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Protein

P2X purinoceptor 6

Gene

P2rx6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-139853 Elevation of cytosolic Ca2+ levels
R-MMU-418346 Platelet homeostasis

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptor 6
Short name:
P2X6
Alternative name(s):
ATP receptor
P2XM
Purinergic receptor
Purinergic receptor P2X-like 1
Gene namesi
Name:P2rx6
Synonyms:P2rxl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1337113 P2rx6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45CytoplasmicSequence analysisAdd BLAST45
Transmembranei46 – 66Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini67 – 335ExtracellularSequence analysisAdd BLAST269
Transmembranei336 – 356Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini357 – 389CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001615581 – 389P2X purinoceptor 6Add BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi129 ↔ 179By similarity
Disulfide bondi140 ↔ 163By similarity
Disulfide bondi146 ↔ 173By similarity
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi230 ↔ 240By similarity
Disulfide bondi274 ↔ 283By similarity

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO54803
PRIDEiO54803

PTM databases

iPTMnetiO54803
PhosphoSitePlusiO54803

Expressioni

Tissue specificityi

Predominantly expressed in skeletal muscle. Also expressed in lung.

Gene expression databases

BgeeiENSMUSG00000022758

Interactioni

Subunit structurei

Unlike most P2XRs, P2RX6 does not seem to form homotrimers or heterotrimers.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023441

Structurei

3D structure databases

ProteinModelPortaliO54803
SMRiO54803
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFJF Eukaryota
ENOG410XR0C LUCA
GeneTreeiENSGT00390000016028
HOGENOMiHOG000232042
HOVERGENiHBG053086
InParanoidiO54803
KOiK05221
OMAiHYSFQLQ
OrthoDBiEOG091G0A2U
TreeFamiTF328633

Family and domain databases

Gene3Di2.60.490.10, 1 hit
InterProiView protein in InterPro
IPR003049 P2X6_purnocptor
IPR027309 P2X_extracellular_dom_sf
IPR001429 P2X_purnocptor
PANTHERiPTHR10125 PTHR10125, 1 hit
PTHR10125:SF21 PTHR10125:SF21, 1 hit
PfamiView protein in Pfam
PF00864 P2X_receptor, 1 hit
PIRSFiPIRSF005713 P2X_purinoceptor, 1 hit
PRINTSiPR01313 P2X6RECEPTOR
PR01307 P2XRECEPTOR
TIGRFAMsiTIGR00863 P2X, 1 hit
PROSITEiView protein in PROSITE
PS01212 P2X_RECEPTOR, 1 hit

Sequencei

Sequence statusi: Complete.

O54803-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLQPAGTGN MASAAAAALV SWGFLDYKTE KYVLTRNCRV GVSQRLLQLA
60 70 80 90 100
VVVYVIGWAL LAKKGYQERD LAPQTSVITK LKGVSVTQVK ELENRLWDVA
110 120 130 140 150
DFVKPSQGEN VFFLVTNFLV TPAQVQGRCP EHPSVPLANC WADEDCPEGE
160 170 180 190 200
TGTYSHGIKT GQCVVFNGTH RTCEIWSWCP VESGAVPRKP LLAQAKNFTL
210 220 230 240 250
FIKNTVTFSK FNFSRSNALL TWDNTYFKHC LYDPLSSPYC PVFRIGDLVA
260 270 280 290 300
MAGGDFEDLA LLGGAVGISI HWDCNLDTKG SDCCPQYSFQ LQQKGYNFRT
310 320 330 340 350
ANHWWAASGV ETRSLLKLYG IRFDILVTGQ AGKFALIPTA ITVGTGAAWL
360 370 380
GMVTFLCDLL LLYVDREAGF YWRTKYEEAR APKTTTNSS
Length:389
Mass (Da):43,099
Last modified:January 31, 2018 - v3
Checksum:i55852B6BECA1B7F4
GO

Sequence cautioni

The sequence BAA24693 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE23697 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti269S → T in BAA24693 (PubMed:9852680).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010883 mRNA Translation: BAA24693.1 Different initiation.
AC115733 Genomic DNA No translation available.
CH466521 Genomic DNA Translation: EDK97466.1
AK138541 mRNA Translation: BAE23697.1 Different initiation.
CCDSiCCDS28007.2
RefSeqiNP_001153033.1, NM_001159561.1
NP_035158.2, NM_011028.2
UniGeneiMm.8032

Genome annotation databases

EnsembliENSMUST00000023441; ENSMUSP00000023441; ENSMUSG00000022758
GeneIDi18440
KEGGimmu:18440
UCSCiuc007yli.2 mouse

Similar proteinsi

Entry informationi

Entry nameiP2RX6_MOUSE
AccessioniPrimary (citable) accession number: O54803
Secondary accession number(s): G3X8W3, Q3UUD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 31, 2018
Last modified: June 20, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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