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Protein

Succinate dehydrogenase flavoprotein subunit

Gene

sdhA

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (bacterial route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase flavoprotein subunit (LH57_18135), Succinate dehydrogenase flavoprotein subunit (sdhA)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (bacterial route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

BioCyciMetaCyc:G185E-7593-MONOMER
UniPathwayiUPA00223; UER01005

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase flavoprotein subunitUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
Name:sdhAImported
Ordered Locus Names:Rv3318Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Organism-specific databases

TubercuListiRv3318

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MTBBASE
  • plasma membrane Source: MTBBASE

Keywords - Cellular componenti

MembraneUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiO53370

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv3318

Structurei

3D structure databases

ProteinModelPortaliO53370
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 401FAD_binding_2InterPro annotationAdd BLAST394
Domaini456 – 590Succ_DH_flav_CInterPro annotationAdd BLAST135

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C00 Bacteria
COG1053 LUCA
HOGENOMiHOG000160475
KOiK00239
OMAiGDSPWEH
PhylomeDBiO53370

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

O53370-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MICQHRYDVV IVGAGGAGMR AAVEAGPRVR TAVLTKLYPT RSHTGAAQGG
60 70 80 90 100
MCAALANVED DNWEWHTFDT VKGGDYLADQ DAVEIMCKEA IDAVLDLEKM
110 120 130 140 150
GMPFNRTPEG RIDQRRFGGH TRDHGKAPVR RACYAADRTG HMILQTLYQN
160 170 180 190 200
CVKHDVEFFN EFYALDLALT QTPSGPVATG VIAYELATGD IHVFHAKAVV
210 220 230 240 250
IATGGSGRMY KTTSNAHTLT GDGIGIVFRK GLPLEDMEFH QFHPTGLAGL
260 270 280 290 300
GILISEAVRG EGGRLLNGEG ERFMERYAPT IVDLAPRDIV ARSMVLEVLE
310 320 330 340 350
GRGAGPLKDY VYIDVRHLGE EVLEAKLPDI TEFARTYLGV DPVTELVPVY
360 370 380 390 400
PTCHYLMGGI PTTVTGQVLR DNTSVVPGLY AAGECACVSV HGANRLGTNS
410 420 430 440 450
LLDINVFGRR AGIAAASYAQ GHDFVDMPPN PEAMVVGWVS DILSEHGNER
460 470 480 490 500
VADIRGALQQ SMDNNAAVFR TEETLKQALT DIHALKERYS RITVHDKGKR
510 520 530 540 550
FNTDLLEAIE LGFLLELAEV TVVGALNRKE SRGGHAREDY PNRDDVNYMR
560 570 580 590
HTMAYKEIGA DKEGPELRSD VRLDFKPVVQ TRYEPKERKY
Length:590
Mass (Da):64,826
Last modified:June 1, 1998 - v1
Checksum:i63AB833980D73AC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP46138.1
RefSeqiNP_217835.1, NC_000962.3
WP_003417273.1, NZ_KK339370.1

Genome annotation databases

EnsemblBacteriaiCCP46138; CCP46138; Rv3318
GeneIDi887639
KEGGimtu:Rv3318
mtv:RVBD_3318
PATRICifig|83332.111.peg.3703

Similar proteinsi

Entry informationi

Entry nameiO53370_MYCTU
AccessioniPrimary (citable) accession number: O53370
Secondary accession number(s): F2GE62, I6X6Z4, Q7D5Q2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: July 18, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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