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UniProtKB - O54792 (HES2_MOUSE)
Protein
Transcription factor HES-2
Gene
Hes2
Organism
Mus musculus (Mouse)
Status
Functioni
Transcriptional repressor of genes that require a bHLH protein for their transcription.
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: MGI
- double-stranded DNA binding Source: MGI
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- anterior/posterior pattern specification Source: GO_Central
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- regulation of neurogenesis Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor HES-2Alternative name(s): Hairy and enhancer of split 2 |
Gene namesi | Name:Hes2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1098624, Hes2 |
VEuPathDBi | HostDB:ENSMUSG00000028940 |
Subcellular locationi
Nucleus
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127207 | 1 – 157 | Transcription factor HES-2Add BLAST | 157 |
Proteomic databases
PaxDbi | O54792 |
PRIDEi | O54792 |
PTM databases
iPTMneti | O54792 |
PhosphoSitePlusi | O54792 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000028940, Expressed in head and 61 other tissues |
Genevisiblei | O54792, MM |
Interactioni
Subunit structurei
Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.
By similarityGO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
ELMi | O54792 |
STRINGi | 10090.ENSMUSP00000030782 |
Miscellaneous databases
RNActi | O54792, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 70 | bHLHPROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 86 – 119 | OrangePROSITE-ProRule annotationAdd BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 124 – 157 | DisorderedSequence analysisAdd BLAST | 34 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 154 – 157 | WRPW motif | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 132 – 157 | Pro residuesSequence analysisAdd BLAST | 26 |
Domaini
Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity
Phylogenomic databases
eggNOGi | KOG4304, Eukaryota |
GeneTreei | ENSGT00940000161602 |
HOGENOMi | CLU_068550_5_0_1 |
InParanoidi | O54792 |
OMAi | THCANEV |
OrthoDBi | 1427802at2759 |
PhylomeDBi | O54792 |
TreeFami | TF351373 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom |
Pfami | View protein in Pfam PF07527, Hairy_orange, 1 hit PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00511, ORANGE, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit |
i Sequence
Sequence statusi: Complete.
O54792-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLPRRVEDA AELRKNLKPL LEKRRRARIN ESLSQLKGLV LPLLGAETSR
60 70 80 90 100
SSKLEKADIL EMTVRFLQEQ PATLYSSAAP GPLNSYLEGY RACLARLARV
110 120 130 140 150
LPACSVLEPA VSARLLEHLR QRTVSDDSPS LTLPPAPAPA PSPPVPPPGS
SGLWRPW
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 – 13 | EL → DV in BAA24091 (PubMed:9570950).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB009967 Genomic DNA Translation: BAA24091.1 AK053792 mRNA Translation: BAC35525.1 AL772240 Genomic DNA No translation available. CH466594 Genomic DNA Translation: EDL14928.1 BC138112 mRNA Translation: AAI38113.1 |
CCDSi | CCDS18995.1 |
RefSeqi | NP_001288734.1, NM_001301805.1 NP_032262.2, NM_008236.4 XP_017175471.1, XM_017319982.1 |
Genome annotation databases
Ensembli | ENSMUST00000030782; ENSMUSP00000030782; ENSMUSG00000028940 |
GeneIDi | 15206 |
KEGGi | mmu:15206 |
UCSCi | uc008vzw.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB009967 Genomic DNA Translation: BAA24091.1 AK053792 mRNA Translation: BAC35525.1 AL772240 Genomic DNA No translation available. CH466594 Genomic DNA Translation: EDL14928.1 BC138112 mRNA Translation: AAI38113.1 |
CCDSi | CCDS18995.1 |
RefSeqi | NP_001288734.1, NM_001301805.1 NP_032262.2, NM_008236.4 XP_017175471.1, XM_017319982.1 |
3D structure databases
AlphaFoldDBi | O54792 |
SMRi | O54792 |
ModBasei | Search... |
Protein-protein interaction databases
ELMi | O54792 |
STRINGi | 10090.ENSMUSP00000030782 |
PTM databases
iPTMneti | O54792 |
PhosphoSitePlusi | O54792 |
Proteomic databases
PaxDbi | O54792 |
PRIDEi | O54792 |
Protocols and materials databases
Antibodypediai | 27325, 284 antibodies from 22 providers |
DNASUi | 15206 |
Genome annotation databases
Ensembli | ENSMUST00000030782; ENSMUSP00000030782; ENSMUSG00000028940 |
GeneIDi | 15206 |
KEGGi | mmu:15206 |
UCSCi | uc008vzw.1, mouse |
Organism-specific databases
CTDi | 54626 |
MGIi | MGI:1098624, Hes2 |
VEuPathDBi | HostDB:ENSMUSG00000028940 |
Phylogenomic databases
eggNOGi | KOG4304, Eukaryota |
GeneTreei | ENSGT00940000161602 |
HOGENOMi | CLU_068550_5_0_1 |
InParanoidi | O54792 |
OMAi | THCANEV |
OrthoDBi | 1427802at2759 |
PhylomeDBi | O54792 |
TreeFami | TF351373 |
Miscellaneous databases
BioGRID-ORCSi | 15206, 2 hits in 75 CRISPR screens |
PROi | PR:O54792 |
RNActi | O54792, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028940, Expressed in head and 61 other tissues |
Genevisiblei | O54792, MM |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom |
Pfami | View protein in Pfam PF07527, Hairy_orange, 1 hit PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00511, ORANGE, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HES2_MOUSE | |
Accessioni | O54792Primary (citable) accession number: O54792 Secondary accession number(s): Q8BKA6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | October 3, 2012 | |
Last modified: | May 25, 2022 | |
This is version 149 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot