UniProtKB - O53478 (HTHAR_MYCTU)
Protein
HTH-type transcriptional regulator Rv2034
Gene
Rv2034
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Involved in the regulation of lipid metabolism and hypoxic response. Positively regulates transcription of various genes, such as phoP, groEL2 and dosR. Negatively regulates its own transcription. Acts by binding to a specific palindromic sequence motif in promoter regions.2 Publications
Activity regulationi
DNA-binding ability is not susceptible to zinc, nickel, cobalt, cadmium, lead, copper and manganese ions.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 33 – 56 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA binding Source: MTBBASE
- DNA-binding transcription factor activity Source: InterPro
- transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: HTH-type transcriptional regulator Rv2034 |
Gene namesi | Ordered Locus Names:Rv2034 |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv2034 |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 32 | A → G: Does not bind DNA, but retains the capacity to form dimers; when associated with G-35. 1 Publication | 1 | |
Mutagenesisi | 35 | E → G: Does not bind DNA, but retains the capacity to form dimers; when associated with G-32. 1 Publication | 1 | |
Mutagenesisi | 61 | C → A: Does not bind DNA and does not form dimers. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000419177 | 1 – 107 | HTH-type transcriptional regulator Rv2034Add BLAST | 107 |
Proteomic databases
PaxDbi | O53478 |
Expressioni
Inductioni
Negatively autoregulated.1 Publication
Interactioni
Subunit structurei
Homodimer.
1 PublicationProtein-protein interaction databases
STRINGi | 83332.Rv2034 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 93 | HTH arsR-typePROSITE-ProRule annotationAdd BLAST | 93 |
Phylogenomic databases
eggNOGi | COG0640, Bacteria |
InParanoidi | O53478 |
OMAi | WVAMADR |
PhylomeDBi | O53478 |
Family and domain databases
CDDi | cd00090, HTH_ARSR, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR011991, ArsR-like_HTH IPR001845, HTH_ArsR_DNA-bd_dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF01022, HTH_5, 1 hit |
PRINTSi | PR00778, HTHARSR |
SMARTi | View protein in SMART SM00418, HTH_ARSR, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50987, HTH_ARSR_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O53478-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTYRSPDRA WQALADGTRR AIVERLAHGP LAVGELARDL PVSRPAVSQH
60 70 80 90 100
LKVLKTARLV CDRPAGTRRV YQLDPTGLAA LRTDLDRFWT RALTGYAQLI
DSEGDDT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44807.1 |
PIRi | A70943 |
RefSeqi | NP_216550.1, NC_000962.3 WP_003410200.1, NZ_NVQJ01000046.1 |
Genome annotation databases
EnsemblBacteriai | CCP44807; CCP44807; Rv2034 |
GeneIDi | 23491785 887859 |
KEGGi | mtu:Rv2034 mtv:RVBD_2034 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44807.1 |
PIRi | A70943 |
RefSeqi | NP_216550.1, NC_000962.3 WP_003410200.1, NZ_NVQJ01000046.1 |
3D structure databases
SMRi | O53478 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv2034 |
Proteomic databases
PaxDbi | O53478 |
Genome annotation databases
EnsemblBacteriai | CCP44807; CCP44807; Rv2034 |
GeneIDi | 23491785 887859 |
KEGGi | mtu:Rv2034 mtv:RVBD_2034 |
Organism-specific databases
TubercuListi | Rv2034 |
Phylogenomic databases
eggNOGi | COG0640, Bacteria |
InParanoidi | O53478 |
OMAi | WVAMADR |
PhylomeDBi | O53478 |
Family and domain databases
CDDi | cd00090, HTH_ARSR, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR011991, ArsR-like_HTH IPR001845, HTH_ArsR_DNA-bd_dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF01022, HTH_5, 1 hit |
PRINTSi | PR00778, HTHARSR |
SMARTi | View protein in SMART SM00418, HTH_ARSR, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50987, HTH_ARSR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HTHAR_MYCTU | |
Accessioni | O53478Primary (citable) accession number: O53478 Secondary accession number(s): L0T8F6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2012 |
Last sequence update: | July 5, 2004 | |
Last modified: | October 7, 2020 | |
This is version 124 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |