UniProtKB - O49354 (COQ3_ARATH)
Protein
Ubiquinone biosynthesis O-methyltransferase, mitochondrial
Gene
COQ3
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.UniRule annotation
Catalytic activityi
- 3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H+ + S-adenosyl-L-homocysteineUniRule annotationEC:2.1.1.114UniRule annotation
- a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + H+ + S-adenosyl-L-homocysteineUniRule annotationEC:2.1.1.64UniRule annotation
: ubiquinone biosynthesis Pathwayi
This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotationView all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 108 | S-adenosyl-L-methionineUniRule annotation | 1 | |
Binding sitei | 139 | S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation | 1 | |
Binding sitei | 160 | S-adenosyl-L-methionineUniRule annotation | 1 | |
Binding sitei | 205 | S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation | 1 |
GO - Molecular functioni
- 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Source: InterPro
- 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity Source: TAIR
- 3-demethylubiquinone-9 3-O-methyltransferase activity Source: UniProtKB-UniRule
- hexaprenyldihydroxybenzoate methyltransferase activity Source: TAIR
GO - Biological processi
- methylation Source: UniProtKB-KW
- ubiquinone biosynthetic process Source: TAIR
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | Ubiquinone biosynthesis |
Ligand | S-adenosyl-L-methionine |
Enzyme and pathway databases
BRENDAi | 2.1.1.114, 399 2.1.1.64, 399 |
UniPathwayi | UPA00232 |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquinone biosynthesis O-methyltransferase, mitochondrialUniRule annotationAlternative name(s): |
Gene namesi | Name:COQ3UniRule annotation Synonyms:EMB3002 Ordered Locus Names:At2g30920 ORF Names:F7F1.13 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT2G30920 |
TAIRi | locus:2052761, AT2G30920 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane UniRule annotation1 Publication; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation
Mitochondrion
- extrinsic component of mitochondrial inner membrane Source: UniProtKB-UniRule
- mitochondrial envelope Source: TAIR
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 37 | Mitochondrion1 PublicationAdd BLAST | 37 | |
ChainiPRO_0000035929 | 38 – 322 | Ubiquinone biosynthesis O-methyltransferase, mitochondrialAdd BLAST | 285 |
Proteomic databases
PaxDbi | O49354 |
PRIDEi | O49354 |
ProteomicsDBi | 241178 |
Expressioni
Gene expression databases
ExpressionAtlasi | O49354, baseline and differential |
Genevisiblei | O49354, AT |
Interactioni
Subunit structurei
Component of a multi-subunit COQ enzyme complex.
UniRule annotationProtein-protein interaction databases
BioGRIDi | 2991, 3 interactors |
IntActi | O49354, 3 interactors |
STRINGi | 3702.AT2G30920.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.UniRule annotation
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1270, Eukaryota |
HOGENOMi | CLU_042432_2_1_1 |
InParanoidi | O49354 |
OMAi | WWDPNSE |
OrthoDBi | 1542938at2759 |
PhylomeDBi | O49354 |
Family and domain databases
HAMAPi | MF_00472, UbiG, 1 hit |
InterProi | View protein in InterPro IPR029063, SAM-dependent_MTases IPR010233, UbiG_MeTrfase |
SUPFAMi | SSF53335, SSF53335, 1 hit |
TIGRFAMsi | TIGR01983, UbiG, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O49354-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLASVRVNQL QRLLLSARRL SSSPIIPPSR LLHQRLFSTS DTDASAASFS
60 70 80 90 100
SSHPKIQTLE GKASNKSRST SSTTSLNEDE LAKFSAIADT WWHSEGPFKP
110 120 130 140 150
LHQMNPTRLA FIRSTLCRHF SKDPSSAKPF EGLKFIDIGC GGGLLSEPLA
160 170 180 190 200
RMGATVTGVD AVDKNVKIAR LHADMDPVTS TIEYLCTTAE KLADEGRKFD
210 220 230 240 250
AVLSLEVIEH VANPAEFCKS LSALTIPNGA TVLSTINRTM RAYASTIVGA
260 270 280 290 300
EYILRWLPKG THQWSSFVTP EEMSMILQRA SVDVKEIAGF VYNPITGRWL
310 320
LSDDISVNYI AYGTKRKDLG DI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 311 | A → T in CAA75340 (PubMed:9628017).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y15055 mRNA Translation: CAA75340.1 AC004669 Genomic DNA Translation: AAC20726.1 CP002685 Genomic DNA Translation: AEC08458.1 CP002685 Genomic DNA Translation: ANM62865.1 AY045828 mRNA Translation: AAK76502.1 AY091366 mRNA Translation: AAM14305.1 |
PIRi | C84714 T52284 |
RefSeqi | NP_001324991.1, NM_001336307.1 NP_180649.1, NM_128644.4 |
Genome annotation databases
EnsemblPlantsi | AT2G30920.1; AT2G30920.1; AT2G30920 AT2G30920.2; AT2G30920.2; AT2G30920 |
GeneIDi | 817642 |
Gramenei | AT2G30920.1; AT2G30920.1; AT2G30920 AT2G30920.2; AT2G30920.2; AT2G30920 |
KEGGi | ath:AT2G30920 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y15055 mRNA Translation: CAA75340.1 AC004669 Genomic DNA Translation: AAC20726.1 CP002685 Genomic DNA Translation: AEC08458.1 CP002685 Genomic DNA Translation: ANM62865.1 AY045828 mRNA Translation: AAK76502.1 AY091366 mRNA Translation: AAM14305.1 |
PIRi | C84714 T52284 |
RefSeqi | NP_001324991.1, NM_001336307.1 NP_180649.1, NM_128644.4 |
3D structure databases
SMRi | O49354 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 2991, 3 interactors |
IntActi | O49354, 3 interactors |
STRINGi | 3702.AT2G30920.1 |
Proteomic databases
PaxDbi | O49354 |
PRIDEi | O49354 |
ProteomicsDBi | 241178 |
Genome annotation databases
EnsemblPlantsi | AT2G30920.1; AT2G30920.1; AT2G30920 AT2G30920.2; AT2G30920.2; AT2G30920 |
GeneIDi | 817642 |
Gramenei | AT2G30920.1; AT2G30920.1; AT2G30920 AT2G30920.2; AT2G30920.2; AT2G30920 |
KEGGi | ath:AT2G30920 |
Organism-specific databases
Araporti | AT2G30920 |
TAIRi | locus:2052761, AT2G30920 |
Phylogenomic databases
eggNOGi | KOG1270, Eukaryota |
HOGENOMi | CLU_042432_2_1_1 |
InParanoidi | O49354 |
OMAi | WWDPNSE |
OrthoDBi | 1542938at2759 |
PhylomeDBi | O49354 |
Enzyme and pathway databases
UniPathwayi | UPA00232 |
BRENDAi | 2.1.1.114, 399 2.1.1.64, 399 |
Miscellaneous databases
PROi | PR:O49354 |
Gene expression databases
ExpressionAtlasi | O49354, baseline and differential |
Genevisiblei | O49354, AT |
Family and domain databases
HAMAPi | MF_00472, UbiG, 1 hit |
InterProi | View protein in InterPro IPR029063, SAM-dependent_MTases IPR010233, UbiG_MeTrfase |
SUPFAMi | SSF53335, SSF53335, 1 hit |
TIGRFAMsi | TIGR01983, UbiG, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COQ3_ARATH | |
Accessioni | O49354Primary (citable) accession number: O49354 Secondary accession number(s): O80857, Q94AS6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | May 27, 2002 | |
Last modified: | December 2, 2020 | |
This is version 160 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families