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Protein

Ras-related protein RABC2a

Gene

RABC2A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Intracellular vesicle trafficking and protein transport.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 27GTPBy similarity8
Nucleotide bindingi67 – 71GTPBy similarity5
Nucleotide bindingi127 – 130GTPBy similarity4
Nucleotide bindingi157 – 158GTPBy similarity2

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: UniProtKB-KW
  • GTP-dependent protein binding Source: TAIR
  • myosin XI tail binding Source: TAIR

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-6798695 Neutrophil degranulation
R-ATH-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-ATH-8873719 RAB geranylgeranylation
R-ATH-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein RABC2a
Short name:
AtRABC2a
Alternative name(s):
Ras-related protein Rab18B
Short name:
AtRab18B
Gene namesi
Name:RABC2A
Synonyms:RAB18B
Ordered Locus Names:At5g03530
ORF Names:F12E4.310
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G03530
TAIRilocus:2831859 AT5G03530

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004073581 – 210Ras-related protein RABC2aAdd BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi208S-geranylgeranyl cysteineBy similarity1
Lipidationi209S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

PaxDbiO49841
PRIDEiO49841

PTM databases

iPTMnetiO49841

Expressioni

Gene expression databases

ExpressionAtlasiO49841 baseline and differential
GenevisibleiO49841 AT

Interactioni

Subunit structurei

Interacts with XI-2/MYA2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
XI-2Q9LKB93EBI-2009559,EBI-2009528

GO - Molecular functioni

Protein-protein interaction databases

BioGridi17086, 1 interactor
IntActiO49841, 1 interactor
STRINGi3702.AT5G03530.1

Structurei

3D structure databases

ProteinModelPortaliO49841
SMRiO49841
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 49Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0080 Eukaryota
ENOG410XPD0 LUCA
HOGENOMiHOG000233968
InParanoidiO49841
KOiK07910
OMAiQPSFDCL
OrthoDBiEOG09360LW8
PhylomeDBiO49841

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR025662 Sigma_54_int_dom_ATP-bd_1
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
PS00675 SIGMA54_INTERACT_1, 1 hit

Sequencei

Sequence statusi: Complete.

O49841-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSSSGQSGY DLSFKILLIG DSGVGKSSLL VSFISSSVED LAPTIGVDFK
60 70 80 90 100
IKQLTVGGKR LKLTIWDTAG QERFRTLTSS YYRGAQGIIL VYDVTRRETF
110 120 130 140 150
TNLVDVWGKE IELYSTNQEC VRMLVGNKVD RESERGVSRE EGIALAKELN
160 170 180 190 200
CMFLECSART RQNVEQCFEE LALKIMEVPS LLEEGSSAVK RNILKQKPEH
210
QTNTQSGCCS
Length:210
Mass (Da):23,306
Last modified:June 1, 1998 - v1
Checksum:i551337D936809B5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89824 mRNA Translation: BAA24074.1
AL162751 Genomic DNA Translation: CAB83314.1
CP002688 Genomic DNA Translation: AED90619.1
CP002688 Genomic DNA Translation: ANM70568.1
AK119027 mRNA Translation: BAC43603.1
BT006101 mRNA Translation: AAP04086.1
PIRiT48379
RefSeqiNP_001332165.1, NM_001342711.1
NP_568121.1, NM_120433.3
UniGeneiAt.346

Genome annotation databases

EnsemblPlantsiAT5G03530.1; AT5G03530.1; AT5G03530
AT5G03530.2; AT5G03530.2; AT5G03530
GeneIDi831810
GrameneiAT5G03530.1; AT5G03530.1; AT5G03530
AT5G03530.2; AT5G03530.2; AT5G03530
KEGGiath:AT5G03530

Similar proteinsi

Entry informationi

Entry nameiRAC2A_ARATH
AccessioniPrimary (citable) accession number: O49841
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: June 1, 1998
Last modified: April 25, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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