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Entry version 120 (16 Oct 2019)
Sequence version 1 (01 Jun 1998)
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Protein

Nitrile-specifier protein 2

Gene

NSP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes simple nitriles, but not epithionitrile or thiocyanate formation. Converts allylglucosinolate and benzylglucosinolate to their corresponding simple nitriles in the presence of myrosinase.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLectin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nitrile-specifier protein 2
Short name:
AtNSP2
Alternative name(s):
Jacalin-related lectin 21
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NSP2
Synonyms:JAL21
Ordered Locus Names:At2g33070
ORF Names:F25I18.19
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G33070

The Arabidopsis Information Resource

More...
TAIRi
locus:2046560 AT2G33070

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003631431 – 471Nitrile-specifier protein 2Add BLAST471

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O49326

PRoteomics IDEntifications database

More...
PRIDEi
O49326

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O49326

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O49326 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O49326 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT2G33070.3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O49326

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 144Jacalin-type lectinPROSITE-ProRule annotationAdd BLAST143
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati47 – 94Kelch 1Add BLAST48
Repeati178 – 226Kelch 2Add BLAST49
Repeati231 – 277Kelch 3Add BLAST47
Repeati281 – 330Kelch 4Add BLAST50
Repeati332 – 379Kelch 5Add BLAST48
Repeati381 – 435Kelch 6Add BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi423 – 426Poly-Glu4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the jacalin lectin family.PROSITE-ProRule annotationCurated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEDY Eukaryota
ENOG410Y2DF LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000217506

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O49326

Identification of Orthologs from Complete Genome Data

More...
OMAi
FCGRELD

Database of Orthologous Groups

More...
OrthoDBi
933937at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O49326

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09612 Jacalin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.100.10.30, 1 hit
2.120.10.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001229 Jacalin-like_lectin_dom
IPR033734 Jacalin-like_lectin_dom_plant
IPR036404 Jacalin-like_lectin_dom_sf
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR035429 NSP1/2/3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01419 Jacalin, 1 hit
PF01344 Kelch_1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038118 Myrosinase-db_jacalin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00915 Jacalin, 1 hit
SM00612 Kelch, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117281 SSF117281, 1 hit
SSF51101 SSF51101, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51752 JACALIN_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O49326-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVQKVEARGG EIGDVWDDGA YDGVRKVYVG QGEDGIAFVK FEYVNGSQEV
60 70 80 90 100
VGDERGKKTL LGAEEFEVDP DDYIVYVEGY HEKVFGVTTK EIISTLTFKT
110 120 130 140 150
YKGKTSPPFG IVSGTKFVLQ GGKIVGFHGR STDVLHSLGA YISSPATPKL
160 170 180 190 200
RGKWIKVEQK GEGPGPRCSH DIAQVGNKIF SFGGELTPNQ PIDKHLYVFD
210 220 230 240 250
LETRTWSISP ATGDVPNLSC LGVRMVSIGS SLYVFGGRDA SRKYNGFYSF
260 270 280 290 300
DTTKNEWKLL TPVEQGPTPR SFHSMTADEN NVYVFGGVSA TVRLKTLDAY
310 320 330 340 350
NIVDHKWVQC STPGGSCSVR GGAGLEVVQG KVWVVYGFNG CEVDDVHCYD
360 370 380 390 400
PAQDKWTQVE TFGEKPCARS VFASAVVGKH ILVFGGEIAM DPKAHEGPGQ
410 420 430 440 450
LSGGTFALDT ETLKWEKLDK LGEEEETPSI RGWSASTTGT IDGKKGLVMF
460 470
GGKAQTNDRF GDLFFYGVDS A
Length:471
Mass (Da):51,215
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i880B8B24E24E2BD8
GO
Isoform 2 (identifier: O49326-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-156: K → KVV

Note: No experimental confirmation available. Derived from EST data.
Show »
Length:473
Mass (Da):51,413
Checksum:iF0B38C2DE6709145
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056709156K → KVV in isoform 2. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC002334 Genomic DNA Translation: AAC04913.1
CP002685 Genomic DNA Translation: AEC08780.1
CP002685 Genomic DNA Translation: AEC08781.1
CP002685 Genomic DNA Translation: AEC08782.1
AY070077 mRNA Translation: AAL49772.1
AY091331 mRNA Translation: AAM14270.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A84741

NCBI Reference Sequences

More...
RefSeqi
NP_001031468.1, NM_001036391.1 [O49326-1]
NP_001189663.1, NM_001202734.1 [O49326-2]
NP_180866.1, NM_128867.3 [O49326-1]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G33070.1; AT2G33070.1; AT2G33070 [O49326-1]
AT2G33070.2; AT2G33070.2; AT2G33070 [O49326-1]
AT2G33070.3; AT2G33070.3; AT2G33070 [O49326-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
817869

Gramene; a comparative resource for plants

More...
Gramenei
AT2G33070.1; AT2G33070.1; AT2G33070 [O49326-1]
AT2G33070.2; AT2G33070.2; AT2G33070 [O49326-1]
AT2G33070.3; AT2G33070.3; AT2G33070 [O49326-2]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G33070

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002334 Genomic DNA Translation: AAC04913.1
CP002685 Genomic DNA Translation: AEC08780.1
CP002685 Genomic DNA Translation: AEC08781.1
CP002685 Genomic DNA Translation: AEC08782.1
AY070077 mRNA Translation: AAL49772.1
AY091331 mRNA Translation: AAM14270.1
PIRiA84741
RefSeqiNP_001031468.1, NM_001036391.1 [O49326-1]
NP_001189663.1, NM_001202734.1 [O49326-2]
NP_180866.1, NM_128867.3 [O49326-1]

3D structure databases

SMRiO49326
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G33070.3

PTM databases

iPTMnetiO49326

Proteomic databases

PaxDbiO49326
PRIDEiO49326

Genome annotation databases

EnsemblPlantsiAT2G33070.1; AT2G33070.1; AT2G33070 [O49326-1]
AT2G33070.2; AT2G33070.2; AT2G33070 [O49326-1]
AT2G33070.3; AT2G33070.3; AT2G33070 [O49326-2]
GeneIDi817869
GrameneiAT2G33070.1; AT2G33070.1; AT2G33070 [O49326-1]
AT2G33070.2; AT2G33070.2; AT2G33070 [O49326-1]
AT2G33070.3; AT2G33070.3; AT2G33070 [O49326-2]
KEGGiath:AT2G33070

Organism-specific databases

AraportiAT2G33070
TAIRilocus:2046560 AT2G33070

Phylogenomic databases

eggNOGiENOG410IEDY Eukaryota
ENOG410Y2DF LUCA
HOGENOMiHOG000217506
InParanoidiO49326
OMAiFCGRELD
OrthoDBi933937at2759
PhylomeDBiO49326

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O49326

Gene expression databases

ExpressionAtlasiO49326 baseline and differential
GenevisibleiO49326 AT

Family and domain databases

CDDicd09612 Jacalin, 1 hit
Gene3Di2.100.10.30, 1 hit
2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR001229 Jacalin-like_lectin_dom
IPR033734 Jacalin-like_lectin_dom_plant
IPR036404 Jacalin-like_lectin_dom_sf
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR035429 NSP1/2/3
PfamiView protein in Pfam
PF01419 Jacalin, 1 hit
PF01344 Kelch_1, 1 hit
PIRSFiPIRSF038118 Myrosinase-db_jacalin, 1 hit
SMARTiView protein in SMART
SM00915 Jacalin, 1 hit
SM00612 Kelch, 3 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF51101 SSF51101, 1 hit
PROSITEiView protein in PROSITE
PS51752 JACALIN_LECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJAL21_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O49326
Secondary accession number(s): F4IUU4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: June 1, 1998
Last modified: October 16, 2019
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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