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Protein

Squalene monooxygenase

Gene
N/A
Organism
Panax ginseng (Korean ginseng)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.By similarity

Catalytic activityi

Squalene + [reduced NADPH--hemoprotein reductase] + O2 = (3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH--hemoprotein reductase] + H2O.By similarity

Cofactori

Pathwayi: lanosterol biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes lanosterol from farnesyl diphosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Squalene monooxygenase
  3. no protein annotated in this organism
This subpathway is part of the pathway lanosterol biosynthesis, which is itself part of Terpene metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lanosterol from farnesyl diphosphate, the pathway lanosterol biosynthesis and in Terpene metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi77 – 104FADSequence analysisAdd BLAST28

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayi
UPA00767;UER00752

Names & Taxonomyi

Protein namesi
Recommended name:
Squalene monooxygenase (EC:1.14.14.17By similarity)
Alternative name(s):
Squalene epoxidase
Short name:
SE
OrganismiPanax ginseng (Korean ginseng)
Taxonomic identifieri4054 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridscampanulidsApialesAraliaceaePanax

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002098461 – 539Squalene monooxygenaseAdd BLAST539

Structurei

3D structure databases

ProteinModelPortaliO48651
SMRiO48651
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the squalene monooxygenase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR013698 Squalene_epoxidase
PfamiView protein in Pfam
PF08491 SE, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits

Sequencei

Sequence statusi: Complete.

O48651-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSSSSTTTT DTLHSFMEAS ALLIDQYFLG WIFAFLFGFL LLLNFKRKRE
60 70 80 90 100
KNNSTEFGTD DSNGYYTPEN IAGSTDVIIV GAGVAGSALA YTLANDGRRV
110 120 130 140 150
HVIERDLTEQ DRIVGELLQP GGYLKLIELG LEDCVNEIDA QRVFGYALYM
160 170 180 190 200
DGKNTRLSYP LEKFHSDVAG RSFHNGRFVQ RMREKAASLP NVRMEQGTVT
210 220 230 240 250
SLVEKKGSVK GVQYKTKDGQ ELSAFAPLTI VCDGCFSNLR RSLCNPKVEV
260 270 280 290 300
PSCFVGLILE NIDLPHINHG HVILADPSPI LFYKISSTEI RCLVDVPGQK
310 320 330 340 350
VPCISNGELA NYLKTVVAPQ VPKQLYNSFI AAVDKGNIRT MPNRSMPADP
360 370 380 390 400
HPTPGALLLG DAFNMRHPLT GGGMTVALSD IVLIRDLLRP LRDLHDSSTL
410 420 430 440 450
CKYLESFYTL RKPVASTINT LAGALYKVFC ASPDKARQEM RNACFDYLSL
460 470 480 490 500
GGICSQGPIA LLSGLNPRPI SLFLHFFAVA IYGVGRLLIP FPSPKRMWLG
510 520 530
ARLILGASGI IFPIIKSEGL RQMFFPAIVP AYYRAPPIH
Length:539
Mass (Da):59,375
Last modified:June 1, 1998 - v1
Checksum:i84AC3547EB591502
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003516 mRNA Translation: BAA24448.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003516 mRNA Translation: BAA24448.1

3D structure databases

ProteinModelPortaliO48651
SMRiO48651
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00767;UER00752

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR013698 Squalene_epoxidase
PfamiView protein in Pfam
PF08491 SE, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiERG1_PANGI
AccessioniPrimary (citable) accession number: O48651
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: February 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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