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Entry version 88 (05 Jun 2019)
Sequence version 1 (01 Jun 1998)
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Protein

Beta-xylanase

Gene

xynC

Organism
Caldicellulosiruptor sp. Rt69B.1
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.UniRule annotation EC:3.2.1.8

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei585NucleophilePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidaseUniRule annotationImported, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradation, Xylan degradationImported

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM22 Carbohydrate-Binding Module Family 22
CBM3 Carbohydrate-Binding Module Family 3
CBM6 Carbohydrate-Binding Module Family 6
GH10 Glycoside Hydrolase Family 10
GH43 Glycoside Hydrolase Family 43

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-xylanaseUniRule annotation (EC:3.2.1.8UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:xynCImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaldicellulosiruptor sp. Rt69B.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri70295 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500415912232 – 1779Beta-xylanaseSequence analysisAdd BLAST1748

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini343 – 671GH10InterPro annotationAdd BLAST329
Domaini726 – 876CBM3InterPro annotationAdd BLAST151
Domaini877 – 1027CBM3InterPro annotationAdd BLAST151
Domaini1110 – 1263CBM3InterPro annotationAdd BLAST154
Domaini1651 – 1778CBM6InterPro annotationAdd BLAST128

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni685 – 717DisorderedSequence analysisAdd BLAST33
Regioni1026 – 1114DisorderedSequence analysisAdd BLAST89
Regioni1262 – 1318DisorderedSequence analysisAdd BLAST57

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi685 – 708Pro-richSequence analysisAdd BLAST24
Compositional biasi1039 – 1101Pro-richSequence analysisAdd BLAST63
Compositional biasi1265 – 1279PolarSequence analysisAdd BLAST15
Compositional biasi1280 – 1318Pro-richSequence analysisAdd BLAST39

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 10 (cellulase F) family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.115.10.20, 1 hit
2.60.120.260, 3 hits
2.60.40.710, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008965 CBM2/CBM3_carb-bd_dom_sf
IPR001956 CBM3
IPR036966 CBM3_sf
IPR006584 Cellulose-bd_IV
IPR003305 CenC_carb-bd
IPR005084 CMB_fam6
IPR008979 Galactose-bd-like_sf
IPR001000 GH10
IPR031158 GH10_AS
IPR006710 Glyco_hydro_43
IPR023296 Glyco_hydro_beta-prop_sf
IPR017853 Glycoside_hydrolase_SF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00942 CBM_3, 3 hits
PF02018 CBM_4_9, 2 hits
PF03422 CBM_6, 1 hit
PF00331 Glyco_hydro_10, 1 hit
PF04616 Glyco_hydro_43, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00134 GLHYDRLASE10

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00606 CBD_IV, 1 hit
SM01067 CBM_3, 3 hits
SM00633 Glyco_10, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49384 SSF49384, 3 hits
SSF49785 SSF49785, 3 hits
SSF51445 SSF51445, 1 hit
SSF75005 SSF75005, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51172 CBM3, 3 hits
PS51175 CBM6, 1 hit
PS00591 GH10_1, 1 hit
PS51760 GH10_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O52374-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKRVISILS LLFFLINTLV GTLIFHQEAK AAAYTVDFEG TDTLSFFAYG
60 70 80 90 100
KSNIAVDMGN AYNGKSSIRV SNRSSIWDGV AVDVKNIMNN GTTWVVSAYV
110 120 130 140 150
KHSYQKPVAF GISAVYDDGS GVKSTLIGEV VAIPNYWKKI VGKWTPNISN
160 170 180 190 200
VRNLLIVVHT IVESGVDYNV DYIQIMDDNS YLSNAVTFSS GFESGTTEGW
210 220 230 240 250
QARGSGVTVK PDSVVAYNGK YSLYVSGRTS NWHGAQIPVD TILEQGKVYK
260 270 280 290 300
ISVWVYQNSG STQKMSLTMQ RRFATDPSTS YENLIYNRDV PSNTWVEPSG
310 320 330 340 350
SYSIPAGVTV SELLLYVEAQ NANLAFWVDD LKIYDLSKLA EPEWEIPSLI
360 370 380 390 400
EKYKDYFKVG VALSYKSIAS DTEKKMVLKH FNSITAGNEM KPSELLISEN
410 420 430 440 450
NYNFSKADEF VNFATSNNIA IRGHTLVWHE QTPDWFFKDA NGNTLSKDAL
460 470 480 490 500
LSRLKQYIYT VVGRYKGKVY AWDVVNEAID ESQGNGFRRS NWYNICGPEY
510 520 530 540 550
IEKAFIWAHE ADPDAKLFYN DYNTENSQKR QFIYNMIKSL KEKGVPIHGI
560 570 580 590 600
GLQCHINLDW PSISEIENTI KLFSSIPGLE IHITELDMSF YQWGSSTSYS
610 620 630 640 650
TPPRDLLIKQ AMRYKELFDL FKKYNVITNV TFWGLKDDYS WLSQNFGKSD
660 670 680 690 700
YPLLFDGNYK SKYAFWSLIE PTVVPVNSTL PAPPAIQVPT PTSTPTPTPT
710 720 730 740 750
PTVSATPTPA PTASPAGGSY WTPSESYGAL KVWYANGNMS STTNVLNPKI
760 770 780 790 800
KIENVGTTAV DLSRVKVRYW YTIDGEAAQS VSVASSINPA YIDVRVVKLG
810 820 830 840 850
ANAGGADYYV EVGFKSGAGV LAAGQSTKEI RLSIQKSSGS YNQSNDYSVR
860 870 880 890 900
SANSYIENEK VTGYIDDVLV WGREPGRNAQ IKVWYANGNL SSPTNVLNPK
910 920 930 940 950
IKIENVGTTA VDLSRVKVRY WYTIDGEATQ SVSVASSINP AYIDVRVVKL
960 970 980 990 1000
GANAGGADYY VEVGFKSGAG VLAAGQSTKE IRLSIQKSSG SYNQSNDYSV
1010 1020 1030 1040 1050
RSANSYIENE KVTGYIDDVL VWGKEPSRGT KPAGEVTPAP TPTSTPTPTP
1060 1070 1080 1090 1100
TTTPAPTSAP TPSPTVTATP TPTPTPTATP TPTPTTTPTP TPTPTVTVTP
1110 1120 1130 1140 1150
TPTPTGTPGT GSGLKVLYKN NETSASTGSI RPWFKIVNGG SSSVDLSRVK
1160 1170 1180 1190 1200
IRYWYTVDGD KPQSAVCDWA QIGASNVTFN FVKLTSGVSG ADYYLEVGFS
1210 1220 1230 1240 1250
SGAGQLQPGK DTGDIQVRFN KNDWSNYNQA DDWSWMQSMT NYGENAKVTL
1260 1270 1280 1290 1300
YVDGVLVWGQ EPGGATPAPT STATPTPTPT ATVTPTPTAT PTPTPTPTAT
1310 1320 1330 1340 1350
TTPIPTPTTP PTKPVGKIPP NNNPLISHKF GADPAVLVYG GRVYMYLTND
1360 1370 1380 1390 1400
ILEYDENGNV KDNSYSKINK ITVISSDDLV NWTDHGEIEV AGPNGVAKWA
1410 1420 1430 1440 1450
NFSWAPAVAY KKINGKDRFF LYFGNSGGGI GVITADSPTG PWSDPLGRPL
1460 1470 1480 1490 1500
ITWSTPGVQG VVWLFDPAVL VDDDGKAYIY FGGGVPQGQD AMPNTARVLQ
1510 1520 1530 1540 1550
PGDDMISVVG SAATIPAPYM FEDSGINKIG NTYYYSYCTN FAQRPQGSPP
1560 1570 1580 1590 1600
AGAIAYMTGK SPVGPWEYRG VILRNPGNFF GVGGNNHHQL FEFNGKWYIA
1610 1620 1630 1640 1650
YHAQTLAKDL GVAKGYRSPH INQVQIENGV IKEVTADYKG VAQVKNFDPY
1660 1670 1680 1690 1700
RMVEAETFAW CAGISTKKAN ASNNMCLTGI DSGDWIALSR VDFGNAGPQK
1710 1720 1730 1740 1750
FEAQVSNING KGYIELRIDS VDGRTIAVAE VLPQSGSSSQ WVKVEANVEN
1760 1770
VTGVHDLYLV FRGEKKSNLF DMDCWRFVR
Length:1,779
Mass (Da):194,305
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE5269B6806B5CED
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AH005808 Genomic DNA Translation: AAB95326.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T31085

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AH005808 Genomic DNA Translation: AAB95326.1
PIRiT31085

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

CAZyiCBM22 Carbohydrate-Binding Module Family 22
CBM3 Carbohydrate-Binding Module Family 3
CBM6 Carbohydrate-Binding Module Family 6
GH10 Glycoside Hydrolase Family 10
GH43 Glycoside Hydrolase Family 43

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.115.10.20, 1 hit
2.60.120.260, 3 hits
2.60.40.710, 3 hits
InterProiView protein in InterPro
IPR008965 CBM2/CBM3_carb-bd_dom_sf
IPR001956 CBM3
IPR036966 CBM3_sf
IPR006584 Cellulose-bd_IV
IPR003305 CenC_carb-bd
IPR005084 CMB_fam6
IPR008979 Galactose-bd-like_sf
IPR001000 GH10
IPR031158 GH10_AS
IPR006710 Glyco_hydro_43
IPR023296 Glyco_hydro_beta-prop_sf
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00942 CBM_3, 3 hits
PF02018 CBM_4_9, 2 hits
PF03422 CBM_6, 1 hit
PF00331 Glyco_hydro_10, 1 hit
PF04616 Glyco_hydro_43, 1 hit
PRINTSiPR00134 GLHYDRLASE10
SMARTiView protein in SMART
SM00606 CBD_IV, 1 hit
SM01067 CBM_3, 3 hits
SM00633 Glyco_10, 1 hit
SUPFAMiSSF49384 SSF49384, 3 hits
SSF49785 SSF49785, 3 hits
SSF51445 SSF51445, 1 hit
SSF75005 SSF75005, 1 hit
PROSITEiView protein in PROSITE
PS51172 CBM3, 3 hits
PS51175 CBM6, 1 hit
PS00591 GH10_1, 1 hit
PS51760 GH10_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO52374_9FIRM
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O52374
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 1998
Last sequence update: June 1, 1998
Last modified: June 5, 2019
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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