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UniProtKB - O51628 (HMDH_BORBU)
Protein
Probable 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Gene
BB_0685
Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Functioni
Converts HMG-CoA to mevalonate.
By similarityCatalytic activityi
- EC:1.1.1.88
: (R)-mevalonate degradation Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate. This subpathway is part of the pathway (R)-mevalonate degradation, which is itself part of Metabolic intermediate metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate, the pathway (R)-mevalonate degradation and in Metabolic intermediate metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 85 | Charge relay systemBy similarity | 1 | |
Active sitei | 278 | Charge relay systemBy similarity | 1 | |
Active sitei | 375 | Proton donorBy similarity | 1 |
GO - Molecular functioni
- hydroxymethylglutaryl-CoA reductase (NADH) activity Source: UniProtKB-EC
- hydroxymethylglutaryl-CoA reductase (NADPH) activity Source: InterPro
GO - Biological processi
- coenzyme A metabolic process Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
UniPathwayi | UPA00257;UER00367 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable 3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC:1.1.1.88)Short name: HMG-CoA reductase |
Gene namesi | Ordered Locus Names:BB_0685 |
Organismi | Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) |
Taxonomic identifieri | 224326 [NCBI] |
Taxonomic lineagei | Bacteria › Spirochaetes › Spirochaetales › Borreliaceae › Borreliella › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000114466 | 1 – 431 | Probable 3-hydroxy-3-methylglutaryl-coenzyme A reductaseAdd BLAST | 431 |
Proteomic databases
PRIDEi | O51628 |
Family & Domainsi
Sequence similaritiesi
Belongs to the HMG-CoA reductase family.Curated
Phylogenomic databases
HOGENOMi | CLU_033422_0_0_12 |
OMAi | ATGNDFR |
Family and domain databases
CDDi | cd00644, HMG-CoA_reductase_classII, 1 hit |
Gene3Di | 3.30.70.420, 1 hit 3.90.770.10, 2 hits |
InterProi | View protein in InterPro IPR002202, HMG_CoA_Rdtase IPR004553, HMG_CoA_Rdtase_bac-typ IPR023074, HMG_CoA_Rdtase_cat_sf IPR009023, HMG_CoA_Rdtase_NAD(P)-bd_sf IPR009029, HMG_CoA_Rdtase_sub-bd_dom_sf |
PANTHERi | PTHR10572, PTHR10572, 1 hit |
Pfami | View protein in Pfam PF00368, HMG-CoA_red, 1 hit |
PRINTSi | PR00071, HMGCOARDTASE |
SUPFAMi | SSF55035, SSF55035, 1 hit SSF56542, SSF56542, 1 hit |
TIGRFAMsi | TIGR00532, HMG_CoA_R_NAD, 1 hit |
PROSITEi | View protein in PROSITE PS50065, HMG_COA_REDUCTASE_4, 1 hit |
i Sequence
Sequence statusi: Complete.
O51628-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNLESLSSFM ELSKNFRHKS VLEKRQEIKS FLELSYKDFF YNNANEDFLF
60 70 80 90 100
NMIENYIGYL SFPIGIVKNL KINGKYYSLP IATEESSVVA ALNFAAKILE
110 120 130 140 150
NADLRYSLGE VLGISQIYIK SEKDLSKIFV DLGDKIKTWI EPLLTNMNQR
160 170 180 190 200
GGGFRRLSTR HIKELGIQKL NIYVDTCDAM GANLLNSIAE RVAEFIFLEF
210 220 230 240 250
GYECVLKVLS NDISEFTAKA RFVLDFKHLL PGKEDSWNLA KKIELISSIG
260 270 280 290 300
FYEEERAVTN NKGIMNGITG VCLATFNDTR ALEASVHKFA SKSGKYFPLS
310 320 330 340 350
KFYTTDNALV GEIEIPLQVG TKGGVISFNE ASILSFKIMN VNSKSEFIGI
360 370 380 390 400
LSCVGLASNF AALRALAFNG IQKGHMRLHV NKILHLLKTK YNISDFEKDK
410 420 430
LLLEMERMNI YSFDFAFKIL KKIRLENENK V
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000783 Genomic DNA Translation: AAC67032.1 |
PIRi | D70185 |
RefSeqi | NP_212819.1, NC_001318.1 WP_010889799.1, NC_001318.1 |
Genome annotation databases
EnsemblBacteriai | AAC67032; AAC67032; BB_0685 |
KEGGi | bbu:BB_0685 |
PATRICi | fig|224326.49.peg.1076 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000783 Genomic DNA Translation: AAC67032.1 |
PIRi | D70185 |
RefSeqi | NP_212819.1, NC_001318.1 WP_010889799.1, NC_001318.1 |
3D structure databases
SMRi | O51628 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224326.BB_0685 |
Proteomic databases
PRIDEi | O51628 |
Genome annotation databases
EnsemblBacteriai | AAC67032; AAC67032; BB_0685 |
KEGGi | bbu:BB_0685 |
PATRICi | fig|224326.49.peg.1076 |
Phylogenomic databases
HOGENOMi | CLU_033422_0_0_12 |
OMAi | ATGNDFR |
Enzyme and pathway databases
UniPathwayi | UPA00257;UER00367 |
Family and domain databases
CDDi | cd00644, HMG-CoA_reductase_classII, 1 hit |
Gene3Di | 3.30.70.420, 1 hit 3.90.770.10, 2 hits |
InterProi | View protein in InterPro IPR002202, HMG_CoA_Rdtase IPR004553, HMG_CoA_Rdtase_bac-typ IPR023074, HMG_CoA_Rdtase_cat_sf IPR009023, HMG_CoA_Rdtase_NAD(P)-bd_sf IPR009029, HMG_CoA_Rdtase_sub-bd_dom_sf |
PANTHERi | PTHR10572, PTHR10572, 1 hit |
Pfami | View protein in Pfam PF00368, HMG-CoA_red, 1 hit |
PRINTSi | PR00071, HMGCOARDTASE |
SUPFAMi | SSF55035, SSF55035, 1 hit SSF56542, SSF56542, 1 hit |
TIGRFAMsi | TIGR00532, HMG_CoA_R_NAD, 1 hit |
PROSITEi | View protein in PROSITE PS50065, HMG_COA_REDUCTASE_4, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HMDH_BORBU | |
Accessioni | O51628Primary (citable) accession number: O51628 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | June 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families