L in CAA73830 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF003954 Genomic DNA Translation: AAC03337.1 Y13400 mRNA Translation: CAA73830.1 |
RefSeqi | NP_446410.1, NM_053958.1 |
Genome annotation databases
GeneIDi | 117027 |
KEGGi | rno:117027 |
UCSCi | RGD:620593, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF003954 Genomic DNA Translation: AAC03337.1 Y13400 mRNA Translation: CAA73830.1 |
RefSeqi | NP_446410.1, NM_053958.1 |
3D structure databases
SMRi | O54814 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000008809 |
Chemistry databases
BindingDBi | O54814 |
ChEMBLi | CHEMBL3928 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
PhosphoSitePlusi | O54814 |
Proteomic databases
PaxDbi | O54814 |
Genome annotation databases
GeneIDi | 117027 |
KEGGi | rno:117027 |
UCSCi | RGD:620593, rat |
Organism-specific databases
CTDi | 1232 |
RGDi | 620593, Ccr3 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
InParanoidi | O54814 |
OrthoDBi | 900867at2759 |
PhylomeDBi | O54814 |
TreeFami | TF330966 |
Enzyme and pathway databases
Reactomei | R-RNO-380108, Chemokine receptors bind chemokines R-RNO-418594, G alpha (i) signalling events |
Miscellaneous databases
PROi | PR:O54814 |
Family and domain databases
InterProi | View protein in InterPro IPR002238, Chemokine_CCR3 IPR000355, Chemokine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00657, CCCHEMOKINER PR01108, CHEMOKINER3 PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCR3_RAT | |
Accessioni | O54814Primary (citable) accession number: O54814 Secondary accession number(s): O55169 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | June 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries