UniProtKB - O54751 (CRX_MOUSE)
Protein
Cone-rod homeobox protein
Gene
Crx
Organism
Mus musculus (Mouse)
Status
Functioni
Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 39 – 98 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- chromatin binding Source: MGI
- DNA binding Source: MGI
- DNA-binding transcription activator activity Source: ARUK-UCL
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- leucine zipper domain binding Source: MGI
- nuclear hormone receptor binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- RNA polymerase II transcription factor binding Source: ARUK-UCL
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- nervous system development Source: UniProtKB-KW
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to stimulus Source: UniProtKB-KW
- retina development in camera-type eye Source: MGI
- visual perception Source: UniProtKB-KW
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Differentiation, Neurogenesis, Sensory transduction, Transcription, Transcription regulation, Vision |
Names & Taxonomyi
Protein namesi | Recommended name: Cone-rod homeobox protein |
Gene namesi | Name:Crx |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1194883, Crx |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Nucleus
- nucleus Source: UniProtKB
- RNA polymerase II transcription regulator complex Source: ARUK-UCL
Other locations
- chromatin Source: ARUK-UCL
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048863 | 1 – 299 | Cone-rod homeobox proteinAdd BLAST | 299 |
Proteomic databases
PaxDbi | O54751 |
PRIDEi | O54751 |
ProteomicsDBi | 285336 |
PTM databases
PhosphoSitePlusi | O54751 |
Expressioni
Tissue specificityi
Retina.1 Publication
Developmental stagei
At 17.5 dpc, expressed in a narrow zone in the peripheral outer nuclear layer of the retina. At P12, expressed over the entire photoreceptor layer.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000041578, Expressed in retina and 67 other tissues |
Genevisiblei | O54751, MM |
Interactioni
Subunit structurei
Interacts (via the homeobox) with NRL (via the leucine-zipper domain).
Interacts with PDC, RAX2, RORB and SCA7.
1 PublicationGO - Molecular functioni
- leucine zipper domain binding Source: MGI
- nuclear hormone receptor binding Source: UniProtKB
- RNA polymerase II transcription factor binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 198905, 3 interactors |
STRINGi | 10090.ENSMUSP00000134400 |
Miscellaneous databases
RNActi | O54751, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the paired homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG2251, Eukaryota |
GeneTreei | ENSGT00940000161634 |
HOGENOMi | CLU_064370_0_0_1 |
InParanoidi | O54751 |
OMAi | TWKFAYN |
OrthoDBi | 1481439at2759 |
PhylomeDBi | O54751 |
TreeFami | TF351179 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR013851, Otx_TF_C |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03529, TF_Otx, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
O54751-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMAYMNPGPH YSVNALALSG PNVDLMHQAV PYSSAPRKQR RERTTFTRSQ
60 70 80 90 100
LEELEALFAK TQYPDVYARE EVALKINLPE SRVQVWFKNR RAKCRQQRQQ
110 120 130 140 150
QKQQQQPPGA QTKARPAKRK AGTSPRPSTD VCTDPLGISD SYSPSLPGPS
160 170 180 190 200
GSPTTAVATV SIWSPASEAP LPEAQRAGLV ASGPSLTSAP YAMTYAPASA
210 220 230 240 250
FCSSPSAYAS PSSYFSGLDP YLSPMVPQLG GPALSPLSGP SVGPSLAQSP
260 270 280 290
TSLSGQSYST YSPVDSLEFK DPTGTWKFTY NPMDPLDYKD QSAWKFQIL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MQN6 | A0A0A0MQN6_MOUSE | Cone-rod homeobox protein | Crx | 323 | Annotation score: | ||
G3UXU9 | G3UXU9_MOUSE | Cone-rod homeobox protein | Crx | 208 | Annotation score: | ||
G3UZE2 | G3UZE2_MOUSE | Cone-rod homeobox protein | Crx | 74 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U77615 mRNA Translation: AAB88585.1 BC016502 mRNA Translation: AAH16502.1 |
CCDSi | CCDS20840.1 |
RefSeqi | NP_001106801.1, NM_001113330.1 NP_031796.1, NM_007770.4 |
Genome annotation databases
Ensembli | ENSMUST00000044434; ENSMUSP00000043436; ENSMUSG00000041578 |
GeneIDi | 12951 |
KEGGi | mmu:12951 |
UCSCi | uc009fgm.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U77615 mRNA Translation: AAB88585.1 BC016502 mRNA Translation: AAH16502.1 |
CCDSi | CCDS20840.1 |
RefSeqi | NP_001106801.1, NM_001113330.1 NP_031796.1, NM_007770.4 |
3D structure databases
SMRi | O54751 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198905, 3 interactors |
STRINGi | 10090.ENSMUSP00000134400 |
PTM databases
PhosphoSitePlusi | O54751 |
Proteomic databases
PaxDbi | O54751 |
PRIDEi | O54751 |
ProteomicsDBi | 285336 |
Protocols and materials databases
Antibodypediai | 31635, 259 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000044434; ENSMUSP00000043436; ENSMUSG00000041578 |
GeneIDi | 12951 |
KEGGi | mmu:12951 |
UCSCi | uc009fgm.2, mouse |
Organism-specific databases
CTDi | 1406 |
MGIi | MGI:1194883, Crx |
Phylogenomic databases
eggNOGi | KOG2251, Eukaryota |
GeneTreei | ENSGT00940000161634 |
HOGENOMi | CLU_064370_0_0_1 |
InParanoidi | O54751 |
OMAi | TWKFAYN |
OrthoDBi | 1481439at2759 |
PhylomeDBi | O54751 |
TreeFami | TF351179 |
Miscellaneous databases
BioGRID-ORCSi | 12951, 3 hits in 54 CRISPR screens |
ChiTaRSi | Crx, mouse |
PROi | PR:O54751 |
RNActi | O54751, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000041578, Expressed in retina and 67 other tissues |
Genevisiblei | O54751, MM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR013851, Otx_TF_C |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03529, TF_Otx, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CRX_MOUSE | |
Accessioni | O54751Primary (citable) accession number: O54751 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | June 1, 1998 | |
Last modified: | April 7, 2021 | |
This is version 165 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families