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Entry version 126 (05 Jun 2019)
Sequence version 1 (01 Jun 1998)
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Protein

Equilibrative nucleoside transporter 2

Gene

Slc29a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is insensitive (EI) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. Specific for nucleosides, but may also transport hypoxanthine. May also play a role in the efflux of inosine and hypoxanthine from muscle cells during the net degradation of purine nucleotides that occurs during strenuous exercise and/or in the reuptake of these purines during the recovery process (By similarity).By similarity

Miscellaneous

Resistant to dipyridamole and dilazep inhibition (anticancer chemotherapeutics drugs).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.57.1.4 the equilibrative nucleoside transporter (ent) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Equilibrative nucleoside transporter 2
Alternative name(s):
Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter
Short name:
Equilibrative NBMPR-insensitive nucleoside transporter
Nucleoside transporter, ei-type
Solute carrier family 29 member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc29a2
Synonyms:Ent2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...
RGDi
69296 Slc29a2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei13 – 29HelicalSequence analysisAdd BLAST17
Topological domaini30 – 68ExtracellularSequence analysisAdd BLAST39
Transmembranei69 – 93HelicalSequence analysisAdd BLAST25
Topological domaini94 – 97CytoplasmicSequence analysis4
Transmembranei98 – 116HelicalSequence analysisAdd BLAST19
Topological domaini117 – 124ExtracellularSequence analysis8
Transmembranei125 – 143HelicalSequence analysisAdd BLAST19
Topological domaini144 – 160CytoplasmicSequence analysisAdd BLAST17
Transmembranei161 – 185HelicalSequence analysisAdd BLAST25
Topological domaini186 – 192ExtracellularSequence analysis7
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 291CytoplasmicSequence analysisAdd BLAST78
Transmembranei292 – 311HelicalSequence analysisAdd BLAST20
Topological domaini312 – 323ExtracellularSequence analysisAdd BLAST12
Transmembranei324 – 342HelicalSequence analysisAdd BLAST19
Topological domaini343 – 359CytoplasmicSequence analysisAdd BLAST17
Transmembranei360 – 378HelicalSequence analysisAdd BLAST19
Topological domaini379 – 393ExtracellularSequence analysisAdd BLAST15
Transmembranei394 – 413HelicalSequence analysisAdd BLAST20
Topological domaini414 – 431CytoplasmicSequence analysisAdd BLAST18
Transmembranei432 – 452HelicalSequence analysisAdd BLAST21
Topological domaini453 – 456ExtracellularSequence analysis4

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1287614

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002093421 – 456Equilibrative nucleoside transporter 2Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei251PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O54699

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O54699

PRoteomics IDEntifications database

More...
PRIDEi
O54699

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000020025 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O54699 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000065813

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O54699

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1479 Eukaryota
ENOG410Y3MT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182898

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007684

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O54699

KEGG Orthology (KO)

More...
KOi
K15014

Identification of Orthologs from Complete Genome Data

More...
OMAi
WFINSFC

Database of Orthologous Groups

More...
OrthoDBi
559763at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O54699

TreeFam database of animal gene trees

More...
TreeFami
TF313950

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034764 ENT1/ENT2
IPR030197 ENT2
IPR002259 Eqnu_transpt
IPR036259 MFS_trans_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10332 PTHR10332, 1 hit
PTHR10332:SF8 PTHR10332:SF8, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01733 Nucleoside_tran, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF016379 ENT, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01130 DERENTRNSPRT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473 SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00939 2a57, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O54699-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHGNAPRDS YHLVGISFFI LGLGTLLPWN FFITAIPYFQ GRLAGTNSSA
60 70 80 90 100
ETPSTNHTSP TDTFNFNNWV TLLSQLPLLL FTLLNSFLYQ CIPESVRILG
110 120 130 140 150
SLLAILLLFA LTAALVKVDL SPGLFFSITM ASVWFINSFC AVLQGSLFGQ
160 170 180 190 200
LGTMPSTYST LFLSGQGLAG IFAALAMLTS LASGVDPQTS ALGYFITPCV
210 220 230 240 250
GILLSIICYL SLPHLKFARY YLTKKPQAPV QELETKAELL GADEKNGIPV
260 270 280 290 300
SPQQAGPTLD LDPEKELELG LEEPQKPGKP SVFVVFRKIW LTALCLVLVF
310 320 330 340 350
TVTLSVFPAI TAMVTTSSNS PGKWSQFFNP ICCFLLFNVM DWLGRSLTSY
360 370 380 390 400
FLWPDEDSQL LPLLVCLRFL FVPLFMLCHV PQRARLPIIF WQDAYFITFM
410 420 430 440 450
LLFAISNGYF VSLTMCLAPR QVLPHEREVA GALMTFFLAL GLSCGASLSF

LFKALL
Length:456
Mass (Da):50,265
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA97C2C578E1EE9D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF015305 mRNA Translation: AAB88050.1

NCBI Reference Sequences

More...
RefSeqi
NP_113926.1, NM_031738.1
XP_017445770.1, XM_017590281.1
XP_017459751.1, XM_017604262.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000027178; ENSRNOP00000027178; ENSRNOG00000020025
ENSRNOT00000071891; ENSRNOP00000065813; ENSRNOG00000050201

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
108348052
65194

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:108348052
rno:65194

UCSC genome browser

More...
UCSCi
RGD:69296 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015305 mRNA Translation: AAB88050.1
RefSeqiNP_113926.1, NM_031738.1
XP_017445770.1, XM_017590281.1
XP_017459751.1, XM_017604262.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065813

Chemistry databases

BindingDBiO54699
ChEMBLiCHEMBL1287614

Protein family/group databases

TCDBi2.A.57.1.4 the equilibrative nucleoside transporter (ent) family

Proteomic databases

jPOSTiO54699
PaxDbiO54699
PRIDEiO54699

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027178; ENSRNOP00000027178; ENSRNOG00000020025
ENSRNOT00000071891; ENSRNOP00000065813; ENSRNOG00000050201
GeneIDi108348052
65194
KEGGirno:108348052
rno:65194
UCSCiRGD:69296 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3177
RGDi69296 Slc29a2

Phylogenomic databases

eggNOGiKOG1479 Eukaryota
ENOG410Y3MT LUCA
GeneTreeiENSGT00950000182898
HOGENOMiHOG000007684
InParanoidiO54699
KOiK15014
OMAiWFINSFC
OrthoDBi559763at2759
PhylomeDBiO54699
TreeFamiTF313950

Enzyme and pathway databases

ReactomeiR-RNO-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O54699

Gene expression databases

BgeeiENSRNOG00000020025 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiO54699 RN

Family and domain databases

InterProiView protein in InterPro
IPR034764 ENT1/ENT2
IPR030197 ENT2
IPR002259 Eqnu_transpt
IPR036259 MFS_trans_sf
PANTHERiPTHR10332 PTHR10332, 1 hit
PTHR10332:SF8 PTHR10332:SF8, 1 hit
PfamiView protein in Pfam
PF01733 Nucleoside_tran, 1 hit
PIRSFiPIRSF016379 ENT, 1 hit
PRINTSiPR01130 DERENTRNSPRT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00939 2a57, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS29A2_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O54699
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: June 5, 2019
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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