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Protein

C-C chemokine receptor type 6

Gene

Ccr6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25122636). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (By similarity). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation (PubMed:19050256). Required for the normal migration of Th17 cells in Peyers patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine (PubMed:19129757). Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors (PubMed:24638065). Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches (PubMed:27174992). Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (PubMed:25505290). Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988).1 PublicationBy similarity8 Publications

GO - Molecular functioni

  • C-C chemokine binding Source: UniProtKB
  • C-C chemokine receptor activity Source: UniProtKB
  • chemokine binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-1461957 Beta defensins
R-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 6
Short name:
C-C CKR-6
Short name:
CC-CKR-6
Short name:
CCR-6
Alternative name(s):
KY411
CD_antigen: CD196
Gene namesi
Name:Ccr6
Synonyms:Cmkbr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1333797 Ccr6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 66Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini67 – 75CytoplasmicSequence analysis9
Transmembranei76 – 96Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini97 – 111ExtracellularSequence analysisAdd BLAST15
Transmembranei112 – 133Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini134 – 151CytoplasmicSequence analysisAdd BLAST18
Transmembranei152 – 172Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini173 – 203ExtracellularSequence analysisAdd BLAST31
Transmembranei204 – 230Helical; Name=5Sequence analysisAdd BLAST27
Topological domaini231 – 246CytoplasmicSequence analysisAdd BLAST16
Transmembranei247 – 271Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini272 – 295ExtracellularSequence analysisAdd BLAST24
Transmembranei296 – 313Helical; Name=7Sequence analysisAdd BLAST18
Topological domaini314 – 367CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692871 – 367C-C chemokine receptor type 6Add BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi35N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi110 ↔ 189PROSITE-ProRule annotationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO54689
PRIDEiO54689

PTM databases

iPTMnetiO54689
PhosphoSitePlusiO54689

Expressioni

Tissue specificityi

Sperm. Mainly localized in the principal piece and neck region of the tail but is also found in the acrosomal region in a small percentage of sperm cells. Expressed in natural regulatory T cells (nTregs) and a subset of early thymocyte progenitor double-negative 1 (DN1) cells. Expressed in memory B cells. Expressed by IL17 producing helper T-cells (Th17), type 1 effector cells (Th1), type 2 effector cells (Th2) and regulatory T-cells (Treg) (at protein level). Expressed by Th17 cells in spleen, Peyers patches, and lamina propria of small and large intestine. Highly expressed in testis, lung, colon, and dendritic cells.5 Publications

Inductioni

Up-regulated on pre-germinal center B-cells in a CD40-dependent manner. Up-regulated and down-regulated in Th17 cells by TGFB1 and IL2 respectively.3 Publications

Gene expression databases

BgeeiENSMUSG00000040899 Expressed in 73 organ(s), highest expression level in subcutaneous adipose tissue
CleanExiMM_CCR6
ExpressionAtlasiO54689 baseline and differential
GenevisibleiO54689 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095029

Structurei

3D structure databases

ProteinModelPortaliO54689
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKPR Eukaryota
ENOG410XSP7 LUCA
GeneTreeiENSGT00930000150843
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiO54689
KOiK04181
OMAiIMKDLWC
OrthoDBiEOG091G08B0
PhylomeDBiO54689
TreeFamiTF330966

Family and domain databases

CDDicd15172 7tmA_CCR6, 1 hit
InterProiView protein in InterPro
IPR004067 Chemokine_CCR6
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR10489:SF611 PTHR10489:SF611, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01529 CHEMOKINER6
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O54689-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSTESYFGT DDYDNTEYYS IPPDHGPCSL EEVRNFTKVF VPIAYSLICV
60 70 80 90 100
FGLLGNIMVV MTFAFYKKAR SMTDVYLLNM AITDILFVLT LPFWAVTHAT
110 120 130 140 150
NTWVFSDALC KLMKGTYAVN FNCGMLLLAC ISMDRYIAIV QATKSFRVRS
160 170 180 190 200
RTLTHSKVIC VAVWFISIII SSPTFIFNKK YELQDRDVCE PRYRSVSEPI
210 220 230 240 250
TWKLLGMGLE LFFGFFTPLL FMVFCYLFII KTLVQAQNSK RHRAIRVVIA
260 270 280 290 300
VVLVFLACQI PHNMVLLVTA VNTGKVGRSC STEKVLAYTR NVAEVLAFLH
310 320 330 340 350
CCLNPVLYAF IGQKFRNYFM KIMKDVWCMR RKNKMPGFLC ARVYSESYIS
360
RQTSETVEND NASSFTM
Length:367
Mass (Da):42,103
Last modified:June 1, 1998 - v1
Checksum:i6A309AF833B1117E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A338P732A0A338P732_MOUSE
C-C chemokine receptor type 6
Ccr6
48Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009369 mRNA Translation: BAA23776.1
AJ222714 Genomic DNA Translation: CAA10956.1
CCDSiCCDS28381.1
RefSeqiNP_001177262.1, NM_001190333.1
NP_001177263.1, NM_001190334.1
NP_001177264.1, NM_001190335.1
NP_001177265.1, NM_001190336.1
NP_001177266.1, NM_001190337.1
NP_033965.1, NM_009835.4
XP_006523349.1, XM_006523286.3
XP_006523351.1, XM_006523288.3
XP_006523353.1, XM_006523290.3
XP_006523354.1, XM_006523291.1
XP_006523355.1, XM_006523292.3
XP_011244488.1, XM_011246186.2
XP_011244490.1, XM_011246188.1
XP_017172707.1, XM_017317218.1
XP_017172708.1, XM_017317219.1
XP_017172709.1, XM_017317220.1
UniGeneiMm.8007

Genome annotation databases

EnsembliENSMUST00000097418; ENSMUSP00000095029; ENSMUSG00000040899
ENSMUST00000164411; ENSMUSP00000131153; ENSMUSG00000040899
ENSMUST00000166348; ENSMUSP00000128559; ENSMUSG00000040899
ENSMUST00000167956; ENSMUSP00000128529; ENSMUSG00000040899
ENSMUST00000177568; ENSMUSP00000137249; ENSMUSG00000040899
ENSMUST00000180103; ENSMUSP00000135945; ENSMUSG00000040899
ENSMUST00000231545; ENSMUSP00000156324; ENSMUSG00000040899
GeneIDi12458
KEGGimmu:12458
UCSCiuc008ajd.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009369 mRNA Translation: BAA23776.1
AJ222714 Genomic DNA Translation: CAA10956.1
CCDSiCCDS28381.1
RefSeqiNP_001177262.1, NM_001190333.1
NP_001177263.1, NM_001190334.1
NP_001177264.1, NM_001190335.1
NP_001177265.1, NM_001190336.1
NP_001177266.1, NM_001190337.1
NP_033965.1, NM_009835.4
XP_006523349.1, XM_006523286.3
XP_006523351.1, XM_006523288.3
XP_006523353.1, XM_006523290.3
XP_006523354.1, XM_006523291.1
XP_006523355.1, XM_006523292.3
XP_011244488.1, XM_011246186.2
XP_011244490.1, XM_011246188.1
XP_017172707.1, XM_017317218.1
XP_017172708.1, XM_017317219.1
XP_017172709.1, XM_017317220.1
UniGeneiMm.8007

3D structure databases

ProteinModelPortaliO54689
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095029

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO54689
PhosphoSitePlusiO54689

Proteomic databases

PaxDbiO54689
PRIDEiO54689

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097418; ENSMUSP00000095029; ENSMUSG00000040899
ENSMUST00000164411; ENSMUSP00000131153; ENSMUSG00000040899
ENSMUST00000166348; ENSMUSP00000128559; ENSMUSG00000040899
ENSMUST00000167956; ENSMUSP00000128529; ENSMUSG00000040899
ENSMUST00000177568; ENSMUSP00000137249; ENSMUSG00000040899
ENSMUST00000180103; ENSMUSP00000135945; ENSMUSG00000040899
ENSMUST00000231545; ENSMUSP00000156324; ENSMUSG00000040899
GeneIDi12458
KEGGimmu:12458
UCSCiuc008ajd.2 mouse

Organism-specific databases

CTDi1235
MGIiMGI:1333797 Ccr6

Phylogenomic databases

eggNOGiENOG410IKPR Eukaryota
ENOG410XSP7 LUCA
GeneTreeiENSGT00930000150843
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiO54689
KOiK04181
OMAiIMKDLWC
OrthoDBiEOG091G08B0
PhylomeDBiO54689
TreeFamiTF330966

Enzyme and pathway databases

ReactomeiR-MMU-1461957 Beta defensins
R-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Miscellaneous databases

PROiPR:O54689
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040899 Expressed in 73 organ(s), highest expression level in subcutaneous adipose tissue
CleanExiMM_CCR6
ExpressionAtlasiO54689 baseline and differential
GenevisibleiO54689 MM

Family and domain databases

CDDicd15172 7tmA_CCR6, 1 hit
InterProiView protein in InterPro
IPR004067 Chemokine_CCR6
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR10489:SF611 PTHR10489:SF611, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01529 CHEMOKINER6
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCR6_MOUSE
AccessioniPrimary (citable) accession number: O54689
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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