RABC2A

Functionⁱ

Intracellular vesicle trafficking and protein transport.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	20 – 27	GTPBy similarity	8
Nucleotide bindingⁱ	67 – 71	GTPBy similarity	5
Nucleotide bindingⁱ	127 – 130	GTPBy similarity	4
Nucleotide bindingⁱ	157 – 158	GTPBy similarity	2

GO - Molecular functionⁱ

GTPase activity Source: InterPro
GTP binding Source: UniProtKB-KW
GTP-dependent protein binding
Source: TAIR
Inferred from physical interactionⁱ
- 18703495
myosin XI tail binding
Source: TAIR
Inferred from physical interactionⁱ
- 18703495

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-ATH-6798695 Neutrophil degranulation R-ATH-6811436 COPI-independent Golgi-to-ER retrograde traffic R-ATH-8873719 RAB geranylgeranylation R-ATH-8876198 RAB GEFs exchange GTP for GDP on RABs

Reactomeⁱ

R-ATH-6798695 Neutrophil degranulation
R-ATH-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-ATH-8873719 RAB geranylgeranylation
R-ATH-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related protein RABC2a Short name: AtRABC2a Alternative name(s): Ras-related protein Rab18B Short name: AtRab18B
Gene namesⁱ	Name:RABC2A Synonyms:RAB18B Ordered Locus Names:At5g03530 ORF Names:F12E4.310
Organismⁱ	Arabidopsis thaliana (Mouse-ear cress)
Taxonomic identifierⁱ	3702 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Mesangiospermae › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis
Proteomesⁱ	UP000006548 Componentⁱ: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal More...Araportⁱ	AT5G03530
TAIRⁱ	locus:2831859 AT5G03530

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000407358	1 – 210	Ras-related protein RABC2aAdd BLAST		210

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Lipidationⁱ	208	S-geranylgeranyl cysteineBy similarity		1
Lipidationⁱ	209	S-geranylgeranyl cysteineBy similarity		1

Keywords - PTMⁱ

Lipoprotein, Prenylation

Proteomic databases

PaxDbⁱ	O49841
PRIDEⁱ	O49841

PTM databases

iPTMnetⁱ	O49841

iPTMnetⁱ

O49841

Expressionⁱ

Gene expression databases

ExpressionAtlasⁱ	O49841 baseline and differential
Genevisibleⁱ	O49841 AT

Interactionⁱ

Subunit structureⁱ

Interacts with XI-2/MYA2.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
XI-2	Q9LKB9	3	EBI-2009559,EBI-2009528

With

Entry

#Exp.

IntAct

Notes

XI-2

Q9LKB9

3

EBI-2009559,EBI-2009528

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	17086, 1 interactor
IntActⁱ	O49841, 1 interactor
STRINGⁱ	3702.AT5G03530.1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O49841
SMRⁱ	O49841
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	41 – 49	Effector regionBy similarity		9

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0080 Eukaryota ENOG410XPD0 LUCA
HOGENOMⁱ	HOG000233968
InParanoidⁱ	O49841
KEGG Orthology (KO) More...KOⁱ	K07910
OMAⁱ	QPSFDCL
Database of Orthologous Groups More...OrthoDBⁱ	EOG09360LW8
PhylomeDBⁱ	O49841

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR025662 Sigma_54_int_dom_ATP-bd_1 IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit PS00675 SIGMA54_INTERACT_1, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O49841-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGSSSGQSGY DLSFKILLIG DSGVGKSSLL VSFISSSVED LAPTIGVDFK 
        60         70         80         90        100
IKQLTVGGKR LKLTIWDTAG QERFRTLTSS YYRGAQGIIL VYDVTRRETF 
       110        120        130        140        150
TNLVDVWGKE IELYSTNQEC VRMLVGNKVD RESERGVSRE EGIALAKELN 
       160        170        180        190        200
CMFLECSART RQNVEQCFEE LALKIMEVPS LLEEGSSAVK RNILKQKPEH 
       210
QTNTQSGCCS

Length:210

Mass (Da):23,306

Last modified:June 1, 1998 - v1

Checksum:ⁱ551337D936809B5B

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D89824 mRNA Translation: BAA24074.1 AL162751 Genomic DNA Translation: CAB83314.1 CP002688 Genomic DNA Translation: AED90619.1 CP002688 Genomic DNA Translation: ANM70568.1 AK119027 mRNA Translation: BAC43603.1 BT006101 mRNA Translation: AAP04086.1
PIRⁱ	T48379
NCBI Reference Sequences More...RefSeqⁱ	NP_001332165.1, NM_001342711.1 NP_568121.1, NM_120433.3
UniGeneⁱ	At.346

Genome annotation databases

EnsemblPlantsⁱ	AT5G03530.1; AT5G03530.1; AT5G03530 AT5G03530.2; AT5G03530.2; AT5G03530
GeneIDⁱ	831810
Grameneⁱ	AT5G03530.1; AT5G03530.1; AT5G03530 AT5G03530.2; AT5G03530.2; AT5G03530
KEGGⁱ	ath:AT5G03530

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O49841	RABC2A		ARATH		210	UniRef100_O49841
Predicted protein		ARALL		210

Protein	Similar proteins		Species	Score	Length	Source
O49841	RABC2A		ARATH		210	UniRef90_O49841
Predicted protein		ARALL		210
Uncharacterized protein		BRARP		212
Uncharacterized protein		Brassica oleracea var. oleracea		212
BnaC02g03050D protein		BRANA		212
+15

Protein	Similar proteins		Species	Score	Length	Source
O49841	Ras-related protein RABC2b		ARATH		205	UniRef50_O49841
Predicted protein		ARALL		210
Uncharacterized protein		BRARP		212
Uncharacterized protein		Brassica oleracea var. oleracea		212
BnaC02g03050D protein		BRANA		212
+506

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D89824 mRNA Translation: BAA24074.1 AL162751 Genomic DNA Translation: CAB83314.1 CP002688 Genomic DNA Translation: AED90619.1 CP002688 Genomic DNA Translation: ANM70568.1 AK119027 mRNA Translation: BAC43603.1 BT006101 mRNA Translation: AAP04086.1
PIRⁱ	T48379
RefSeqⁱ	NP_001332165.1, NM_001342711.1 NP_568121.1, NM_120433.3
UniGeneⁱ	At.346

3D structure databases

ProteinModelPortalⁱ	O49841
SMRⁱ	O49841
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	17086, 1 interactor
IntActⁱ	O49841, 1 interactor
STRINGⁱ	3702.AT5G03530.1

PTM databases

iPTMnetⁱ	O49841

iPTMnetⁱ

O49841

Proteomic databases

PaxDbⁱ	O49841
PRIDEⁱ	O49841

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblPlantsⁱ	AT5G03530.1; AT5G03530.1; AT5G03530 AT5G03530.2; AT5G03530.2; AT5G03530
GeneIDⁱ	831810
Grameneⁱ	AT5G03530.1; AT5G03530.1; AT5G03530 AT5G03530.2; AT5G03530.2; AT5G03530
KEGGⁱ	ath:AT5G03530

Organism-specific databases

Araportⁱ	AT5G03530
TAIRⁱ	locus:2831859 AT5G03530

Phylogenomic databases

eggNOGⁱ	KOG0080 Eukaryota ENOG410XPD0 LUCA
HOGENOMⁱ	HOG000233968
InParanoidⁱ	O49841
KOⁱ	K07910
OMAⁱ	QPSFDCL
OrthoDBⁱ	EOG09360LW8
PhylomeDBⁱ	O49841

Enzyme and pathway databases

Reactomeⁱ	R-ATH-6798695 Neutrophil degranulation R-ATH-6811436 COPI-independent Golgi-to-ER retrograde traffic R-ATH-8873719 RAB geranylgeranylation R-ATH-8876198 RAB GEFs exchange GTP for GDP on RABs

Reactomeⁱ

R-ATH-6798695 Neutrophil degranulation
R-ATH-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-ATH-8873719 RAB geranylgeranylation
R-ATH-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O49841

PROⁱ

PR:O49841

Gene expression databases

ExpressionAtlasⁱ	O49841 baseline and differential
Genevisibleⁱ	O49841 AT

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR025662 Sigma_54_int_dom_ATP-bd_1 IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit PS00675 SIGMA54_INTERACT_1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RAC2A_ARATH
Accessionⁱ	O49841Primary (citable) accession number: O49841
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 3, 2011
	Last sequence update:	June 1, 1998
	Last modified:	April 25, 2018
	This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Plant Protein Annotation Program

UniProtKB

UniParc

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Proteomes

Annotation systems

Supporting data

UniProtKB - O49841 (RAC2A_ARATH)

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Ras-related protein RABC2a

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Golgi apparatus

Peroxisome

Plasma Membrane

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ