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UniProtKB - O54783 (CHKB_RAT)
Protein
Choline/ethanolamine kinase
Gene
Chkb
Organism
Rattus norvegicus (Rat)
Status
Functioni
Has a key role in phospholipid metabolism, and catalyzes the first step of phosphatidylethanolamine and phosphatidylcholine biosynthesis.
By similarityCatalytic activityi
- EC:2.7.1.32By similarityThis reaction proceeds in the forwardBy similarity direction.
- EC:2.7.1.82By similarityThis reaction proceeds in the forwardBy similarity direction.
: phosphatidylethanolamine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes phosphatidylethanolamine from ethanolamine.By similarity This subpathway is part of the pathway phosphatidylethanolamine biosynthesis, which is itself part of Phospholipid metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylethanolamine from ethanolamine, the pathway phosphatidylethanolamine biosynthesis and in Phospholipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 104 | ATPBy similarity | 1 | |
Binding sitei | 244 | ATPBy similarity | 1 | |
Binding sitei | 264 | ATPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 75 – 81 | ATPBy similarity | 7 | |
Nucleotide bindingi | 146 – 152 | ATPBy similarity | 7 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- choline kinase activity Source: RGD
- ethanolamine kinase activity Source: RGD
GO - Biological processi
- CDP-choline pathway Source: GO_Central
- muscle organ development Source: RGD
- phosphatidylcholine biosynthetic process Source: RGD
- phosphatidylethanolamine biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-RNO-1483191, Synthesis of PC R-RNO-1483213, Synthesis of PE |
SABIO-RKi | O54783 |
UniPathwayi | UPA00558;UER00741 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Chkb Synonyms:Chetk, Chkl |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 61826, Chkb |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000206224 | 2 – 394 | Choline/ethanolamine kinaseAdd BLAST | 393 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
PaxDbi | O54783 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000011404, Expressed in pancreas and 21 other tissues |
Genevisiblei | O54783, RN |
Interactioni
Subunit structurei
Homodimer, and heterodimer with CHKA.
By similarityProtein-protein interaction databases
BioGRIDi | 248021, 1 interactor |
STRINGi | 10116.ENSRNOP00000015374 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 22 – 42 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 77 – 79 | Substrate bindingBy similarity | 3 |
Sequence similaritiesi
Belongs to the choline/ethanolamine kinase family.Curated
Phylogenomic databases
eggNOGi | KOG2686, Eukaryota |
GeneTreei | ENSGT00950000182939 |
HOGENOMi | CLU_012712_2_1_1 |
InParanoidi | O54783 |
OMAi | YAQARFQ |
OrthoDBi | 1469912at2759 |
PhylomeDBi | O54783 |
TreeFami | TF313549 |
Family and domain databases
InterProi | View protein in InterPro IPR026712, Cho/Etha_kinase IPR011009, Kinase-like_dom_sf |
PANTHERi | PTHR22603:SF35, PTHR22603:SF35, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O54783-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAADGTGVVG GGAVGGPLSK DGLLDAKCPE PIPNRRRSSS LSRDAQRRAY
60 70 80 90 100
QWCREYLGGA WRRARPEELS VCPVSGGLSN LLFRCSLPNH VPSMGGEPRE
110 120 130 140 150
VLLRLYGAIL QGVDSLVLES VMFAILAERS LGPQLYGVFP EGRLEQYLPS
160 170 180 190 200
RPLKTQELRD PVLSGAIATK MARFHGMEMP FTKEPRWLFG TMERYLKQIQ
210 220 230 240 250
DLPSTSLPQM NLVEMYSLKD EMNHLRTLLD ATPSPVVFCH NDIQEGNILL
260 270 280 290 300
LSEPDSDDNL MLVDFEYSSY NYRGFDIGNH FCEWVYDYTY EEWPFYKARP
310 320 330 340 350
ADYPTREQQL LFIRHYLAEV QKGEVLSEEE QKKQEEDLLI EISRYALASH
360 370 380 390
FFWGLWSTLQ ASMSTIEFGY LEYAQSRFQF YFQQKGQLTS FLSP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB006607 mRNA Translation: BAA24366.1 BC060515 mRNA Translation: AAH60515.1 |
RefSeqi | NP_058873.1, NM_017177.1 |
Genome annotation databases
Ensembli | ENSRNOT00000015374; ENSRNOP00000015374; ENSRNOG00000011404 |
GeneIDi | 29367 |
KEGGi | rno:29367 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB006607 mRNA Translation: BAA24366.1 BC060515 mRNA Translation: AAH60515.1 |
RefSeqi | NP_058873.1, NM_017177.1 |
3D structure databases
SMRi | O54783 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 248021, 1 interactor |
STRINGi | 10116.ENSRNOP00000015374 |
Proteomic databases
PaxDbi | O54783 |
Genome annotation databases
Ensembli | ENSRNOT00000015374; ENSRNOP00000015374; ENSRNOG00000011404 |
GeneIDi | 29367 |
KEGGi | rno:29367 |
Organism-specific databases
CTDi | 1120 |
RGDi | 61826, Chkb |
Phylogenomic databases
eggNOGi | KOG2686, Eukaryota |
GeneTreei | ENSGT00950000182939 |
HOGENOMi | CLU_012712_2_1_1 |
InParanoidi | O54783 |
OMAi | YAQARFQ |
OrthoDBi | 1469912at2759 |
PhylomeDBi | O54783 |
TreeFami | TF313549 |
Enzyme and pathway databases
UniPathwayi | UPA00558;UER00741 |
Reactomei | R-RNO-1483191, Synthesis of PC R-RNO-1483213, Synthesis of PE |
SABIO-RKi | O54783 |
Miscellaneous databases
PROi | PR:O54783 |
Gene expression databases
Bgeei | ENSRNOG00000011404, Expressed in pancreas and 21 other tissues |
Genevisiblei | O54783, RN |
Family and domain databases
InterProi | View protein in InterPro IPR026712, Cho/Etha_kinase IPR011009, Kinase-like_dom_sf |
PANTHERi | PTHR22603:SF35, PTHR22603:SF35, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CHKB_RAT | |
Accessioni | O54783Primary (citable) accession number: O54783 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 133 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families