Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peroxidase 6

Gene

PER6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei58Transition state stabilizerPROSITE-ProRule annotation1
Active sitei62Proton acceptorPROSITE-ProRule annotation1
Metal bindingi63Calcium 1PROSITE-ProRule annotation1
Metal bindingi66Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi68Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi70Calcium 1PROSITE-ProRule annotation1
Metal bindingi72Calcium 1PROSITE-ProRule annotation1
Metal bindingi190Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi191Calcium 2PROSITE-ProRule annotation1
Metal bindingi242Calcium 2PROSITE-ProRule annotation1
Metal bindingi245Calcium 2PROSITE-ProRule annotation1
Metal bindingi250Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT1G24110-MONOMER

Protein family/group databases

PeroxiBasei82 AtPrx06

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 6 (EC:1.11.1.7)
Short name:
Atperox P6
Gene namesi
Name:PER6
Synonyms:P6
Ordered Locus Names:At1g24110
ORF Names:F3I6.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G24110
TAIRilocus:2032392 AT1G24110

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002367221 – 326Peroxidase 6Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi31 ↔ 112PROSITE-ProRule annotation
Disulfide bondi64 ↔ 69PROSITE-ProRule annotation
Disulfide bondi118 ↔ 318PROSITE-ProRule annotation
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi197 ↔ 228PROSITE-ProRule annotation
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi230N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO48677

Expressioni

Gene expression databases

ExpressionAtlasiO48677 baseline and differential
GenevisibleiO48677 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G24110.1

Structurei

3D structure databases

ProteinModelPortaliO48677
SMRiO48677
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH5P Eukaryota
ENOG410YA7M LUCA
HOGENOMiHOG000237556
InParanoidiO48677
KOiK00430
OMAiNAEHSAD
OrthoDBiEOG09360HTJ
PhylomeDBiO48677

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O48677-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSFGLCLFI LVSSPCLLQA NLSSDYYTKT CPEFEETLVQ IVTDKQIAAP
60 70 80 90 100
TTAVGTLRLF FHDCMVDGCD ASILVASTPR KTSERDADIN RSLPGDAFDV
110 120 130 140 150
ITRIKTAVEL KCPNIVSCSD ILVGATRSLI SMVGGPRVNV KFGRKDSLVS
160 170 180 190 200
DMNRVEGKLA RPNMTMDHII SIFESSGLTV QEMVALVGAH TIGFSHCKEF
210 220 230 240 250
ASRIFNKSDQ NGPVEMNPKY AAELRKLCAN YTNDEQMSAF NDVFTPGKFD
260 270 280 290 300
NMYYKNLKHG YGLLQSDHAI AFDNRTRSLV DLYAEDETAF FDAFAKAMEK
310 320
VSEKNVKTGK LGEVRRRCDQ YNDYKG
Length:326
Mass (Da):36,253
Last modified:June 1, 1998 - v1
Checksum:i38363A08266EAEAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002396 Genomic DNA Translation: AAC00571.1
CP002684 Genomic DNA Translation: AEE30479.1
DQ056462 mRNA Translation: AAY78619.1
PIRiT00640
RefSeqiNP_173821.1, NM_102257.2
UniGeneiAt.51747

Genome annotation databases

EnsemblPlantsiAT1G24110.1; AT1G24110.1; AT1G24110
GeneIDi839023
GrameneiAT1G24110.1; AT1G24110.1; AT1G24110
KEGGiath:AT1G24110

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002396 Genomic DNA Translation: AAC00571.1
CP002684 Genomic DNA Translation: AEE30479.1
DQ056462 mRNA Translation: AAY78619.1
PIRiT00640
RefSeqiNP_173821.1, NM_102257.2
UniGeneiAt.51747

3D structure databases

ProteinModelPortaliO48677
SMRiO48677
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G24110.1

Protein family/group databases

PeroxiBasei82 AtPrx06

Proteomic databases

PaxDbiO48677

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G24110.1; AT1G24110.1; AT1G24110
GeneIDi839023
GrameneiAT1G24110.1; AT1G24110.1; AT1G24110
KEGGiath:AT1G24110

Organism-specific databases

AraportiAT1G24110
TAIRilocus:2032392 AT1G24110

Phylogenomic databases

eggNOGiENOG410IH5P Eukaryota
ENOG410YA7M LUCA
HOGENOMiHOG000237556
InParanoidiO48677
KOiK00430
OMAiNAEHSAD
OrthoDBiEOG09360HTJ
PhylomeDBiO48677

Enzyme and pathway databases

BioCyciARA:AT1G24110-MONOMER

Miscellaneous databases

PROiPR:O48677

Gene expression databases

ExpressionAtlasiO48677 baseline and differential
GenevisibleiO48677 AT

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPER6_ARATH
AccessioniPrimary (citable) accession number: O48677
Secondary accession number(s): Q4PT24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: June 1, 1998
Last modified: October 10, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again