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Protein

Elongation factor 1-alpha

Gene

EF1

Organism
Manihot esculenta (Cassava) (Jatropha manihot)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 21GTPBy similarity8
Nucleotide bindingi91 – 95GTPBy similarity5
Nucleotide bindingi153 – 156GTPBy similarity4

GO - Molecular functioni

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 1-alpha
Short name:
EF-1-alpha
Gene namesi
Name:EF1
OrganismiManihot esculenta (Cassava) (Jatropha manihot)
Taxonomic identifieri3983 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesEuphorbiaceaeCrotonoideaeManihoteaeManihot

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000909401 – 449Elongation factor 1-alphaAdd BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2895-glutamyl glycerylphosphorylethanolamineBy similarity1
Modified residuei3625-glutamyl glycerylphosphorylethanolamineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO49169

Structurei

3D structure databases

ProteinModelPortaliO49169
SMRiO49169
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 230tr-type GAdd BLAST226

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni14 – 21G1By similarity8
Regioni70 – 74G2By similarity5
Regioni91 – 94G3By similarity4
Regioni153 – 156G4By similarity4
Regioni194 – 196G5By similarity3

Sequence similaritiesi

Family and domain databases

HAMAPiMF_00118_A EF_Tu_A, 1 hit
InterProiView protein in InterPro
IPR004161 EFTu-like_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
IPR004539 Transl_elong_EF1A_euk/arc
IPR004160 Transl_elong_EFTu/EF1A_C
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PF03143 GTP_EFTU_D3, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00483 EF-1_alpha, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

O49169-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKEKVHINI VVIGHVDSGK STTTGHLIYK LGGIDKRVIE RFEKEAAEMN
60 70 80 90 100
KRSFKYAWVL DKLKAERERG ITIDIALWKF ETTKYYCTVI DAPGHRDFIK
110 120 130 140 150
NMITGTSQAD CAVLIIDSTT GGFEAGISKD GQTREHALLA FTLGVKQMIC
160 170 180 190 200
CCNKMDATTP KYSKARYDEI VKEVSSYLKK VGYNPDKIPF VPISGFEGDN
210 220 230 240 250
MIERSTNLDW YKGPTLLEAL DQIQEPKRPS DKPLRLPLQD VYKIGGIGTV
260 270 280 290 300
PVGRVETGIL KPGMVVTFGP TGLTTEVKSV EMHHEALQEA LPGDNVGFNV
310 320 330 340 350
KNVAVKDLKR GIVASNSKDD PAKEAANFTS QVIIMNHPGQ IGNGYAPVLD
360 370 380 390 400
CHTSHIAVKF AEILTKIDRR SGKELEKEPK FLKNGDAGFV KMIPTKPMVV
410 420 430 440
ETFSAYPPLG RFAVRDMRQT VAVGVIKSVE KKDPSGAKVT KSAAKKGGK
Length:449
Mass (Da):49,371
Last modified:June 1, 1998 - v1
Checksum:i779E3858DBE16104
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041463 Genomic DNA Translation: AAC39447.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041463 Genomic DNA Translation: AAC39447.1

3D structure databases

ProteinModelPortaliO49169
SMRiO49169
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO49169

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

HAMAPiMF_00118_A EF_Tu_A, 1 hit
InterProiView protein in InterPro
IPR004161 EFTu-like_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
IPR004539 Transl_elong_EF1A_euk/arc
IPR004160 Transl_elong_EFTu/EF1A_C
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PF03143 GTP_EFTU_D3, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00483 EF-1_alpha, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
PS51722 G_TR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEF1A_MANES
AccessioniPrimary (citable) accession number: O49169
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: November 22, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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