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UniProtKB - O52027 (ARSA_HALSA)
Protein
Putative arsenical pump-driving ATPase
Gene
arsA
Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Functioni
Anion-transporting ATPase. Catalyzes the extrusion of arsenite (By similarity).
Involved in resistance to arsenite and antimonite but not to arsenate.
By similarity1 PublicationCatalytic activityi
- EC:7.3.2.7
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 26 – 33 | ATPSequence analysis | 8 | |
Nucleotide bindingi | 350 – 357 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATPase-coupled arsenite transmembrane transporter activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: InterPro
Keywordsi
Molecular function | Translocase |
Biological process | Arsenical resistance |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Putative arsenical pump-driving ATPase (EC:7.3.2.7)Alternative name(s): Arsenical resistance ATPase Arsenite-translocating ATPase Arsenite-transporting ATPase |
Gene namesi | Name:arsA Synonyms:arsA2 Ordered Locus Names:VNG_5180G |
Encoded oni | Plasmid pNRC100 |
Organismi | Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) |
Taxonomic identifieri | 64091 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Stenosarchaea group › Halobacteria › Halobacteriales › Halobacteriaceae › Halobacterium › |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
Deletion of the arsADRC operon results in increased sensitivity to arsenite and antimonite but not arsenate.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000152259 | 1 – 644 | Putative arsenical pump-driving ATPaseAdd BLAST | 644 |
Expressioni
Inductioni
By arsenite and antimonite.1 Publication
Family & Domainsi
Sequence similaritiesi
Belongs to the arsA ATPase family.Curated
Phylogenomic databases
HOGENOMi | CLU_021619_0_0_2 |
InParanoidi | O52027 |
OMAi | YRQHVLE |
OrthoDBi | 84406at2157 |
PhylomeDBi | O52027 |
Family and domain databases
Gene3Di | 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR025723, Anion-transp_ATPase-like_dom IPR027541, Ars_ATPase IPR016300, ATPase_ArsA/GET3 IPR027417, P-loop_NTPase |
PANTHERi | PTHR10803, PTHR10803, 3 hits |
Pfami | View protein in Pfam PF02374, ArsA_ATPase, 3 hits |
PIRSFi | PIRSF001327, Arsenical_pump-driving_ATPase, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
TIGRFAMsi | TIGR00345, GET3_arsA_TRC40, 2 hits |
i Sequence
Sequence statusi: Complete.
O52027-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTATQTPAKE VVEPNSEDTE FVFFSGKGGV GKSTVSCATA TWLADNDYDT
60 70 80 90 100
LLVTTDPAPN LSDIFNQDIG HEVTAIDDVP NLSAIEIDPD VAAEEYRQET
110 120 130 140 150
IEPMRALLGD EEIQTVEEQL NSPCVEEIAA FDNFVDFMDS PEYDVVVFDT
160 170 180 190 200
APTGHTIRLM ELPSDWNAEL EKGGSTCIGP AASMDDKKAD YERAIDTLSD
210 220 230 240 250
ESRTSFAFVG KPESSSIDEI ERSASDLAEL GISSQLLVVN GYLPESVCED
260 270 280 290 300
PFFEGKRADE QAVIDRVEST FDQQALATYP LQPGEIAGLE LLSDVGGVLY
310 320 330 340 350
DGEEATVDVD AATRRATNED TVDFDTFTDA DAVAEELVPV EETRYLFFTG
360 370 380 390 400
KGGVGKSTIA STTAVSLAEA GYETLVVTTD PAAHLADIFE QPVGHEPTSV
410 420 430 440 450
GQANLDAARI DQERALEEYR TQVLDHVREM YDEKDDTQID VEAAVANVEE
460 470 480 490 500
ELESPCAEEM AALEKFVSYF EEDGYDIVVF DTAPTGHTLR LLELPSDWKG
510 520 530 540 550
FMDLGSLTKG AAPANGGKYD EVIETMQDPS RSSFAFVMYP EFTPMMEAYR
560 570 580 590 600
AAMDLQDQVG IETSVVVANY LLPEDYGDNA FFENRRAQQA EYLEEISERF
610 620 630 640
DVPMMLAPLR QEEPVGLDDL REFGADVTGL DGVGEDDREE VTVS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF016485 Genomic DNA Translation: AAC82907.1 |
PIRi | T08340 |
RefSeqi | WP_010890458.1, NZ_BK010830.1 |
Genome annotation databases
EnsemblBacteriai | AAC82907; AAC82907; AAC82907 |
GeneIDi | 5954920 62888362 |
KEGGi | hal:arsA |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF016485 Genomic DNA Translation: AAC82907.1 |
PIRi | T08340 |
RefSeqi | WP_010890458.1, NZ_BK010830.1 |
3D structure databases
SMRi | O52027 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | AAC82907; AAC82907; AAC82907 |
GeneIDi | 5954920 62888362 |
KEGGi | hal:arsA |
Phylogenomic databases
HOGENOMi | CLU_021619_0_0_2 |
InParanoidi | O52027 |
OMAi | YRQHVLE |
OrthoDBi | 84406at2157 |
PhylomeDBi | O52027 |
Family and domain databases
Gene3Di | 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR025723, Anion-transp_ATPase-like_dom IPR027541, Ars_ATPase IPR016300, ATPase_ArsA/GET3 IPR027417, P-loop_NTPase |
PANTHERi | PTHR10803, PTHR10803, 3 hits |
Pfami | View protein in Pfam PF02374, ArsA_ATPase, 3 hits |
PIRSFi | PIRSF001327, Arsenical_pump-driving_ATPase, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
TIGRFAMsi | TIGR00345, GET3_arsA_TRC40, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ARSA_HALSA | |
Accessioni | O52027Primary (citable) accession number: O52027 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | June 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Plasmid, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families