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Protein

Equilibrative nucleoside transporter 2

Gene

Slc29a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is insensitive (EI) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. Specific for nucleosides, but may also transport hypoxanthine. May also play a role in the efflux of inosine and hypoxanthine from muscle cells during the net degradation of purine nucleotides that occurs during strenuous exercise and/or in the reuptake of these purines during the recovery process (By similarity).By similarity

Miscellaneous

Resistant to dipyridamole and dilazep inhibition (anticancer chemotherapeutics drugs).

GO - Molecular functioni

  • nucleoside transmembrane transporter activity Source: RGD

GO - Biological processi

  • adenine transport Source: RGD
  • cellular response to insulin stimulus Source: RGD
  • guanine transport Source: RGD
  • hypoxanthine transport Source: RGD
  • lactation Source: RGD
  • nucleoside transport Source: RGD
  • thymine transport Source: RGD
  • uridine transport Source: RGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-RNO-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Protein family/group databases

TCDBi2.A.57.1.4 the equilibrative nucleoside transporter (ent) family

Names & Taxonomyi

Protein namesi
Recommended name:
Equilibrative nucleoside transporter 2
Alternative name(s):
Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter
Short name:
Equilibrative NBMPR-insensitive nucleoside transporter
Nucleoside transporter, ei-type
Solute carrier family 29 member 2
Gene namesi
Name:Slc29a2
Synonyms:Ent2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi69296 Slc29a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 29HelicalSequence analysisAdd BLAST17
Topological domaini30 – 68ExtracellularSequence analysisAdd BLAST39
Transmembranei69 – 93HelicalSequence analysisAdd BLAST25
Topological domaini94 – 97CytoplasmicSequence analysis4
Transmembranei98 – 116HelicalSequence analysisAdd BLAST19
Topological domaini117 – 124ExtracellularSequence analysis8
Transmembranei125 – 143HelicalSequence analysisAdd BLAST19
Topological domaini144 – 160CytoplasmicSequence analysisAdd BLAST17
Transmembranei161 – 185HelicalSequence analysisAdd BLAST25
Topological domaini186 – 192ExtracellularSequence analysis7
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 291CytoplasmicSequence analysisAdd BLAST78
Transmembranei292 – 311HelicalSequence analysisAdd BLAST20
Topological domaini312 – 323ExtracellularSequence analysisAdd BLAST12
Transmembranei324 – 342HelicalSequence analysisAdd BLAST19
Topological domaini343 – 359CytoplasmicSequence analysisAdd BLAST17
Transmembranei360 – 378HelicalSequence analysisAdd BLAST19
Topological domaini379 – 393ExtracellularSequence analysisAdd BLAST15
Transmembranei394 – 413HelicalSequence analysisAdd BLAST20
Topological domaini414 – 431CytoplasmicSequence analysisAdd BLAST18
Transmembranei432 – 452HelicalSequence analysisAdd BLAST21
Topological domaini453 – 456ExtracellularSequence analysis4

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1287614

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002093421 – 456Equilibrative nucleoside transporter 2Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei251PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO54699
PRIDEiO54699

Expressioni

Gene expression databases

BgeeiENSRNOG00000020025 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiO54699 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065813

Chemistry databases

BindingDBiO54699

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1479 Eukaryota
ENOG410Y3MT LUCA
GeneTreeiENSGT00390000002232
HOGENOMiHOG000007684
HOVERGENiHBG074626
InParanoidiO54699
KOiK15014
OMAiVWFINSF
OrthoDBiEOG091G09WB
PhylomeDBiO54699
TreeFamiTF313950

Family and domain databases

InterProiView protein in InterPro
IPR034764 ENT1/ENT2
IPR030197 ENT2
IPR002259 Eqnu_transpt
IPR036259 MFS_trans_sf
PANTHERiPTHR10332 PTHR10332, 1 hit
PTHR10332:SF8 PTHR10332:SF8, 1 hit
PfamiView protein in Pfam
PF01733 Nucleoside_tran, 1 hit
PIRSFiPIRSF016379 ENT, 1 hit
PRINTSiPR01130 DERENTRNSPRT
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00939 2a57, 1 hit

Sequencei

Sequence statusi: Complete.

O54699-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHGNAPRDS YHLVGISFFI LGLGTLLPWN FFITAIPYFQ GRLAGTNSSA
60 70 80 90 100
ETPSTNHTSP TDTFNFNNWV TLLSQLPLLL FTLLNSFLYQ CIPESVRILG
110 120 130 140 150
SLLAILLLFA LTAALVKVDL SPGLFFSITM ASVWFINSFC AVLQGSLFGQ
160 170 180 190 200
LGTMPSTYST LFLSGQGLAG IFAALAMLTS LASGVDPQTS ALGYFITPCV
210 220 230 240 250
GILLSIICYL SLPHLKFARY YLTKKPQAPV QELETKAELL GADEKNGIPV
260 270 280 290 300
SPQQAGPTLD LDPEKELELG LEEPQKPGKP SVFVVFRKIW LTALCLVLVF
310 320 330 340 350
TVTLSVFPAI TAMVTTSSNS PGKWSQFFNP ICCFLLFNVM DWLGRSLTSY
360 370 380 390 400
FLWPDEDSQL LPLLVCLRFL FVPLFMLCHV PQRARLPIIF WQDAYFITFM
410 420 430 440 450
LLFAISNGYF VSLTMCLAPR QVLPHEREVA GALMTFFLAL GLSCGASLSF

LFKALL
Length:456
Mass (Da):50,265
Last modified:June 1, 1998 - v1
Checksum:iDA97C2C578E1EE9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015305 mRNA Translation: AAB88050.1
RefSeqiNP_113926.1, NM_031738.1
XP_017445770.1, XM_017590281.1
XP_017459751.1, XM_017604262.1
UniGeneiRn.37517

Genome annotation databases

EnsembliENSRNOT00000027178; ENSRNOP00000027178; ENSRNOG00000020025
ENSRNOT00000071891; ENSRNOP00000065813; ENSRNOG00000050201
GeneIDi108348052
65194
KEGGirno:108348052
rno:65194
UCSCiRGD:69296 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015305 mRNA Translation: AAB88050.1
RefSeqiNP_113926.1, NM_031738.1
XP_017445770.1, XM_017590281.1
XP_017459751.1, XM_017604262.1
UniGeneiRn.37517

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065813

Chemistry databases

BindingDBiO54699
ChEMBLiCHEMBL1287614

Protein family/group databases

TCDBi2.A.57.1.4 the equilibrative nucleoside transporter (ent) family

Proteomic databases

PaxDbiO54699
PRIDEiO54699

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027178; ENSRNOP00000027178; ENSRNOG00000020025
ENSRNOT00000071891; ENSRNOP00000065813; ENSRNOG00000050201
GeneIDi108348052
65194
KEGGirno:108348052
rno:65194
UCSCiRGD:69296 rat

Organism-specific databases

CTDi3177
RGDi69296 Slc29a2

Phylogenomic databases

eggNOGiKOG1479 Eukaryota
ENOG410Y3MT LUCA
GeneTreeiENSGT00390000002232
HOGENOMiHOG000007684
HOVERGENiHBG074626
InParanoidiO54699
KOiK15014
OMAiVWFINSF
OrthoDBiEOG091G09WB
PhylomeDBiO54699
TreeFamiTF313950

Enzyme and pathway databases

ReactomeiR-RNO-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Miscellaneous databases

PROiPR:O54699

Gene expression databases

BgeeiENSRNOG00000020025 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiO54699 RN

Family and domain databases

InterProiView protein in InterPro
IPR034764 ENT1/ENT2
IPR030197 ENT2
IPR002259 Eqnu_transpt
IPR036259 MFS_trans_sf
PANTHERiPTHR10332 PTHR10332, 1 hit
PTHR10332:SF8 PTHR10332:SF8, 1 hit
PfamiView protein in Pfam
PF01733 Nucleoside_tran, 1 hit
PIRSFiPIRSF016379 ENT, 1 hit
PRINTSiPR01130 DERENTRNSPRT
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00939 2a57, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS29A2_RAT
AccessioniPrimary (citable) accession number: O54699
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: September 12, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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