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UniProtKB - O54750 (CP2J6_MOUSE)
Protein
Cytochrome P450 2J6
Gene
Cyp2j6
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
- an organic molecule + O2 + reduced [NADPH—hemoprotein reductase] = an alcohol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]EC:1.14.14.1
Cofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 447 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- arachidonic acid 11,12-epoxygenase activity Source: MGI
- arachidonic acid 14,15-epoxygenase activity Source: MGI
- arachidonic acid epoxygenase activity Source: MGI
- arachidonic acid monooxygenase activity Source: MGI
- aromatase activity Source: UniProtKB-EC
- heme binding Source: GO_Central
- iron ion binding Source: InterPro
- isomerase activity Source: MGI
- linoleic acid epoxygenase activity Source: MGI
- NADPH-hemoprotein reductase activity Source: MGI
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: GO_Central
- steroid hydroxylase activity Source: GO_Central
GO - Biological processi
- arachidonic acid metabolic process Source: MGI
- epoxygenase P450 pathway Source: MGI
- icosanoid metabolic process Source: MGI
- linoleic acid metabolic process Source: MGI
- negative regulation of collagen biosynthetic process Source: MGI
- negative regulation of peroxisome proliferator activated receptor signaling pathway Source: MGI
- organic acid metabolic process Source: GO_Central
- positive regulation of tumor necrosis factor production Source: MGI
- retinoid metabolic process Source: MGI
- xenobiotic metabolic process Source: GO_Central
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
Reactomei | R-MMU-211935, Fatty acids R-MMU-211981, Xenobiotics R-MMU-2142670, Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome P450 2J6 (EC:1.14.14.1)Alternative name(s): Arachidonic acid epoxygenase CYPIIJ6 |
Gene namesi | Name:Cyp2j6 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1270148, Cyp2j6 |
VEuPathDBi | HostDB:ENSMUSG00000052914 |
Subcellular locationi
Endoplasmic reticulum
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
- endoplasmic reticulum membrane Source: MGI
Other locations
- cytoplasm Source: GO_Central
- intracellular membrane-bounded organelle Source: MGI
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051772 | 1 – 501 | Cytochrome P450 2J6Add BLAST | 501 |
Proteomic databases
jPOSTi | O54750 |
MaxQBi | O54750 |
PaxDbi | O54750 |
PeptideAtlasi | O54750 |
PRIDEi | O54750 |
ProteomicsDBi | 283444 |
PTM databases
iPTMneti | O54750 |
PhosphoSitePlusi | O54750 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000052914, Expressed in jejunum and 280 other tissues |
Genevisiblei | O54750, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000030303 |
Miscellaneous databases
RNActi | O54750, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0156, Eukaryota |
GeneTreei | ENSGT00950000182879 |
HOGENOMi | CLU_001570_22_0_1 |
InParanoidi | O54750 |
OMAi | AEPRDFI |
OrthoDBi | 702827at2759 |
PhylomeDBi | O54750 |
TreeFami | TF352043 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR008071, Cyt_P450_E_grp-I_CYP2J-like IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR01688, EP450ICYP2J PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
O54750-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLAATGSLLA TIWAALHPRT LLVAAVTFLL LADYFKNRRP KNYPPGPWGL
60 70 80 90 100
PFVGNIFQLD FGQPHLSIQP LVKKYGNIFS LNLGDITSVV ITGLPLIKEA
110 120 130 140 150
LTQMEQNIMN RPLSVMQERI SNKNGLIFSS GQIWKEQRRF ALMTLRNFGL
160 170 180 190 200
GKKSLEERMQ EEASHLVEAI REEEGKPFNP HFSINNAVSN IICSVTFGER
210 220 230 240 250
FDYHDSRFQE MLRLLDEVMY LETTMISQLY NIFPWIMKYI PGSHQKVFRN
260 270 280 290 300
WEKLKLFVSC MIDDHRKDWN PDEPRDFIDA FLKEMTKYPE KTTSFNEENL
310 320 330 340 350
ICSTLDLFFA GTETTSTTLR WALLYMALYP EVQEKVQAEI DRVIGQKRAA
360 370 380 390 400
RLADRESMPY TNAVIHEVQR MGNIIPLNVP REVAMDTNLN GFHLPKGTMV
410 420 430 440 450
LTNLTALHRD PKEWATPDVF NPEHFLENGQ FKKRESFLPF SMGKRACLGE
460 470 480 490 500
QLARSELFIF FTSLMQKFTF NPPINEKLSP KFRNGLTLSP VSHRICAVPR
Q
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 369 | Q → R in AAB87636 (PubMed:9570962).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U62295 mRNA Translation: AAB87636.1 AK045421 mRNA Translation: BAC32356.1 AK165663 mRNA Translation: BAE38325.1 AL683816 Genomic DNA No translation available. CH466527 Genomic DNA Translation: EDL30913.1 BC050832 mRNA Translation: AAH50832.1 |
CCDSi | CCDS18369.1 |
RefSeqi | NP_034138.3, NM_010008.4 |
Genome annotation databases
Ensembli | ENSMUST00000030303; ENSMUSP00000030303; ENSMUSG00000052914 |
GeneIDi | 13110 |
KEGGi | mmu:13110 |
UCSCi | uc008tti.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U62295 mRNA Translation: AAB87636.1 AK045421 mRNA Translation: BAC32356.1 AK165663 mRNA Translation: BAE38325.1 AL683816 Genomic DNA No translation available. CH466527 Genomic DNA Translation: EDL30913.1 BC050832 mRNA Translation: AAH50832.1 |
CCDSi | CCDS18369.1 |
RefSeqi | NP_034138.3, NM_010008.4 |
3D structure databases
SMRi | O54750 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000030303 |
PTM databases
iPTMneti | O54750 |
PhosphoSitePlusi | O54750 |
Proteomic databases
jPOSTi | O54750 |
MaxQBi | O54750 |
PaxDbi | O54750 |
PeptideAtlasi | O54750 |
PRIDEi | O54750 |
ProteomicsDBi | 283444 |
Protocols and materials databases
DNASUi | 13110 |
Genome annotation databases
Ensembli | ENSMUST00000030303; ENSMUSP00000030303; ENSMUSG00000052914 |
GeneIDi | 13110 |
KEGGi | mmu:13110 |
UCSCi | uc008tti.2, mouse |
Organism-specific databases
CTDi | 13110 |
MGIi | MGI:1270148, Cyp2j6 |
VEuPathDBi | HostDB:ENSMUSG00000052914 |
Phylogenomic databases
eggNOGi | KOG0156, Eukaryota |
GeneTreei | ENSGT00950000182879 |
HOGENOMi | CLU_001570_22_0_1 |
InParanoidi | O54750 |
OMAi | AEPRDFI |
OrthoDBi | 702827at2759 |
PhylomeDBi | O54750 |
TreeFami | TF352043 |
Enzyme and pathway databases
Reactomei | R-MMU-211935, Fatty acids R-MMU-211981, Xenobiotics R-MMU-2142670, Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) |
Miscellaneous databases
BioGRID-ORCSi | 13110, 3 hits in 66 CRISPR screens |
ChiTaRSi | Cyp2j6, mouse |
PROi | PR:O54750 |
RNActi | O54750, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000052914, Expressed in jejunum and 280 other tissues |
Genevisiblei | O54750, MM |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR008071, Cyt_P450_E_grp-I_CYP2J-like IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR01688, EP450ICYP2J PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CP2J6_MOUSE | |
Accessioni | O54750Primary (citable) accession number: O54750 Secondary accession number(s): Q8BR78 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 23, 2022 | |
This is version 163 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families