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Entry version 144 (12 Aug 2020)
Sequence version 2 (08 Feb 2011)
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Protein

Probable phosphoglucomutase, cytoplasmic 1

Gene

At1g23190

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This enzyme participates in both the breakdown and synthesis of glucose.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei20SubstrateBy similarity1
Binding sitei24SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei123Phosphoserine intermediateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi123Magnesium; via phosphate groupBy similarity1
Binding sitei136SubstrateBy similarity1
Metal bindingi299MagnesiumBy similarity1
Metal bindingi301MagnesiumBy similarity1
Metal bindingi303MagnesiumBy similarity1
Binding sitei367SubstrateBy similarity1
Binding sitei399SubstrateBy similarity1
Binding sitei536SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Glucose metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
5.4.2.2, 399

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable phosphoglucomutase, cytoplasmic 1 (EC:5.4.2.2)
Short name:
PGM 1
Alternative name(s):
Glucose phosphomutase 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:At1g23190
ORF Names:F26F24.1, T26J12.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G23190

The Arabidopsis Information Resource

More...
TAIRi
locus:2028110, AT1G23190

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001477981 – 583Probable phosphoglucomutase, cytoplasmic 1Add BLAST583

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O49299

PRoteomics IDEntifications database

More...
PRIDEi
O49299

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
236152

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O49299

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
O49299

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O49299, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O49299, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
24166, 7 interactors

Protein interaction database and analysis system

More...
IntActi
O49299, 3 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT1G23190.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O49299

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni123 – 124Substrate bindingBy similarity2
Regioni303 – 304Substrate bindingBy similarity2
Regioni386 – 388Substrate bindingBy similarity3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0625, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009330_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O49299

KEGG Orthology (KO)

More...
KOi
K01835

Identification of Orthologs from Complete Genome Data

More...
OMAi
MMEDLEI

Database of Orthologous Groups

More...
OrthoDBi
555015at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O49299

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005844, A-D-PHexomutase_a/b/a-I
IPR016055, A-D-PHexomutase_a/b/a-I/II/III
IPR005845, A-D-PHexomutase_a/b/a-II
IPR005846, A-D-PHexomutase_a/b/a-III
IPR005843, A-D-PHexomutase_C
IPR036900, A-D-PHexomutase_C_sf
IPR016066, A-D-PHexomutase_CS
IPR005841, Alpha-D-phosphohexomutase_SF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02878, PGM_PMM_I, 1 hit
PF02879, PGM_PMM_II, 1 hit
PF02880, PGM_PMM_III, 1 hit
PF00408, PGM_PMM_IV, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00509, PGMPMM

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53738, SSF53738, 3 hits
SSF55957, SSF55957, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00710, PGM_PMM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O49299-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVFKVSTVST SPIDGQKPGT SGLRKKVKVF KQPNYLENFV QATFNALTAE
60 70 80 90 100
KVKGATLVVS GDGRYYSKDA VQIIIKMAAA NGVRRVWVGK NTLLSTPAVS
110 120 130 140 150
AVIRERSGAD GSKATGAFIL TASHNPGGPT EDFGIKYNME NGGPAPESIT
160 170 180 190 200
DKIYENTKTI KEYPIAQDLP NVDISAVGVT SFEGPEGKFD VEVFDPADDY
210 220 230 240 250
VKLMKSIFDF EAIRKLLSSP KFTFCYDALH GVAGAYAHRI FVEELGAQES
260 270 280 290 300
ALLNCTPKED FGGGHPDPNL TYAKELVARM GLGKSDTGGE PPEFGAAADG
310 320 330 340 350
DADRNMILGK RFFVTPSDSV AIIAANAIGA IPYFSSGLKG VARSMPTSAA
360 370 380 390 400
LDVVAKSLNL KFFEVPTGWK FFGNLMDAGM CSVCGEESFG TGSDHIREKD
410 420 430 440 450
GIWAVLAWMS ILAHKNKGNI DGNAKLVSVE DIVRQHWATY GRHYYTRYDY
460 470 480 490 500
ENVDAGKAKE LMEHLVKLQS SIPEVNKIVK GIRSDVASVA SADEFEYKDP
510 520 530 540 550
VDGSISKHQG IRYLFEDGSR LVFRLSGTGS EGATIRLYIE QYEKDASKTG
560 570 580
RESQEALSPL VDLALKLSKM EEFTGRSAPT VIT
Length:583
Mass (Da):63,171
Last modified:February 8, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D39B37F75FA7F90
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC00601 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAF86992 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC002311 Genomic DNA Translation: AAC00601.1 Sequence problems.
AC005292 Genomic DNA Translation: AAF86992.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE30353.1
AY059926 mRNA Translation: AAL24408.1
AY081589 mRNA Translation: AAM10151.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B86366

NCBI Reference Sequences

More...
RefSeqi
NP_173732.1, NM_102167.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G23190.1; AT1G23190.1; AT1G23190

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
838927

Gramene; a comparative resource for plants

More...
Gramenei
AT1G23190.1; AT1G23190.1; AT1G23190

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G23190

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002311 Genomic DNA Translation: AAC00601.1 Sequence problems.
AC005292 Genomic DNA Translation: AAF86992.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE30353.1
AY059926 mRNA Translation: AAL24408.1
AY081589 mRNA Translation: AAM10151.1
PIRiB86366
RefSeqiNP_173732.1, NM_102167.4

3D structure databases

SMRiO49299
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi24166, 7 interactors
IntActiO49299, 3 interactors
STRINGi3702.AT1G23190.1

PTM databases

iPTMnetiO49299
MetOSiteiO49299

Proteomic databases

PaxDbiO49299
PRIDEiO49299
ProteomicsDBi236152

Genome annotation databases

EnsemblPlantsiAT1G23190.1; AT1G23190.1; AT1G23190
GeneIDi838927
GrameneiAT1G23190.1; AT1G23190.1; AT1G23190
KEGGiath:AT1G23190

Organism-specific databases

AraportiAT1G23190
TAIRilocus:2028110, AT1G23190

Phylogenomic databases

eggNOGiKOG0625, Eukaryota
HOGENOMiCLU_009330_0_1_1
InParanoidiO49299
KOiK01835
OMAiMMEDLEI
OrthoDBi555015at2759
PhylomeDBiO49299

Enzyme and pathway databases

BRENDAi5.4.2.2, 399

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O49299

Gene expression databases

ExpressionAtlasiO49299, baseline and differential
GenevisibleiO49299, AT

Family and domain databases

InterProiView protein in InterPro
IPR005844, A-D-PHexomutase_a/b/a-I
IPR016055, A-D-PHexomutase_a/b/a-I/II/III
IPR005845, A-D-PHexomutase_a/b/a-II
IPR005846, A-D-PHexomutase_a/b/a-III
IPR005843, A-D-PHexomutase_C
IPR036900, A-D-PHexomutase_C_sf
IPR016066, A-D-PHexomutase_CS
IPR005841, Alpha-D-phosphohexomutase_SF
PfamiView protein in Pfam
PF02878, PGM_PMM_I, 1 hit
PF02879, PGM_PMM_II, 1 hit
PF02880, PGM_PMM_III, 1 hit
PF00408, PGM_PMM_IV, 1 hit
PRINTSiPR00509, PGMPMM
SUPFAMiSSF53738, SSF53738, 3 hits
SSF55957, SSF55957, 1 hit
PROSITEiView protein in PROSITE
PS00710, PGM_PMM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPGMC1_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O49299
Secondary accession number(s): Q93Y04, Q9LR42
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: February 8, 2011
Last modified: August 12, 2020
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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