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Protein

Transcription factor HES-2

Gene

Hes2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor of genes that require a bHLH protein for their transcription.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor HES-2
Alternative name(s):
Hairy and enhancer of split 2
Gene namesi
Name:Hes2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1098624 Hes2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272071 – 157Transcription factor HES-2Add BLAST157

Proteomic databases

PaxDbiO54792
PRIDEiO54792

PTM databases

iPTMnetiO54792
PhosphoSitePlusiO54792

Expressioni

Gene expression databases

BgeeiENSMUSG00000028940 Expressed in 32 organ(s), highest expression level in kidney interstitium
CleanExiMM_HES2
GenevisibleiO54792 MM

Interactioni

Subunit structurei

Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.By similarity

GO - Molecular functioni

Protein-protein interaction databases

ELMiO54792
STRINGi10090.ENSMUSP00000030782

Structurei

3D structure databases

ProteinModelPortaliO54792
SMRiO54792
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 70bHLHPROSITE-ProRule annotationAdd BLAST58
Domaini86 – 119OrangePROSITE-ProRule annotationAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi154 – 157WRPW motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi139 – 148Pro-rich10

Domaini

Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity

Phylogenomic databases

eggNOGiKOG4304 Eukaryota
ENOG4111F0X LUCA
GeneTreeiENSGT00700000104168
HOGENOMiHOG000236346
HOVERGENiHBG005960
InParanoidiO54792
KOiK09087
OMAiPVPCDSY
OrthoDBiEOG091G0GBN
TreeFamiTF351373

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF07527 Hairy_orange, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00511 ORANGE, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit

Sequencei

Sequence statusi: Complete.

O54792-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLPRRVEDA AELRKNLKPL LEKRRRARIN ESLSQLKGLV LPLLGAETSR
60 70 80 90 100
SSKLEKADIL EMTVRFLQEQ PATLYSSAAP GPLNSYLEGY RACLARLARV
110 120 130 140 150
LPACSVLEPA VSARLLEHLR QRTVSDDSPS LTLPPAPAPA PSPPVPPPGS

SGLWRPW
Length:157
Mass (Da):17,259
Last modified:October 3, 2012 - v2
Checksum:iA6600DDD4FE93E7C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12 – 13EL → DV in BAA24091 (PubMed:9570950).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009967 Genomic DNA Translation: BAA24091.1
AK053792 mRNA Translation: BAC35525.1
AL772240 Genomic DNA Translation: CAM19694.1
CH466594 Genomic DNA Translation: EDL14928.1
BC138112 mRNA Translation: AAI38113.1
CCDSiCCDS18995.1
RefSeqiNP_001288734.1, NM_001301805.1
NP_032262.2, NM_008236.4
XP_017175471.1, XM_017319982.1
UniGeneiMm.57038

Genome annotation databases

EnsembliENSMUST00000030782; ENSMUSP00000030782; ENSMUSG00000028940
GeneIDi15206
KEGGimmu:15206
UCSCiuc008vzw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009967 Genomic DNA Translation: BAA24091.1
AK053792 mRNA Translation: BAC35525.1
AL772240 Genomic DNA Translation: CAM19694.1
CH466594 Genomic DNA Translation: EDL14928.1
BC138112 mRNA Translation: AAI38113.1
CCDSiCCDS18995.1
RefSeqiNP_001288734.1, NM_001301805.1
NP_032262.2, NM_008236.4
XP_017175471.1, XM_017319982.1
UniGeneiMm.57038

3D structure databases

ProteinModelPortaliO54792
SMRiO54792
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiO54792
STRINGi10090.ENSMUSP00000030782

PTM databases

iPTMnetiO54792
PhosphoSitePlusiO54792

Proteomic databases

PaxDbiO54792
PRIDEiO54792

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030782; ENSMUSP00000030782; ENSMUSG00000028940
GeneIDi15206
KEGGimmu:15206
UCSCiuc008vzw.1 mouse

Organism-specific databases

CTDi54626
MGIiMGI:1098624 Hes2

Phylogenomic databases

eggNOGiKOG4304 Eukaryota
ENOG4111F0X LUCA
GeneTreeiENSGT00700000104168
HOGENOMiHOG000236346
HOVERGENiHBG005960
InParanoidiO54792
KOiK09087
OMAiPVPCDSY
OrthoDBiEOG091G0GBN
TreeFamiTF351373

Miscellaneous databases

PROiPR:O54792
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028940 Expressed in 32 organ(s), highest expression level in kidney interstitium
CleanExiMM_HES2
GenevisibleiO54792 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF07527 Hairy_orange, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00511 ORANGE, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHES2_MOUSE
AccessioniPrimary (citable) accession number: O54792
Secondary accession number(s): Q8BKA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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