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UniProtKB - O49894 (PROF_MERAN)
Protein
Profilin
Gene
N/A
Organism
Mercurialis annua (Annual mercury)
Status
Functioni
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).
By similarityGO - Molecular functioni
- actin binding Source: UniProtKB-KW
Keywordsi
Molecular function | Actin-binding |
Names & Taxonomyi
Protein namesi | Recommended name: ProfilinAlternative name(s): Pollen allergen Mer a 1 Allergen: Mer a 1 |
Organismi | Mercurialis annua (Annual mercury) |
Taxonomic identifieri | 3986 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › fabids › Malpighiales › Euphorbiaceae › Acalyphoideae › Acalypheae › Mercurialis |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Allergenic propertiesi
Causes an allergic reaction in human.1 Publication
Keywords - Diseasei
AllergenProtein family/group databases
Allergomei | 3375, Mer a 1.0101 476, Mer a 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000199654 | 2 – 133 | ProfilinAdd BLAST | 132 |
Interactioni
Subunit structurei
Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
Family & Domainsi
Sequence similaritiesi
Belongs to the profilin family.Curated
Family and domain databases
CDDi | cd00148, PROF, 1 hit |
InterProi | View protein in InterPro IPR005455, PFN IPR036140, PFN_sf IPR027310, Profilin_CS |
PANTHERi | PTHR11604, PTHR11604, 1 hit |
Pfami | View protein in Pfam PF00235, Profilin, 1 hit |
PRINTSi | PR00392, PROFILIN PR01640, PROFILINPLNT |
SMARTi | View protein in SMART SM00392, PROF, 1 hit |
SUPFAMi | SSF55770, SSF55770, 1 hit |
PROSITEi | View protein in PROSITE PS00414, PROFILIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O49894-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSWQTYVDDH LMCDIDGQGQ HLAAASIVGH DGSIWAQSAS FPQLKPEEIT
60 70 80 90 100
GIMKDFDEPG HLAPTGLYIA GTKYMVIQGE SGAVIRGKKG SGGITIKKTG
110 120 130
QALVFGIYEE PVTPGQCNMV VERLGDYLIE QGM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y13271 mRNA Translation: CAA73720.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y13271 mRNA Translation: CAA73720.1 |
3D structure databases
AlphaFoldDBi | O49894 |
SMRi | O49894 |
ModBasei | Search... |
Protein family/group databases
Allergomei | 3375, Mer a 1.0101 476, Mer a 1 |
Family and domain databases
CDDi | cd00148, PROF, 1 hit |
InterProi | View protein in InterPro IPR005455, PFN IPR036140, PFN_sf IPR027310, Profilin_CS |
PANTHERi | PTHR11604, PTHR11604, 1 hit |
Pfami | View protein in Pfam PF00235, Profilin, 1 hit |
PRINTSi | PR00392, PROFILIN PR01640, PROFILINPLNT |
SMARTi | View protein in SMART SM00392, PROF, 1 hit |
SUPFAMi | SSF55770, SSF55770, 1 hit |
PROSITEi | View protein in PROSITE PS00414, PROFILIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PROF_MERAN | |
Accessioni | O49894Primary (citable) accession number: O49894 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | June 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 75 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Documents
- Allergens
Nomenclature of allergens and list of entries - SIMILARITY comments
Index of protein domains and families