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Protein

C-C chemokine receptor type 3

Gene

Ccr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for a C-C type chemokine. Binds to eotaxin, MCP-3, MCP-4 and RANTES and subsequently transduces a signal by increasing the intracellular calcium ions level (By similarity).By similarity

GO - Molecular functioni

  • C-C chemokine receptor activity Source: InterPro
  • chemokine receptor activity Source: RGD

GO - Biological processi

  • angioblast cell migration Source: RGD
  • eosinophil chemotaxis Source: RGD
  • ERK1 and ERK2 cascade Source: RGD
  • inflammatory response Source: RGD
  • mast cell chemotaxis Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 3
Short name:
C-C CKR-3
Short name:
CC-CKR-3
Short name:
CCR-3
Short name:
CCR3
Short name:
CKR3
Alternative name(s):
CD_antigen: CD193
Gene namesi
Name:Ccr3
Synonyms:Cmkbr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620593 Ccr3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43ExtracellularSequence analysisAdd BLAST43
Transmembranei44 – 64Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini65 – 74CytoplasmicSequence analysis10
Transmembranei75 – 95Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini96 – 112ExtracellularSequence analysisAdd BLAST17
Transmembranei113 – 133Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini134 – 154CytoplasmicSequence analysisAdd BLAST21
Transmembranei155 – 175Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini176 – 206ExtracellularSequence analysisAdd BLAST31
Transmembranei207 – 227Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini228 – 243CytoplasmicSequence analysisAdd BLAST16
Transmembranei244 – 264Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini265 – 288ExtracellularSequence analysisAdd BLAST24
Transmembranei289 – 309Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini310 – 359CytoplasmicSequence analysisAdd BLAST50

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3928

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692431 – 359C-C chemokine receptor type 3Add BLAST359

Proteomic databases

PaxDbiO54814
PRIDEiO54814

PTM databases

PhosphoSitePlusiO54814

Expressioni

Tissue specificityi

Expressed in spleen but not in astrocytes or microglia.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008809

Chemistry databases

BindingDBiO54814

Structurei

3D structure databases

ProteinModelPortaliO54814
SMRiO54814
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiO54814
KOiK04178
PhylomeDBiO54814
TreeFamiTF330966

Family and domain databases

InterProiView protein in InterPro
IPR002238 Chemokine_CCR3
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01108 CHEMOKINER3
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O54814-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNEEELKT VVETFETTPY EYEWAPPCEK VSIRELGSWL LPPLYSLVFI
60 70 80 90 100
VGLLGNMMVV LILIKYRKLQ IMTNIYLLNL AISDLLFLFT VPFWIHYVLW
110 120 130 140 150
NEWGFGHCMC KMLSGLYYLA LYSEIFFIIL LTIDRYLAIV HAVLALRART
160 170 180 190 200
VTFATITSII TWGFAVLAAL PEFIFHESQD NFGDLSCSPR YPEGEEDSWK
210 220 230 240 250
RFHALRMNIF GLALPLLIMV ICYSGIIKTL LRCPNKKKHK AIQLIFVVMI
260 270 280 290 300
VFFIFWTPYN LVLLLSAFHS TFLETSCQQS IHLDLAMQVT EVITHTHCCI
310 320 330 340 350
NPIIYAFVGE RFRKHLRLFF HRNVAIYLRK YISFLPGEKL ERTSSVSPST

GEQEISVVF
Length:359
Mass (Da):41,643
Last modified:June 1, 1998 - v1
Checksum:i880F682984F501DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti164F → L in CAA73830 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003954 Genomic DNA Translation: AAC03337.1
Y13400 mRNA Translation: CAA73830.1
RefSeqiNP_446410.1, NM_053958.1
UniGeneiRn.9890

Genome annotation databases

GeneIDi117027
KEGGirno:117027
UCSCiRGD:620593 rat

Similar proteinsi

Entry informationi

Entry nameiCCR3_RAT
AccessioniPrimary (citable) accession number: O54814
Secondary accession number(s): O55169
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: June 20, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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