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Protein

Cone-rod homeobox protein

Gene

Crx

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi39 – 98HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Sensory transduction, Transcription, Transcription regulation, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Cone-rod homeobox protein
Gene namesi
Name:Crx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1194883 Crx

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488631 – 299Cone-rod homeobox proteinAdd BLAST299

Proteomic databases

PaxDbiO54751
PRIDEiO54751

PTM databases

PhosphoSitePlusiO54751

Expressioni

Tissue specificityi

Retina.1 Publication

Developmental stagei

At 17.5 dpc, expressed in a narrow zone in the peripheral outer nuclear layer of the retina. At P12, expressed over the entire photoreceptor layer.1 Publication

Gene expression databases

BgeeiENSMUSG00000041578 Expressed in 54 organ(s), highest expression level in retina
CleanExiMM_CRX
ExpressionAtlasiO54751 baseline and differential
GenevisibleiO54751 MM

Interactioni

Subunit structurei

Interacts (via the homeobox) with NRL (via the leucine-zipper domain). Interacts with PDC, RAX2, RORB and SCA7.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198905, 3 interactors
STRINGi10090.ENSMUSP00000126642

Structurei

3D structure databases

ProteinModelPortaliO54751
SMRiO54751
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2251 Eukaryota
ENOG4111XIJ LUCA
GeneTreeiENSGT00920000148948
HOGENOMiHOG000082677
HOVERGENiHBG004028
InParanoidiO54751
KOiK09337
PhylomeDBiO54751
TreeFamiTF351179

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR032966 CRX
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR013851 Otx_TF_C
PANTHERiPTHR24329:SF331 PTHR24329:SF331, 1 hit
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03529 TF_Otx, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O54751-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMAYMNPGPH YSVNALALSG PNVDLMHQAV PYSSAPRKQR RERTTFTRSQ
60 70 80 90 100
LEELEALFAK TQYPDVYARE EVALKINLPE SRVQVWFKNR RAKCRQQRQQ
110 120 130 140 150
QKQQQQPPGA QTKARPAKRK AGTSPRPSTD VCTDPLGISD SYSPSLPGPS
160 170 180 190 200
GSPTTAVATV SIWSPASEAP LPEAQRAGLV ASGPSLTSAP YAMTYAPASA
210 220 230 240 250
FCSSPSAYAS PSSYFSGLDP YLSPMVPQLG GPALSPLSGP SVGPSLAQSP
260 270 280 290
TSLSGQSYST YSPVDSLEFK DPTGTWKFTY NPMDPLDYKD QSAWKFQIL
Length:299
Mass (Da):32,374
Last modified:June 1, 1998 - v1
Checksum:i4FE2C27D8070B524
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQN6A0A0A0MQN6_MOUSE
Cone-rod homeobox protein
Crx
323Annotation score:
G3UXU9G3UXU9_MOUSE
Cone-rod homeobox protein
Crx
208Annotation score:
G3UZE2G3UZE2_MOUSE
Cone-rod homeobox protein
Crx
74Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77615 mRNA Translation: AAB88585.1
BC016502 mRNA Translation: AAH16502.1
CCDSiCCDS20840.1
RefSeqiNP_001106801.1, NM_001113330.1
NP_031796.1, NM_007770.4
UniGeneiMm.441911

Genome annotation databases

EnsembliENSMUST00000044434; ENSMUSP00000043436; ENSMUSG00000041578
GeneIDi12951
KEGGimmu:12951
UCSCiuc009fgm.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77615 mRNA Translation: AAB88585.1
BC016502 mRNA Translation: AAH16502.1
CCDSiCCDS20840.1
RefSeqiNP_001106801.1, NM_001113330.1
NP_031796.1, NM_007770.4
UniGeneiMm.441911

3D structure databases

ProteinModelPortaliO54751
SMRiO54751
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198905, 3 interactors
STRINGi10090.ENSMUSP00000126642

PTM databases

PhosphoSitePlusiO54751

Proteomic databases

PaxDbiO54751
PRIDEiO54751

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044434; ENSMUSP00000043436; ENSMUSG00000041578
GeneIDi12951
KEGGimmu:12951
UCSCiuc009fgm.2 mouse

Organism-specific databases

CTDi1406
MGIiMGI:1194883 Crx

Phylogenomic databases

eggNOGiKOG2251 Eukaryota
ENOG4111XIJ LUCA
GeneTreeiENSGT00920000148948
HOGENOMiHOG000082677
HOVERGENiHBG004028
InParanoidiO54751
KOiK09337
PhylomeDBiO54751
TreeFamiTF351179

Miscellaneous databases

PROiPR:O54751
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041578 Expressed in 54 organ(s), highest expression level in retina
CleanExiMM_CRX
ExpressionAtlasiO54751 baseline and differential
GenevisibleiO54751 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR032966 CRX
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR013851 Otx_TF_C
PANTHERiPTHR24329:SF331 PTHR24329:SF331, 1 hit
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03529 TF_Otx, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCRX_MOUSE
AccessioniPrimary (citable) accession number: O54751
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: September 12, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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