Rv2034

Functionⁱ

Involved in the regulation of lipid metabolism and hypoxic response. Positively regulates transcription of various genes, such as phoP, groEL2 and dosR. Negatively regulates its own transcription. Acts by binding to a specific palindromic sequence motif in promoter regions.2 Publications

Activity regulationⁱ

DNA-binding ability is not susceptible to zinc, nickel, cobalt, cadmium, lead, copper and manganese ions.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	33 – 56	H-T-H motifPROSITE-ProRule annotationAdd BLAST		24

GO - Molecular functionⁱ

DNA binding
Source: MTBBASE
Inferred from direct assayⁱ
- 19228590
DNA-binding transcription factor activity Source: InterPro
transcription regulatory region DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of chaperone-mediated protein complex assembly
Source: MTBBASE
Inferred from direct assayⁱ
- 19228590
regulation of fatty acid metabolic process
Source: MTBBASE
Inferred from direct assayⁱ
- 19228590
regulation of transcription, DNA-templated
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: HTH-type transcriptional regulator Rv2034
Gene namesⁱ	Ordered Locus Names:Rv2034
Organismⁱ	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifierⁱ	83332 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Actinobacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › Mycobacterium tuberculosis
Proteomesⁱ	UP000001584 Componentⁱ: Chromosome

Organism-specific databases

TubercuListⁱ	Rv2034

TubercuListⁱ

Rv2034

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	32	A → G: Does not bind DNA, but retains the capacity to form dimers; when associated with G-35. 1 Publication	1
Mutagenesisⁱ	35	E → G: Does not bind DNA, but retains the capacity to form dimers; when associated with G-32. 1 Publication	1
Mutagenesisⁱ	61	C → A: Does not bind DNA and does not form dimers. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000419177	1 – 107	HTH-type transcriptional regulator Rv2034Add BLAST		107

Proteomic databases

PaxDbⁱ	O53478

PaxDbⁱ

O53478

Expressionⁱ

Inductionⁱ

Negatively autoregulated.1 Publication

Interactionⁱ

Subunit structureⁱ

Homodimer.1 Publication

Protein-protein interaction databases

STRINGⁱ	83332.Rv2034

STRINGⁱ

83332.Rv2034

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O53478
SMRⁱ	O53478
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 93	HTH arsR-typePROSITE-ProRule annotationAdd BLAST		93

Phylogenomic databases

eggNOGⁱ	ENOG4105MHT Bacteria COG0640 LUCA
HOGENOMⁱ	HOG000144508
InParanoidⁱ	O53478
OMAⁱ	WVAMADR
PhylomeDBⁱ	O53478

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00090 HTH_ARSR, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011991 ArsR-like_HTH IPR001845 HTH_ArsR_DNA-bd_dom IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01022 HTH_5, 1 hit
PRINTSⁱ	PR00778 HTHARSR
SMARTⁱ	View protein in SMART SM00418 HTH_ARSR, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS50987 HTH_ARSR_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O53478-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSTYRSPDRA WQALADGTRR AIVERLAHGP LAVGELARDL PVSRPAVSQH 
        60         70         80         90        100
LKVLKTARLV CDRPAGTRRV YQLDPTGLAA LRTDLDRFWT RALTGYAQLI 

DSEGDDT

Length:107

Mass (Da):11,856

Last modified:July 5, 2004 - v3

Checksum:ⁱ975FB95505F826E2

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL123456 Genomic DNA Translation: CCP44807.1
PIRⁱ	A70943
NCBI Reference Sequences More...RefSeqⁱ	NP_216550.1, NC_000962.3 WP_003410200.1, NZ_NVQJ01000046.1

Genome annotation databases

EnsemblBacteriaⁱ	CCP44807; CCP44807; Rv2034
GeneIDⁱ	887859
KEGGⁱ	mtu:Rv2034

Protein	Similar proteins		Species	Score	Length	Source
O53478	ArsR family transcriptional regulator		MYCTX		107	UniRef100_O53478
ArsR family HTH-type transcriptional repressor		Mycobacterium tuberculosis variant microti		107
Putative ArsR-type repressor protein		MYCCP		107
Transcriptional regulator		Mycobacterium tuberculosis variant pinnipedii		107
ArsR family transcriptional regulator		MYCBI		107
+8

Protein	Similar proteins		Species	Score	Length	Source
O53478	ArsR family transcriptional regulator		MYCTX		107	UniRef90_O53478
ArsR family HTH-type transcriptional repressor		Mycobacterium tuberculosis variant microti		107
Putative ArsR-type repressor protein		MYCCP		107
Transcriptional regulator		Mycobacterium tuberculosis variant pinnipedii		107
ArsR family transcriptional regulator		MYCBI		107
+21

Protein	Similar proteins		Species	Score	Length	Source
O53478	ArsR family transcriptional regulator		MYCTX		107	UniRef50_O53478
ArsR family HTH-type transcriptional repressor		Mycobacterium tuberculosis variant microti		107
Putative ArsR-type repressor protein		MYCCP		107
Transcriptional regulator		Mycobacterium tuberculosis variant pinnipedii		107
ArsR family transcriptional regulator		MYCBI		107
+93

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL123456 Genomic DNA Translation: CCP44807.1
PIRⁱ	A70943
RefSeqⁱ	NP_216550.1, NC_000962.3 WP_003410200.1, NZ_NVQJ01000046.1

3D structure databases

ProteinModelPortalⁱ	O53478
SMRⁱ	O53478
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	83332.Rv2034

STRINGⁱ

83332.Rv2034

Proteomic databases

PaxDbⁱ	O53478

PaxDbⁱ

O53478

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	CCP44807; CCP44807; Rv2034
GeneIDⁱ	887859
KEGGⁱ	mtu:Rv2034

Organism-specific databases

TubercuListⁱ	Rv2034

TubercuListⁱ

Rv2034

Phylogenomic databases

eggNOGⁱ	ENOG4105MHT Bacteria COG0640 LUCA
HOGENOMⁱ	HOG000144508
InParanoidⁱ	O53478
OMAⁱ	WVAMADR
PhylomeDBⁱ	O53478

Family and domain databases

CDDⁱ	cd00090 HTH_ARSR, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011991 ArsR-like_HTH IPR001845 HTH_ArsR_DNA-bd_dom IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF01022 HTH_5, 1 hit
PRINTSⁱ	PR00778 HTHARSR
SMARTⁱ	View protein in SMART SM00418 HTH_ARSR, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS50987 HTH_ARSR_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HTHAR_MYCTU
Accessionⁱ	O53478Primary (citable) accession number: O53478 Secondary accession number(s): L0T8F6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 3, 2012
	Last sequence update:	July 5, 2004
	Last modified:	November 7, 2018
	This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O53478 (HTHAR_MYCTU)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

HTH-type transcriptional regulator Rv2034

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ