UniProtKB - O50017 (PARP2_MAIZE)
Protein
Poly [ADP-ribose] polymerase 2
Gene
PARP2
Organism
Zea mays (Maize)
Status
Functioni
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity).By similarity
Catalytic activityi
- NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.By similarity EC:2.4.2.30
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- NAD+ ADP-ribosyltransferase activity Source: GO_Central
- protein ADP-ribosylase activity Source: GO_Central
GO - Biological processi
- double-strand break repair Source: GO_Central
- protein poly-ADP-ribosylation Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Glycosyltransferase, Transferase |
Ligand | NAD |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PARP2 Synonyms:PARP |
Organismi | Zea mays (Maize) |
Taxonomic identifieri | 4577 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › PACMAD clade › Panicoideae › Andropogonodae › Andropogoneae › Tripsacinae › Zea |
Proteomesi |
|
Organism-specific databases
MaizeGDBi | 403201 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000260499 | 1 – 653 | Poly [ADP-ribose] polymerase 2Add BLAST | 653 |
Keywords - PTMi
ADP-ribosylationProteomic databases
PaxDbi | O50017 |
PRIDEi | O50017 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 36 | SAP 1PROSITE-ProRule annotationAdd BLAST | 35 | |
Domaini | 91 – 125 | SAP 2PROSITE-ProRule annotationAdd BLAST | 35 | |
Domaini | 301 – 419 | PARP alpha-helicalPROSITE-ProRule annotationAdd BLAST | 119 | |
Domaini | 427 – 653 | PARP catalyticPROSITE-ProRule annotationAdd BLAST | 227 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 69 – 72 | Nuclear localization signalSequence analysis | 4 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG1037, Eukaryota |
Family and domain databases
Gene3Di | 1.10.720.30, 1 hit 1.20.142.10, 1 hit 2.20.140.10, 1 hit |
InterProi | View protein in InterPro IPR012317, Poly(ADP-ribose)pol_cat_dom IPR004102, Poly(ADP-ribose)pol_reg_dom IPR036616, Poly(ADP-ribose)pol_reg_dom_sf IPR003034, SAP_dom IPR036361, SAP_dom_sf IPR036930, WGR_dom_sf IPR008893, WGR_domain |
Pfami | View protein in Pfam PF00644, PARP, 1 hit PF02877, PARP_reg, 1 hit PF02037, SAP, 1 hit PF05406, WGR, 1 hit |
SMARTi | View protein in SMART SM00513, SAP, 2 hits SM00773, WGR, 1 hit |
SUPFAMi | SSF142921, SSF142921, 1 hit SSF47587, SSF47587, 1 hit SSF68906, SSF68906, 1 hit |
PROSITEi | View protein in PROSITE PS51060, PARP_ALPHA_HD, 1 hit PS51059, PARP_CATALYTIC, 1 hit PS50800, SAP, 2 hits |
i Sequence
Sequence statusi: Complete.
O50017-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSARLRVADV RAELQRRGLD VSGTKPALVR RLDAAICEAE KAVVAAAPTS
60 70 80 90 100
VANGYDVAVD GKRNCGNNKR KRSGDGGEEG NGDTCTDVTK LEGMSYRELQ
110 120 130 140 150
GLAKARGVAA NGGKKDVIQR LLSATAGPAA VADGGPLGAK EVIKGGDEEV
160 170 180 190 200
EVKKEKMVTA TKKGAAVLDQ HIPDHIKVNY HVLQVGDEIY DATLNQTNVG
210 220 230 240 250
DNNNKFYIIQ VLESDAGGSF MVYNRWGRVG VRGQDKLHGP SPTRDQAIYE
260 270 280 290 300
FEGKFHNKTN NHWSDRKNFK CYAKKYTWLE MDYGETEKEI EKGSITDQIK
310 320 330 340 350
ETKLETRIAQ FISLICNISM MKQRMVEIGY NAEKLPLGKL RKATILKGYH
360 370 380 390 400
VLKRISDVIS KADRRHLEQL TGEFYTVIPH DFGFRKMREF IIDTPQKLKA
410 420 430 440 450
KLEMVEALGE IEIATKLLED DSSDQDDPLY ARYKQLHCDF TPLEADSDEY
460 470 480 490 500
SMIKSYLRNT HGKTHSGYTV DIVQIFKVSR HGETERFQKF ASTRNRMLLW
510 520 530 540 550
HGSRLSNWAG ILSQGLRIAP PEAPVTGYMF GKGVYFADMF SKSANYCYAS
560 570 580 590 600
EACRSGVLLL CEVALGDMNE LLNADYDANN LPKGKLRSKG VGQTAPNMVE
610 620 630 640 650
SKVADDGVVV PLGEPKQEPS KRGGLLYNEY IVYNVDQIRM RYVLHVNFNF
KRR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ222588 mRNA Translation: CAA10888.1 |
PIRi | T03656 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ222588 mRNA Translation: CAA10888.1 |
PIRi | T03656 |
3D structure databases
SMRi | O50017 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4577.GRMZM2G099231_P01 |
Proteomic databases
PaxDbi | O50017 |
PRIDEi | O50017 |
Organism-specific databases
MaizeGDBi | 403201 |
Phylogenomic databases
eggNOGi | KOG1037, Eukaryota |
Gene expression databases
ExpressionAtlasi | O50017, baseline and differential |
Family and domain databases
Gene3Di | 1.10.720.30, 1 hit 1.20.142.10, 1 hit 2.20.140.10, 1 hit |
InterProi | View protein in InterPro IPR012317, Poly(ADP-ribose)pol_cat_dom IPR004102, Poly(ADP-ribose)pol_reg_dom IPR036616, Poly(ADP-ribose)pol_reg_dom_sf IPR003034, SAP_dom IPR036361, SAP_dom_sf IPR036930, WGR_dom_sf IPR008893, WGR_domain |
Pfami | View protein in Pfam PF00644, PARP, 1 hit PF02877, PARP_reg, 1 hit PF02037, SAP, 1 hit PF05406, WGR, 1 hit |
SMARTi | View protein in SMART SM00513, SAP, 2 hits SM00773, WGR, 1 hit |
SUPFAMi | SSF142921, SSF142921, 1 hit SSF47587, SSF47587, 1 hit SSF68906, SSF68906, 1 hit |
PROSITEi | View protein in PROSITE PS51060, PARP_ALPHA_HD, 1 hit PS51059, PARP_CATALYTIC, 1 hit PS50800, SAP, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PARP2_MAIZE | |
Accessioni | O50017Primary (citable) accession number: O50017 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | June 1, 1998 | |
Last modified: | August 12, 2020 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |