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Protein

HTH-type transcriptional regulator Rv2034

Gene

Rv2034

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the regulation of lipid metabolism and hypoxic response. Positively regulates transcription of various genes, such as phoP, groEL2 and dosR. Negatively regulates its own transcription. Acts by binding to a specific palindromic sequence motif in promoter regions.2 Publications

Activity regulationi

DNA-binding ability is not susceptible to zinc, nickel, cobalt, cadmium, lead, copper and manganese ions.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi33 – 56H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • DNA binding Source: MTBBASE
  • DNA-binding transcription factor activity Source: InterPro
  • transcription regulatory region DNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator Rv2034
Gene namesi
Ordered Locus Names:Rv2034
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv2034

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi32A → G: Does not bind DNA, but retains the capacity to form dimers; when associated with G-35. 1 Publication1
Mutagenesisi35E → G: Does not bind DNA, but retains the capacity to form dimers; when associated with G-32. 1 Publication1
Mutagenesisi61C → A: Does not bind DNA and does not form dimers. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004191771 – 107HTH-type transcriptional regulator Rv2034Add BLAST107

Proteomic databases

PaxDbiO53478

Expressioni

Inductioni

Negatively autoregulated.1 Publication

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi83332.Rv2034

Structurei

3D structure databases

ProteinModelPortaliO53478
SMRiO53478
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 93HTH arsR-typePROSITE-ProRule annotationAdd BLAST93

Phylogenomic databases

eggNOGiENOG4105MHT Bacteria
COG0640 LUCA
HOGENOMiHOG000144508
InParanoidiO53478
OMAiWVAMADR
PhylomeDBiO53478

Family and domain databases

CDDicd00090 HTH_ARSR, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011991 ArsR-like_HTH
IPR001845 HTH_ArsR_DNA-bd_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01022 HTH_5, 1 hit
PRINTSiPR00778 HTHARSR
SMARTiView protein in SMART
SM00418 HTH_ARSR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50987 HTH_ARSR_2, 1 hit

Sequencei

Sequence statusi: Complete.

O53478-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTYRSPDRA WQALADGTRR AIVERLAHGP LAVGELARDL PVSRPAVSQH
60 70 80 90 100
LKVLKTARLV CDRPAGTRRV YQLDPTGLAA LRTDLDRFWT RALTGYAQLI

DSEGDDT
Length:107
Mass (Da):11,856
Last modified:July 5, 2004 - v3
Checksum:i975FB95505F826E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44807.1
PIRiA70943
RefSeqiNP_216550.1, NC_000962.3
WP_003410200.1, NZ_NVQJ01000046.1

Genome annotation databases

EnsemblBacteriaiCCP44807; CCP44807; Rv2034
GeneIDi887859
KEGGimtu:Rv2034

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44807.1
PIRiA70943
RefSeqiNP_216550.1, NC_000962.3
WP_003410200.1, NZ_NVQJ01000046.1

3D structure databases

ProteinModelPortaliO53478
SMRiO53478
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv2034

Proteomic databases

PaxDbiO53478

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCP44807; CCP44807; Rv2034
GeneIDi887859
KEGGimtu:Rv2034

Organism-specific databases

TubercuListiRv2034

Phylogenomic databases

eggNOGiENOG4105MHT Bacteria
COG0640 LUCA
HOGENOMiHOG000144508
InParanoidiO53478
OMAiWVAMADR
PhylomeDBiO53478

Family and domain databases

CDDicd00090 HTH_ARSR, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011991 ArsR-like_HTH
IPR001845 HTH_ArsR_DNA-bd_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01022 HTH_5, 1 hit
PRINTSiPR00778 HTHARSR
SMARTiView protein in SMART
SM00418 HTH_ARSR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50987 HTH_ARSR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHTHAR_MYCTU
AccessioniPrimary (citable) accession number: O53478
Secondary accession number(s): L0T8F6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
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