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Protein

Natural killer cells antigen CD94

Gene

Klrd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
LigandLectin

Enzyme and pathway databases

ReactomeiR-MMU-2172127 DAP12 interactions
R-MMU-2424491 DAP12 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Natural killer cells antigen CD94
Alternative name(s):
Killer cell lectin-like receptor subfamily D member 1
CD_antigen: CD94
Gene namesi
Name:Klrd1
Synonyms:Cd94
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1196275 Klrd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini32 – 179ExtracellularSequence analysisAdd BLAST148

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003784581 – 179Natural killer cells antigen CD94Add BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 70PROSITE-ProRule annotation
Disulfide bondi59Interchain (with C-116 in NGK2A)PROSITE-ProRule annotation
Disulfide bondi61 ↔ 72PROSITE-ProRule annotation
Disulfide bondi89 ↔ 174PROSITE-ProRule annotation
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi152 ↔ 166PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO54707
PaxDbiO54707
PRIDEiO54707

PTM databases

PhosphoSitePlusiO54707

Expressioni

Gene expression databases

BgeeiENSMUSG00000030165 Expressed in 63 organ(s), highest expression level in blood
ExpressionAtlasiO54707 baseline and differential
GenevisibleiO54707 MM

Interactioni

Subunit structurei

Can form disulfide-bonded heterodimer with NKG2 family members.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107694

Structurei

3D structure databases

ProteinModelPortaliO54707
SMRiO54707
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 175C-type lectinPROSITE-ProRule annotationAdd BLAST108

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00730000110282
HOGENOMiHOG000220925
InParanoidiO54707
KOiK06516
OMAiYSEEHHA
PhylomeDBiO54707
TreeFamiTF336674

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O54707-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVSRITRWR LMSVIFGIKC LFLMVTLGVL LINSFTIQNI QSTPSPTTTV
60 70 80 90 100
EFQEVSECCV CLDKWVGHQC NCYFISKEEK SWKRSRDFCA SQNSSLLQPQ
110 120 130 140 150
SRNELSFMNF SQTFFWIGMH YSEKRNAWLW EDGTVPSKDL FPEFSVIRPE
160 170
HCIVYSPSKS VSAESCENKN RYICKKLPI
Length:179
Mass (Da):20,808
Last modified:June 1, 1998 - v1
Checksum:iDD343419E93B3465
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q3T9E9Q3T9_MOUSE
Natural killer cells antigen CD94
Klrd1
155Annotation score:
D3Z626D3Z626_MOUSE
Natural killer cells antigen CD94
Klrd1
198Annotation score:
E0CZ14E0CZ14_MOUSE
Natural killer cells antigen CD94
Klrd1
70Annotation score:
A0A0N4SUJ9A0A0N4SUJ9_MOUSE
Natural killer cells antigen CD94
Klrd1
57Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti83K → E2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030311 mRNA Translation: AAC28243.1
AF030312 mRNA Translation: AAC28244.1
AF057714 mRNA Translation: AAC33713.1
AF039025 mRNA Translation: AAD02116.1
AK136548 mRNA Translation: BAE23039.1
CH466523 Genomic DNA Translation: EDK99936.1
BC117112 mRNA Translation: AAI17113.1
BC120854 mRNA Translation: AAI20855.1
CCDSiCCDS57456.1
RefSeqiNP_034784.1, NM_010654.3
XP_006505718.1, XM_006505655.1
UniGeneiMm.391515

Genome annotation databases

EnsembliENSMUST00000112063; ENSMUSP00000107694; ENSMUSG00000030165
GeneIDi16643
KEGGimmu:16643
UCSCiuc009egd.2 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030311 mRNA Translation: AAC28243.1
AF030312 mRNA Translation: AAC28244.1
AF057714 mRNA Translation: AAC33713.1
AF039025 mRNA Translation: AAD02116.1
AK136548 mRNA Translation: BAE23039.1
CH466523 Genomic DNA Translation: EDK99936.1
BC117112 mRNA Translation: AAI17113.1
BC120854 mRNA Translation: AAI20855.1
CCDSiCCDS57456.1
RefSeqiNP_034784.1, NM_010654.3
XP_006505718.1, XM_006505655.1
UniGeneiMm.391515

3D structure databases

ProteinModelPortaliO54707
SMRiO54707
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107694

PTM databases

PhosphoSitePlusiO54707

Proteomic databases

EPDiO54707
PaxDbiO54707
PRIDEiO54707

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112063; ENSMUSP00000107694; ENSMUSG00000030165
GeneIDi16643
KEGGimmu:16643
UCSCiuc009egd.2 mouse

Organism-specific databases

CTDi3824
MGIiMGI:1196275 Klrd1

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00730000110282
HOGENOMiHOG000220925
InParanoidiO54707
KOiK06516
OMAiYSEEHHA
PhylomeDBiO54707
TreeFamiTF336674

Enzyme and pathway databases

ReactomeiR-MMU-2172127 DAP12 interactions
R-MMU-2424491 DAP12 signaling

Miscellaneous databases

PROiPR:O54707
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030165 Expressed in 63 organ(s), highest expression level in blood
ExpressionAtlasiO54707 baseline and differential
GenevisibleiO54707 MM

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKLRD1_MOUSE
AccessioniPrimary (citable) accession number: O54707
Secondary accession number(s): O54708
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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