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Protein

AP-3 complex subunit delta-1

Gene

Ap3d1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes (By similarity). Involved in process of CD8+ T-cell and NK cell degranulation (By similarity). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (PubMed:21998198).By similarity1 Publication

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit delta-1
Alternative name(s):
AP-3 complex subunit delta
Adaptor-related protein complex 3 subunit delta-1
Delta-adaptin
Short name:
mBLVR1
Gene namesi
Name:Ap3d1
Synonyms:Ap3d
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:107734 Ap3d1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001937672 – 1199AP-3 complex subunit delta-1Add BLAST1198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei632PhosphoserineCombined sources1
Modified residuei634PhosphoserineCombined sources1
Modified residuei636PhosphoserineCombined sources1
Modified residuei688PhosphoserineBy similarity1
Modified residuei754PhosphoserineCombined sources1
Modified residuei755PhosphoserineCombined sources1
Modified residuei758PhosphothreonineCombined sources1
Modified residuei760PhosphoserineCombined sources1
Modified residuei784PhosphoserineCombined sources1
Modified residuei825PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO54774
MaxQBiO54774
PaxDbiO54774
PeptideAtlasiO54774
PRIDEiO54774

PTM databases

iPTMnetiO54774
PhosphoSitePlusiO54774
SwissPalmiO54774

Expressioni

Gene expression databases

BgeeiENSMUSG00000020198 Expressed in 290 organ(s), highest expression level in vestibular membrane of cochlear duct
ExpressionAtlasiO54774 baseline and differential
GenevisibleiO54774 MM

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2) (By similarity). AP-3 associates with the BLOC-1 complex. Interacts with SLC30A2.By similarity

Protein-protein interaction databases

BioGridi198134, 2 interactors
DIPiDIP-32163N
IntActiO54774, 10 interactors
MINTiO54774
STRINGi10090.ENSMUSP00000020420

Structurei

3D structure databases

ProteinModelPortaliO54774
SMRiO54774
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 71HEAT 1Add BLAST38
Repeati142 – 179HEAT 2Add BLAST38
Repeati180 – 216HEAT 3Add BLAST37
Repeati218 – 254HEAT 4Add BLAST37
Repeati257 – 296HEAT 5Add BLAST40
Repeati298 – 336HEAT 6Add BLAST39
Repeati337 – 373HEAT 7Add BLAST37
Repeati375 – 409HEAT 8Add BLAST35
Repeati521 – 558HEAT 9Add BLAST38

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili659 – 679Sequence analysisAdd BLAST21
Coiled coili722 – 750Sequence analysisAdd BLAST29
Coiled coili843 – 863Sequence analysisAdd BLAST21
Coiled coili911 – 934Sequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi836 – 944Lys-richAdd BLAST109
Compositional biasi956 – 960Poly-Glu5

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1059 Eukaryota
ENOG410XQFB LUCA
GeneTreeiENSGT00550000075067
HOGENOMiHOG000000981
HOVERGENiHBG050520
InParanoidiO54774
KOiK12396
OMAiMTYDIQG
OrthoDBiEOG091G04IL
PhylomeDBiO54774
TreeFamiTF105666

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR017105 AP3_complex_dsu
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
PANTHERiPTHR22781 PTHR22781, 1 hit
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O54774-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALKMVKGSI DRMFDKNLQD LVRGIRNHKE DEAKYISQCI DEIKQELKQD
60 70 80 90 100
NIAVKANAVC KLTYLQMLGY DISWAAFNII EVMSASKFTF KRVGYLAASQ
110 120 130 140 150
CFHEGTDVIM LTTNQIRKDL SSPSQYDTGV ALTGLSCFVT PDLARDLAND
160 170 180 190 200
IMTLMSHTKP YIRKKAVLIM YKVFLKYPES LRPAFPRLKE KLEDPDPGVQ
210 220 230 240 250
SAAVNVICEL ARRNPKNYLS LAPLFFKLMT SSTNNWVLIK IIKLFGALTP
260 270 280 290 300
LEPRLGKKLI EPLTNLIHST SAMSLLYECV NTVIAVLISL SSGMPNHSAS
310 320 330 340 350
IQLCVQKLRI LIEDSDQNLK YLGLLAMSKI LKTHPKSVQS HKDLILQCLD
360 370 380 390 400
DKDESIRLRA LDLLYGMVSK KNLMEIVKKL MTHVDKAEGT TYRDELLTKI
410 420 430 440 450
IDICSQSNYQ HITNFEWYIS ILVELTRLEG TRHGHLIAAQ MLDVAIRVKA
460 470 480 490 500
IRKFAVSQMS SLLDSAHLVA SSTQRNGICE VLYAAAWICG EFSEHLQGPQ
510 520 530 540 550
QTLEAMLRPK VTTLPGHIQA VYVQNVVKLY ASILQQKEQA ADTEAAQEVT
560 570 580 590 600
QLLVERLPQF VQSADLEVQE RASCILQLVK HVQKLQAKGV PVAEEVSALF
610 620 630 640 650
AGELNPVAPK AQKKVPVPEG LDLDAWINEP PSDSESEDEK PKAIFHEEEP
660 670 680 690 700
RHTRRRQPEE DEEELARRRE ARKQEQANNP FYIKSSPSPQ KRYQDAPGVE
710 720 730 740 750
HIPVVQIDLS VPLKVPGMPM SDQYVKLEEQ RRHRQRLEKD KKRKKKEKGK
760 770 780 790 800
RRHSSLPTES DEDIAPAQRV DIITEEMPEN ALPSDEDDKD PNDPYRALDI
810 820 830 840 850
DLDKPLADSE KLPVQKHRNA EAVKSPEKEG VLGVEKKSKK PKKKEKKTKE
860 870 880 890 900
REREKKDKKG EDLDFWLSTT PPPAAAPIPA PSTEELAAST ITSPKDECEV
910 920 930 940 950
LKGEEEDHVD HDQERKSSRH KKKKHRKEKE KEERPRDKKK AKKKQVAPLE
960 970 980 990 1000
NGAAAEEEEE PIPPMSSYCL LAESPYIKVT YDIQASLQKD SQVTVSIILE
1010 1020 1030 1040 1050
NQSSSFLKNM ELNVLDSLNT KMTRPEGSSV HDGVPVPFQL PPGVSNEAQF
1060 1070 1080 1090 1100
VFTIQSIVMA QKLKGTLSFI AKDDEGATHE KLDFRLHFSC SSYLITTPCY
1110 1120 1130 1140 1150
SDAFAKLLES GDLSMNSIKV DGISMSFQNL LAKICFYHHF SVVERVDSCA
1160 1170 1180 1190
SMYSRSIQGH HVCLLVKKGE SSVSVDGKCS DATLLSSLLE EMKTTLAQC
Length:1,199
Mass (Da):135,081
Last modified:June 1, 1998 - v1
Checksum:i29D2D036B36C3B05
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P6Q6A0A1W2P6Q6_MOUSE
AP-3 complex subunit delta-1
Ap3d1
122Annotation score:
A0A1W2P7Z2A0A1W2P7Z2_MOUSE
AP-3 complex subunit delta-1
Ap3d1
116Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004305 mRNA Translation: BAA24578.1
BC048786 mRNA Translation: AAH48786.1
BC053066 mRNA Translation: AAH53066.1
CCDSiCCDS35984.1
PIRiT13946
RefSeqiNP_031486.1, NM_007460.1
UniGeneiMm.209294
Mm.27082

Genome annotation databases

EnsembliENSMUST00000020420; ENSMUSP00000020420; ENSMUSG00000020198
GeneIDi11776
KEGGimmu:11776
UCSCiuc007gek.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004305 mRNA Translation: BAA24578.1
BC048786 mRNA Translation: AAH48786.1
BC053066 mRNA Translation: AAH53066.1
CCDSiCCDS35984.1
PIRiT13946
RefSeqiNP_031486.1, NM_007460.1
UniGeneiMm.209294
Mm.27082

3D structure databases

ProteinModelPortaliO54774
SMRiO54774
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198134, 2 interactors
DIPiDIP-32163N
IntActiO54774, 10 interactors
MINTiO54774
STRINGi10090.ENSMUSP00000020420

PTM databases

iPTMnetiO54774
PhosphoSitePlusiO54774
SwissPalmiO54774

Proteomic databases

EPDiO54774
MaxQBiO54774
PaxDbiO54774
PeptideAtlasiO54774
PRIDEiO54774

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020420; ENSMUSP00000020420; ENSMUSG00000020198
GeneIDi11776
KEGGimmu:11776
UCSCiuc007gek.1 mouse

Organism-specific databases

CTDi8943
MGIiMGI:107734 Ap3d1

Phylogenomic databases

eggNOGiKOG1059 Eukaryota
ENOG410XQFB LUCA
GeneTreeiENSGT00550000075067
HOGENOMiHOG000000981
HOVERGENiHBG050520
InParanoidiO54774
KOiK12396
OMAiMTYDIQG
OrthoDBiEOG091G04IL
PhylomeDBiO54774
TreeFamiTF105666

Miscellaneous databases

ChiTaRSiAp3d1 mouse
PROiPR:O54774
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020198 Expressed in 290 organ(s), highest expression level in vestibular membrane of cochlear duct
ExpressionAtlasiO54774 baseline and differential
GenevisibleiO54774 MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR017105 AP3_complex_dsu
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
PANTHERiPTHR22781 PTHR22781, 1 hit
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAP3D1_MOUSE
AccessioniPrimary (citable) accession number: O54774
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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