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Entry version 114 (07 Apr 2021)
Sequence version 1 (01 Jun 1998)
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Protein

Suppressor of mec-8 and unc-52 protein homolog 2

Gene

SMU2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Auxiliary spliceosomal protein involved in splicing of specific pre-mRNAs that affect multiple aspects of development.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • mRNA splicing, via spliceosome Source: GO_Central
  • RNA splicing Source: TAIR

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Suppressor of mec-8 and unc-52 protein homolog 2
Short name:
AtSMU-2
Alternative name(s):
Protein RED-like
RNA splicing protein SMU2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SMU2
Ordered Locus Names:At2g26460
ORF Names:T9J22.13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G26460

The Arabidopsis Information Resource

More...
TAIRi
locus:2066221, AT2G26460

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype, but slower growth.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004298421 – 585Suppressor of mec-8 and unc-52 protein homolog 2Add BLAST585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei579PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O48713

PRoteomics IDEntifications database

More...
PRIDEi
O48713

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
234472

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O48713

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in seedlings at 7 days after germination, young flowers before anthesis and developing siliques. Expressed at lower levels in roots, expanding leaves, open flowers, dry seeds and inflorescences. Not detected in senescing leaves.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O48713, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O48713, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the spliceosome.

Interacts with SMU1.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
2539, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT2G26460.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O48713

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati16 – 17R-[ED] 12
Repeati29 – 30R-[ED] 22
Repeati36 – 37R-[ED] 32
Repeati258 – 259R-[ED] 42
Repeati322 – 323R-[ED] 52
Repeati436 – 437R-[ED] 62
Repeati445 – 446R-[ED] 72
Repeati450 – 451R-[ED] 82
Repeati540 – 541R-[ED] 92
Repeati542 – 543R-[ED] 102

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi216 – 230Lys-richAdd BLAST15
Compositional biasi262 – 269Poly-Pro8
Compositional biasi289 – 292Poly-Asp4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RED family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2498, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_026814_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O48713

Identification of Orthologs from Complete Genome Data

More...
OMAi
PDMKSGI

Database of Orthologous Groups

More...
OrthoDBi
500537at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O48713

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039896, Red-like
IPR012492, RED_C
IPR012916, RED_N

The PANTHER Classification System

More...
PANTHERi
PTHR12765, PTHR12765, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07807, RED_C, 1 hit
PF07808, RED_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O48713-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPSKSHHKE KTARRREEKL EESDNPKYRD RAKERRENQN PDYDPSELSS
60 70 80 90 100
FHAVAPPGAV DIRAADALKI SIENSKYLGG DVEHTHLVKG LDYALLNKVR
110 120 130 140 150
SEIVKKPDGE DGDGGKTSAP KEDQRVTFRT IAAKSVYQWI VKPQTIIKSN
160 170 180 190 200
EMFLPGRMTF VYDMEGGYTH DIPTTLYRSK ADCPVPEEFV TVNVDGSVLD
210 220 230 240 250
RIAKIMSYLR LGSSGKVLKK KKKEKDGKGK MSTIANDYDE DDNKSKIENG
260 270 280 290 300
SSVNISDREV LPPPPPLPPG INHLDLSTKQ EEPPVARTDD DDIFVGEGVD
310 320 330 340 350
YTVPGKDVTQ SPISEDMEES PRDKEKVSYF DEPAYGPVQE KVPYFAEPAY
360 370 380 390 400
GPVQPSAGQE WQDMSAYGAM QTQGLAPGYP GEWQEYQYAE QTGYQEQYLQ
410 420 430 440 450
PGMEGYEVQP ETDVLLDPQL MSQEEKDRGL GSVFKRDDQR LQQLRESDAR
460 470 480 490 500
EKDPTFVSES YSECYPGYQE YNHEIVGSDE EPDLSKMDMG GKAKGGLHRW
510 520 530 540 550
DFETEEEWEK YNEQKEAMPK AAFQFGVKMQ DGRKTRKQNR DRDQKLNNEL
560 570 580
HQINKILTRK KMEKEGGDVA SLDAAEAQTP KRSKH
Length:585
Mass (Da):66,331
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i77AC4B56A6BE5227
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC002505 Genomic DNA Translation: AAC14495.1
CP002685 Genomic DNA Translation: AEC07841.1
BT011249 mRNA Translation: AAR92285.1
BT012549 mRNA Translation: AAS99693.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T00979

NCBI Reference Sequences

More...
RefSeqi
NP_180214.1, NM_128203.2

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G26460.1; AT2G26460.1; AT2G26460

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
817187

Gramene; a comparative resource for plants

More...
Gramenei
AT2G26460.1; AT2G26460.1; AT2G26460

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G26460

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002505 Genomic DNA Translation: AAC14495.1
CP002685 Genomic DNA Translation: AEC07841.1
BT011249 mRNA Translation: AAR92285.1
BT012549 mRNA Translation: AAS99693.1
PIRiT00979
RefSeqiNP_180214.1, NM_128203.2

3D structure databases

SMRiO48713
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi2539, 1 interactor
STRINGi3702.AT2G26460.1

PTM databases

iPTMnetiO48713

Proteomic databases

PaxDbiO48713
PRIDEiO48713
ProteomicsDBi234472

Genome annotation databases

EnsemblPlantsiAT2G26460.1; AT2G26460.1; AT2G26460
GeneIDi817187
GrameneiAT2G26460.1; AT2G26460.1; AT2G26460
KEGGiath:AT2G26460

Organism-specific databases

AraportiAT2G26460
TAIRilocus:2066221, AT2G26460

Phylogenomic databases

eggNOGiKOG2498, Eukaryota
HOGENOMiCLU_026814_1_0_1
InParanoidiO48713
OMAiPDMKSGI
OrthoDBi500537at2759
PhylomeDBiO48713

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O48713

Gene expression databases

ExpressionAtlasiO48713, baseline and differential
GenevisibleiO48713, AT

Family and domain databases

InterProiView protein in InterPro
IPR039896, Red-like
IPR012492, RED_C
IPR012916, RED_N
PANTHERiPTHR12765, PTHR12765, 1 hit
PfamiView protein in Pfam
PF07807, RED_C, 1 hit
PF07808, RED_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMU2_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O48713
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: June 1, 1998
Last modified: April 7, 2021
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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