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Protein

Transcription factor MafF

Gene

Maff

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition.By similarity

GO - Molecular functioni

GO - Biological processi

  • in utero embryonic development Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of epidermal cell differentiation Source: MGI
  • skeletal muscle cell differentiation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor MafF
Alternative name(s):
V-maf musculoaponeurotic fibrosarcoma oncogene homolog F
Gene namesi
Name:Maff
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96910 Maff

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764981 – 156Transcription factor MafFAdd BLAST156

Proteomic databases

PaxDbiO54791
PeptideAtlasiO54791
PRIDEiO54791

PTM databases

iPTMnetiO54791
PhosphoSitePlusiO54791

Expressioni

Tissue specificityi

Highly expressed in the lung, lower expression in the brain, thymus, liver, spleen, intestine, kidney, heart, muscle, and ovary. Not significantly expressed in hematopoietic cells.

Developmental stagei

Detected at 6.5 dpc in the boundary between the extraembryonic and embryonic regions. At 8.5 dpc, weakly expressed in the future gut, allantois, yolk sac endoderm and the ectoplacental cone. At 9.5 dpc, strong expression in the primordial gut and presumptive fetal liver, in the floorplate of the myelencephalon, neural crest cells, spongiotrophoblasts, and giant cells of the placenta. At 12.5 dpc, detected in hepotocytes, in the outflow tract of the heart in a specific subset of dorsal root ganglia, in the cranial nerve ganglia, in the lung primordium, and in the epithelium of the expiratory tract. In newborn, strongly expressed in keratinocytes, in the cartilage, in bronchial epithelia, and bone membrane.1 Publication

Gene expression databases

BgeeiENSMUSG00000042622
ExpressionAtlasiO54791 baseline and differential
GenevisibleiO54791 MM

Interactioni

Subunit structurei

Monomer and homo- or heterodimer. Interacts with MIP. Forms high affinity heterodimers with members of the CNC-bZIP family such as NFE2L1/NRF1.By similarity

Protein-protein interaction databases

BioGridi201282, 1 interactor
STRINGi10090.ENSMUSP00000094076

Structurei

3D structure databases

ProteinModelPortaliO54791
SMRiO54791
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 114bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 76Basic motifPROSITE-ProRule annotationAdd BLAST26
Regioni79 – 93Leucine-zipperPROSITE-ProRule annotationAdd BLAST15

Sequence similaritiesi

Belongs to the bZIP family. Maf subfamily.Curated

Phylogenomic databases

eggNOGiKOG4196 Eukaryota
ENOG41102C7 LUCA
GeneTreeiENSGT00550000074549
HOGENOMiHOG000045475
HOVERGENiHBG001725
InParanoidiO54791
KOiK09037
OMAiNRQLKLR
OrthoDBiEOG091G0H46
PhylomeDBiO54791
TreeFamiTF325689

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR004826 bZIP_Maf
IPR033531 MafF
IPR008917 TF_DNA-bd_sf
IPR024874 Transciption_factor_Maf_fam
PANTHERiPTHR10129 PTHR10129, 1 hit
PTHR10129:SF25 PTHR10129:SF25, 1 hit
PfamiView protein in Pfam
PF03131 bZIP_Maf, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

Sequencei

Sequence statusi: Complete.

O54791-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVDPLSSKA LKVKRELSEN TPHLSDEALM GLSVRELNRN LRGLSAEEVT
60 70 80 90 100
RLKQRRRTLK NRGYAASCRV KRVCQKEELQ KQKSELEREV DKLARENAAM
110 120 130 140 150
RLELDALRGK CEALQGFARS VAAARGPAAL VAPASVITIV KSAPGPAPAA

DPAPCS
Length:156
Mass (Da):16,955
Last modified:June 1, 1998 - v1
Checksum:i574DD05499819037
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009694 Genomic DNA Translation: BAA24029.1
BC022952 mRNA Translation: AAH22952.1
CCDSiCCDS27638.1
RefSeqiNP_001291759.1, NM_001304830.1
NP_034885.1, NM_010755.4
XP_006520609.2, XM_006520546.3
XP_006520613.1, XM_006520550.3
XP_011243786.1, XM_011245484.2
UniGeneiMm.86646

Genome annotation databases

EnsembliENSMUST00000096350; ENSMUSP00000094076; ENSMUSG00000042622
ENSMUST00000163691; ENSMUSP00000131628; ENSMUSG00000042622
ENSMUST00000229130; ENSMUSP00000154850; ENSMUSG00000042622
GeneIDi17133
KEGGimmu:17133
UCSCiuc007wth.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMAFF_MOUSE
AccessioniPrimary (citable) accession number: O54791
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 1, 1998
Last modified: June 20, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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