UniProtKB - O53871 (Y0859_MYCTU)
Protein
Putative acyltransferase Rv0859
Gene
fadA
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 92 | Acyl-thioester intermediateBy similarity | 1 | |
Active sitei | 359 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Active sitei | 389 | Proton acceptorPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- acetyl-CoA C-acetyltransferase activity Source: GO_Central
- acetyl-CoA C-acyltransferase activity Source: GO_Central
GO - Biological processi
- fatty acid beta-oxidation Source: GO_Central
Keywordsi
Molecular function | Acyltransferase, Transferase |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:fadA Ordered Locus Names:Rv0859 |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv0859 |
Subcellular locationi
GO - Cellular componenti
- cell wall Source: MTBBASE
- plasma membrane Source: MTBBASE
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000395883 | 1 – 403 | Putative acyltransferase Rv0859Add BLAST | 403 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 189 | Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)1 Publication |
Post-translational modificationi
Pupylated at Lys-189 by the prokaryotic ubiquitin-like protein Pup, which probably leads to its degradation by the proteasome.1 Publication
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
PaxDbi | O53871 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O53871 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0183, Bacteria |
InParanoidi | O53871 |
OMAi | TNVCCTT |
PhylomeDBi | O53871 |
Family and domain databases
CDDi | cd00751, thiolase, 1 hit |
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR002155, Thiolase IPR016039, Thiolase-like IPR020615, Thiolase_acyl_enz_int_AS IPR020610, Thiolase_AS IPR020617, Thiolase_C IPR020613, Thiolase_CS IPR020616, Thiolase_N |
Pfami | View protein in Pfam PF02803, Thiolase_C, 1 hit PF00108, Thiolase_N, 1 hit |
PIRSFi | PIRSF000429, Ac-CoA_Ac_transf, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR01930, AcCoA-C-Actrans, 1 hit |
PROSITEi | View protein in PROSITE PS00098, THIOLASE_1, 1 hit PS00737, THIOLASE_2, 1 hit PS00099, THIOLASE_3, 1 hit |
i Sequence
Sequence statusi: Complete.
O53871-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEEAFIYEA IRTPRGKQKN GSLHEVKPLS LVVGLIDELR KRHPDLDENL
60 70 80 90 100
ISDVILGCVS PVGDQGGDIA RAAVLASGMP VTSGGVQLNR FCASGLEAVN
110 120 130 140 150
TAAQKVRSGW DDLVLAGGVE SMSRVPMGSD GGAMGLDPAT NYDVMFVPQS
160 170 180 190 200
IGADLIATIE GFSREDVDAY ALRSQQKAAE AWSGGYFAKS VVPVRDQNGL
210 220 230 240 250
LILDHDEHMR PDTTKEGLAK LKPAFEGLAA LGGFDDVALQ KYHWVEKINH
260 270 280 290 300
VHTGGNSSGI VDGAALVMIG SAAAGKLQGL TPRARIVATA TSGADPVIML
310 320 330 340 350
TGPTPATRKV LDRAGLTVDD IDLFELNEAF ASVVLKFQKD LNIPDEKLNV
360 370 380 390 400
NGGAIAMGHP LGATGAMILG TMVDELERRN ARRALITLCI GGGMGVATII
ERV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP43607.1 |
PIRi | C70815 |
RefSeqi | NP_215374.1, NC_000962.3 WP_009934956.1, NZ_NVQJ01000040.1 |
Genome annotation databases
EnsemblBacteriai | CCP43607; CCP43607; Rv0859 |
GeneIDi | 23493018 885774 |
KEGGi | mtu:Rv0859 mtv:RVBD_0859 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP43607.1 |
PIRi | C70815 |
RefSeqi | NP_215374.1, NC_000962.3 WP_009934956.1, NZ_NVQJ01000040.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4B3H | X-ray | 2.30 | C/D | 1-403 | [»] | |
4B3I | X-ray | 2.63 | C/D | 1-403 | [»] | |
4B3J | X-ray | 2.50 | C/D | 1-403 | [»] | |
SMRi | O53871 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv0859 |
Proteomic databases
PaxDbi | O53871 |
Genome annotation databases
EnsemblBacteriai | CCP43607; CCP43607; Rv0859 |
GeneIDi | 23493018 885774 |
KEGGi | mtu:Rv0859 mtv:RVBD_0859 |
Organism-specific databases
TubercuListi | Rv0859 |
Phylogenomic databases
eggNOGi | COG0183, Bacteria |
InParanoidi | O53871 |
OMAi | TNVCCTT |
PhylomeDBi | O53871 |
Family and domain databases
CDDi | cd00751, thiolase, 1 hit |
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR002155, Thiolase IPR016039, Thiolase-like IPR020615, Thiolase_acyl_enz_int_AS IPR020610, Thiolase_AS IPR020617, Thiolase_C IPR020613, Thiolase_CS IPR020616, Thiolase_N |
Pfami | View protein in Pfam PF02803, Thiolase_C, 1 hit PF00108, Thiolase_N, 1 hit |
PIRSFi | PIRSF000429, Ac-CoA_Ac_transf, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR01930, AcCoA-C-Actrans, 1 hit |
PROSITEi | View protein in PROSITE PS00098, THIOLASE_1, 1 hit PS00737, THIOLASE_2, 1 hit PS00099, THIOLASE_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Y0859_MYCTU | |
Accessioni | O53871Primary (citable) accession number: O53871 Secondary accession number(s): L0T7Y0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 10, 2010 |
Last sequence update: | June 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families