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Protein

WNT1-inducible-signaling pathway protein 1

Gene

Wisp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Downstream regulator in the Wnt/Frizzled-signaling pathway (By similarity). Associated with cell survival. Adheres to skin and melanoma fibroblasts (By similarity). In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan (By similarity). Suppresses tumor growth in vivo.By similarity

GO - Molecular functioni

  • heparin binding Source: GO_Central
  • insulin-like growth factor binding Source: InterPro
  • integrin binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell adhesion, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
WNT1-inducible-signaling pathway protein 1
Short name:
WISP-1
Alternative name(s):
CCN family member 4
ELM-1
Gene namesi
Name:Wisp1
Synonyms:Ccn4, Elm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1197008 Wisp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001440723 – 367WNT1-inducible-signaling pathway protein 1Add BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi273 ↔ 310By similarity
Glycosylationi284N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi290 ↔ 324By similarity
Disulfide bondi301 ↔ 340By similarity
Disulfide bondi304 ↔ 342By similarity
Disulfide bondi309 ↔ 346By similarity
Glycosylationi343N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO54775
PeptideAtlasiO54775
PRIDEiO54775

PTM databases

PhosphoSitePlusiO54775

Expressioni

Tissue specificityi

Highly expressed in kidney and lung. Lower levels in heart, brain, spleen, liver, skeletal muscle and testis. Expressed in low metastatic melanoma cells.

Gene expression databases

BgeeiENSMUSG00000005124 Expressed in 229 organ(s), highest expression level in molar tooth
CleanExiMM_WISP1
ExpressionAtlasiO54775 baseline and differential
GenevisibleiO54775 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005255

Structurei

3D structure databases

ProteinModelPortaliO54775
SMRiO54775
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 118IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST74
Domaini121 – 186VWFCPROSITE-ProRule annotationAdd BLAST66
Domaini215 – 260TSP type-1PROSITE-ProRule annotationAdd BLAST46
Domaini273 – 347CTCKPROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Belongs to the CCN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH8M Eukaryota
ENOG410ZWR5 LUCA
GeneTreeiENSGT00760000119225
HOGENOMiHOG000231462
HOVERGENiHBG000635
InParanoidiO54775
KOiK22471
OMAiGEVEPWH
OrthoDBiEOG091G0SQP
PhylomeDBiO54775
TreeFamiTF326070

Family and domain databases

Gene3Di2.20.100.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR006208 Glyco_hormone_CN
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
IPR012395 IGFBP_CNN
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR001007 VWF_dom
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
PF00219 IGFBP, 1 hit
PF00090 TSP_1, 1 hit
PF00093 VWC, 1 hit
PIRSFiPIRSF036495 IGFBP_rP_CNN, 1 hit
SMARTiView protein in SMART
SM00041 CT, 1 hit
SM00121 IB, 1 hit
SM00209 TSP1, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF82895 SSF82895, 1 hit
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS50092 TSP1, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O54775-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRWLLPWTLA AVAVLRVGNI LATALSPTPT TMTFTPAPLE ETTTRPEFCK
60 70 80 90 100
WPCECPQSPP RCPLGVSLIT DGCECCKICA QQLGDNCTEA AICDPHRGLY
110 120 130 140 150
CDYSGDRPRY AIGVCAQVVG VGCVLDGVRY TNGESFQPNC RYNCTCIDGT
160 170 180 190 200
VGCTPLCLSP RPPRLWCRQP RHVRVPGQCC EQWVCDDDAR RPRQTALLDT
210 220 230 240 250
RAFAASGAVE QRYENCIAYT SPWSPCSTTC GLGISTRISN VNARCWPEQE
260 270 280 290 300
SRLCNLRPCD VDIQLHIKAG KKCLAVYQPE EATNFTLAGC VSTRTYRPKY
310 320 330 340 350
CGVCTDNRCC IPYKSKTISV DFQCPEGPGF SRQVLWINAC FCNLSCRNPN
360
DIFADLESYP DFEEIAN
Length:367
Mass (Da):40,703
Last modified:June 1, 1998 - v1
Checksum:i3B7C0569EFAB5E96
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z6X6D3Z6X6_MOUSE
WNT1-inducible-signaling pathway pr...
Wisp1
153Annotation score:
A0A0R4J1T7A0A0R4J1T7_MOUSE
WNT1-inducible-signaling pathway pr...
Wisp1
52Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79C → R in AAH52677 (PubMed:15489334).Curated1
Sequence conflicti199D → G in AAH52677 (PubMed:15489334).Curated1
Sequence conflicti316K → R in AAH52677 (PubMed:15489334).Curated1
Sequence conflicti363E → G in AAH52677 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004873 mRNA Translation: BAA24949.1
AF100777 mRNA Translation: AAC96319.1
BC048791 mRNA Translation: AAH48791.1
BC052677 mRNA Translation: AAH52677.1
CCDSiCCDS27510.1
RefSeqiNP_061353.1, NM_018865.2
UniGeneiMm.10222

Genome annotation databases

EnsembliENSMUST00000005255; ENSMUSP00000005255; ENSMUSG00000005124
GeneIDi22402
KEGGimmu:22402
UCSCiuc007wau.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004873 mRNA Translation: BAA24949.1
AF100777 mRNA Translation: AAC96319.1
BC048791 mRNA Translation: AAH48791.1
BC052677 mRNA Translation: AAH52677.1
CCDSiCCDS27510.1
RefSeqiNP_061353.1, NM_018865.2
UniGeneiMm.10222

3D structure databases

ProteinModelPortaliO54775
SMRiO54775
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005255

PTM databases

PhosphoSitePlusiO54775

Proteomic databases

PaxDbiO54775
PeptideAtlasiO54775
PRIDEiO54775

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005255; ENSMUSP00000005255; ENSMUSG00000005124
GeneIDi22402
KEGGimmu:22402
UCSCiuc007wau.1 mouse

Organism-specific databases

CTDi8840
MGIiMGI:1197008 Wisp1

Phylogenomic databases

eggNOGiENOG410IH8M Eukaryota
ENOG410ZWR5 LUCA
GeneTreeiENSGT00760000119225
HOGENOMiHOG000231462
HOVERGENiHBG000635
InParanoidiO54775
KOiK22471
OMAiGEVEPWH
OrthoDBiEOG091G0SQP
PhylomeDBiO54775
TreeFamiTF326070

Miscellaneous databases

ChiTaRSiWisp1 mouse
PROiPR:O54775
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005124 Expressed in 229 organ(s), highest expression level in molar tooth
CleanExiMM_WISP1
ExpressionAtlasiO54775 baseline and differential
GenevisibleiO54775 MM

Family and domain databases

Gene3Di2.20.100.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR006208 Glyco_hormone_CN
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
IPR012395 IGFBP_CNN
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR001007 VWF_dom
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
PF00219 IGFBP, 1 hit
PF00090 TSP_1, 1 hit
PF00093 VWC, 1 hit
PIRSFiPIRSF036495 IGFBP_rP_CNN, 1 hit
SMARTiView protein in SMART
SM00041 CT, 1 hit
SM00121 IB, 1 hit
SM00209 TSP1, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF82895 SSF82895, 1 hit
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS50092 TSP1, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWISP1_MOUSE
AccessioniPrimary (citable) accession number: O54775
Secondary accession number(s): Q80ZL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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