UniProtKB - O49339 (PTI12_ARATH)
Protein
PTI1-like tyrosine-protein kinase 2
Gene
PTI12
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Probable tyrosine-protein kinase involved in oxidative burst-mediated signaling leading to specific genes expression.1 Publication
Catalytic activityi
- EC:2.7.10.2PROSITE-ProRule annotation
Activity regulationi
Strongly activated in response to phosphatidic acid (PA) and xylanase in a OXI1- and PDK1-dependent manner, and, to a lesser extent, by hydrogen peroxide and flagellin in a OXI1-dependent manner.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 99 | ATPCurated | 1 | |
Active sitei | 203 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 77 – 85 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
- protein kinase binding Source: UniProtKB
- transmembrane receptor protein tyrosine kinase activity Source: RHEA
GO - Biological processi
- defense response Source: UniProtKB-KW
Keywordsi
Molecular function | Kinase, Transferase, Tyrosine-protein kinase |
Biological process | Plant defense |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PTI12 Ordered Locus Names:At2g30740 ORF Names:T11J7.13 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT2G30740 |
TAIRi | locus:2054502, AT2G30740 |
Subcellular locationi
Peroxisome
- peroxisome Source: TAIR
Plasma Membrane
- plasma membrane Source: TAIR
Other locations
- plasmodesma Source: TAIR
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 99 | K → N: Reduced phosphorylation and impaired kinase activity. No phosphorylation; when associated with A-238. 1 Publication | 1 | |
Mutagenesisi | 238 | T → A: No phosphorylation; when associated with N-99. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000403323 | 1 – 366 | PTI1-like tyrosine-protein kinase 2Add BLAST | 366 |
Post-translational modificationi
Autophosphorylated and phosphorylated by OXI1.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | O49339 |
PRIDEi | O49339 |
ProteomicsDBi | 226171 |
PTM databases
iPTMneti | O49339 |
SwissPalmi | O49339 |
Expressioni
Gene expression databases
ExpressionAtlasi | O49339, baseline and differential |
Genevisiblei | O49339, AT |
Interactioni
Subunit structurei
Interacts with OXI1.
1 PublicationGO - Molecular functioni
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 2974, 5 interactors |
STRINGi | 3702.AT2G30740.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 71 – 353 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 283 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1187, Eukaryota |
HOGENOMi | CLU_000288_21_4_1 |
InParanoidi | O49339 |
OMAi | HLKSPWQ |
OrthoDBi | 684563at2759 |
PhylomeDBi | O49339 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit |
SMARTi | View protein in SMART SM00219, TyrKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
i Sequence
Sequence statusi: Complete.
O49339-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRRWICCGDK KGDSDLSNEE VHLKSPWQNS EANQKNQKPQ AVVKPEAQKE
60 70 80 90 100
ALPIEVPPLS VDEVKEKTDN FGSKSLIGEG SYGRVYYATL NDGKAVALKK
110 120 130 140 150
LDVAPEAETN TEFLNQVSMV SRLKHENLIQ LVGYCVDENL RVLAYEFATM
160 170 180 190 200
GSLHDILHGR KGVQGAQPGP TLDWLTRVKI AVEAARGLEY LHEKVQPPVI
210 220 230 240 250
HRDIRSSNVL LFEDYQAKVA DFNLSNQAPD NAARLHSTRV LGTFGYHAPE
260 270 280 290 300
YAMTGQLTQK SDVYSFGVVL LELLTGRKPV DHTMPRGQQS LVTWATPRLS
310 320 330 340 350
EDKVKQCVDP KLKGEYPPKS VAKLAAVAAL CVQYESEFRP NMSIVVKALQ
360
PLLKPPAPAP APVPES
Sequence databases
Genome annotation databases
Similar proteinsi
Cross-referencesi
Web resourcesi
Arabidopsis protein tyrosine kinases |
Sequence databases
3D structure databases
SMRi | O49339 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 2974, 5 interactors |
STRINGi | 3702.AT2G30740.1 |
PTM databases
iPTMneti | O49339 |
SwissPalmi | O49339 |
Proteomic databases
PaxDbi | O49339 |
PRIDEi | O49339 |
ProteomicsDBi | 226171 |
Genome annotation databases
Organism-specific databases
Araporti | AT2G30740 |
TAIRi | locus:2054502, AT2G30740 |
Phylogenomic databases
eggNOGi | KOG1187, Eukaryota |
HOGENOMi | CLU_000288_21_4_1 |
InParanoidi | O49339 |
OMAi | HLKSPWQ |
OrthoDBi | 684563at2759 |
PhylomeDBi | O49339 |
Miscellaneous databases
PROi | PR:O49339 |
Gene expression databases
ExpressionAtlasi | O49339, baseline and differential |
Genevisiblei | O49339, AT |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit |
SMARTi | View protein in SMART SM00219, TyrKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PTI12_ARATH | |
Accessioni | O49339Primary (citable) accession number: O49339 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2011 |
Last sequence update: | June 1, 1998 | |
Last modified: | April 7, 2021 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families